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Items: 48

1.

Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.

Shang J, Tschirret-Guth R, Cancilla M, Samuel K, Chen Q, Chobanian HR, Thomas A, Tong W, Josien H, Buevich AV, Mitra K.

Chem Res Toxicol. 2019 Oct 14. doi: 10.1021/acs.chemrestox.9b00226. [Epub ahead of print]

PMID:
31566356
2.

Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation.

Niyonsaba E, Easton MW, Feng E, Yu Z, Zhang Z, Sheng H, Kong J, Easterling LF, Milton J, Chobanian HR, Deprez NR, Cancilla MT, Kilaz G, Kenttämaa HI.

Anal Chem. 2019 Sep 3;91(17):11388-11396. doi: 10.1021/acs.analchem.9b02717. Epub 2019 Aug 16.

PMID:
31381321
3.

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Marcotte D, McDowell B, Mertsching E, Negrou E, Otipoby KL, Poreci U, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M.

Bioorg Med Chem. 2019 Jul 1;27(13):2905-2913. doi: 10.1016/j.bmc.2019.05.021. Epub 2019 May 14.

PMID:
31138459
4.

Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2.

Mihaila R, Ruhela D, Galinski B, Card A, Cancilla M, Shadel T, Kang J, Tep S, Wei J, Haas RM, Caldwell J, Flanagan WM, Kuklin N, Cherkaev E, Ason B.

Mol Ther Nucleic Acids. 2019 Jun 7;16:367-377. doi: 10.1016/j.omtn.2019.03.004. Epub 2019 Mar 23.

5.

Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells.

Brandish PE, Palmieri A, Antonenko S, Beaumont M, Benso L, Cancilla M, Cheng M, Fayadat-Dilman L, Feng G, Figueroa I, Firdos J, Garbaccio R, Garvin-Queen L, Gately D, Geda P, Haines C, Hseih S, Hodges D, Kern J, Knudsen N, Kwasnjuk K, Liang L, Ma H, Manibusan A, Miller PL, Moy LY, Qu Y, Shah S, Shin JS, Stivers P, Sun Y, Tomazela D, Woo HC, Zaller D, Zhang S, Zhang Y, Zielstorff M.

Bioconjug Chem. 2018 Jul 18;29(7):2357-2369. doi: 10.1021/acs.bioconjchem.8b00312. Epub 2018 Jul 2.

PMID:
29923706
6.

2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).

Neubert H, Song A, Lee A, Wei C, Duggan J, Xu K, Woolf E, Evans C, Palandra J, Laterza O, Amur S, Berger I, Bustard M, Cancilla M, Chen SC, Cho SJ, Ciccimaro E, Cludts I, Cocea L, D'Arienzo C, Danan-Leon L, Donato LD, Garofolo F, Haidar S, Ishii-Watabe A, Jiang H, Kadavil J, Kassim S, Kurki P, Blaye OL, Liu K, Mathews R, Lima Santos GM, Niwa M, Pedras-Vasconcelos J, Qian M, Rago B, Saad O, Saito Y, Savoie N, Su D, Szapacs M, Tampal N, Vinter S, Wang J, Welink J, Whale E, Wilson A, Xue YJ.

Bioanalysis. 2017 Dec;9(23):1895-1912. doi: 10.4155/bio-2017-4973. Epub 2017 Dec 5.

7.

2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).

Welink J, Yang E, Hughes N, Rago B, Woolf E, Sydor J, Coppola L, Ackermann B, Li W, Alley SC, Arnold M, Berger I, Briscoe C, Buonarati M, Bustard M, Cancilla M, Cho SJ, Duggan J, Fraier D, Garofolo F, Green R, Haidar S, Hittle L, Ishii-Watabe A, Islam R, Jenkins R, Jones B, Kadavil J, Kassim S, Kavetska O, Blaye OL, Lee A, Liu H, Mehl J, Lima Santos GM, Musuku A, Ramanathan R, Saito Y, Savoie N, Summerfield S, Surapaneni S, Szapacs M, Tampal N, Verhaeghe T, Vinter S, Whale E.

Bioanalysis. 2017 Nov;9(22):1807-1825. doi: 10.4155/bio-2017-4975. Epub 2017 Nov 17.

8.

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.

PMID:
27121751
9.

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates.

