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Items: 1 to 50 of 199

1.

Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite.

Cerioni L, Guidarelli A, Fiorani M, Cantoni O.

Front Pharmacol. 2019 Jul 12;10:781. doi: 10.3389/fphar.2019.00781. eCollection 2019.

2.
3.

Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2.

Guidarelli A, Fiorani M, Cantoni O.

J Pharmacol Exp Ther. 2018 Oct;367(1):184-193. doi: 10.1124/jpet.118.250480. Epub 2018 Aug 1.

PMID:
30068729
4.

Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid.

Scotti M, Fiorani M, Guidarelli A, Cantoni O.

Oxid Med Cell Longev. 2018 Feb 8;2018:4194502. doi: 10.1155/2018/4194502. eCollection 2018.

5.

The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection.

Fiorani M, Guidarelli A, Capellacci V, Cerioni L, Crinelli R, Cantoni O.

Toxicol Appl Pharmacol. 2018 Apr 15;345:26-35. doi: 10.1016/j.taap.2018.03.008. Epub 2018 Mar 8.

PMID:
29526526
6.

Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca2+-Independent Mechanism.

Guidarelli A, Cerioni L, Fiorani M, Cantoni O.

Int J Mol Sci. 2017 Aug 2;18(8). pii: E1686. doi: 10.3390/ijms18081686.

7.

Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition.

Guidarelli A, Fiorani M, Cerioni L, Scotti M, Cantoni O.

Biofactors. 2017 Sep 10;43(5):673-684. doi: 10.1002/biof.1375. Epub 2017 Jul 13.

PMID:
28703385
8.

Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn from Cell Culture Studies?

Cantoni O, Guidarelli A, Fiorani M.

Antioxid Redox Signal. 2018 Nov 20;29(15):1502-1515. doi: 10.1089/ars.2017.7253. Epub 2017 Aug 9. Review.

PMID:
28699359
9.

Cross-Talk Between NO Synthase Isoforms in Neuro-Inflammation: Possible Implications in HIV-Associated Neurocognitive Disorders.

Persichini T, Mariotto S, Suzuki H, Butturini E, Mastrantonio R, Cantoni O, Colasanti M.

Curr Med Chem. 2016;23(24):2706-2714. Review.

PMID:
27516196
10.

The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells.

Guidarelli A, Fiorani M, Carloni S, Cerioni L, Balduini W, Cantoni O.

Toxicol Appl Pharmacol. 2016 Sep 15;307:35-44. doi: 10.1016/j.taap.2016.07.012. Epub 2016 Jul 20.

PMID:
27450018
11.

Mitochondrial ascorbic acid prevents mitochondrial O₂·⁻ formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms.

Guidarelli A, Carloni S, Balduini W, Fiorani M, Cantoni O.

Biofactors. 2016 Mar-Apr;42(2):190-200. doi: 10.1002/biof.1263. Epub 2016 Feb 19.

PMID:
26893200
12.

Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria.

Fiorani M, Azzolini C, Guidarelli A, Cerioni L, Scotti M, Cantoni O.

Pharmacol Res. 2015 Sep;99:289-95. doi: 10.1016/j.phrs.2015.07.004. Epub 2015 Jul 15.

PMID:
26188149
13.

U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin.

Guidarelli A, Fiorani M, Azzolini C, Cerioni L, Scotti M, Cantoni O.

Biofactors. 2015 Mar-Apr;41(2):101-10. doi: 10.1002/biof.1204. Epub 2015 Mar 23.

PMID:
25809564
14.

The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium.

Fiorani M, Azzolini C, Cerioni L, Scotti M, Guidarelli A, Ciacci C, Cantoni O.

Biochim Biophys Acta. 2015 Jun;1848(6):1393-401. doi: 10.1016/j.bbamem.2015.03.009. Epub 2015 Mar 15.

15.

The role of arachidonic acid in the regulation of nitric oxide synthase isoforms by HIV gp120 protein in astroglial cells.

