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Items: 49


Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.

Morgan MA, Canman CE.

Cancer Res. 2018 Dec 15;78(24):6713-6716. doi: 10.1158/0008-5472.CAN-18-2439. Epub 2018 Nov 29. Review.


A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.

Fritzen R, Delbos F, De Smet A, Palancade B, Canman CE, Aoufouchi S, Weill JC, Reynaud CA, Storck S.

DNA Repair (Amst). 2016 Oct;46:37-46. doi: 10.1016/j.dnarep.2016.07.002. Epub 2016 Jul 25.


Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.

Ziv O, Zeisel A, Mirlas-Neisberg N, Swain U, Nevo R, Ben-Chetrit N, Martelli MP, Rossi R, Schiesser S, Canman CE, Carell T, Geacintov NE, Falini B, Domany E, Livneh Z.

Nat Commun. 2014 Nov 25;5:5437. doi: 10.1038/ncomms6437.


A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N.

J Biol Chem. 2014 Mar 7;289(10):7109-20. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28.


PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.

Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, Logothetis CJ, Araujo JC, Pisters LL, Tewari AK, Canman CE, Knudsen KE, Kitabayashi N, Rubin MA, Demichelis F, Lawrence TS, Chinnaiyan AM, Feng FY.

Cancer Res. 2014 Mar 15;74(6):1651-60. doi: 10.1158/0008-5472.CAN-13-3159. Epub 2014 Jan 28.


ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells.

Wang L, Yang H, Palmbos PL, Ney G, Detzler TA, Coleman D, Leflein J, Davis M, Zhang M, Tang W, Hicks JK, Helchowski CM, Prasad J, Lawrence TS, Xu L, Yu X, Canman CE, Ljungman M, Simeone DM.

Cancer Res. 2014 Mar 15;74(6):1778-88. doi: 10.1158/0008-5472.CAN-13-2289. Epub 2014 Jan 27.


Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.

Ladd B, Ackroyd JJ, Hicks JK, Canman CE, Flanagan SA, Shewach DS.

DNA Repair (Amst). 2013 Dec;12(12):1114-21. doi: 10.1016/j.dnarep.2013.10.008. Epub 2013 Nov 11.


A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.

Helchowski CM, Skow LF, Roberts KH, Chute CL, Canman CE.

Cell Cycle. 2013 Dec 15;12(24):3749-58. doi: 10.4161/cc.26640. Epub 2013 Oct 3.


BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.

Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13558-63. doi: 10.1073/pnas.1306534110. Epub 2013 Jul 30. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16283.


The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.

Sharma S, Helchowski CM, Canman CE.

Mutat Res. 2013 Mar-Apr;743-744:97-110. doi: 10.1016/j.mrfmmm.2012.11.002. Epub 2012 Nov 26. Review.


REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.

Sharma S, Canman CE.

Environ Mol Mutagen. 2012 Dec;53(9):725-40. doi: 10.1002/em.21736. Epub 2012 Oct 13. Review.


DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.

Sharma S, Shah NA, Joiner AM, Roberts KH, Canman CE.

Mol Pharmacol. 2012 Jun;81(6):778-87. doi: 10.1124/mol.111.076828. Epub 2012 Mar 2.


REV1 and polymerase ζ facilitate homologous recombination repair.

Sharma S, Hicks JK, Chute CL, Brennan JR, Ahn JY, Glover TW, Canman CE.

Nucleic Acids Res. 2012 Jan;40(2):682-91. doi: 10.1093/nar/gkr769. Epub 2011 Sep 16.


Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS.

Cancer Res. 2010 Jun 15;70(12):4972-81. doi: 10.1158/0008-5472.CAN-09-3573. Epub 2010 May 25.


Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE.

Mol Cell Biol. 2010 Mar;30(5):1217-30. doi: 10.1128/MCB.00993-09. Epub 2009 Dec 22.


Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

Parsels LA, Morgan MA, Tanska DM, Parsels JD, Palmer BD, Booth RJ, Denny WA, Canman CE, Kraker AJ, Lawrence TS, Maybaum J.

Mol Cancer Ther. 2009 Jan;8(1):45-54. doi: 10.1158/1535-7163.MCT-08-0662.


Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner.

