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Items: 1 to 50 of 238

1.

A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells.

Li N, Oquendo E, Capaldi RA, Robinson JP, He YD, Hamadeh HK, Afshari CA, Lightfoot-Dunn R, Narayanan PK.

Toxicol Sci. 2014 Nov;142(1):261-73. doi: 10.1093/toxsci/kfu176. Epub 2014 Aug 27.

PMID:
25163676
2.

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J.

J Cell Biol. 2014 Mar 31;204(7):1083-6. doi: 10.1083/jcb.201401006.

3.

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.

Li Q, Vande Velde C, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland DW, Miller TM.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21146-51. doi: 10.1073/pnas.1014862107. Epub 2010 Nov 15.

4.

Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction.

Marusich MF, Murray J, Xie J, Capaldi RA.

Int J Biochem Cell Biol. 2009 Oct;41(10):2081-8. doi: 10.1016/j.biocel.2009.05.009. Epub 2009 May 19. Review.

PMID:
19460456
5.

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis.

Nadanaciva S, Willis JH, Barker ML, Gharaibeh D, Capaldi RA, Marusich MF, Will Y.

J Immunol Methods. 2009 Mar 31;343(1):1-12. doi: 10.1016/j.jim.2008.12.002. Epub 2009 Jan 17.

PMID:
19152798
6.

Screening for the metabolic basis of neurodegeneration: developing a focused proteomic approach.

Murray J, Capaldi RA.

Ann N Y Acad Sci. 2008 Dec;1147:348-57. doi: 10.1196/annals.1427.025. Review.

PMID:
19076456
7.

Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays.

Willis JH, Capaldi RA, Huigsloot M, Rodenburg RJ, Smeitink J, Marusich MF.

Biochim Biophys Acta. 2009 May;1787(5):533-8. doi: 10.1016/j.bbabio.2008.10.009. Epub 2008 Nov 10.

8.

Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status.

Shikuma CM, Gerschenson M, Chow D, Libutti DE, Willis JH, Murray J, Capaldi RA, Marusich M.

AIDS Res Hum Retroviruses. 2008 Oct;24(10):1255-62. doi: 10.1089/aid.2007.0262.

9.

Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress.

Murray J, Oquendo CE, Willis JH, Marusich MF, Capaldi RA.

Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1497-503. doi: 10.1016/j.addr.2008.05.003. Epub 2008 Jul 4. Review.

PMID:
18647628
10.

Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers.

Willis JH, Isaya G, Gakh O, Capaldi RA, Marusich MF.

Mol Genet Metab. 2008 Aug;94(4):491-7. doi: 10.1016/j.ymgme.2008.03.019. Epub 2008 May 15.

11.

Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model.

Baden KN, Murray J, Capaldi RA, Guillemin K.

J Biol Chem. 2007 Nov 30;282(48):34839-49. Epub 2007 Aug 30.

12.

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.

Nadanaciva S, Dykens JA, Bernal A, Capaldi RA, Will Y.

Toxicol Appl Pharmacol. 2007 Sep 15;223(3):277-87. Epub 2007 Jun 21.

PMID:
17658574
13.
14.

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.

Chi SL, Wahl ML, Mowery YM, Shan S, Mukhopadhyay S, Hilderbrand SC, Kenan DJ, Lipes BD, Johnson CE, Marusich MF, Capaldi RA, Dewhirst MW, Pizzo SV.

Cancer Res. 2007 May 15;67(10):4716-24.

15.

Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount.

Murray J, Schilling B, Row RH, Yoo CB, Gibson BW, Marusich MF, Capaldi RA.

Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78.

PMID:
17508937
17.
18.

Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis.

Hagiwara M, Yamagata K, Capaldi RA, Koyama A.

Kidney Int. 2006 Apr;69(7):1146-52.

19.

Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria.

Schilling B, Murray J, Yoo CB, Row RH, Cusack MP, Capaldi RA, Gibson BW.

