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Items: 1 to 50 of 170

1.

The kinetic component in drug discovery: Using the most basic pharmacological concepts to advance in selecting drugs to combat CNS diseases.

Franco R, Castelló J, Canela EI.

Curr Neuropharmacol. 2019 Oct 1. doi: 10.2174/1570159X17666191001144309. [Epub ahead of print]

PMID:
31573886
2.

Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists.

Franco R, Reyes-Resina I, Aguinaga D, Lillo A, Jiménez J, Raïch I, Borroto-Escuela DO, Ferreiro-Vera C, Canela EI, Sánchez de Medina V, Del Ser-Badia A, Fuxe K, Saura CA, Navarro G.

Glia. 2019 Dec;67(12):2410-2423. doi: 10.1002/glia.23694. Epub 2019 Aug 19.

PMID:
31429130
3.

Biased G Protein-Independent Signaling of Dopamine D1-D3 Receptor Heteromers in the Nucleus Accumbens.

Guitart X, Moreno E, Rea W, Sánchez-Soto M, Cai NS, Quiroz C, Kumar V, Bourque L, Cortés A, Canela EI, Bishop C, Newman AH, Casadó V, Ferré S.

Mol Neurobiol. 2019 Oct;56(10):6756-6769. doi: 10.1007/s12035-019-1564-8. Epub 2019 Mar 27.

PMID:
30919214
4.

Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E, Sánchez C.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3863-3872. doi: 10.1073/pnas.1815034116. Epub 2019 Feb 7. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6505.

5.

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model.

Casadó-Anguera V, Moreno E, Mallol J, Ferré S, Canela EI, Cortés A, Casadó V.

Pharmacol Res. 2019 Jan;139:337-347. doi: 10.1016/j.phrs.2018.11.032. Epub 2018 Nov 22.

PMID:
30472462
6.

Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex.

Navarro G, Medrano M, Aguinaga D, Vega-Quiroga I, Lillo A, Jiménez J, Casanovas M, Canela EI, Mallol J, Gysling K, Franco R.

Neuropharmacology. 2019 Jul 1;152:102-111. doi: 10.1016/j.neuropharm.2018.11.014. Epub 2018 Nov 19.

PMID:
30465812
7.

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice.

Franco R, Aguinaga D, Reyes I, Canela EI, Lillo J, Tarutani A, Hasegawa M, Del Ser-Badia A, Del Rio JA, Kreutz MR, Saura CA, Navarro G.

Front Mol Neurosci. 2018 Aug 28;11:273. doi: 10.3389/fnmol.2018.00273. eCollection 2018.

8.

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1-CB2 Heteroreceptor Complexes.

Navarro G, Varani K, Reyes-Resina I, Sánchez de Medina V, Rivas-Santisteban R, Sánchez-Carnerero Callado C, Vincenzi F, Casano S, Ferreiro-Vera C, Canela EI, Borea PA, Nadal X, Franco R.

Front Pharmacol. 2018 Jun 21;9:632. doi: 10.3389/fphar.2018.00632. eCollection 2018.

9.

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.

Aguinaga D, Medrano M, Cordomí A, Jiménez-Rosés M, Angelats E, Casanovas M, Vega-Quiroga I, Canela EI, Petrovic M, Gysling K, Pardo L, Franco R, Navarro G.

Mol Neurobiol. 2019 Feb;56(2):1196-1210. doi: 10.1007/s12035-018-1140-7. Epub 2018 Jun 7.

PMID:
29876881
10.

Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases.

Reyes-Resina I, Navarro G, Aguinaga D, Canela EI, Schoeder CT, Załuski M, Kieć-Kononowicz K, Saura CA, Müller CE, Franco R.

Biochem Pharmacol. 2018 Nov;157:169-179. doi: 10.1016/j.bcp.2018.06.001. Epub 2018 Jun 2.

11.

Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron.

