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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

Willoughby CE, Jiang Y, Thomas HD, Willmore E, Kyle S, Wittner A, Phillips N, Zhao Y, Tudhope SJ, Prendergast L, Junge G, Lourenco LM, Finlay MRV, Turner P, Munck JM, Griffin RJ, Rennison T, Pickles J, Cano C, Newell DR, Reeves HL, Ryan AJ, Wedge SR.

J Clin Invest. 2020 Jan 2;130(1):258-271. doi: 10.1172/JCI127483.


Synthetic cannabinoid receptor agonists: classification and nomenclature.

Potts AJ, Cano C, Thomas SHL, Hill SL.

Clin Toxicol (Phila). 2020 Feb;58(2):82-98. doi: 10.1080/15563650.2019.1661425. Epub 2019 Sep 16.


Molecular dynamics simulations reveal the determinants of cyclin-dependent kinase 2 inhibition by 5-nitrosopyrimidine derivatives.

Guglielmo S, Cortese D, Cano C, Fruttero R.

J Biomol Struct Dyn. 2019 Sep 23:1-9. doi: 10.1080/07391102.2019.1666032. [Epub ahead of print]


Alternative estimates of the well-known negative relationship between the US interest rate risk and the flow-through capability.

Jareño F, Tolentino M, Cano C.

Heliyon. 2019 Jun 17;5(6):e01901. doi: 10.1016/j.heliyon.2019.e01901. eCollection 2019 Jun.


Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?

Salazar J, Rojas-Quintero J, Cano C, Pérez JL, Ramírez P, Carrasquero R, Torres W, Espinoza C, Chacín-González M, Bermúdez V.

Curr Cardiol Rev. 2020;16(1):25-35. doi: 10.2174/1573403X15666190625160352.


Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C.

Eur J Med Chem. 2019 Sep 15;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. Epub 2019 May 25.


Ozone-Based Interventions To Improve the Microbiological Safety and Quality of Poultry Carcasses and Parts: A Review.

Cano C, Meneses Y, Chaves BD.

J Food Prot. 2019 Jun;82(6):940-947. doi: 10.4315/0362-028X.JFP-18-489.


FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.

Wood DJ, Lopez-Fernandez JD, Knight LE, Al-Khawaldeh I, Gai C, Lin S, Martin MP, Miller DC, Cano C, Endicott JA, Hardcastle IR, Noble MEM, Waring MJ.

J Med Chem. 2019 Apr 11;62(7):3741-3752. doi: 10.1021/acs.jmedchem.9b00304. Epub 2019 Mar 26.


Reference values for handgrip strength and their association with intrinsic capacity domains among older adults.

Ramírez-Vélez R, Correa-Bautista JE, García-Hermoso A, Cano CA, Izquierdo M.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):278-286. doi: 10.1002/jcsm.12373. Epub 2019 Mar 6.


Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960-1999 and registered in the Italian Off-Therapy Registry.

Bagnasco F, Caruso S, Andreano A, Valsecchi MG, Jankovic M, Biondi A, Miligi L, Casella C, Terenziani M, Massimino M, Sacerdote C, Morsellino V, Erminio G, Garaventa A, Faraci M, Micalizzi C, Garrè ML, Pillon M, Basso G, Biasin E, Fagioli F, Rondelli R, Pession A, Locatelli F, Santoro N, Indolfi P, Palumbo G, Russo G, Verzegnassi F, Favre C, Zecca M, Mura R, D'Angelo P, Cano C, Byrne J, Haupt R; OTR-AIEOP Registry.

Eur J Cancer. 2019 Mar;110:86-97. doi: 10.1016/j.ejca.2018.12.021. Epub 2019 Feb 14.


The impact of the extension of the post-natal in the adherence to breastfeeding Cohort study.

Madrid Muñoz R, Cano C C, Cortés Rojas R.

Rev Chil Pediatr. 2018 Aug;89(4):484-490. doi: 10.4067/S0370-41062018005000701. Epub 2018 Aug 13. English, Spanish.


Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients.

Poizot-Martin I, Rosenthal E, Gilbert C, Cano CE, Simon A, Lascoux-Combe C, Alric L, Gervais A, Neau D, Esterle L, Salmon D, Sogni P, Wittkop L; ANRS CO13 HEPAVIH Study Group.

J Acquir Immune Defic Syndr. 2019 Apr 1;80(4):461-466. doi: 10.1097/QAI.0000000000001940.


Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism.

Palacio Rojas M, Prieto C, Bermúdez V, Garicano C, Núñez Nava T, Martínez MS, Salazar J, Rojas E, Pérez A, Marca Vicuña P, González Martínez N, Maldonado Parra S, Hoedebecke K, D'Addosio R, Cano C, Rojas J.

Version 2. F1000Res. 2017 Nov 30 [revised 2018 Jan 1];6:2073. doi: 10.12688/f1000research.12938.2. eCollection 2017. Review.


HIV infection and care pathway: From guidelines to clinical practice.

Poizot-Martin I, Obry-Roguet V, Zaegel-Faucher O, Lions C, Cano C, Ivanova A, Ritleng A, Debreux C, Bregigeon S.

Med Mal Infect. 2019 Feb;49(1):23-33. doi: 10.1016/j.medmal.2018.07.005. Epub 2018 Sep 5.


Risk factors associated with overweight and obesity in HIV-infected people: Aging, behavioral factors but not cART in a cross-sectional study.

Obry-Roguet V, Brégigeon S, Cano CE, Lions C, Zaegel-Faucher O, Laroche H, Galie S, De Lamarlière PG, Orticoni M, Soavi MJ, Saout A, Poizot-Martin I.

Medicine (Baltimore). 2018 Jun;97(23):e10956. doi: 10.1097/MD.0000000000010956.


Recent advances in CDK inhibitors for cancer therapy.

Heptinstall AB, Adiyasa I, Cano C, Hardcastle IR.

Future Med Chem. 2018 Jun 1;10(11):1369-1388. doi: 10.4155/fmc-2017-0246. Epub 2018 May 30. Review.


Author Correction: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.

Stoodley CJ, D'Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT.

Nat Neurosci. 2018 Jul;21(7):1016. doi: 10.1038/s41593-018-0096-2.


Cancer risk in HIV-infected patients: elite controllers are also concerned.

Poizot-Martin I, Laroche H, Cano CE, Nicolino-Brunet C, Zaegel-Faucher O, Bregigeon S, Tamalet C, Dignat-George F.

AIDS. 2018 Mar 13;32(5):673-675. doi: 10.1097/QAD.0000000000001736. No abstract available.


Redesigning the Maternal, Infant and Early Childhood Home Visiting Program Performance Measurement System.

Labiner-Wolfe J, Vladutiu CJ, Peplinski K, Cano C, Willis D.

Matern Child Health J. 2018 Apr;22(4):467-473. doi: 10.1007/s10995-018-2486-1.


Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C.

Org Biomol Chem. 2018 Mar 14;16(11):1843-1850. doi: 10.1039/c8ob00099a.


Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).

Unterlass JE, Wood RJ, Baslé A, Tucker J, Cano C, Noble MME, Curtin NJ.

Oncotarget. 2017 Nov 6;8(61):104478-104491. doi: 10.18632/oncotarget.22327. eCollection 2017 Nov 28.


Edentulism and its relationship with self-rated health: secondary analysis of the SABE Ecuador 2009 Study.

Borda MG, Castellanos-Perilla N, Patiño JA, Castelblanco S, Cano CA, Chavarro-Carvajal D, Pérez-Zepeda MU.

Acta Odontol Latinoam. 2017 Aug;30(2):83-89.


Primary Pediatric Cutaneous T-Cell Lymphoproliferative Disorders: 3 New Cases.

Guerzoni ME, Pruccoli F, Palazzi G, Mariotti I, Cano C, Cellini M, Cesinaro AM, Mataca E, Iughetti L.

J Pediatr Hematol Oncol. 2018 Apr;40(3):231-234. doi: 10.1097/MPH.0000000000001021.


ProphTools: general prioritization tools for heterogeneous biological networks.

Navarro C, Martínez V, Blanco A, Cano C.

Gigascience. 2017 Dec 1;6(12):1-8. doi: 10.1093/gigascience/gix111.


Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.

Stoodley CJ, D'Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT.

Nat Neurosci. 2017 Dec;20(12):1744-1751. doi: 10.1038/s41593-017-0004-1. Epub 2017 Oct 30. Erratum in: Nat Neurosci. 2018 Mar 16;:.


Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc.

Conde-Muiño R, Cano C, Sánchez-Martín V, Herrera A, Comino A, Medina PP, Palma P, Cuadros M.

