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Items: 13

1.

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.

Shen H, Holenarsipur VK, Mariappan TT, Drexler DM, Cantone JL, Rajanna P, Singh Gautam S, Zhang Y, Gan J, Shipkova PA, Marathe P, Humphreys WG.

J Pharmacol Exp Ther. 2019 Jan;368(1):136-145. doi: 10.1124/jpet.118.252643. Epub 2018 Oct 25.

PMID:
30361237
2.

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

Zhuo X, Cantone JL, Wang Y, Leet JE, Drexler DM, Yeung KS, Huang XS, Eastman KJ, Parcella KE, Mosure KW, Soars MG, Kadow JF, Johnson BM.

Drug Metab Dispos. 2016 Aug;44(8):1332-1340. doi: 10.1124/dmd.115.069062. Epub 2016 Mar 9.

PMID:
26961241
3.

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds.

Barnaby OS, Benitex Y, Cantone JL, McNaney CA, Olah TV, Drexler DM.

Bioanalysis. 2015 Oct;7(19):2501-13. doi: 10.4155/bio.15.171. Epub 2015 Oct 15.

PMID:
26466806
4.

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Polson C, Cantone JL, Wei C, Drexler DM, Meredith JE Jr.

Anal Biochem. 2014 Dec 1;466:65-71. doi: 10.1016/j.ab.2014.08.011. Epub 2014 Aug 28.

PMID:
25175011
5.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858. Epub 2014 Jul 8.

6.

Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.

Lemm JA, Leet JE, O'Boyle DR 2nd, Romine JL, Huang XS, Schroeder DR, Alberts J, Cantone JL, Sun JH, Nower PT, Martin SW, Serrano-Wu MH, Meanwell NA, Snyder LB, Gao M.

Antimicrob Agents Chemother. 2011 Aug;55(8):3795-802. doi: 10.1128/AAC.00146-11. Epub 2011 May 16.

7.

Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.

Cantone JL, Xu-Lin A, Toyn JH, Drexler DM.

J Neurosci Methods. 2009 Jun 15;180(2):255-60. doi: 10.1016/j.jneumeth.2009.03.018. Epub 2009 Mar 31.

PMID:
19464516
8.

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.

Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, Roach AH, Cantone JL, Ford MJ, Drexler DM, Olson RE, Yang MG, Bergstrom CP, McElhone KE, Bronson JJ, Macor JE, Blat Y, Grafstrom RH, Stern AM, Seiffert DA, Zaczek R, Albright CF, Toyn JH.

J Biol Chem. 2008 Aug 22;283(34):22992-3003. doi: 10.1074/jbc.M804175200. Epub 2008 Jun 23.

9.

N-Demethylation of nocathiacin I via photo-oxidation.

Li W, Huang S, Liu X, Leet JE, Cantone JL, Lam KS.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4051-3. doi: 10.1016/j.bmcl.2008.05.112. Epub 2008 Jun 4.

PMID:
18556203
10.

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Leet JE, Liu X, Drexler DM, Cantone JL, Huang S, Mamber SW, Fairchild CR, Hussain R, Newman DJ, Kingston DG.

J Nat Prod. 2008 Mar;71(3):460-3. doi: 10.1021/np070523l. Epub 2008 Feb 5.

11.

Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.

Ford MJ, Cantone JL, Polson C, Toyn JH, Meredith JE, Drexler DM.

J Neurosci Methods. 2008 Mar 15;168(2):465-74. doi: 10.1016/j.jneumeth.2007.11.019. Epub 2007 Nov 29.

PMID:
18187205
12.

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

Drexler DM, Garrett TJ, Cantone JL, Diters RW, Mitroka JG, Prieto Conaway MC, Adams SP, Yost RA, Sanders M.

J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):279-88. Epub 2006 Dec 5.

PMID:
17222568
13.

Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.

Leet JE, Li W, Ax HA, Matson JA, Huang S, Huang R, Cantone JL, Drexler D, Dalterio RA, Lam KS.

J Antibiot (Tokyo). 2003 Mar;56(3):232-42.

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