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The Janus Face of Cereals: Wheat-Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High Fat/High Sucrose Diet.

Olivares M, Rodriguez J, Pötgens SA, Neyrinck AM, Cani PD, Bindels LB, Delzenne NM.

Mol Nutr Food Res. 2019 Oct 13:e1900632. doi: 10.1002/mnfr.201900632. [Epub ahead of print]


Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.

Neyrinck AM, Catry E, Taminiau B, Cani PD, Bindels LB, Daube G, Dessy C, Delzenne NM.

Sci Rep. 2019 Oct 2;9(1):14150. doi: 10.1038/s41598-019-50700-4.


Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice.

Salazar N, Neyrinck AM, Bindels LB, Druart C, Ruas-Madiedo P, Cani PD, de Los Reyes-Gavilán CG, Delzenne NM.

Front Microbiol. 2019 Aug 7;10:1809. doi: 10.3389/fmicb.2019.01809. eCollection 2019.


Oral vancomycin treatment does not alter markers of postprandial inflammation in lean and obese subjects.

Bakker GJ, Schnitzler JG, Bekkering S, de Clercq NC, Koopen AM, Hartstra AV, Meessen ECE, Scheithauer TP, Winkelmeijer M, Dallinga-Thie GM, Cani PD, Kemper EM, Soeters MR, Kroon J, Groen AK, van Raalte DH, Herrema H, Nieuwdorp M.

Physiol Rep. 2019 Aug;7(16):e14199. doi: 10.14814/phy2.14199.


Novel strategy for oral peptide delivery in incretin-based diabetes treatment.

Xu Y, Van Hul M, Suriano F, Préat V, Cani PD, Beloqui A.

Gut. 2019 Aug 10. pii: gutjnl-2019-319146. doi: 10.1136/gutjnl-2019-319146. [Epub ahead of print]


Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice.

Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, Smits HH, Bouter KE, Rensen PCN, Quax PHA, Nieuwdorp M, Netea MG, de Vos WM, Cani PD, Belzer C, van Dijk KW, Berbée JFP, van Harmelen V.

Mol Nutr Food Res. 2019 Aug 6:e1900732. doi: 10.1002/mnfr.201900732. [Epub ahead of print]


Targeting the Enteric Nervous System to Treat Metabolic Disorders? "Enterosynes" as Therapeutic Gut Factors.

Knauf C, Abot A, Wemelle E, Cani PD.

Neuroendocrinology. 2019 Jul 2. doi: 10.1159/000500602. [Epub ahead of print] Review.


Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement.

Dao MC, Belda E, Prifti E, Everard A, Kayser BD, Bouillot JL, Chevallier JM, Pons N, Le Chatelier E, Ehrlich SD, Doré J, Aron-Wisnewsky J, Zucker JD, Cani PD, Clément K.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E446-E459. doi: 10.1152/ajpendo.00140.2019. Epub 2019 Jul 2.


Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.

Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, de Barsy M, Loumaye A, Hermans MP, Thissen JP, de Vos WM, Cani PD.

Nat Med. 2019 Jul;25(7):1096-1103. doi: 10.1038/s41591-019-0495-2. Epub 2019 Jul 1.


Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter.

Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD.

Int J Syst Evol Microbiol. 2019 Jun 24. doi: 10.1099/ijsem.0.003547. [Epub ahead of print]


Targeting Carbohydrates and Polyphenols for a Healthy Microbiome and Healthy Weight.

Van Hul M, Cani PD.

Curr Nutr Rep. 2019 Jun 3. doi: 10.1007/s13668-019-00281-5. [Epub ahead of print] Review.


Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans.

Hiel S, Bindels LB, Pachikian BD, Kalala G, Broers V, Zamariola G, Chang BPI, Kambashi B, Rodriguez J, Cani PD, Neyrinck AM, Thissen JP, Luminet O, Bindelle J, Delzenne NM.