Oncotarget. 2017 Jul 19;8(47):82294-82302. doi: 10.18632/oncotarget.19393. eCollection 2017 Oct 10.


Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification.

Hill SL, Dunn M, Cano C, Harnor SJ, Hardcastle IR, Grundlingh J, Dargan PI, Wood DM, Tucker S, Bartram T, Thomas SHL.

Clin Chem. 2018 Feb;64(2):346-354. doi: 10.1373/clinchem.2017.275867. Epub 2017 Oct 16.


Sub-therapeutic darunavir concentration and garlic consumption; a «Mediterranean» drug-food interaction, about 2 cases.

Cloarec N, Solas C, Ladaique A, Tamalet C, Zaegel-Faucher O, Bregigeon S, Canet B, Cano CE, Poizot-Martin I.

Eur J Clin Pharmacol. 2017 Oct;73(10):1331-1333. doi: 10.1007/s00228-017-2300-9. Epub 2017 Jul 11. No abstract available.


Oropharyngeal dysphagia in older adults: The well-known tale.

Borda MG, Venegas-Sanabria LC, Puentes-Leal GA, Garcia-Cifuentes E, Chavarro-Carvajal DA, Cano CA.

Geriatr Gerontol Int. 2017 Jun;17(6):1031-1033. doi: 10.1111/ggi.13012. No abstract available.


Efficacy and Tolerability of Peritendinous Hyaluronic Acid in Patients with Supraspinatus Tendinopathy: a Multicenter, Randomized, Controlled Trial.

Flores C, Balius R, Álvarez G, Buil MA, Varela L, Cano C, Casariego J.

Sports Med Open. 2017 Dec;3(1):22. doi: 10.1186/s40798-017-0089-9. Epub 2017 Jun 5.


Frailty in HIV infected people: a new risk factor for bone mineral density loss.

Bregigeon S, Galinier A, Zaegel-Faucher O, Cano CE, Obry V, Laroche H, Trijau S, Saout A, Poizot-Martin I.

AIDS. 2017 Jul 17;31(11):1573-1577. doi: 10.1097/QAD.0000000000001507. Erratum in: AIDS. 2017 Nov 13;31(17):2441.


Targeting DNA-Dependent Protein Kinase for Cancer Therapy.

Harnor SJ, Brennan A, Cano C.

ChemMedChem. 2017 Jun 21;12(12):895-900. doi: 10.1002/cmdc.201700143. Epub 2017 May 29. Review.


Rapid Assessment of Ecosystem Service Co-Benefits of Biodiversity Priority Areas in Madagascar.

Neugarten RA, Honzák M, Carret P, Koenig K, Andriamaro L, Cano CA, Grantham HS, Hole D, Juhn D, McKinnon M, Rasolohery A, Steininger M, Wright TM, Turner WR.

PLoS One. 2016 Dec 22;11(12):e0168575. doi: 10.1371/journal.pone.0168575. eCollection 2016.


Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Coxon CR, Anscombe E, Harnor SJ, Martin MP, Carbain B, Golding BT, Hardcastle IR, Harlow LK, Korolchuk S, Matheson CJ, Newell DR, Noble ME, Sivaprakasam M, Tudhope SJ, Turner DM, Wang LZ, Wedge SR, Wong C, Griffin RJ, Endicott JA, Cano C.

J Med Chem. 2017 Mar 9;60(5):1746-1767. doi: 10.1021/acs.jmedchem.6b01254. Epub 2017 Feb 14.


Structure-guided design of purine-based probes for selective Nek2 inhibition.

Coxon CR, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C.

Oncotarget. 2017 Mar 21;8(12):19089-19124. doi: 10.18632/oncotarget.13249.


CMV+ Serostatus Associates Negatively with CD4:CD8 Ratio Normalization in Controlled HIV-Infected Patients on cART.

Poizot-Martin I, Allavena C, Duvivier C, Cano CE, Guillouet de Salvador F, Rey D, Dellamonica P, Cuzin L, Cheret A, Hoen B; Dat'AIDS Study Group.

PLoS One. 2016 Nov 8;11(11):e0165774. doi: 10.1371/journal.pone.0165774. eCollection 2016.


A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB.

Malar J. 2016 Nov 7;15(1):535.


First-line cART regimen impacts the course of CD8+ T-cell counts in HIV-infected patients that achieve sustained undetectable viral load.