Biochim Biophys Acta. 2006 Feb;1762(2):213-22. Epub 2005 Aug 3.

20.

Immunological approaches to the characterization and diagnosis of mitochondrial disease.

Capaldi RA, Murray J, Byrne L, Janes MS, Marusich MF.

Mitochondrion. 2004 Sep;4(5-6):417-26. Epub 2004 Oct 1.

PMID:
16120403
21.

Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines.

Margineantu DH, Gregory Cox W, Sundell L, Sherwood SW, Beechem JM, Capaldi RA.

Mitochondrion. 2002 May;1(5):425-35.

PMID:
16120295
22.

Heterogeneous distribution of pyruvate dehydrogenase in the matrix of mitochondria.

Margineantu DH, Brown RM, Brown GK, Marcus AH, Capaldi RA.

Mitochondrion. 2002 Feb;1(4):327-38.

PMID:
16120287
23.

Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases.

Hanson BJ, Marusich MF, Capaldi RA.

Mitochondrion. 2001 Oct;1(3):237-48.

PMID:
16120281
24.

Mass spectrometric identification of a novel phosphorylation site in subunit NDUFA10 of bovine mitochondrial complex I.

Schilling B, Aggeler R, Schulenberg B, Murray J, Row RH, Capaldi RA, Gibson BW.

FEBS Lett. 2005 Apr 25;579(11):2485-90.

25.

Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

Schilling B, Bharath M M S, Row RH, Murray J, Cusack MP, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW.

Mol Cell Proteomics. 2005 Jan;4(1):84-96. Epub 2004 Dec 10.

26.

Focused proteomics: towards a high throughput monoclonal antibody-based resolution of proteins for diagnosis of mitochondrial diseases.

Murray J, Yonally S, Aggeler R, Marusich MF, Capaldi RA.

Biochim Biophys Acta. 2004 Dec 6;1659(2-3):206-11.

27.

An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.

Burwick NR, Wahl ML, Fang J, Zhong Z, Moser TL, Li B, Capaldi RA, Kenan DJ, Pizzo SV.

J Biol Chem. 2005 Jan 21;280(3):1740-5. Epub 2004 Nov 4.

28.

Characterization of dynamic and steady-state protein phosphorylation using a fluorescent phosphoprotein gel stain and mass spectrometry.

Schulenberg B, Goodman TN, Aggeler R, Capaldi RA, Patton WF.

Electrophoresis. 2004 Aug;25(15):2526-32.

PMID:
15300772
30.

Rapid analysis of mitochondrial DNA depletion by fluorescence in situ hybridization and immunocytochemistry: potential strategies for HIV therapeutic monitoring.

Janes MS, Hanson BJ, Hill DM, Buller GM, Agnew JY, Sherwood SW, Cox WG, Yamagata K, Capaldi RA.

J Histochem Cytochem. 2004 Aug;52(8):1011-8.

PMID:
15258176
31.

Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells.

Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA.

Cancer Res. 2004 Feb 1;64(3):985-93.

32.

Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators.

Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ.

J Biol Chem. 2004 Mar 26;279(13):13044-53. Epub 2004 Jan 13.

33.

Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.

Murray J, Taylor SW, Zhang B, Ghosh SS, Capaldi RA.

J Biol Chem. 2003 Sep 26;278(39):37223-30. Epub 2003 Jul 11.

34.

The cristal membrane of mitochondria is the principal site of oxidative phosphorylation.

Gilkerson RW, Selker JM, Capaldi RA.

FEBS Lett. 2003 Jul 10;546(2-3):355-8.

35.

Analysis of steady-state protein phosphorylation in mitochondria using a novel fluorescent phosphosensor dye.

Schulenberg B, Aggeler R, Beechem JM, Capaldi RA, Patton WF.

J Biol Chem. 2003 Jul 18;278(29):27251-5. Epub 2003 May 20.

36.

Oxidative post-translational modification of tryptophan residues in cardiac mitochondrial proteins.

