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Items: 1 to 50 of 730

1.

Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.

Mullarky E, Xu J, Robin AD, Huggins DJ, Jennings A, Noguchi N, Olland A, Lakshminarasimhan D, Miller M, Tomita D, Michino M, Su T, Zhang G, Stamford AW, Meinke PT, Kargman S, Cantley LC.

Bioorg Med Chem Lett. 2019 Jul 6. pii: S0960-894X(19)30456-1. doi: 10.1016/j.bmcl.2019.07.011. [Epub ahead of print]

PMID:
31327531
2.

Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury.

Xu L, Sharkey D, Cantley LG.

J Am Soc Nephrol. 2019 Jul 17. pii: ASN.2019010068. doi: 10.1681/ASN.2019010068. [Epub ahead of print]

PMID:
31315923
3.

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.

Xing Y, Lin NU, Maurer MA, Chen H, Mahvash A, Sahin A, Akcakanat A, Li Y, Abramson V, Litton J, Chavez-MacGregor M, Valero V, Piha-Paul SA, Hong D, Do KA, Tarco E, Riall D, Eterovic AK, Wulf GM, Cantley LC, Mills GB, Doyle LA, Winer E, Hortobagyi GN, Gonzalez-Angulo AM, Meric-Bernstam F.

Breast Cancer Res. 2019 Jul 5;21(1):78. doi: 10.1186/s13058-019-1154-8.

4.

Cohort Profile: The American Manufacturing Cohort (AMC) study.

Elser H, Neophytou AM, Tribett E, Galusha D, Modrek S, Noth EM, Meausoone V, Eisen EA, Cantley LF, Cullen MR.

Int J Epidemiol. 2019 Apr 9. pii: dyz059. doi: 10.1093/ije/dyz059. [Epub ahead of print] No abstract available.

PMID:
31220278
5.

Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry.

Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG.

JCI Insight. 2019 Jun 20;4(12). pii: 129477. doi: 10.1172/jci.insight.129477. eCollection 2019 Jun 20.

6.

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, Cantley LC, Green MR, Lin H, Melnick AM.

Cancer Cell. 2019 Jun 10;35(6):916-931.e9. doi: 10.1016/j.ccell.2019.05.002.

PMID:
31185214
7.

Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis.

Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR.

JCI Insight. 2019 May 16;4(10). pii: 127456. doi: 10.1172/jci.insight.127456. eCollection 2019 May 16.

8.

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC.

Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070.

9.

Voltage gated inter-cation selective ion channels from graphene nanopores.

Cantley L, Swett JL, Lloyd D, Cullen DA, Zhou K, Bedworth PV, Heise S, Rondinone AJ, Xu Z, Sinton S, Bunch JS.

Nanoscale. 2019 May 28;11(20):9856-9861. doi: 10.1039/c8nr10360g. Epub 2019 May 15.

PMID:
31089608
10.

Targeting cancer vulnerabilities with high-dose vitamin C.

Ngo B, Van Riper JM, Cantley LC, Yun J.

Nat Rev Cancer. 2019 May;19(5):271-282. doi: 10.1038/s41568-019-0135-7. Review.

PMID:
30967651
11.

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.

Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ.

J Proteome Res. 2019 May 3;18(5):2078-2087. doi: 10.1021/acs.jproteome.8b00969. Epub 2019 Apr 18.

PMID:
30964683
12.

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):804-817.e12. doi: 10.1016/j.chembiol.2019.02.015. Epub 2019 Mar 28.

PMID:
30930164
13.

High-fructose corn syrup enhances intestinal tumor growth in mice.

Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J.

Science. 2019 Mar 22;363(6433):1345-1349. doi: 10.1126/science.aat8515.

PMID:
30898933
14.

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.

Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA.

Lancet Oncol. 2019 Apr;20(4):570-580. doi: 10.1016/S1470-2045(18)30905-7. Epub 2019 Mar 14.

PMID:
30880072
15.

Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.

Zheng Y, Ramsamooj S, Li Q, Johnson JL, Yaron TM, Sharra K, Cantley LC.

Sci Rep. 2019 Mar 12;9(1):4190. doi: 10.1038/s41598-019-40950-7.

