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Items: 43


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.


Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Cannons JL, Preite S, Kapnick SM, Uzel G, Schwartzberg PL.

Front Immunol. 2018 Aug 2;9:1758. doi: 10.3389/fimmu.2018.01758. eCollection 2018.


X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.

Panchal N, Booth C, Cannons JL, Schwartzberg PL.

Front Immunol. 2018 Apr 4;9:666. doi: 10.3389/fimmu.2018.00666. eCollection 2018. Review.


SAP and Lessons Learned from a Primary Immunodeficiency.

Cannons JL, Schwartzberg PL.

J Immunol. 2017 Sep 1;199(5):1531-1533. doi: 10.4049/jimmunol.1701007. No abstract available.


Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ.

J Immunol. 2014 Mar 1;192(5):2156-66. doi: 10.4049/jimmunol.1300675. Epub 2014 Jan 31.


Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G.

Nat Immunol. 2014 Jan;15(1):88-97. doi: 10.1038/ni.2771. Epub 2013 Oct 28.


Ncking BCR-mediated PI3K activation.

Cannons JL, Zhao F, Schwartzberg PL.

EMBO Rep. 2013 Oct;14(10):852-3. doi: 10.1038/embor.2013.133. Epub 2013 Aug 23. No abstract available.


Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.

Dervovic DD, Liang HC, Cannons JL, Elford AR, Mohtashami M, Ohashi PS, Schwartzberg PL, Zúñiga-Pflücker JC.

J Immunol. 2013 Aug 15;191(4):1704-15. doi: 10.4049/jimmunol.1300417. Epub 2013 Jul 12.


T follicular helper cell diversity and plasticity.

Cannons JL, Lu KT, Schwartzberg PL.

Trends Immunol. 2013 May;34(5):200-7. doi: 10.1016/ Epub 2013 Feb 8. Review.


A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.

Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.

J Immunol. 2013 Mar 1;190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25.


Lymph node choreography: B cells take the lead.

Cannons JL, Lu KT, Schwartzberg PL.

Nat Immunol. 2012 Jun 19;13(7):630-2. doi: 10.1038/ni.2349. No abstract available.


The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

Kageyama R, Cannons JL, Zhao F, Yusuf I, Lao C, Locci M, Schwartzberg PL, Crotty S.

Immunity. 2012 Jun 29;36(6):986-1002. doi: 10.1016/j.immuni.2012.05.016. Epub 2012 Jun 7.


Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL.

Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7.


Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.

Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG, Anderson SM, Wei L, Sun H, O'Shea JJ, Schwartzberg PL.

Immunity. 2011 Oct 28;35(4):622-32. doi: 10.1016/j.immuni.2011.07.015. Epub 2011 Oct 20.


A mosaic activating mutation in AKT1 associated with the Proteus syndrome.

Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG.

N Engl J Med. 2011 Aug 18;365(7):611-9. doi: 10.1056/NEJMoa1104017. Epub 2011 Jul 27.


Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.

Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, Wohlfert EA, Chou DB, Oldenhove G, Robinson M, Grigg ME, Kastenmayer R, Schwartzberg PL, Belkaid Y.

Immunity. 2011 Mar 25;34(3):435-47. doi: 10.1016/j.immuni.2011.03.003.


SLAM family receptors and SAP adaptors in immunity.

Cannons JL, Tangye SG, Schwartzberg PL.

Annu Rev Immunol. 2011;29:665-705. doi: 10.1146/annurev-immunol-030409-101302. Review.


Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.

Andrés AM, Dennis MY, Kretzschmar WW, Cannons JL, Lee-Lin SQ, Hurle B; NISC Comparative Sequencing Program, Schwartzberg PL, Williamson SH, Bustamante CD, Nielsen R, Clark AG, Green ED.

PLoS Genet. 2010 Oct 14;6(10):e1001157. doi: 10.1371/journal.pgen.1001157.


Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.

Cannons JL, Wu JZ, Gomez-Rodriguez J, Zhang J, Dong B, Liu Y, Shaw S, Siminovitch KA, Schwartzberg PL.

J Immunol. 2010 Sep 1;185(5):2819-27. doi: 10.4049/jimmunol.0902182. Epub 2010 Jul 28.


Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

Cannons JL, Qi H, Lu KT, Dutta M, Gomez-Rodriguez J, Cheng J, Wakeland EK, Germain RN, Schwartzberg PL.

Immunity. 2010 Feb 26;32(2):253-65. doi: 10.1016/j.immuni.2010.01.010. Epub 2010 Feb 11.


