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Items: 14

1.

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Dec 14;28(6):831. doi: 10.1016/j.ccell.2015.11.003. Epub 2015 Dec 14. No abstract available.

2.

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Nov 9;28(5):623-637. doi: 10.1016/j.ccell.2015.09.009. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831.

3.

A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.

Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE.

Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3.

4.

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB.

Cell Rep. 2013 Nov 27;5(4):868-77. doi: 10.1016/j.celrep.2013.10.025. Epub 2013 Nov 14.

5.

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.

6.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.

7.

Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network.

Cannell IG, Yaffe MB.

Crit Care Med. 2011 Jul;39(7):1836-7. doi: 10.1097/CCM.0b013e3182204ad1. No abstract available.

8.

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

Kress TR, Cannell IG, Brenkman AB, Samans B, Gaestel M, Roepman P, Burgering BM, Bushell M, Rosenwald A, Eilers M.

Mol Cell. 2011 Feb 18;41(4):445-57. doi: 10.1016/j.molcel.2011.01.023.

9.

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

Reinhardt HC, Cannell IG, Morandell S, Yaffe MB.

Cell Cycle. 2011 Jan 1;10(1):23-7. Epub 2011 Jan 1. Review.

10.

Regulation of Myc by miR-34c: A mechanism to prevent genomic instability?

Cannell IG, Bushell M.

Cell Cycle. 2010 Jul 15;9(14):2726-30. Epub 2010 Jul 27. Review.

PMID:
20603603
11.

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. doi: 10.1073/pnas.0910015107. Epub 2010 Mar 8.

12.

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.

Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509.

13.

How do microRNAs regulate gene expression?

Cannell IG, Kong YW, Bushell M.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1224-31. doi: 10.1042/BST0361224. Review.

PMID:
19021530
14.

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.

Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8866-71. doi: 10.1073/pnas.0800650105. Epub 2008 Jun 25.

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