Rivera-Oliver M, Moreno E, Álvarez-Bagnarol Y, Ayala-Santiago C, Cruz-Reyes N, Molina-Castro GC, Clemens S, Canela EI, Ferré S, Casadó V, Díaz-Ríos M.

Mol Neurobiol. 2019 Feb;56(2):797-811. doi: 10.1007/s12035-018-1120-y. Epub 2018 May 24.

PMID:
29797183
12.

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S.

Nat Commun. 2018 Mar 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.

13.

α2A- and α2C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.

Sánchez-Soto M, Casadó-Anguera V, Yano H, Bender BJ, Cai NS, Moreno E, Canela EI, Cortés A, Meiler J, Casadó V, Ferré S.

Mol Neurobiol. 2018 Nov;55(11):8438-8454. doi: 10.1007/s12035-018-1004-1. Epub 2018 Mar 18.

PMID:
29552726
14.

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins.

Moreno E, Canet J, Gracia E, Lluís C, Mallol J, Canela EI, Cortés A, Casadó V.

Front Pharmacol. 2018 Feb 15;9:106. doi: 10.3389/fphar.2018.00106. eCollection 2018.

15.

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, McCormick PJ, Franco R.

BMC Biol. 2018 Feb 28;16(1):24. doi: 10.1186/s12915-018-0491-x.

16.

Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression.

Aguinaga D, Medrano M, Vega-Quiroga I, Gysling K, Canela EI, Navarro G, Franco R.

Front Mol Neurosci. 2018 Feb 12;11:17. doi: 10.3389/fnmol.2018.00017. eCollection 2018.

17.

Cannabis Users Show Enhanced Expression of CB1-5HT2A Receptor Heteromers in Olfactory Neuroepithelium Cells.

Galindo L, Moreno E, López-Armenta F, Guinart D, Cuenca-Royo A, Izquierdo-Serra M, Xicota L, Fernandez C, Menoyo E, Fernández-Fernández JM, Benítez-King G, Canela EI, Casadó V, Pérez V, de la Torre R, Robledo P.

Mol Neurobiol. 2018 Aug;55(8):6347-6361. doi: 10.1007/s12035-017-0833-7. Epub 2018 Jan 2.

PMID:
29294249
18.

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors.

Martínez-Pinilla E, Varani K, Reyes-Resina I, Angelats E, Vincenzi F, Ferreiro-Vera C, Oyarzabal J, Canela EI, Lanciego JL, Nadal X, Navarro G, Borea PA, Franco R.

Front Pharmacol. 2017 Oct 23;8:744. doi: 10.3389/fphar.2017.00744. eCollection 2017.

19.

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia.

Navarro G, Borroto-Escuela D, Angelats E, Etayo Í, Reyes-Resina I, Pulido-Salgado M, Rodríguez-Pérez AI, Canela EI, Saura J, Lanciego JL, Labandeira-García JL, Saura CA, Fuxe K, Franco R.

Brain Behav Immun. 2018 Jan;67:139-151. doi: 10.1016/j.bbi.2017.08.015. Epub 2017 Aug 24.

PMID:
28843453
20.

Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.

Medrano M, Aguinaga D, Reyes-Resina I, Canela EI, Mallol J, Navarro G, Franco R.

Mol Neurobiol. 2018 Jun;55(6):4718-4730. doi: 10.1007/s12035-017-0670-8. Epub 2017 Jul 17.

PMID:
28717967
21.

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M.

Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19.

22.

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

Moreno E, Quiroz C, Rea W, Cai NS, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, Ferré S.

J Neurosci. 2017 Feb 1;37(5):1176-1186. doi: 10.1523/JNEUROSCI.2442-16.2016. Epub 2016 Dec 22.

23.

Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease.

Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Franco R.

Mol Neurobiol. 2017 Aug;54(6):4537-4550. doi: 10.1007/s12035-016-9995-y. Epub 2016 Jul 1.

PMID:
27370794
24.