Kern JC, Cancilla M, Dooney D, Kwasnjuk K, Zhang R, Beaumont M, Figueroa I, Hsieh S, Liang L, Tomazela D, Zhang J, Brandish PE, Palmieri A, Stivers P, Cheng M, Feng G, Geda P, Shah S, Beck A, Bresson D, Firdos J, Gately D, Knudsen N, Manibusan A, Schultz PG, Sun Y, Garbaccio RM.

J Am Chem Soc. 2016 Feb 3;138(4):1430-45. doi: 10.1021/jacs.5b12547. Epub 2016 Jan 25.

PMID:
26745435
10.

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.

Andrikopoulos S, Fam BC, Holdsworth A, Visinoni S, Ruan Z, Stathopoulos M, Thorburn AW, Joannides CN, Cancilla M, Balmer L, Proietto J, Morahan G.

J Endocrinol. 2016 Jan;228(1):61-73. doi: 10.1530/JOE-15-0290. Epub 2015 Oct 22.

11.

Making Safe Surgery Affordable: Design of a Surgical Drill Cover System for Scale.

Buchan LL, Black MS, Cancilla MA, Huisman ES, Kooyman JJ, Nelson SC, OʼHara NN, OʼBrien PJ, Blachut PA.

J Orthop Trauma. 2015 Oct;29 Suppl 10:S29-32. doi: 10.1097/BOT.0000000000000403. Review.

PMID:
26356212
12.

Top-down interrogation of chemically modified oligonucleotides by negative electron transfer and collision induced dissociation.

Gao Y, Yang J, Cancilla MT, Meng F, McLuckey SA.

Anal Chem. 2013 May 7;85(9):4713-20. doi: 10.1021/ac400448t. Epub 2013 Apr 10.

PMID:
23534847
13.

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L.

Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17.

PMID:
21459573
14.

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA.

Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22.

PMID:
21427169
15.

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, Mathur M, Sachs AB, Flanagan WM.

Nucleic Acids Res. 2010 Jan;38(2):660-71. doi: 10.1093/nar/gkp913. Epub 2009 Nov 16.

16.

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

Cancilla MT, He MM, Viswanathan N, Simmons RL, Taylor M, Fung AD, Cao K, Erlanson DA.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. doi: 10.1016/j.bmcl.2008.06.011. Epub 2008 Jun 10.

PMID:
18579375
17.

Small-molecule inhibition of TNF-alpha.

He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC.

Science. 2005 Nov 11;310(5750):1022-5.

18.

Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue.

Hansen SK, Cancilla MT, Shiau TP, Kung J, Chen T, Erlanson DA.

Biochemistry. 2005 May 31;44(21):7704-12.

PMID:
15909985
19.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P.

Cancer Cell. 2005 Apr;7(4):325-36.

20.
21.

High-throughput gene mapping in Caenorhabditis elegans.

Swan KA, Curtis DE, McKusick KB, Voinov AV, Mapa FA, Cancilla MR.

Genome Res. 2002 Jul;12(7):1100-5.

22.

Discovery of estrogen sulfotransferase inhibitors from a purine library screen.

Verdugo DE, Cancilla MT, Ge X, Gray NS, Chang YT, Schultz PG, Negishi M, Leary JA, Bertozzi CR.

J Med Chem. 2001 Aug 16;44(17):2683-6. No abstract available.

PMID:
11495578
23.

Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.

Saffery R, Wong LH, Irvine DV, Bateman MA, Griffiths B, Cutts SM, Cancilla MR, Cendron AC, Stafford AJ, Choo KH.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5705-10. Epub 2001 May 1.

25.

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele.

Morahan G, Huang D, Ymer SI, Cancilla MR, Stephen K, Dabadghao P, Werther G, Tait BD, Harrison LC, Colman PG.

Nat Genet. 2001 Feb;27(2):218-21. Erratum in: Nat Genet 2001 Mar;27(3):346.

PMID:
11175794
26.

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR, Herlihy AS, Croker BA, Baca M, Nicola NA, Hilton DJ, Alexander WS.

Gene. 2000 Nov 27;258(1-2):31-41.

PMID:
11111040
27.

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA.

J Exp Med. 2000 Nov 20;192(10):1403-14.

28.

Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries.