The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).

Steinfelder S, Andersen JF, Cannons JL, Feng CG, Joshi M, Dwyer D, Caspar P, Schwartzberg PL, Sher A, Jankovic D.

J Exp Med. 2009 Aug 3;206(8):1681-90. doi: 10.1084/jem.20082462. Epub 2009 Jul 27.


Follicular helper T cells are required for systemic autoimmunity.

Linterman MA, Rigby RJ, Wong RK, Yu D, Brink R, Cannons JL, Schwartzberg PL, Cook MC, Walters GD, Vinuesa CG.

J Exp Med. 2009 Mar 16;206(3):561-76. doi: 10.1084/jem.20081886. Epub 2009 Feb 16.


SLAM receptors and SAP influence lymphocyte interactions, development and function.

Schwartzberg PL, Mueller KL, Qi H, Cannons JL.

Nat Rev Immunol. 2009 Jan;9(1):39-46. doi: 10.1038/nri2456. Review.


Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

Sahu N, Venegas AM, Jankovic D, Mitzner W, Gomez-Rodriguez J, Cannons JL, Sommers C, Love P, Sher A, Schwartzberg PL, August A.

J Immunol. 2008 Nov 1;181(9):6125-31.


SAP-controlled T-B cell interactions underlie germinal centre formation.

Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN.

Nature. 2008 Oct 9;455(7214):764-9. doi: 10.1038/nature07345.


The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.

Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A.

Nat Immunol. 2008 Nov;9(11):1279-87. doi: 10.1038/ni.1653. Epub 2008 Sep 21.


Requirements for selection of conventional and innate T lymphocyte lineages.

Horai R, Mueller KL, Handon RA, Cannons JL, Anderson SM, Kirby MR, Schwartzberg PL.

Immunity. 2007 Nov;27(5):775-85.


CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.

Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP.

Blood. 2007 Apr 15;109(8):3432-40. Epub 2006 Dec 21.


SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.

Cannons JL, Yu LJ, Jankovic D, Crotty S, Horai R, Kirby M, Anderson S, Cheever AW, Sher A, Schwartzberg PL.

J Exp Med. 2006 Jun 12;203(6):1551-65. Epub 2006 Jun 5.


Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity.

Cuss AK, Avery DT, Cannons JL, Yu LJ, Nichols KE, Shaw PJ, Tangye SG.

J Immunol. 2006 Feb 1;176(3):1506-16.


Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency.

Loftus SK, Cannons JL, Incao A, Pak E, Chen A, Zerfas PM, Bryant MA, Biesecker LG, Schwartzberg PL, Pavan WJ.

PLoS Genet. 2005 Sep;1(3):e38.


Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.

Cannons JL, Chamberlain G, Howson J, Smink LJ, Todd JA, Peterson LB, Wicker LS, Watts TH.

J Autoimmun. 2005 Aug;25(1):13-20.


Regulation of NKT cell development by SAP, the protein defective in XLP.

Nichols KE, Hom J, Gong SY, Ganguly A, Ma CS, Cannons JL, Tangye SG, Schwartzberg PL, Koretzky GA, Stein PL.

Nat Med. 2005 Mar;11(3):340-5. Epub 2005 Feb 13.


Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.

Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, Tangye SG.

Immunol Rev. 2005 Feb;203:180-99. Review.


SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.

Cannons JL, Yu LJ, Hill B, Mijares LA, Dombroski D, Nichols KE, Antonellis A, Koretzky GA, Gardner K, Schwartzberg PL.

Immunity. 2004 Nov;21(5):693-706.


Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?

Cannons JL, Schwartzberg PL.

Curr Opin Immunol. 2004 Jun;16(3):296-303. Review.


4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.

Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.

J Immunol. 2001 Aug 1;167(3):1313-24.


Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB.

Cannons JL, Hoeflich KP, Woodgett JR, Watts TH.

J Immunol. 1999 Sep 15;163(6):2990-8.


HPRT- mutant T cells in the peripheral blood and synovial tissue of patients with rheumatoid arthritis.

Cannons JL, Karsh J, Birnboim HC, Goldstein R.

Arthritis Rheum. 1998 Oct;41(10):1772-82.


CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

Saoulli K, Lee SY, Cannons JL, Yeh WC, Santana A, Goldstein MD, Bangia N, DeBenedette MA, Mak TW, Choi Y, Watts TH.

J Exp Med. 1998 Jun 1;187(11):1849-62.

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