16.

Correction: PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL.

Clin Cancer Res. 2019 Feb 15;25(4):1432. doi: 10.1158/1078-0432.CCR-18-4269. No abstract available.

PMID:
30770491
17.

Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance.

Paddock MN, Field SJ, Cantley LC.

J Lipid Res. 2019 Apr;60(4):747-752. doi: 10.1194/jlr.S092130. Epub 2019 Feb 4.

PMID:
30718284
18.

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Hodakoski C, Hopkins BD, Zhang G, Su T, Cheng Z, Morris R, Rhee KY, Goncalves MD, Cantley LC.

Cancers (Basel). 2019 Jan 2;11(1). pii: E37. doi: 10.3390/cancers11010037.

19.

Toward a better understanding of folate metabolism in health and disease.

Zheng Y, Cantley LC.

J Exp Med. 2019 Feb 4;216(2):253-266. doi: 10.1084/jem.20181965. Epub 2018 Dec 26. Review.

PMID:
30587505
20.

A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification.

Browne CM, Jiang B, Ficarro SB, Doctor ZM, Johnson JL, Card JD, Sivakumaren SC, Alexander WM, Yaron TM, Murphy CJ, Kwiatkowski NP, Zhang T, Cantley LC, Gray NS, Marto JA.

J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.

PMID:
30518210
21.

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC.

Cell. 2018 Nov 29;175(6):1546-1560.e17. doi: 10.1016/j.cell.2018.09.041.

PMID:
30500537
22.

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.

Goncalves MD, Hopkins BD, Cantley LC.

N Engl J Med. 2018 Nov 22;379(21):2052-2062. doi: 10.1056/NEJMra1704560. Review. No abstract available.

PMID:
30462943
23.

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.

Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA.

Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12.

PMID:
30365304
24.

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant.

Cohen SB, Bainter W, Johnson JL, Lin TY, Wong JCY, Wallace JG, Jones J, Qureshi S, Mir F, Qamar F, Cantley LC, Geha RS, Chou J.

J Allergy Clin Immunol. 2019 Feb;143(2):797-799.e2. doi: 10.1016/j.jaci.2018.10.005. Epub 2018 Oct 16. No abstract available.

PMID:
30336224
25.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15.

PMID:
30323273
26.

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Lee HS, Lin Z, Chae S, Yoo YS, Kim BG, Lee Y, Johnson JL, Kim YS, Cantley LC, Lee CW, Yu H, Cho H.

Nat Commun. 2018 Sep 21;9(1):3848. doi: 10.1038/s41467-018-06377-w.

27.

Injury Prevention and Environmental Health: Key Messages from Disease Control Priorities, Third Edition.

Mock CN, Smith KR, Kobusingye O, Nugent R, Abdalla S, Ahuja RB, Apramian SS, Bachani AM, Bellis MA, Butchart A, Cantley L, Chase C, Cullen M, Dabestani N, Ebi KL, Fang X, Gururaj G, Guttikunda S, Hess JJ, Hoe C, Hutton G, Hyder AA, Ivers R, Jamison DT, Jawahar P, Keay L, Levin C, Liao J, Mackie D, Malik K, Meddings D, Nguyen NP, Norton R, Olson Z, Partridge I, Peden M, Pillarisetti A, Rahman F, Rosenberg ML, Staples JA, Verguet S, Ward CL, Watkins DA.

In: Mock CN, Nugent R, Kobusingye O, Smith KR, editors. Injury Prevention and Environmental Health. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Oct 27. Chapter 1.

28.

Occupation and Risk for Injuries.

Abdalla S, Apramian SS, Cantley LF, Cullen MR.

In: Mock CN, Nugent R, Kobusingye O, Smith KR, editors. Injury Prevention and Environmental Health. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Oct 27. Chapter 6.

29.

Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease.

Cassini MF, Kakade VR, Kurtz E, Sulkowski P, Glazer P, Torres R, Somlo S, Cantley LG.

J Am Soc Nephrol. 2018 Oct;29(10):2471-2481. doi: 10.1681/ASN.2018050518. Epub 2018 Sep 12.

PMID:
30209078
30.

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Bakhoum SF, Cantley LC.

