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Items: 1 to 50 of 54

1.

FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.

Ponnusamy A, Sinha S, Hyde GD, Borland SJ, Taylor RF, Pond E, Eyre HJ, Inkson CA, Gilmore A, Ashton N, Kalra PA, Canfield AE.

PLoS One. 2018 Apr 24;13(4):e0196232. doi: 10.1371/journal.pone.0196232. eCollection 2018.

2.

Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J.

J Lipid Res. 2018 Jan;59(1):69-78. doi: 10.1194/jlr.M079731. Epub 2017 Nov 22.

3.

Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ.

Borland SJ, Morris TG, Borland SC, Morgan MR, Francis SE, Merry CLR, Canfield AE.

Cardiovasc Res. 2017 Nov 1;113(13):1639-1652. doi: 10.1093/cvr/cvx178.

4.

Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.

Holley RJ, Tai G, Williamson AJ, Taylor S, Cain SA, Richardson SM, Merry CL, Whetton AD, Kielty CM, Canfield AE.

Stem Cell Reports. 2015 Mar 10;4(3):473-88. doi: 10.1016/j.stemcr.2015.01.007. Epub 2015 Feb 13.

5.

Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia.

Hyde GD, Taylor RF, Ashton N, Borland SJ, Wu HS, Gilmore AP, Canfield AE.

PLoS One. 2014 Jul 14;9(7):e102096. doi: 10.1371/journal.pone.0102096. eCollection 2014.

6.

Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential.

Ball SG, Worthington JJ, Canfield AE, Merry CL, Kielty CM.

Stem Cells. 2014 Mar;32(3):694-705. doi: 10.1002/stem.1538.

7.

Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation.

Newton PT, Staines KA, Spevak L, Boskey AL, Teixeira CC, Macrae VE, Canfield AE, Farquharson C.

Int J Mol Med. 2012 Nov;30(5):1187-93. doi: 10.3892/ijmm.2012.1114. Epub 2012 Aug 31.

8.

HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro.

Liu Y, Wang T, Yan J, Jiagbogu N, Heideman DA, Canfield AE, Alexander MY.

Atherosclerosis. 2011 Dec;219(2):440-7. doi: 10.1016/j.atherosclerosis.2011.08.033. Epub 2011 Aug 26.

9.

Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.

Siddals KW, Allen J, Sinha S, Canfield AE, Kalra PA, Gibson JM.

J Biol Chem. 2011 May 13;286(19):16623-30. doi: 10.1074/jbc.M110.202929. Epub 2011 Mar 16.

10.

Cyclic stretch-induced TGFbeta1/Smad signaling inhibits adipogenesis in umbilical cord progenitor cells.

Turner NJ, Jones HS, Davies JE, Canfield AE.

Biochem Biophys Res Commun. 2008 Dec 26;377(4):1147-51. doi: 10.1016/j.bbrc.2008.10.131. Epub 2008 Nov 5.

PMID:
18983975
11.

Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.

Alam MU, Kirton JP, Wilkinson FL, Towers E, Sinha S, Rouhi M, Vizard TN, Sage AP, Martin D, Ward DT, Alexander MY, Riccardi D, Canfield AE.

Cardiovasc Res. 2009 Feb 1;81(2):260-8. doi: 10.1093/cvr/cvn279. Epub 2008 Oct 13.

PMID:
18852253
12.

HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains.

Hadfield KD, Rock CF, Inkson CA, Dallas SL, Sudre L, Wallis GA, Boot-Handford RP, Canfield AE.

J Biol Chem. 2008 Feb 29;283(9):5928-38. Epub 2007 Dec 22.

13.

The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment.

Williamson MR, Shuttleworth A, Canfield AE, Black RA, Kielty CM.

Biomaterials. 2007 Dec;28(35):5307-18. Epub 2007 Sep 11.

PMID:
17850863
14.

Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?

Kirton JP, Crofts NJ, George SJ, Brennan K, Canfield AE.

Circ Res. 2007 Sep 14;101(6):581-9. Epub 2007 Aug 2.

PMID:
17673669
15.

HtrA1: a novel regulator of physiological and pathological matrix mineralization?

Canfield AE, Hadfield KD, Rock CF, Wylie EC, Wilkinson FL.