Persichini T, Mastrantonio R, Del Matto S, Palomba L, Cantoni O, Colasanti M.

Free Radic Biol Med. 2014 Sep;74:14-20. doi: 10.1016/j.freeradbiomed.2014.06.009. Epub 2014 Jun 19.

PMID:
24953535
16.

A novel biological role of dehydroascorbic acid: Inhibition of Na(+)-dependent transport of ascorbic acid.

Fiorani M, Azzolini C, Guidarelli A, Cerioni L, Cantoni O.

Pharmacol Res. 2014 Jun;84:12-7. doi: 10.1016/j.phrs.2014.04.006. Epub 2014 Apr 24.

PMID:
24769194
17.

Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents.

Vantaggiato C, Cantoni O, Guidarelli A, Romaniello R, Citterio A, Arrigoni F, Doneda C, Castelli M, Airoldi G, Bresolin N, Borgatti R, Bassi MT.

Brain Dev. 2014 Sep;36(8):682-9. doi: 10.1016/j.braindev.2013.10.003. Epub 2013 Oct 31.

PMID:
24183476
18.

Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite.

Guidarelli A, Cerioni L, Fiorani M, Azzolini C, Cantoni O.

Biofactors. 2014 Mar-Apr;40(2):236-46. doi: 10.1002/biof.1139. Epub 2013 Sep 16.

PMID:
24105898
19.

Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.

Azzolini C, Fiorani M, Cerioni L, Guidarelli A, Cantoni O.

IUBMB Life. 2013 Feb;65(2):149-53. doi: 10.1002/iub.1124. Epub 2013 Jan 3.

20.

Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise nontoxic levels of reactive oxygen/nitrogen species.

Fiorani M, Azzolini C, Cerioni L, Guidarelli A, Cantoni O.

J Nutr Biochem. 2013 Feb;24(2):467-74. doi: 10.1016/j.jnutbio.2012.01.009. Epub 2012 May 26.

PMID:
22633911
21.

A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response.

Cerioni L, Fiorani M, Azzolini C, Cantoni O.

Pharmacol Res. 2012 Mar;65(3):379-86. doi: 10.1016/j.phrs.2011.12.006. Epub 2011 Dec 29.

PMID:
22214866
22.

Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells.

Azzolini C, Fiorani M, Guidarelli A, Cantoni O.

Br J Nutr. 2012 Mar;107(5):691-6. doi: 10.1017/S0007114511003540. Epub 2011 Jul 28.

PMID:
21794197
23.

A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.

Crimella C, Cantoni O, Guidarelli A, Vantaggiato C, Martinuzzi A, Fiorani M, Azzolini C, Orso G, Bresolin N, Bassi MT.

Hum Mutat. 2011 Apr;32(4):E2118-33. doi: 10.1002/humu.21464. Epub 2011 Feb 8.

PMID:
21412945
24.
26.
27.

Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite.

Guidarelli A, Cerioni L, Fiorani M, Cantoni O.

J Immunol. 2009 Oct 1;183(7):4449-57. doi: 10.4049/jimmunol.0901260. Epub 2009 Sep 4.

28.

Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin.

Airoldi G, Guidarelli A, Cantoni O, Panzeri C, Vantaggiato C, Bonato S, Grazia D'Angelo M, Falcone S, De Palma C, Tonelli A, Crimella C, Bondioni S, Bresolin N, Clementi E, Bassi MT.

Neurogenetics. 2010 Feb;11(1):91-100. doi: 10.1007/s10048-009-0206-0. Epub 2009 Jul 11.

PMID:
19593598
29.

Arachidonic acid: a key molecule for astrocyte survival to peroxynitrite.

Palomba L, Cerioni L, Cantoni O.

Glia. 2009 Nov 15;57(15):1672-9. doi: 10.1002/glia.20879.

PMID:
19455584
30.

Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid.

Fiorani M, Guidarelli A, Blasa M, Azzolini C, Candiracci M, Piatti E, Cantoni O.