Am J Clin Nutr. 2019 Jun 1;109(6):1683-1695. doi: 10.1093/ajcn/nqz001.


The Gut Microbiome Influences Host Endocrine Functions.

Rastelli M, Cani PD, Knauf C.

Endocr Rev. 2019 Oct 1;40(5):1271-1284. doi: 10.1210/er.2018-00280.


Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols.

Lefort C, Van Hul M, Delzenne NM, Everard A, Cani PD.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E99-E108. doi: 10.1152/ajpendo.00082.2019. Epub 2019 Apr 30.


Is colonic propionate delivery a novel solution to improve metabolism and inflammation in overweight or obese subjects?

Cani PD.

Gut. 2019 Aug;68(8):1352-1353. doi: 10.1136/gutjnl-2019-318776. Epub 2019 Apr 26. No abstract available.


Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.

Johanns M, Kviklyte S, Chuang SJ, Corbeels K, Jacobs R, Herinckx G, Vertommen D, Schakman O, Duparc T, Cani PD, Bouzin C, Andersén H, Bohlooly-Y M, Van der Schueren B, Oscarsson J, Rider MH.

Mol Genet Metab. 2019 Apr;126(4):377-387. doi: 10.1016/j.ymgme.2019.01.017. Epub 2019 Feb 14.


Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas.

Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD.

Int J Syst Evol Microbiol. 2019 Mar;69(3):833-838. doi: 10.1099/ijsem.0.003249. Epub 2019 Feb 1.


Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.

Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD.

Nat Commun. 2019 Jan 28;10(1):457. doi: 10.1038/s41467-018-08051-7.


Targeting gut microbiota with a complex mix of dietary fibers improves metabolic diseases.

Cani PD.

Kidney Int. 2019 Jan;95(1):14-16. doi: 10.1016/j.kint.2018.11.012. No abstract available.


Microbiota and metabolites in metabolic diseases.

Cani PD.

Nat Rev Endocrinol. 2019 Feb;15(2):69-70. doi: 10.1038/s41574-018-0143-9. Review. No abstract available.


Elevated high density lipoprotein cholesterol and low grade systemic inflammation is associated with increased gut permeability in normoglycemic men.

Robertson MD, Pedersen C, Hinton PJ, Mendis ASJR, Cani PD, Griffin BA.

Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1296-1303. doi: 10.1016/j.numecd.2018.07.006. Epub 2018 Aug 1.


Erratum. The Transplantation of ω3 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders. Diabetes 2018;67:1512-1523.

Bidu C, Escoula Q, Bellenger S, Spor A, Galan M, Geissler A, Bouchot A, Dardevet D, Morio-Liondor B, Cani PD, Lagrost L, Narce M, Bellenger J.

Diabetes. 2019 Jan;68(1):235. doi: 10.2337/db19-er01a. Epub 2018 Nov 19. No abstract available.


Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System.

Bessac A, Cani PD, Meunier E, Dietrich G, Knauf C.

Front Neurosci. 2018 Oct 10;12:725. doi: 10.3389/fnins.2018.00725. eCollection 2018. Review.


Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell. 2018 Oct 18;175(3):679-694.e22. doi: 10.1016/j.cell.2018.09.004.


Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction.

Pötgens SA, Brossel H, Sboarina M, Catry E, Cani PD, Neyrinck AM, Delzenne NM, Bindels LB.

Sci Rep. 2018 Aug 17;8(1):12321. doi: 10.1038/s41598-018-30569-5.


Severe obesity and gut microbiota: does bariatric surgery really reset the system?

Cani PD.

Gut. 2019 Jan;68(1):5-6. doi: 10.1136/gutjnl-2018-316815. Epub 2018 Jul 10. No abstract available.


Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.

Abot A, Cani PD, Knauf C.

Front Endocrinol (Lausanne). 2018 Jun 22;9:328. doi: 10.3389/fendo.2018.00328. eCollection 2018. Review.