Poizot-Martin I, Allavena C, Delpierre C, Duvivier C, Obry-Roguet V, Cano CE, Guillouet de Salvador F, Rey D, Dellamonica P, Cheret A, Cuzin L, Katlama C, Cabié A, Hoen B; Dat’AIDS Study Group.

Medicine (Baltimore). 2016 Oct;95(41):e5087.


Cervical Spondylodiscitis After Oxygen-Ozone Therapy for Treatment of a Cervical Disc Herniation: a Case Report and Review of the Literature.

Andrés-Cano P, Vela T, Cano C, García G, Vera JC, Andrés-García JA.

HSS J. 2016 Oct;12(3):278-283. Epub 2016 Apr 18. No abstract available.


The Adc/Lmb System Mediates Zinc Acquisition in Streptococcus agalactiae and Contributes to Bacterial Growth and Survival.

Moulin P, Patron K, Cano C, Zorgani MA, Camiade E, Borezée-Durant E, Rosenau A, Mereghetti L, Hiron A.

J Bacteriol. 2016 Nov 18;198(24):3265-3277. Print 2016 Dec 15.


Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

Unterlass JE, Baslé A, Blackburn TJ, Tucker J, Cano C, Noble MEM, Curtin NJ.

Oncotarget. 2016 Aug 22;9(17):13139-13153. doi: 10.18632/oncotarget.11487. eCollection 2018 Mar 2.


Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.

Beale G, Haagensen EJ, Thomas HD, Wang LZ, Revill CH, Payne SL, Golding BT, Hardcastle IR, Newell DR, Griffin RJ, Cano C.

Br J Cancer. 2016 Sep 6;115(6):682-90. doi: 10.1038/bjc.2016.238. Epub 2016 Aug 16.


A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety.

Poizot-Martin I, Brégigeon S, Tamalet C, Bouabdallah R, Zaegel-Faucher O, Obry-Roguet V, Ivanova A, Cano CE, Solas C.

Case Rep Oncol Med. 2016;2016:8515218. doi: 10.1155/2016/8515218. Epub 2016 Jul 20.


High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors.

Myers SM, Bawn RH, Bisset LC, Blackburn TJ, Cottyn B, Molyneux L, Wong AC, Cano C, Clegg W, Harrington RW, Leung H, Rigoreau L, Vidot S, Golding BT, Griffin RJ, Hammonds T, Newell DR, Hardcastle IR.

ACS Comb Sci. 2016 Aug 8;18(8):444-55. doi: 10.1021/acscombsci.5b00155. Epub 2016 Jul 20.


Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors.

Cortese D, Chegaev K, Guglielmo S, Wang LZ, Golding BT, Cano C, Fruttero R.

ChemMedChem. 2016 Aug 19;11(16):1705-8. doi: 10.1002/cmdc.201600108. Epub 2016 Jun 29.


Investor Behavior and Flow-through Capability in the US Stock Market.

Cano C, Jareño F, Tolentino M.

Front Psychol. 2016 May 9;7:668. doi: 10.3389/fpsyg.2016.00668. eCollection 2016.


Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.

Reuillon T, Alhasan SF, Beale GS, Bertoli A, Brennan A, Cano C, Reeves HL, Newell DR, Golding BT, Miller DC, Griffin RJ.

Chem Sci. 2016 Apr 21;7(4):2821-2826. doi: 10.1039/c5sc03612g. Epub 2016 Jan 11.


Tumefactive demyelination following herbal supplement use: Cause or coincidence?

Dubey D, Golden E, Suss A, Cano CA, Krishnan G, Stuve O.

J Postgrad Med. 2016 Apr-Jun;62(2):136-7. doi: 10.4103/0022-3859.180577. No abstract available.


Update on monitoring and adverse effects of first generation disease modifying therapies and their recently approved versions in relapsing forms of multiple sclerosis.

Dubey D, Cano CA, Stüve O.

Curr Opin Neurol. 2016 Jun;29(3):272-7. doi: 10.1097/WCO.0000000000000320. Review.


Frailty and sarcopenia in Bogotá: results from the SABE Bogotá Study.

Samper-Ternent R, Reyes-Ortiz C, Ottenbacher KJ, Cano CA.

Aging Clin Exp Res. 2017 Apr;29(2):265-272. doi: 10.1007/s40520-016-0561-2. Epub 2016 Mar 31.


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