J Nutr Biochem. 2010 May;21(5):397-404. doi: 10.1016/j.jnutbio.2009.01.014. Epub 2009 Mar 17.

PMID:
19278846
32.

Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants.

Cantoni O, Guidarelli A.

IUBMB Life. 2008 Nov;60(11):753-6. doi: 10.1002/iub.116. Review.

33.

The arachidonate-dependent survival signaling preventing toxicity in monocytes/macrophages exposed to peroxynitrite.

Cantoni O, Tommasini I, Cerioni L.

Methods Enzymol. 2008;441:73-82. doi: 10.1016/S0076-6879(08)01205-6.

PMID:
18554530
34.

Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite.

Guidarelli A, Palomba L, Fiorani M, Cantoni O.

Free Radic Biol Med. 2008 Aug 15;45(4):521-9. doi: 10.1016/j.freeradbiomed.2008.05.005. Epub 2008 May 17.

PMID:
18514075
35.

Pivotal role of arachidonic acid in the regulation of neuronal nitric oxide synthase activity and inducible nitric oxide synthase expression in activated astrocytes.

Cantoni O, Palomba L, Persichini T, Mariotto S, Suzuki H, Colasanti M.

Methods Enzymol. 2008;440:243-52. doi: 10.1016/S0076-6879(07)00815-4.

PMID:
18423222
36.

Indirect mechanisms of DNA strand scission by peroxynitrite.

Cantoni O, Guidarelli A.

Methods Enzymol. 2008;440:111-20. doi: 10.1016/S0076-6879(07)00806-3.

PMID:
18423213
37.

Mitochondrial H2O2 limits U937 cell survival to peroxynitrite by promoting ERK1/2 dephosphorylation.

Cerioni L, Cantoni O.

Biochim Biophys Acta. 2008 Mar;1783(3):492-502. doi: 10.1016/j.bbamcr.2007.12.002. Epub 2007 Dec 8.

38.

Cross-talk between NO and arachidonic acid in inflammation.

Mariotto S, Suzuki Y, Persichini T, Colasanti M, Suzuki H, Cantoni O.

Curr Med Chem. 2007;14(18):1940-4. Review.

PMID:
17691936
40.
41.

ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite.

Cerioni L, Cantoni O.

J Cell Physiol. 2007 Jan;210(1):177-82.

PMID:
16998804
42.

TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.

Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E.

J Clin Invest. 2006 Oct;116(10):2791-8. Epub 2006 Sep 14.

43.

5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.

Tommasini I, Guidarelli A, Palomba L, Cerioni L, Cantoni O.

J Leukoc Biol. 2006 Oct;80(4):929-38. Epub 2006 Aug 2.

PMID:
16885503
45.

Cross-talk between constitutive and inducible NO synthase: an update.

Persichini T, Cantoni O, Suzuki H, Colasanti M.

Antioxid Redox Signal. 2006 May-Jun;8(5-6):949-54. Review.

PMID:
16771684
46.

Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite.

Guidarelli A, Cerioni L, Tommasini I, Fiorani M, Brüne B, Cantoni O.

Free Radic Biol Med. 2005 Dec 15;39(12):1638-49. Epub 2005 Sep 7.

PMID:
16298689
47.

Peroxynitrite-induced mitochondrial translocation of PKCalpha causes U937 cell survival.

Cerioni L, Palomba L, Brüne B, Cantoni O.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):126-31. Epub 2005 Nov 9.

PMID:
16293228
48.

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO.

Science. 2005 Oct 14;310(5746):314-7.

49.

Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sulfoxide differentiated U937 cells to peroxynitrite.

Guidarelli A, Fiorani M, Tommasini I, Cerioni L, Cantoni O.

Int J Biochem Cell Biol. 2006 Jan;38(1):56-68. Epub 2005 Aug 1.

PMID:
16103003
50.

Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage.

Cantoni O, Tommasini I, Cerioni L, Palomba L, Carloni E, Guidarelli A.

Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):118-23. Epub 2005 Jun 17. Review.

PMID:
15964776

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