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Items: 26


Indoles from commensal bacteria extend healthspan.

Sonowal R, Swimm A, Sahoo A, Luo L, Matsunaga Y, Wu Z, Bhingarde JA, Ejzak EA, Ranawade A, Qadota H, Powell DN, Capaldo CT, Flacker JM, Jones RM, Benian GM, Kalman D.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7506-E7515. doi: 10.1073/pnas.1706464114. Epub 2017 Aug 21.


Layered defense: how mucus and tight junctions seal the intestinal barrier.

Capaldo CT, Powell DN, Kalman D.

J Mol Med (Berl). 2017 Sep;95(9):927-934. doi: 10.1007/s00109-017-1557-x. Epub 2017 Jul 13. Review.


Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades.

Lili LN, Farkas AE, Gerner-Smidt C, Overgaard CE, Moreno CS, Parkos CA, Capaldo CT, Nusrat A.

Tissue Barriers. 2016 Jul 19;4(3):e1214038. doi: 10.1080/21688370.2016.1214038. eCollection 2016 Jul-Sep.


Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions.

Schlingmann B, Overgaard CE, Molina SA, Lynn KS, Mitchell LA, Dorsainvil White S, Mattheyses AL, Guidot DM, Capaldo CT, Koval M.

Nat Commun. 2016 Jul 25;7:12276. doi: 10.1038/ncomms12276.


Cryosectioning Method for Microdissection of Murine Colonic Mucosa.

Farkas AE, Gerner-Smidt C, Lili L, Nusrat A, Capaldo CT.

J Vis Exp. 2015 Jul 12;(101):e53112. doi: 10.3791/53112.


HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.

Am J Pathol. 2015 Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023.


Claudin switching: Physiological plasticity of the Tight Junction.

Capaldo CT, Nusrat A.

Semin Cell Dev Biol. 2015 Jun;42:22-9. doi: 10.1016/j.semcdb.2015.04.003. Epub 2015 May 7. Review.


Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins.

Capaldo CT, Farkas AE, Hilgarth RS, Krug SM, Wolf MF, Benedik JK, Fromm M, Koval M, Parkos C, Nusrat A.

Mol Biol Cell. 2014 Sep 15;25(18):2710-9. doi: 10.1091/mbc.E14-02-0773. Epub 2014 Jul 16.


Epithelial adhesive junctions.

Capaldo CT, Farkas AE, Nusrat A.

F1000Prime Rep. 2014 Jan 2;6:1. doi: 10.12703/P6-1. eCollection 2014. Review.


Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation.

Koch S, Capaldo CT, Hilgarth RS, Fournier B, Parkos CA, Nusrat A.

Mucosal Immunol. 2013 Jan;6(1):136-45. doi: 10.1038/mi.2012.57. Epub 2012 Jul 4.


Regulation of epithelial proliferation by tight junction proteins.

Farkas AE, Capaldo CT, Nusrat A.

Ann N Y Acad Sci. 2012 Jul;1258:115-24. doi: 10.1111/j.1749-6632.2012.06556.x.


IFN-γ and TNF-α-induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling.

Capaldo CT, Beeman N, Hilgarth RS, Nava P, Louis NA, Naschberger E, Stürzl M, Parkos CA, Nusrat A.

Mucosal Immunol. 2012 Nov;5(6):681-90. doi: 10.1038/mi.2012.41. Epub 2012 Jun 13.


Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.

Capaldo CT, Koch S, Kwon M, Laur O, Parkos CA, Nusrat A.

Mol Biol Cell. 2011 May 15;22(10):1677-85. doi: 10.1091/mbc.E10-08-0677. Epub 2011 Mar 16.


JAM-A regulates epithelial proliferation through Akt/β-catenin signalling.

Nava P, Capaldo CT, Koch S, Kolegraff K, Rankin CR, Farkas AE, Feasel ME, Li L, Addis C, Parkos CA, Nusrat A.

EMBO Rep. 2011 Apr;12(4):314-20. doi: 10.1038/embor.2011.16. Epub 2011 Mar 4.


Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways.

Nava P, Koch S, Laukoetter MG, Lee WY, Kolegraff K, Capaldo CT, Beeman N, Addis C, Gerner-Smidt K, Neumaier I, Skerra A, Li L, Parkos CA, Nusrat A.

Immunity. 2010 Mar 26;32(3):392-402. doi: 10.1016/j.immuni.2010.03.001. Epub 2010 Mar 18.


Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium.

Ivanov AI, Young C, Den Beste K, Capaldo CT, Humbert PO, Brennwald P, Parkos CA, Nusrat A.

Am J Pathol. 2010 Jan;176(1):134-45. doi: 10.2353/ajpath.2010.090220. Epub 2009 Dec 3.


Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells.

Koch S, Capaldo CT, Samarin S, Nava P, Neumaier I, Skerra A, Sacks DB, Parkos CA, Nusrat A.

Mol Biol Cell. 2009 Nov;20(22):4816-25. doi: 10.1091/mbc.E09-05-0415. Epub 2009 Sep 23.


Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration.

Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA.

Mol Biol Cell. 2009 Apr;20(7):1916-25. doi: 10.1091/mbc.E08-10-1014. Epub 2009 Jan 28.


Cytokine regulation of tight junctions.

Capaldo CT, Nusrat A.

Biochim Biophys Acta. 2009 Apr;1788(4):864-71. doi: 10.1016/j.bbamem.2008.08.027. Epub 2008 Oct 8. Review.


Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.

Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA, Nusrat A.

J Immunol. 2008 Oct 1;181(7):5035-44.


JAM-A regulates permeability and inflammation in the intestine in vivo.

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, Dermody TS, Nusrat A, Parkos CA.

J Exp Med. 2007 Dec 24;204(13):3067-76. Epub 2007 Nov 26.


Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.

McNeil E, Capaldo CT, Macara IG.

Mol Biol Cell. 2006 Apr;17(4):1922-32. Epub 2006 Jan 25.


Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.

Garrard SM, Capaldo CT, Gao L, Rosen MK, Macara IG, Tomchick DR.

EMBO J. 2003 Mar 3;22(5):1125-33.


Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.

Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham RT, Lawrence JC Jr.

J Biol Chem. 2000 Oct 27;275(43):33836-43.

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