Targeting the dopamine D3 receptor: an overview of drug design strategies.

Cortés A, Moreno E, Rodríguez-Ruiz M, Canela EI, Casadó V.

Expert Opin Drug Discov. 2016 Jul;11(7):641-64. doi: 10.1080/17460441.2016.1185413. Epub 2016 May 30. Review.

PMID:
27135354
25.

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

Navarro G, Aguinaga D, Angelats E, Medrano M, Moreno E, Mallol J, Cortés A, Canela EI, Casadó V, McCormick PJ, Lluís C, Ferré S.

J Biol Chem. 2016 Jun 17;291(25):13048-62. doi: 10.1074/jbc.M116.715144. Epub 2016 Apr 25.

26.

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ, Franco R.

BMC Biol. 2016 Apr 5;14:26. doi: 10.1186/s12915-016-0247-4.

27.

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.

Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, de La Torre R, Gasperini P, Navarro G, Howell LA, Pardo L, Lluís C, Canela EI, McCormick PJ, Maldonado R, Robledo P.

PLoS Biol. 2015 Jul 9;13(7):e1002194. doi: 10.1371/journal.pbio.1002194. eCollection 2015 Jul.

28.

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.

Bonaventura J, Navarro G, Casadó-Anguera V, Azdad K, Rea W, Moreno E, Brugarolas M, Mallol J, Canela EI, Lluís C, Cortés A, Volkow ND, Schiffmann SN, Ferré S, Casadó V.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3609-18. doi: 10.1073/pnas.1507704112. Epub 2015 Jun 22.

29.

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.

Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS, Aguinaga D, Howell LA, Hausch F, Cortés A, Mallol J, Casadó V, Lluís C, Canela EI, Ferré S, McCormick PJ.

J Neurosci. 2015 Apr 29;35(17):6639-53. doi: 10.1523/JNEUROSCI.4364-14.2015.

30.

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer.

Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, Stickeler E, Staebler A, Bauer M, Arnold N, Soriano J, Pérez-Martínez M, Megías D, Moreno-Bueno G, Ortega-Gutiérrez S, Artola M, Vázquez-Villa H, Quintanilla M, Fernández-Piqueras J, Canela EI, McCormick PJ, Guzmán M, Sánchez C.

J Natl Cancer Inst. 2015 Apr 8;107(6):djv077. doi: 10.1093/jnci/djv077. Print 2015 Jun.

31.

Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers.

Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V, Mikhaylova M, Kreutz MR, Lluís C, Canela EI, McCormick PJ, Ferré S.

Chem Biol. 2014 Nov 20;21(11):1546-56. doi: 10.1016/j.chembiol.2014.10.004.

32.

Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.

Farré D, Muñoz A, Moreno E, Reyes-Resina I, Canet-Pons J, Dopeso-Reyes IG, Rico AJ, Lluís C, Mallol J, Navarro G, Canela EI, Cortés A, Labandeira-García JL, Casadó V, Lanciego JL, Franco R.

Mol Neurobiol. 2015 Dec;52(3):1408-1420. doi: 10.1007/s12035-014-8936-x. Epub 2014 Oct 26.

PMID:
25344317
33.

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.

Guitart X, Navarro G, Moreno E, Yano H, Cai NS, Sánchez-Soto M, Kumar-Barodia S, Naidu YT, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Ferré S.

Mol Pharmacol. 2014 Oct;86(4):417-29. doi: 10.1124/mol.114.093096. Epub 2014 Aug 5.

34.

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

J Biol Chem. 2014 Aug 8;289(32):21960-72. doi: 10.1074/jbc.M114.561761. Epub 2014 Jun 18.

35.

Moonlighting adenosine deaminase: a target protein for drug development.

Cortés A, Gracia E, Moreno E, Mallol J, Lluís C, Canela EI, Casadó V.

Med Res Rev. 2015 Jan;35(1):85-125. doi: 10.1002/med.21324. Epub 2014 Jun 16. Review.