Biochem Soc Trans. 2007 Aug;35(Pt 4):669-71. Review.

PMID:
17635117
16.

Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development.

Liu Y, Wilkinson FL, Kirton JP, Jeziorska M, Iizasa H, Sai Y, Nakashima E, Heagerty AM, Canfield AE, Alexander MY.

J Pathol. 2007 May;212(1):12-9.

PMID:
17405187
17.

Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells.

Collett GD, Sage AP, Kirton JP, Alexander MY, Gilmore AP, Canfield AE.

Circ Res. 2007 Mar 2;100(4):502-9. Epub 2007 Jan 25.

PMID:
17255529
18.

Contribution of VCAF-positive cells to neovascularization and calcification in atherosclerotic plaque development.

Wilkinson FL, Liu Y, Rucka AK, Jeziorska M, Hoyland JA, Heagerty AM, Canfield AE, Alexander MY.

J Pathol. 2007 Feb;211(3):362-9.

19.

Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study.

Turner NJ, Murphy MO, Kielty CM, Shuttleworth CA, Black RA, Humphries MJ, Walker MG, Canfield AE.

Circulation. 2006 Aug 22;114(8):820-9. Epub 2006 Aug 14.

PMID:
16908762
20.
21.

Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.

Alexander MY, Wilkinson FL, Kirton JP, Rock CF, Collett GD, Jeziorska M, Smyth JV, Heagerty AM, Canfield AE.

Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1851-7. Epub 2005 Jun 30.

PMID:
15994437
22.

Angiogenesis and pericytes in the initiation of ectopic calcification.

Collett GD, Canfield AE.

Circ Res. 2005 May 13;96(9):930-8. Review.

PMID:
15890980
23.

Chondrogenic and adipogenic potential of microvascular pericytes.

Farrington-Rock C, Crofts NJ, Doherty MJ, Ashton BA, Griffin-Jones C, Canfield AE.

Circulation. 2004 Oct 12;110(15):2226-32. Epub 2004 Oct 4.

PMID:
15466630
24.

A novel hyaluronan-based biomaterial (Hyaff-11) as a scaffold for endothelial cells in tissue engineered vascular grafts.

Turner NJ, Kielty CM, Walker MG, Canfield AE.

Biomaterials. 2004 Dec;25(28):5955-64.

PMID:
15183610
25.

Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes.

Collett G, Wood A, Alexander MY, Varnum BC, Boot-Handford RP, Ohanian V, Ohanian J, Fridell YW, Canfield AE.

Circ Res. 2003 May 30;92(10):1123-9. Epub 2003 May 1.

PMID:
12730092
26.

The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.

Canfield AE, Farrington C, Dziobon MD, Boot-Handford RP, Heagerty AM, Kumar SN, Roberts IS.

J Pathol. 2002 Feb;196(2):228-34.

PMID:
11793375
27.

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

Flasza M, Gorman P, Roylance R, Canfield AE, Baron M.

Biochem Biophys Res Commun. 2002 Jan 11;290(1):431-7.

PMID:
11779188
28.

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

Sinha S, Kielty CM, Heagerty AM, Canfield AE, Shuttleworth CA.

Int J Exp Pathol. 2001 Oct;82(5):295-302.

29.

Matrix Gla protein is differentially expressed during the deposition of a calcified matrix by vascular pericytes.

Canfield AE, Doherty MJ, Kelly V, Newman B, Farrington C, Grant ME, Boot-Handford RP.

FEBS Lett. 2000 Dec 29;487(2):267-71.

30.

1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo.

Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE.

Circ Res. 2000 Aug 4;87(3):214-20.

PMID:
10926872
31.

Identification of genes expressed during the osteogenic differentiation of vascular pericytes in vitro.

Doherty M, Boot-Handford RP, Grant ME, Canfield AE.

Biochem Soc Trans. 1998 Feb;26(1):S4. No abstract available.

PMID:
10909762
32.

The expression of cartilage oligomeric matrix protein, thrombospondin-1, bone sialoprotein and osteopontin in calcified and non-calcified arterial lesions.

Farrington C, Roberts IS, Heagerty AM, Canfield AE.