Cell. 2018 Sep 6;174(6):1347-1360. doi: 10.1016/j.cell.2018.08.027. Review.

PMID:
30193109
31.

Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC.

Nature. 2018 Nov;563(7731):E24. doi: 10.1038/s41586-018-0506-3.

PMID:
30158705
32.

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC.

Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4. Erratum in: Nature. 2018 Aug 29;:.

33.

A Glycolysis Outsider Steps into the Cancer Spotlight.

Goncalves MD, Cantley LC.

Cell Metab. 2018 Jul 3;28(1):3-4. doi: 10.1016/j.cmet.2018.06.017.

34.

Cancer metabolism gets physical.

DelNero P, Hopkins BD, Cantley LC, Fischbach C.

Sci Transl Med. 2018 May 23;10(442). pii: eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Review.

35.

Diverting Glycolysis to Combat Oxidative Stress.

Mullarky E, Cantley LC.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.

36.

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. doi: 10.1016/j.bmcl.2018.04.061. Epub 2018 Apr 27.

PMID:
29731362
37.

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM.

Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037.

38.

Risk of Injury by Unionization: Survival Analysis of a Large Industrial Cohort.

Altassan KA, Sakr CJ, Galusha D, Slade MD, Tessier-Sherman B, Cantley LF.

J Occup Environ Med. 2018 Sep;60(9):827-831. doi: 10.1097/JOM.0000000000001347.

PMID:
29727399
39.

Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring.

Rauniyar N, Yu X, Cantley J, Voss EZ, Belcher J, Colangelo CM, Stone KL, Dahl N, Parikh C, Lam TT, Cantley LG.

Proteomics Clin Appl. 2018 Sep;12(5):e1700157. doi: 10.1002/prca.201700157. Epub 2018 May 2.

PMID:
29573172
40.

Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.

41.

Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Feb 20;:.

42.

Assessing Hearing Conservation Program Effectiveness: Results of a Multisite Assessment.

Rabinowitz P, Cantley LF, Galusha D, Trufan S, Swersey A, Dixon-Ernst C, Ramirez V, Neitzel R.

J Occup Environ Med. 2018 Jan;60(1):29-35. doi: 10.1097/JOM.0000000000001125.

PMID:
29309362
43.

Introduction: Understanding Human AKI.

Cantley LG.

Semin Nephrol. 2018 Jan;38(1):1-2. doi: 10.1016/j.semnephrol.2017.09.009. No abstract available.

PMID:
29291756
44.

PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL.

Clin Cancer Res. 2018 Mar 15;24(6):1426-1435. doi: 10.1158/1078-0432.CCR-17-2141. Epub 2017 Dec 28. Erratum in: Clin Cancer Res. 2019 Feb 15;25(4):1432.

45.

Costs and effectiveness of hearing conservation programs at 14 US metal manufacturing facilities.

Sayler SK, Rabinowitz PM, Cantley LF, Galusha D, Neitzel RL.

Int J Audiol. 2018 Feb;57(sup1):S3-S11. doi: 10.1080/14992027.2017.1410237. Epub 2017 Dec 7.

46.

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC.

Cancer Discov. 2018 Mar;8(3):354-369. doi: 10.1158/2159-8290.CD-17-0679. Epub 2017 Dec 4. Erratum in: Cancer Discov. 2018 Aug;8(8):1044.

47.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

48.

Patterns of Opioid Prescribing and Predictors of Chronic Opioid Use in an Industrial Cohort, 2003 to 2013.

Pensa MA, Galusha DH, Cantley LF.

J Occup Environ Med. 2018 May;60(5):457-461. doi: 10.1097/JOM.0000000000001231.

49.

Occupational noise exposure and risk of hypertension in an industrial workforce.

Tessier-Sherman B, Galusha D, Cantley LF, Cullen MR, Rabinowitz PM, Neitzel RL.

Am J Ind Med. 2017 Dec;60(12):1031-1038. doi: 10.1002/ajim.22775. Epub 2017 Sep 22.

50.

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK.

Cancer Cell. 2017 Sep 11;32(3):392. doi: 10.1016/j.ccell.2017.08.008. No abstract available.

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