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Items: 39


CRISPResso2 provides accurate and rapid genome editing sequence analysis.

Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L.

Nat Biotechnol. 2019 Mar;37(3):224-226. doi: 10.1038/s41587-019-0032-3. No abstract available.


Improved Performance of a Rapid Immunochromatographic Assay for the Detection of PBP2a in non-Staphylococcus aureus Staphylococcal Species.

Canver MC, Gonzalez MD, Ford BA, Arnold AR, Lawhon SD, Burnham CA, Jenkins SG, Burd EM, Westblade LF.

J Clin Microbiol. 2019 Jan 16. pii: JCM.01417-18. doi: 10.1128/JCM.01417-18. [Epub ahead of print]


CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.

Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L.

Nat Methods. 2018 Dec;15(12):992-993. doi: 10.1038/s41592-018-0225-6. No abstract available.


DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways, and protein complexes from CRISPR screens.

Canver MC, Bauer DE, Maeda T, Pinello L.

Bioinformatics. 2018 Nov 5. doi: 10.1093/bioinformatics/bty913. [Epub ahead of print]


CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis.

Schoonenberg VAC, Cole MA, Yao Q, Macias-Treviño C, Sher F, Schupp PG, Canver MC, Maeda T, Pinello L, Bauer DE.

Genome Biol. 2018 Oct 19;19(1):169. doi: 10.1186/s13059-018-1563-5.


Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

MacLean GA, McEldoon J, Huang J, Allred J, Canver MC, Orkin SH.

Sci Rep. 2018 May 22;8(1):8001. doi: 10.1038/s41598-018-26123-y.


Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12.


Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.

Cancer Cell. 2018 Mar 12;33(3):386-400.e5. doi: 10.1016/j.ccell.2018.01.012. Epub 2018 Feb 22.


Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, Canver MC.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11257-E11266. doi: 10.1073/pnas.1714640114. Epub 2017 Dec 11.


High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.

Montalbano A, Canver MC, Sanjana NE.

Mol Cell. 2017 Oct 5;68(1):44-59. doi: 10.1016/j.molcel.2017.09.017. Review.


Functional interrogation of non-coding DNA through CRISPR genome editing.

Canver MC, Bauer DE, Orkin SH.

Methods. 2017 May 15;121-122:118-129. doi: 10.1016/j.ymeth.2017.03.008. Epub 2017 Mar 10. Review.


Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH.

Nat Genet. 2017 Apr;49(4):625-634. doi: 10.1038/ng.3793. Epub 2017 Feb 20.


Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. No abstract available.


Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA.

J Clin Invest. 2016 Oct 3;126(10):3868-3878. doi: 10.1172/JCI87885. Epub 2016 Sep 6.


Analyzing CRISPR genome-editing experiments with CRISPResso.

Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, Yuan GC.

Nat Biotechnol. 2016 Jul 12;34(7):695-7. doi: 10.1038/nbt.3583. No abstract available.


Interferon-α signaling promotes embryonic HSC maturation.

Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ.

Blood. 2016 Jul 14;128(2):204-16. doi: 10.1182/blood-2016-01-689281. Epub 2016 Apr 19.


Customizing the genome as therapy for the β-hemoglobinopathies.

Canver MC, Orkin SH.

Blood. 2016 May 26;127(21):2536-45. doi: 10.1182/blood-2016-01-678128. Epub 2016 Apr 6. Review.


Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.


BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.

Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16.


EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL.

Blood. 2015 Oct 15;126(16):1930-9. doi: 10.1182/blood-2015-06-649087. Epub 2015 Aug 28.


PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.

Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH.

Cell Rep. 2015 Sep 1;12(9):1456-70. doi: 10.1016/j.celrep.2015.07.053. Epub 2015 Aug 20.


miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA.

Mol Ther. 2015 Sep;23(9):1465-74. doi: 10.1038/mt.2015.113. Epub 2015 Jun 17.


Embryonic stem cells as sources of donor-independent platelets.

Canver MC, Bauer DE, Orkin SH.

J Clin Invest. 2015 Jun;125(6):2261-3. doi: 10.1172/JCI82348. Epub 2015 May 11.


Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.

Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, Bernstein ID, Aster JC, White RM, Zon LI.

Elife. 2015 Feb 25;4. doi: 10.7554/eLife.05544.


Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9.

Bauer DE, Canver MC, Orkin SH.

J Vis Exp. 2015 Jan 3;(95):e52118. doi: 10.3791/52118.


Triple threat.

Canver MC.

IEEE Pulse. 2014 Jan-Feb;5(1):9-10. No abstract available.


The Match Day that could have been.

Canver MC.

IEEE Pulse. 2014 Jul-Aug;5(4):6, 9. No abstract available.


Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2014 Aug 1;289(31):21312-24. doi: 10.1074/jbc.M114.564625. Epub 2014 Jun 6. Erratum in: J Biol Chem. 2017 Feb 10;292(6):2556.


The figure one problem.

Canver MC.

IEEE Pulse. 2014 Mar-Apr;5(2):7. No abstract available.


Novel mathematical algorithm for pupillometric data analysis.

Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC.

Comput Methods Programs Biomed. 2014;113(1):221-5. doi: 10.1016/j.cmpb.2013.08.008. Epub 2013 Sep 13.


An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH.

Science. 2013 Oct 11;342(6155):253-7. doi: 10.1126/science.1242088.


Risk versus reward.

Canver MC.

IEEE Pulse. 2013 Mar-Apr;4(2):8-9. No abstract available.


Graduate school: the problem of choice.

Canver MC.

IEEE Pulse. 2012 Jul;3(4):8, 10. No abstract available.


Transitioning to a physician scientist.

Canver MC.

IEEE Pulse. 2012 May-Jun;3(3):10, 12. No abstract available.


Second preclinical year [perspectives on graduate life].

Canver MC.

IEEE Pulse. 2012 Mar;3(2):7-8. No abstract available.


The last summer of your life.

Canver MC.

IEEE Pulse. 2011 Nov;2(6):10. No abstract available.


The end of the first year.

Canver MC.

IEEE Pulse. 2011 Sep-Oct;2(5):11. No abstract available.


Medicine and memorization.

Canver MC.

IEEE Pulse. 2011 Mar-Apr;2(2):9-10. No abstract available.


Histamine H1 and H2 receptor-mediated vasoreactivity of human internal thoracic and radial arteries.

Daneshmand MA, Keller RS, Canver MC, Canver AC, Canver CC.

Surgery. 2004 Aug;136(2):458-63.


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