Human gut microbiome: hopes, threats and promises.

Cani PD.

Gut. 2018 Sep;67(9):1716-1725. doi: 10.1136/gutjnl-2018-316723. Epub 2018 Jun 22. Review.


The gut microbiota metabolite indole alleviates liver inflammation in mice.

Beaumont M, Neyrinck AM, Olivares M, Rodriguez J, de Rocca Serra A, Roumain M, Bindels LB, Cani PD, Evenepoel P, Muccioli GG, Demoulin JB, Delzenne NM.

FASEB J. 2018 Jun 15:fj201800544. doi: 10.1096/fj.201800544. [Epub ahead of print]


Prebiotics Supplementation Impact on the Reinforcing and Motivational Aspect of Feeding.

Delbès AS, Castel J, Denis RGP, Morel C, Quiñones M, Everard A, Cani PD, Massiera F, Luquet SH.

Front Endocrinol (Lausanne). 2018 May 29;9:273. doi: 10.3389/fendo.2018.00273. eCollection 2018.


Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer.

Cani PD, Jordan BF.

Nat Rev Gastroenterol Hepatol. 2018 Nov;15(11):671-682. doi: 10.1038/s41575-018-0025-6. Review.


The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice.

Olivares M, Neyrinck AM, Pötgens SA, Beaumont M, Salazar N, Cani PD, Bindels LB, Delzenne NM.

Diabetologia. 2018 Aug;61(8):1838-1848. doi: 10.1007/s00125-018-4647-6. Epub 2018 May 25.


The Transplantation of ω3 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders.

Bidu C, Escoula Q, Bellenger S, Spor A, Galan M, Geissler A, Bouchot A, Dardevet D, Morio B, Cani PD, Lagrost L, Narce M, Bellenger J.

Diabetes. 2018 Aug;67(8):1512-1523. doi: 10.2337/db17-1488. Epub 2018 May 23. Erratum in: Diabetes. 2019 Jan;68(1):235.


Increased gut permeability in cancer cachexia: mechanisms and clinical relevance.

Bindels LB, Neyrinck AM, Loumaye A, Catry E, Walgrave H, Cherbuy C, Leclercq S, Van Hul M, Plovier H, Pachikian B, Bermúdez-Humarán LG, Langella P, Cani PD, Thissen JP, Delzenne NM.

Oncotarget. 2018 Apr 6;9(26):18224-18238. doi: 10.18632/oncotarget.24804. eCollection 2018 Apr 6.


Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine.

Hiel S, Neyrinck AM, Rodriguez J, Pachikian BD, Bouzin C, Thissen JP, Cani PD, Bindels LB, Delzenne NM.

Nutrients. 2018 Apr 25;10(5). pii: E532. doi: 10.3390/nu10050532.


Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders.

Rastelli M, Knauf C, Cani PD.

Obesity (Silver Spring). 2018 May;26(5):792-800. doi: 10.1002/oby.22175. Review.


Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans.

Pedersen C, Ijaz UZ, Gallagher E, Horton F, Ellis RJ, Jaiyeola E, Duparc T, Russell-Jones D, Hinton P, Cani PD, La Ragione RM, Robertson MD.

Physiol Rep. 2018 Apr;6(7):e13649. doi: 10.14814/phy2.13649.


Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice.

Neyrinck AM, Hiel S, Bouzin C, Campayo VG, Cani PD, Bindels LB, Delzenne NM.

Nutr Diabetes. 2018 Mar 7;8(1):15. doi: 10.1038/s41387-018-0019-z.


Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons.

Abot A, Lucas A, Bautzova T, Bessac A, Fournel A, Le-Gonidec S, Valet P, Moro C, Cani PD, Knauf C.

Mol Metab. 2018 Apr;10:100-108. doi: 10.1016/j.molmet.2018.01.020. Epub 2018 Jan 31.


Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis.

