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High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration.

Walker JN, Flores-Mireles AL, Lynch AJL, Pinkner C, Caparon MG, Hultgren SJ, Desai A.

World J Urol. 2019 Dec 2. doi: 10.1007/s00345-019-03027-8. [Epub ahead of print]


Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.

Yu L, O'Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson ED, Hultgren SJ, Hannan TJ.

Elife. 2019 Aug 20;8. pii: e46677. doi: 10.7554/eLife.46677.


Glutathione Synthesis Contributes to Virulence of Streptococcus agalactiae in a Murine Model of Sepsis.

Walker EA, Port GC, Caparon MG, Janowiak BE.

J Bacteriol. 2019 Sep 20;201(20). pii: e00367-19. doi: 10.1128/JB.00367-19. Print 2019 Oct 15.


CcpA Coordinates Growth/Damage Balance for Streptococcus pyogenes Pathogenesis.

Paluscio E, Watson ME Jr, Caparon MG.

Sci Rep. 2018 Sep 24;8(1):14254. doi: 10.1038/s41598-018-32558-0.


Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.

Xu W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG.

NPJ Biofilms Microbiomes. 2017 Nov 6;3:28. doi: 10.1038/s41522-017-0036-z. eCollection 2017.


Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.

Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL 4th, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8721-E8730. doi: 10.1073/pnas.1707572114. Epub 2017 Sep 25.


Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.

Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M.

Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3.


SpxA1 and SpxA2 Act Coordinately To Fine-Tune Stress Responses and Virulence in Streptococcus pyogenes.

Port GC, Cusumano ZT, Tumminello PR, Caparon MG.

mBio. 2017 Mar 28;8(2). pii: e00288-17. doi: 10.1128/mBio.00288-17.


Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections.

Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG.

mBio. 2016 Oct 25;7(5). pii: e01653-16. doi: 10.1128/mBio.01653-16.


Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.

Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon MG, Walker MJ, Watson ME, Ulett GC.

Sci Rep. 2016 May 31;6:26836. doi: 10.1038/srep26836.


Animal Models of Streptococcus pyogenes Infection.

Watson ME Jr., Neely MN, Caparon MG.

In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes : Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016-.
2016 Feb 10.


Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.

Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A.

J Urol. 2016 Aug;196(2):416-421. doi: 10.1016/j.juro.2016.01.100. Epub 2016 Jan 28.


Complete Genome Sequences of emm6 Streptococcus pyogenes JRS4 and Parental Strain D471.

Port GC, Paluscio E, Caparon MG.

Genome Announc. 2015 Jul 2;3(4). pii: e00725-15. doi: 10.1128/genomeA.00725-15.


Dual modes of membrane binding direct pore formation by Streptolysin O.

Mozola CC, Caparon MG.

Mol Microbiol. 2015 Sep;97(6):1036-50. doi: 10.1111/mmi.13085. Epub 2015 Jul 4.


The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release.

Chandrasekaran S, Caparon MG.

Cell Microbiol. 2015 Sep;17(9):1376-90. doi: 10.1111/cmi.12442. Epub 2015 Apr 28.


Citrulline protects Streptococcus pyogenes from acid stress using the arginine deiminase pathway and the F1Fo-ATPase.

Cusumano ZT, Caparon MG.

J Bacteriol. 2015 Apr;197(7):1288-96. doi: 10.1128/JB.02517-14. Epub 2015 Feb 2.


Streptococcus pyogenes malate degradation pathway links pH regulation and virulence.

Paluscio E, Caparon MG.

Infect Immun. 2015 Mar;83(3):1162-71. doi: 10.1128/IAI.02814-14. Epub 2015 Jan 12.


EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.

Flores-Mireles AL, Pinkner JS, Caparon MG, Hultgren SJ.

Sci Transl Med. 2014 Sep 17;6(254):254ra127. doi: 10.1126/scitranslmed.3009384.


A novel cholesterol-insensitive mode of membrane binding promotes cytolysin-mediated translocation by Streptolysin O.

Mozola CC, Magassa N, Caparon MG.

Mol Microbiol. 2014 Nov;94(3):675-87. doi: 10.1111/mmi.12786. Epub 2014 Sep 23.


Streptococcus pyogenes polymyxin B-resistant mutants display enhanced ExPortal integrity.

Port GC, Vega LA, Nylander AB, Caparon MG.

J Bacteriol. 2014 Jul;196(14):2563-77. doi: 10.1128/JB.01596-14. Epub 2014 May 2.


Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

Kandaswamy K, Liew TH, Wang CY, Huston-Warren E, Meyer-Hoffert U, Hultenby K, Schröder JM, Caparon MG, Normark S, Henriques-Normark B, Hultgren SJ, Kline KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20230-5. doi: 10.1073/pnas.1319066110. Epub 2013 Nov 4.


Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity.

Cusumano ZT, Watson ME Jr, Caparon MG.

Infect Immun. 2014 Jan;82(1):233-42. doi: 10.1128/IAI.00916-13. Epub 2013 Oct 21.


An association between peptidoglycan synthesis and organization of the Streptococcus pyogenes ExPortal.

Vega LA, Port GC, Caparon MG.

mBio. 2013 Sep 24;4(5):e00485-13. doi: 10.1128/mBio.00485-13.