Derheimer FA, Hicks JK, Paulsen MT, Canman CE, Ljungman M.

Mol Pharmacol. 2009 Mar;75(3):599-607. doi: 10.1124/mol.108.051698. Epub 2008 Dec 8.


Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.

Nyati MK, Feng FY, Maheshwari D, Varambally S, Zielske SP, Ahsan A, Chun PY, Arora VA, Davis MA, Jung M, Ljungman M, Canman CE, Chinnaiyan AM, Lawrence TS.

Cancer Res. 2006 Dec 15;66(24):11554-9.


Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS.

Mol Cancer Res. 2003 Jul;1(9):674-81.


Checkpoint mediators: relaying signals from DNA strand breaks.

Canman CE.

Curr Biol. 2003 Jun 17;13(12):R488-90. Review.


Replication checkpoint: preventing mitotic catastrophe.

Canman CE.

Curr Biol. 2001 Feb 20;11(4):R121-4. Review.


Expression and assay of recombinant ATM.

Ziv Y, Banin S, Lim DS, Canman CE, Kastan MB, Shiloh Y.

Methods Mol Biol. 2000;99:99-108. Review. No abstract available.


Substrate specificities and identification of putative substrates of ATM kinase family members.

Kim ST, Lim DS, Canman CE, Kastan MB.

J Biol Chem. 1999 Dec 31;274(53):37538-43.


The role of ATM in DNA damage responses and cancer.

Canman CE, Lim DS.

Oncogene. 1998 Dec 24;17(25):3301-8. Review.


Loss of atm radiosensitizes multiple p53 null tissues.

Westphal CH, Hoyes KP, Canman CE, Huang X, Kastan MB, Hendry JH, Leder P.

Cancer Res. 1998 Dec 15;58(24):5637-9.


Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD.

Science. 1998 Sep 11;281(5383):1677-9.


ATM binds to beta-adaptin in cytoplasmic vesicles.

Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, Darnell RB, Shiloh Y, Kastan MB.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10146-51.


Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.

Metcalfe SM, Canman CE, Milner J, Morris RE, Goldman S, Kastan MB.

Oncogene. 1997 Oct 2;15(14):1635-42.


DNA damage induces phosphorylation of the amino terminus of p53.

Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB.

Genes Dev. 1997 Dec 15;11(24):3471-81.


Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.

Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, Barlow C, Baltimore D, Wynshaw-Boris A, Kastan MB, Wang JY.

Nature. 1997 May 29;387(6632):516-9.


Role of p53 in apoptosis.

Canman CE, Kastan MB.

Adv Pharmacol. 1997;41:429-60. Review. No abstract available.


Signal transduction. Three paths to stress relief.

Canman CE, Kastan MB.

Nature. 1996 Nov 21;384(6606):213-4. No abstract available.


Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.

Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB, Look AT.

Nature. 1996 Aug 8;382(6591):541-4.


Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity.

Lawrence TS, Davis MA, Chang EY, Canman CE, Maybaum J, Radany EH.

Radiat Res. 1995 Sep;143(3):281-5.


Growth factor modulation of p53-mediated growth arrest versus apoptosis.

Canman CE, Gilmer TM, Coutts SB, Kastan MB.

Genes Dev. 1995 Mar 1;9(5):600-11.


P53, cell cycle control and apoptosis: implications for cancer.

Kastan MB, Canman CE, Leonard CJ.

Cancer Metastasis Rev. 1995 Mar;14(1):3-15. Review.


Induction of apoptosis by tumor suppressor genes and oncogenes.

Canman CE, Kastan MB.

Semin Cancer Biol. 1995 Feb;6(1):17-25. Review.


The role of p53 in cell-cycle control and apoptosis: implications for cancer.

Leonard CJ, Canman CE, Kastan MB.

Important Adv Oncol. 1995:33-42. Review. No abstract available.


The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

Canman CE, Wolff AC, Chen CY, Fornace AJ Jr, Kastan MB.

Cancer Res. 1994 Oct 1;54(19):5054-8.


WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al.

Cancer Res. 1994 Mar 1;54(5):1169-74.


DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.

Canman CE, Chen CY, Lee MH, Kastan MB.

Cold Spring Harb Symp Quant Biol. 1994;59:277-86. Review. No abstract available.


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