PMID:
24933472
36.

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.

Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, Casadó V, Armentero MT, Franco R.

Exp Neurol. 2014 Mar;253:180-91. doi: 10.1016/j.expneurol.2013.12.021. Epub 2014 Jan 9.

PMID:
24412491
37.

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.

Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V, Franco R.

Neuropharmacology. 2014 Apr;79:90-100. doi: 10.1016/j.neuropharm.2013.10.036. Epub 2013 Nov 11.

PMID:
24230991
38.

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine.

Gracia E, Moreno E, Cortés A, Lluís C, Mallol J, McCormick PJ, Canela EI, Casadó V.

Neuropharmacology. 2013 Aug;71:56-69. doi: 10.1016/j.neuropharm.2013.03.005. Epub 2013 Mar 22.

PMID:
23523559
39.

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology.

Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI, Ferré S.

Methods Mol Biol. 2013;964:95-105. doi: 10.1007/978-1-62703-251-3_7.

PMID:
23296780
40.

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors.

Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI, McCormick PJ, Franco R, Fanelli F, Casadó V.

FASEB J. 2013 Mar;27(3):1048-61. doi: 10.1096/fj.12-212621. Epub 2012 Nov 27.

PMID:
23193172
41.

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F.

Gene. 2012 Oct 25;508(2):199-205. doi: 10.1016/j.gene.2012.07.074. Epub 2012 Aug 7.

PMID:
22892378
42.

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain.

Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL, Franco R, Lluis C, Canela EI, McCormick PJ.

J Biol Chem. 2012 Jun 15;287(25):20851-65. doi: 10.1074/jbc.M111.335273. Epub 2012 Apr 24.

43.

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function.

Ferré S, Quiroz C, Orru M, Guitart X, Navarro G, Cortés A, Casadó V, Canela EI, Lluis C, Franco R.

Front Neuroanat. 2011 Jun 17;5:36. doi: 10.3389/fnana.2011.00036. eCollection 2011.

44.

Production of functional recombinant G-protein coupled receptors for heteromerization studies.

Cavić M, Lluís C, Moreno E, Bakešová J, Canela EI, Navarro G.

J Neurosci Methods. 2011 Aug 15;199(2):258-64. doi: 10.1016/j.jneumeth.2011.05.021. Epub 2011 May 31.

PMID:
21658412
45.

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI, McCormick PJ, Lluis C, Franco R, Ribeiro JA, Sebastião AM, Ferré S.

J Neurosci. 2011 May 18;31(20):7412-23. doi: 10.1523/JNEUROSCI.0191-11.2011.

46.

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase.

Gracia E, Pérez-Capote K, Moreno E, Barkešová J, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI.

Biochem J. 2011 May 1;435(3):701-9. doi: 10.1042/BJ20101749.

PMID:
21306300
47.

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists.

Orru M, Bakešová J, Brugarolas M, Quiroz C, Beaumont V, Goldberg SR, Lluís C, Cortés A, Franco R, Casadó V, Canela EI, Ferré S.

PLoS One. 2011 Jan 11;6(1):e16088. doi: 10.1371/journal.pone.0016088.

48.

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.

Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R.

J Biol Chem. 2011 Feb 18;286(7):5846-54. doi: 10.1074/jbc.M110.161489. Epub 2010 Dec 20.

49.

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.

Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortés A, Casadó V, Canela EI, Ortiz J, Fuxe K, Lluís C, Ferré S, Franco R.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18676-81. doi: 10.1073/pnas.1008911107. Epub 2010 Oct 18.

50.

G protein-coupled receptor heteromers as new targets for drug development.

Ferré S, Navarro G, Casadó V, Cortés A, Mallol J, Canela EI, Lluís C, Franco R.

Prog Mol Biol Transl Sci. 2010;91:41-52. doi: 10.1016/S1877-1173(10)91002-8. Review.

PMID:
20691958

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