Complete Genome Sequence of emm Type 14 Streptococcus pyogenes Strain HSC5.

Port GC, Paluscio E, Caparon MG.

Genome Announc. 2013 Aug 15;1(4). pii: e00612-13. doi: 10.1128/genomeA.00612-13.


Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

J Bacteriol. 2013 Oct;195(19):4484-95. doi: 10.1128/JB.00451-13. Epub 2013 Aug 2.


Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the Streptococcus pyogenes NAD+ glycohydrolase.

Chandrasekaran S, Ghosh J, Port GC, Koh EI, Caparon MG.

J Biol Chem. 2013 Jul 5;288(27):20064-75. doi: 10.1074/jbc.M113.481556. Epub 2013 May 20.


Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes.

Watson ME Jr, Nielsen HV, Hultgren SJ, Caparon MG.

Infect Immun. 2013 May;81(5):1606-17. doi: 10.1128/IAI.00021-13. Epub 2013 Mar 4.


Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.

Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ.

Infect Immun. 2013 Jan;81(1):329-39. doi: 10.1128/IAI.00856-12. Epub 2012 Nov 6.


The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

mBio. 2012 Jul 24;3(4):e00177-12. doi: 10.1128/mBio.00177-12. Print 2012.


Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal.

Vega LA, Caparon MG.

Mol Microbiol. 2012 Sep;85(6):1119-32. doi: 10.1111/j.1365-2958.2012.08163.x. Epub 2012 Jul 26.


Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ.

Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45. doi: 10.1128/AAC.00447-12. Epub 2012 Jun 25.


Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes.

Sperry JB, Smith CL, Caparon MG, Ellenberger T, Gross ML.

Biochemistry. 2011 May 17;50(19):4038-45. doi: 10.1021/bi200244k. Epub 2011 Apr 19.


Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.

Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T.

Structure. 2011 Feb 9;19(2):192-202. doi: 10.1016/j.str.2010.12.013.


Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection.

Kietzman CC, Caparon MG.

Infect Immun. 2011 Feb;79(2):812-21. doi: 10.1128/IAI.01026-10. Epub 2010 Nov 22.


Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections.

Guiton PS, Hung CS, Hancock LE, Caparon MG, Hultgren SJ.

Infect Immun. 2010 Oct;78(10):4166-75. doi: 10.1128/IAI.00711-10. Epub 2010 Aug 9.


Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.

Riddle DJ, Bessen DE, Caparon MG.

J Bacteriol. 2010 Jul;192(14):3735-46. doi: 10.1128/JB.00234-10. Epub 2010 May 21.


A tale of two pili: assembly and function of pili in bacteria.

Kline KA, Dodson KW, Caparon MG, Hultgren SJ.

Trends Microbiol. 2010 May;18(5):224-32. doi: 10.1016/j.tim.2010.03.002. Epub 2010 Apr 8. Review.


Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O.

Magassa N, Chandrasekaran S, Caparon MG.

EMBO Rep. 2010 May;11(5):400-5. doi: 10.1038/embor.2010.37. Epub 2010 Mar 26.


Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.

Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ.

Infect Immun. 2010 May;78(5):1943-51. doi: 10.1128/IAI.01235-09. Epub 2010 Feb 22.


Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis.

Ghosh J, Anderson PJ, Chandrasekaran S, Caparon MG.

J Biol Chem. 2010 Feb 19;285(8):5683-94. doi: 10.1074/jbc.M109.070300. Epub 2009 Dec 15.


CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.

Kietzman CC, Caparon MG.

Infect Immun. 2010 Jan;78(1):241-52. doi: 10.1128/IAI.00746-09. Epub 2009 Oct 19.


Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection.

Lin A, Loughman JA, Zinselmeyer BH, Miller MJ, Caparon MG.

Infect Immun. 2009 Nov;77(11):5190-201. doi: 10.1128/IAI.00420-09. Epub 2009 Aug 17.


Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development.

Guiton PS, Hung CS, Kline KA, Roth R, Kau AL, Hayes E, Heuser J, Dodson KW, Caparon MG, Hultgren SJ.

Infect Immun. 2009 Sep;77(9):3626-38. doi: 10.1128/IAI.00219-09. Epub 2009 Jun 15.


The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence.

Weston BF, Brenot A, Caparon MG.

Infect Immun. 2009 Jul;77(7):2840-8. doi: 10.1128/IAI.01299-08. Epub 2009 Apr 27.


Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.

Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ.

J Bacteriol. 2009 May;191(10):3237-47. doi: 10.1128/JB.01837-08. Epub 2009 Mar 13.


tRNA modification by GidA/MnmE is necessary for Streptococcus pyogenes virulence: a new strategy to make live attenuated strains.

Cho KH, Caparon MG.

Infect Immun. 2008 Jul;76(7):3176-86. doi: 10.1128/IAI.01721-07. Epub 2008 Apr 21.


The signal recognition particle pathway is required for virulence in Streptococcus pyogenes.

Rosch JW, Vega LA, Beyer JM, Lin A, Caparon MG.

Infect Immun. 2008 Jun;76(6):2612-9. doi: 10.1128/IAI.00239-07. Epub 2008 Apr 14.


Role of group A Streptococcus HtrA in the maturation of SpeB protease.

Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ.

Proteomics. 2007 Dec;7(24):4488-98.


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