Cancilla MT, Leavell MD, Chow J, Leary JA.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12008-13.

29.

Mass spectral characterization of lipooligosaccharides from Haemophilus influenzae 2019.

Gaucher SP, Cancilla MT, Phillips NJ, Gibson BW, Leary JA.

Biochemistry. 2000 Oct 10;39(40):12406-14.

PMID:
11015221
30.
31.

The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modification.

Barry AE, Bateman M, Howman EV, Cancilla MR, Tainton KM, Irvine DV, Saffery R, Choo KH.

Genome Res. 2000 Jun;10(6):832-8.

32.

Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis.

Nicholas GM, Hong TW, Molinski TF, Lerch ML, Cancilla MT, Lebrilla CB.

J Nat Prod. 1999 Dec;62(12):1678-81.

PMID:
10654417
33.

Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase.

Earle E, Saxena A, MacDonald A, Hudson DF, Shaffer LG, Saffery R, Cancilla MR, Cutts SM, Howman E, Choo KH.

Hum Mol Genet. 2000 Jan 22;9(2):187-94.

PMID:
10607829
34.

Fragmentation reactions in the mass spectrometry analysis of neutral oligosaccharides.

Cancilla MT, Wong AW, Voss LR, Lebrilla CB.

Anal Chem. 1999 Aug 1;71(15):3206-18.

PMID:
10450162
35.

Sequence analysis of an 80 kb human neocentromere.

Barry AE, Howman EV, Cancilla MR, Saffery R, Choo KH.

Hum Mol Genet. 1999 Feb;8(2):217-27.

PMID:
9931329
36.

Anion dopant for oligosaccharides in matrix-assisted laser desorption/ionization mass spectrometry.

Wong AW, Cancilla MT, Voss LR, Lebrilla CB.

Anal Chem. 1999 Jan 1;71(1):205-11.

PMID:
9921128
37.

Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights.

Hudson DF, Fowler KJ, Earle E, Saffery R, Kalitsis P, Trowell H, Hill J, Wreford NG, de Kretser DM, Cancilla MR, Howman E, Hii L, Cutts SM, Irvine DV, Choo KH.

J Cell Biol. 1998 Apr 20;141(2):309-19.

38.

Direct cloning of human 10q25 neocentromere DNA using transformation-associated recombination (TAR) in yeast.

Cancilla MR, Tainton KM, Barry AE, Larionov V, Kouprina N, Resnick MA, Sart DD, Choo KH.

Genomics. 1998 Feb 1;47(3):399-404.

PMID:
9480754
40.

Rapid cloning of mouse DNA as yeast artificial chromosomes by transformation-associated recombination (TAR).

Cancilla MR, Graves J, Matesic LE, Reeves RH, Tainton KM, Choo KH, Resnick MA, Larionov VL, Kouprina NY.

Mamm Genome. 1998 Feb;9(2):157-9. No abstract available.

PMID:
9457679
41.

Specific isolation of human rDNA genes by TAR cloning.

Kouprina N, Graves J, Cancilla MR, Resnick MA, Larionov V.

Gene. 1997 Sep 15;197(1-2):269-76.

PMID:
9332375
42.

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA.

du Sart D, Cancilla MR, Earle E, Mao JI, Saffery R, Tainton KM, Kalitsis P, Martyn J, Barry AE, Choo KH.

Nat Genet. 1997 Jun;16(2):144-53.

PMID:
9171825
43.
44.

A dual vacuum chamber fourier transform mass spectrometer with rapidly interchangeable LSIMS, MALDI, and ESI sources: initial results with LSIMS and MALDI.

Carroll JA, Penn SG, Fannin ST, Wu J, Cancilla MT, Green MK, Lebrilla CB.

Anal Chem. 1996 May 15;68(10):1798-804.

PMID:
8651485
45.
46.

The Lactococcus lactis triosephosphate isomerase gene, tpi, is monocistronic.

Cancilla MR, Davidson BE, Hillier AJ, Nguyen NY, Thompson J.

Microbiology. 1995 Jan;141 ( Pt 1):229-38.

PMID:
7534588
47.
48.

Anterior lenticonus; review and case report.

STRAATSMA BR, CANCILLA ML, HOHN A.

Am J Ophthalmol. 1954 Feb;37(2):197-204. No abstract available.

PMID:
13124440

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