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Twisting the bone marrow stem cell niche.

Niu H, Cancelas JA.

Haematologica. 2018 Dec;103(12):1937-1939. doi: 10.3324/haematol.2018.206029. Epub 2018 Nov 30. No abstract available.


Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data.

Cancelas JA.

Transfusion. 2019 Apr;59(S2):1467-1473. doi: 10.1111/trf.15163.


Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.

Trump LR, Nayak RC, Singh AK, Emberesh S, Wellendorf AM, Lutzko CM, Cancelas JA.

Stem Cells Transl Med. 2019 Jun;8(6):557-567. doi: 10.1002/sctm.18-0255. Epub 2019 Feb 21.


The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nayak RC, Hegde S, Althoff MJ, Wellendorf AM, Mohmoud F, Perentesis J, Reina-Campos M, Reynaud D, Zheng Y, Diaz-Meco MT, Moscat J, Cancelas JA.

Nat Commun. 2019 Jan 4;10(1):46. doi: 10.1038/s41467-018-07846-y.


Towards increasing shelf life and haemostatic potency of stored platelet concentrates.

Hegde S, Akbar H, Zheng Y, Cancelas JA.

Curr Opin Hematol. 2018 Nov;25(6):500-508. doi: 10.1097/MOH.0000000000000456.


Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia.

Slichter SJ, Dumont LJ, Cancelas JA, Jones M, Gernsheimer TB, Szczepiorkowski ZM, Dunbar NM, Prakash G, Medlin S, Rugg N, Kinne B, Macdonald VW, Housler G, Valiyaveettil M, Hmel P, Ransom JH.

Transfusion. 2018 Sep;58(9):2129-2138. doi: 10.1111/trf.14780.


KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.

Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA.

Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3.


Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.

Mock DM, Nalbant D, Kyosseva SV, Schmidt RL, An G, Matthews NI, Vlaar APJ, van Bruggen R, de Korte D, Strauss RG, Cancelas JA, Franco RS, Veng-Pedersen P, Widness JA.

Transfusion. 2018 Aug;58(8):2068-2081. doi: 10.1111/trf.14647. Epub 2018 May 16. Review.


Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy.

Roy S, Rai P, Eiymo Mwa Mpollo MS, Chang KH, Rizvi T, Shanmukhappa SK, VandenHeuvel K, Aronow B, Inagami T, Cancelas JA, Malik P.

Am J Hematol. 2018 Jul;93(7):E177-E181. doi: 10.1002/ajh.25118. Epub 2018 May 15. No abstract available.


TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.

Fang J, Muto T, Kleppe M, Bolanos LC, Hueneman KM, Walker CS, Sampson L, Wellendorf AM, Chetal K, Choi K, Salomonis N, Choi Y, Zheng Y, Cancelas JA, Levine RL, Starczynowski DT.

Cell Rep. 2018 Jan 30;22(5):1250-1262. doi: 10.1016/j.celrep.2018.01.013.


Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.

Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27.


Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.

Lee JM, Govindarajah V, Goddard B, Hinge A, Muench DE, Filippi MD, Aronow B, Cancelas JA, Salomonis N, Grimes HL, Reynaud D.

J Exp Med. 2018 Feb 5;215(2):627-644. doi: 10.1084/jem.20170690. Epub 2017 Dec 27.


In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.

Nalbant D, Cancelas JA, Mock DM, Kyosseva SV, Schmidt RL, Cress GA, Zimmerman MB, Strauss RG, Widness JA.

Transfusion. 2018 Feb;58(2):352-358. doi: 10.1111/trf.14396. Epub 2017 Nov 29.


Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.

Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G.

Haematologica. 2018 Jan;103(1):40-50. doi: 10.3324/haematol.2017.172775. Epub 2017 Oct 19.


Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice.

Noel JG, Ramser BJ, Cancelas JA, McCormack FX, Gardner JC.

Exp Hematol. 2017 Dec;56:16-30. doi: 10.1016/j.exphem.2017.08.005. Epub 2017 Sep 1.


Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.

Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H.

EMBO J. 2017 May 15;36(10):1463. doi: 10.15252/embj.201796968. No abstract available.


Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations.

Worsham DN, Reems JA, Szczepiorkowski ZM, McKenna DH, Leemhuis T, Mathew AJ, Cancelas JA; Biomedical Excellence for Safer Transfusion (BEST) Collaborative Group.

Transfusion. 2017 Jun;57(6):1555-1565. doi: 10.1111/trf.14112. Epub 2017 Apr 28.


Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage.

Cancelas JA, Slichter SJ, Rugg N, Pratt PG, Nestheide S, Corson J, Pellham E, Huntington M, Goodrich RP.

Transfusion. 2017 May;57(5):1218-1225. doi: 10.1111/trf.14084. Epub 2017 Mar 31.


Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives.

Daily K, Ho Sui SJ, Schriml LM, Dexheimer PJ, Salomonis N, Schroll R, Bush S, Keddache M, Mayhew C, Lotia S, Perumal TM, Dang K, Pantano L, Pico AR, Grassman E, Nordling D, Hide W, Hatzopoulos AK, Malik P, Cancelas JA, Lutzko C, Aronow BJ, Omberg L.

Sci Data. 2017 Mar 28;4:170030. doi: 10.1038/sdata.2017.30.


Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.

Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, Siddiqui Z, Bouso MF, Latif T, Xu M, Komurov K, Mulloy JC, Cancelas JA, Grimes HL, Azam M.

Nat Med. 2017 Apr;23(4):472-482. doi: 10.1038/nm.4310. Epub 2017 Mar 20.


The purified vepoloxamer prevents haemolysis in 42-day stored, DEHP/PVC-free red blood cell units.

Cancelas JA, Rugg N, Nestheide S, Hill SE, Emanuele RM, Mckenzie DS.

Blood Transfus. 2017 Mar;15(2):165-171. doi: 10.2450/2017.0351-16.


Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.

Schmidt RL, Mock DM, Franco RS, Cohen RM, North AK, Cancelas JA, Geisen C, Strauss RG, Vlaar AP, Nalbant D, Widness JA.

Transfusion. 2017 Jun;57(6):1488-1496. doi: 10.1111/trf.14075. Epub 2017 Mar 5.


An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.

Choi K, Komurov K, Fletcher JS, Jousma E, Cancelas JA, Wu J, Ratner N.

Sci Rep. 2017 Mar 3;7:43315. doi: 10.1038/srep43315.


Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.

Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H.

EMBO J. 2017 Apr 3;36(7):840-853. doi: 10.15252/embj.201694969. Epub 2017 Mar 2. Erratum in: EMBO J. 2017 May 15;36(10 ):1463.


Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study.

Cancelas JA, Gottschall JL, Rugg N, Graminske S, Schott MA, North A, Huang N, Mufti N, Erickson A, Rico S, Corash L.

Vox Sang. 2017 Apr;112(3):210-218. doi: 10.1111/vox.12500. Epub 2017 Feb 21. Erratum in: Vox Sang. 2017 Jul;112(5):495.


Plasma Protein Timings: Relative Contributions of Storage Time, Donor Age and Donation Season.

Cancelas JA, Rugg N.

EBioMedicine. 2016 Oct;12:32-33. doi: 10.1016/j.ebiom.2016.10.005. Epub 2016 Oct 5. No abstract available.


Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two-center, crossover, randomized trial.

Cancelas JA, Scott EP, Bill JR.

Transfusion. 2016 Nov;56(11):2824-2832. doi: 10.1111/trf.13769. Epub 2016 Sep 2.


Dissecting the metabolic pathways controlling platelet survival in vivo: are our platelets what they eat?

Hegde S, Cancelas JA.

Transfusion. 2016 Aug;56(8):1928-31. doi: 10.1111/trf.13684. No abstract available.


Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium.

Salomonis N, Dexheimer PJ, Omberg L, Schroll R, Bush S, Huo J, Schriml L, Ho Sui S, Keddache M, Mayhew C, Shanmukhappa SK, Wells J, Daily K, Hubler S, Wang Y, Zambidis E, Margolin A, Hide W, Hatzopoulos AK, Malik P, Cancelas JA, Aronow BJ, Lutzko C.

Stem Cell Reports. 2016 Jul 12;7(1):110-25. doi: 10.1016/j.stemcr.2016.05.006. Epub 2016 Jun 9.


Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N.

Cell Rep. 2016 Mar 1;14(8):1979-90. doi: 10.1016/j.celrep.2016.01.074. Epub 2016 Feb 18.


Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence.

Serrano-Lopez J, Cancelas JA.

Cell Stem Cell. 2016 Feb 4;18(2):158-60. doi: 10.1016/j.stem.2016.01.004.


Granulocyte transfusion: questions remain.

Cancelas JA.

Blood. 2015 Oct 29;126(18):2082-3. doi: 10.1182/blood-2015-09-669085. No abstract available.


Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.

González-Nieto D, Chang KH, Fasciani I, Nayak R, Fernandez-García L, Barrio LC, Cancelas JA.

Int Rev Cell Mol Biol. 2015;318:27-62. doi: 10.1016/bs.ircmb.2015.06.001. Epub 2015 Jul 22. Review.


Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

Nayak RC, Trump LR, Aronow BJ, Myers K, Mehta P, Kalfa T, Wellendorf AM, Valencia CA, Paddison PJ, Horwitz MS, Grimes HL, Lutzko C, Cancelas JA.