Pachikian BD, Druart C, Catry E, Bindels LB, Neyrinck AM, Larondelle Y, Cani PD, Delzenne NM.

PLoS One. 2018 Feb 1;13(2):e0192447. doi: 10.1371/journal.pone.0192447. eCollection 2018.


Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice.

Hänninen A, Toivonen R, Pöysti S, Belzer C, Plovier H, Ouwerkerk JP, Emani R, Cani PD, De Vos WM.

Gut. 2018 Aug;67(8):1445-1453. doi: 10.1136/gutjnl-2017-314508. Epub 2017 Dec 21.


Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells.

Xu Y, Carradori D, Alhouayek M, Muccioli GG, Cani PD, Préat V, Beloqui A.

Mol Pharm. 2018 Jan 2;15(1):108-115. doi: 10.1021/acs.molpharmaceut.7b00742. Epub 2017 Dec 15.


Adipose Tissue Metabolism and Cancer Progression: Novel Insights from Gut Microbiota?

Jordan BF, Gourgue F, Cani PD.

Curr Pathobiol Rep. 2017;5(4):315-322. doi: 10.1007/s40139-017-0154-6. Epub 2017 Oct 24. Review.


Intestinal Ralstonia pickettii augments glucose intolerance in obesity.

Udayappan SD, Kovatcheva-Datchary P, Bakker GJ, Havik SR, Herrema H, Cani PD, Bouter KE, Belzer C, Witjes JJ, Vrieze A, de Sonnaville ESV, Chaplin A, van Raalte DH, Aalvink S, Dallinga-Thie GM, Heilig HGHJ, Bergström G, van der Meij S, van Wagensveld BA, Hoekstra JBL, Holleman F, Stroes ESG, Groen AK, Bäckhed F, de Vos WM, Nieuwdorp M.

PLoS One. 2017 Nov 22;12(11):e0181693. doi: 10.1371/journal.pone.0181693. eCollection 2017. Erratum in: PLoS One. 2018 Jan 30;13(1):e0192339.


Host-microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice.

Molinaro A, Caesar R, Holm LM, Tremaroli V, Cani PD, Bäckhed F.

Mol Metab. 2017 Nov;6(11):1371-1380. doi: 10.1016/j.molmet.2017.08.016. Epub 2017 Sep 21.


Combined endogenous MR biomarkers to predict basal tumor oxygenation and response to hyperoxic challenge.

Cao-Pham TT, Joudiou N, Van Hul M, Bouzin C, Cani PD, Gallez B, Jordan BF.

NMR Biomed. 2017 Dec;30(12). doi: 10.1002/nbm.3836. Epub 2017 Oct 11.


Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila.

Cani PD, de Vos WM.

Front Microbiol. 2017 Sep 22;8:1765. doi: 10.3389/fmicb.2017.01765. eCollection 2017. Review.


Enteroendocrine Cells: Metabolic Relays between Microbes and Their Host.

Plovier H, Cani PD.

Endocr Dev. 2017;32:139-164. doi: 10.1159/000475736. Epub 2017 Aug 15. Review.


Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier.

Van Hul M, Geurts L, Plovier H, Druart C, Everard A, Ståhlman M, Rhimi M, Chira K, Teissedre PL, Delzenne NM, Maguin E, Guilbot A, Brochot A, Gérard P, Bäckhed F, Cani PD.

Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E334-E352. doi: 10.1152/ajpendo.00107.2017. Epub 2017 Sep 5.


Ffar2 expression regulates leukaemic cell growth in vivo.

Bindels LB, Porporato PE, Ducastel S, Sboarina M, Neyrinck AM, Dewulf EM, Feron O, Lestavel S, Cani PD, Staels B, Sonveaux P, Delzenne NM.

Br J Cancer. 2017 Oct 24;117(9):1336-1340. doi: 10.1038/bjc.2017.307. Epub 2017 Sep 5.

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