Biochem Soc Trans. 1998 Feb;26(1):S3. No abstract available.

PMID:
10909761
33.

The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development.

Green H, Canfield AE, Hillarby MC, Grant ME, Boot-Handford RP, Freemont AJ, Wallis GA.

J Bone Miner Res. 2000 Jun;15(6):1066-75.

34.

Role of pericytes in vascular calcification: a review.

Canfield AE, Doherty MJ, Wood AC, Farrington C, Ashton B, Begum N, Harvey B, Poole A, Grant ME, Boot-Handford RP.

Z Kardiol. 2000;89 Suppl 2:20-7. Review.

PMID:
10769400
35.

Gene expression during vascular pericyte differentiation.

Doherty MJ, Canfield AE.

Crit Rev Eukaryot Gene Expr. 1999;9(1):1-17. Review.

PMID:
10200908
36.

Vascular pericytes express osteogenic potential in vitro and in vivo.

Doherty MJ, Ashton BA, Walsh S, Beresford JN, Grant ME, Canfield AE.

J Bone Miner Res. 1998 May;13(5):828-38.

37.

Association of thrombospondin-1 with osteogenic differentiation of retinal pericytes in vitro.

Canfield AE, Sutton AB, Hoyland JA, Schor AM.

J Cell Sci. 1996 Feb;109 ( Pt 2):343-53.

38.

Pericyte differentiation.

Schor AM, Canfield AE, Sutton AB, Arciniegas E, Allen TD.

Clin Orthop Relat Res. 1995 Apr;(313):81-91.

PMID:
7543836
39.

Evidence that tenascin and thrombospondin-1 modulate sprouting of endothelial cells.

Canfield AE, Schor AM.

J Cell Sci. 1995 Feb;108 ( Pt 2):797-809.

40.

Alpha- and beta-xylosides modulate the synthesis of fibronectin and thrombospondin-1 by endothelial cells.

Canfield AE, Sutton AB, Hiscock DR, Gallagher JT, Schor AM.

Biochim Biophys Acta. 1994 Aug 18;1200(3):249-58.

PMID:
8068710
41.

Heterogeneity in collagen biosynthesis by sprouting retinal endothelial cells.

Canfield AE, Schor AM.

J Cell Physiol. 1994 Apr;159(1):19-28.

PMID:
7511145
42.

Aortic endothelial cell heterogeneity in vitro. Lack of association between morphological phenotype and collagen biosynthesis.

Canfield AE, Wren FE, Schor SL, Grant ME, Schor AM.

J Cell Sci. 1992 Aug;102 ( Pt 4):807-14.

43.

The behaviour of pericytes in vitro: relevance to angiogenesis and differentiation.

Schor AM, Canfield AE, Sutton AB, Allen TD, Sloan P, Schor SL.

EXS. 1992;61:167-78. No abstract available.

PMID:
1617229
44.

Aortic endothelial cells in culture: factors which modulate their morphological and biosynthetic phenotypes.

Canfield AE, Sutton AB, Schor SL, Grant ME, Schor AM.

EXS. 1992;61:158-66. No abstract available.

PMID:
1617228
45.

Maintenance of collagen IV expression by bovine retinal pericytes isolated directly onto Matrigel film.

Murdoch AD, Canfield AE, Grant ME, Boot-Handford RP.

Biochem Soc Trans. 1991 Nov;19(4):368S. No abstract available.

PMID:
1794502
46.

The response of endothelial cells to TGF beta-1 is dependent upon cell shape, proliferative state and the nature of the substratum.

Sutton AB, Canfield AE, Schor SL, Grant ME, Schor AM.

J Cell Sci. 1991 Aug;99 ( Pt 4):777-87.

47.

Differentiation of pericytes in culture is accompanied by changes in the extracellular matrix.

Schor AM, Canfield AE, Sloan P, Schor SL.

In Vitro Cell Dev Biol. 1991 Aug;27A(8):651-9.

PMID:
1717427
49.

Pericytes derived from the retinal microvasculature undergo calcification in vitro.

Schor AM, Allen TD, Canfield AE, Sloan P, Schor SL.

J Cell Sci. 1990 Nov;97 ( Pt 3):449-61.

50.

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