J Clin Invest. 2015 Aug 3;125(8):3103-16. doi: 10.1172/JCI80924. Epub 2015 Jul 20.


Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.

Chang KH, Nayak RC, Roy S, Perumbeti A, Wellendorf AM, Bezold KY, Pirman M, Hill SE, Starnes J, Loberg A, Zhou X, Inagami T, Zheng Y, Malik P, Cancelas JA.

Nat Commun. 2015 Jan 9;6:5914. doi: 10.1038/ncomms6914.


p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.

Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA.

Cell Rep. 2014 Dec 24;9(6):2084-97. doi: 10.1016/j.celrep.2014.11.031. Epub 2014 Dec 18.


Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial.

Cancelas JA, Padmanabhan A, Le T, Ambruso DR, Rugg N, Worsham DN, Pinkard SL, Graminske S, Buck J, Goldberg J, Bill J.

Transfusion. 2015 Apr;55(4):748-55. doi: 10.1111/trf.12907. Epub 2014 Nov 10.


Overnight, room temperature hold of whole blood followed by 42-day storage of red blood cells in additive solution-7.

Dumont LJ, Cancelas JA, Maes LA, Rugg N, Whitley P, Herschel L, Siegal AH, Szczepiorkowski ZM, Hess JR, Zia M.

Transfusion. 2015 Mar;55(3):485-90. doi: 10.1111/trf.12868. Epub 2014 Sep 19.


Additive solution-7 reduces the red blood cell cold storage lesion.

Cancelas JA, Dumont LJ, Maes LA, Rugg N, Herschel L, Whitley PH, Szczepiokowski ZM, Siegel AH, Hess JR, Zia M.

Transfusion. 2015 Mar;55(3):491-8. doi: 10.1111/trf.12867. Epub 2014 Sep 19.


The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collection.

Dumont LJ, Cancelas JA, Maes LA, Rugg N, Whitley P, Herschel L, Siegel AH, Szczepiorkowski ZM, Hess JR, Zia M.

Transfusion. 2015 Mar;55(3):476-84. doi: 10.1111/trf.12864. Epub 2014 Sep 19.


Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT.

Cell Rep. 2014 Sep 11;8(5):1328-38. doi: 10.1016/j.celrep.2014.07.062. Epub 2014 Sep 4.


Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFRα initiated chronic eosinophilic leukemia/systemic mastocytosis.

Yamada Y, Cancelas JA, Rothenberg ME.

Methods Mol Biol. 2014;1178:309-20. doi: 10.1007/978-1-4939-1016-8_26.


Measurement of posttransfusion red cell survival with the biotin label.

Mock DM, Widness JA, Veng-Pedersen P, Strauss RG, Cancelas JA, Cohen RM, Lindsell CJ, Franco RS.

Transfus Med Rev. 2014 Jul;28(3):114-25. doi: 10.1016/j.tmrv.2014.03.003. Epub 2014 Apr 5. Review.


The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.

Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI.

Oncogene. 2015 Apr 30;34(18):2325-36. doi: 10.1038/onc.2014.173. Epub 2014 Jun 23.


Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL.

J Clin Invest. 2014 Jan;124(1):222-36. doi: 10.1172/JCI66005. Epub 2013 Dec 16.


Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.

Tidwell T, Wechsler J, Nayak RC, Trump L, Salipante SJ, Cheng JC, Donadieu J, Glaubach T, Corey SJ, Grimes HL, Lutzko C, Cancelas JA, Horwitz MS.

Blood. 2014 Jan 23;123(4):562-9. doi: 10.1182/blood-2013-07-513242. Epub 2013 Nov 1.


Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.

Nayak RC, Chang KH, Vaitinadin NS, Cancelas JA.

Immunol Rev. 2013 Nov;256(1):255-68. doi: 10.1111/imr.12119. Review.


RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.

Zhou X, Florian MC, Arumugam P, Chen X, Cancelas JA, Lang R, Malik P, Geiger H, Zheng Y.

J Exp Med. 2013 Oct 21;210(11):2371-85. doi: 10.1084/jem.20122348. Epub 2013 Oct 7.


Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.

Mayes DA, Rizvi TA, Titus-Mitchell H, Oberst R, Ciraolo GM, Vorhees CV, Robinson AP, Miller SD, Cancelas JA, Stemmer-Rachamimov AO, Ratner N.

Cell Rep. 2013 Sep 26;4(6):1197-212. doi: 10.1016/j.celrep.2013.08.011. Epub 2013 Sep 12.


Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.

Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Thomas G, Kozma S, Pang Q, Zheng Y.

Haematologica. 2013 Sep;98(9):1353-8. doi: 10.3324/haematol.2012.080424. Epub 2013 May 28.

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