Taylor SW, Fahy E, Murray J, Capaldi RA, Ghosh SS.

J Biol Chem. 2003 May 30;278(22):19587-90. Epub 2003 Apr 4.

37.

An alternative strategy to determine the mitochondrial proteome using sucrose gradient fractionation and 1D PAGE on highly purified human heart mitochondria.

Taylor SW, Warnock DE, Glenn GM, Zhang B, Fahy E, Gaucher SP, Capaldi RA, Gibson BW, Ghosh SS.

J Proteome Res. 2002 Sep-Oct;1(5):451-8.

PMID:
12645917
38.

Immunocapture and microplate-based activity measurement of mammalian pyruvate dehydrogenase complex.

Lib M, Rodriguez-Mari A, Marusich MF, Capaldi RA.

Anal Biochem. 2003 Mar 1;314(1):121-7.

PMID:
12633610
39.

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF, Ghosh SS, Capaldi RA.

J Biol Chem. 2003 Apr 18;278(16):13619-22. Epub 2003 Feb 28.

40.

Characterization of the human heart mitochondrial proteome.

Taylor SW, Fahy E, Zhang B, Glenn GM, Warnock DE, Wiley S, Murphy AN, Gaucher SP, Capaldi RA, Gibson BW, Ghosh SS.

Nat Biotechnol. 2003 Mar;21(3):281-6. Epub 2003 Feb 18.

PMID:
12592411
41.

Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells.

Knowles MK, Guenza MG, Capaldi RA, Marcus AH.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14772-7. Epub 2002 Nov 4.

43.

An immunocytochemical approach to detection of mitochondrial disorders.

Hanson BJ, Capaldi RA, Marusich MF, Sherwood SW.

J Histochem Cytochem. 2002 Oct;50(10):1281-8.

PMID:
12364561
44.

A replicating module as the unit of mitochondrial structure and functioning.

Capaldi RA, Aggeler R, Gilkerson R, Hanson G, Knowles M, Marcus A, Margineantu D, Marusich M, Murray J, Oglesbee D, Remington SJ, Rossignol R.

Biochim Biophys Acta. 2002 Sep 10;1555(1-3):192-5.

45.

A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies.

Aggeler R, Coons J, Taylor SW, Ghosh SS, Garcia JJ, Capaldi RA, Marusich MF.

J Biol Chem. 2002 Sep 13;277(37):33906-12. Epub 2002 Jul 10.

46.

Detection of pyruvate dehydrogenase E1 alpha-subunit deficiencies in females by immunohistochemical demonstration of mosaicism in cultured fibroblasts.

Lib MY, Brown RM, Brown GK, Marusich MF, Capaldi RA.

J Histochem Cytochem. 2002 Jul;50(7):877-84.

PMID:
12070266
47.

Mechanism of the F(1)F(0)-type ATP synthase, a biological rotary motor.

Capaldi RA, Aggeler R.

Trends Biochem Sci. 2002 Mar;27(3):154-60. Review.

PMID:
11893513
48.

The conformation of the epsilon- and gamma-subunits within the Escherichia coli F(1) ATPase.

Hausrath AC, Capaldi RA, Matthews BW.

J Biol Chem. 2001 Dec 14;276(50):47227-32. Epub 2001 Oct 3.

49.

Large conformational changes of the epsilon subunit in the bacterial F1F0 ATP synthase provide a ratchet action to regulate this rotary motor enzyme.

Tsunoda SP, Rodgers AJ, Aggeler R, Wilce MC, Yoshida M, Capaldi RA.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6560-4. Epub 2001 May 29.

50.

A novel mtDNA mutation in the ATPase6 gene studied by E. coli modeling.

Carrozzo R, Murray J, Capuano O, Tessa A, Chichierchia G, Neglia MR, Capaldi RA, Santorelli FM.

Neurol Sci. 2000;21(5 Suppl):S983-4.

PMID:
11382202

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