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Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing.

Nardini M, Perteghella S, Mastracci L, Grillo F, Marrubini G, Bari E, Formica M, Gentili C, Cancedda R, Torre ML, Mastrogiacomo M.

Pharmaceutics. 2020 Feb 3;12(2). pii: E120. doi: 10.3390/pharmaceutics12020120.


CFSE: A New Method for Identifying Human Limbal Stem Cells and Following Their Migration in Human Cornea.

Bonzano C, Canciani B, Olivari S, Papadia M, Bagnis A, Cutolo CA, Bonzano E, Pagani P, Cancedda R, Traverso CE.

In Vivo. 2019 Nov-Dec;33(6):1851-1855. doi: 10.21873/invivo.11678.


Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability.

Romaldini A, Ulivi V, Nardini M, Mastrogiacomo M, Cancedda R, Descalzi F.

Cells. 2019 Apr 9;8(4). pii: E331. doi: 10.3390/cells8040331.


Synchrotron radiation techniques boost the research in bone tissue engineering.

Mastrogiacomo M, Campi G, Cancedda R, Cedola A.

Acta Biomater. 2019 Apr 15;89:33-46. doi: 10.1016/j.actbio.2019.03.031. Epub 2019 Mar 15. Review.


Beta-tricalcium phosphate ceramic triggers fast and robust bone formation by human mesenchymal stem cells.

Pereira RC, Benelli R, Canciani B, Scaranari M, Daculsi G, Cancedda R, Gentili C.

J Tissue Eng Regen Med. 2019 Jun;13(6):1007-1018. doi: 10.1002/term.2848. Epub 2019 Apr 15.


Platelet Lysate Activates Human Subcutaneous Adipose Tissue Cells by Promoting Cell Proliferation and Their Paracrine Activity Toward Epidermal Keratinocytes.

Romaldini A, Mastrogiacomo M, Cancedda R, Descalzi F.

Front Bioeng Biotechnol. 2018 Dec 21;6:203. doi: 10.3389/fbioe.2018.00203. eCollection 2018.


Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.

Lo Sicco C, Reverberi D, Villa F, Pfeffer U, Quarto R, Cancedda R, Tasso R.

Stem Cell Res Ther. 2018 Nov 8;9(1):300. doi: 10.1186/s13287-018-1056-1.


Electrospun silk fibroin fibers for storage and controlled release of human platelet lysate.

Pignatelli C, Perotto G, Nardini M, Cancedda R, Mastrogiacomo M, Athanassiou A.

Acta Biomater. 2018 Jun;73:365-376. doi: 10.1016/j.actbio.2018.04.025. Epub 2018 Apr 17.


High-Resolution X-Ray Tomography: A 3D Exploration Into the Skeletal Architecture in Mouse Models Submitted to Microgravity Constraints.

Giuliani A, Mazzoni S, Ruggiu A, Canciani B, Cancedda R, Tavella S.

Front Physiol. 2018 Mar 6;9:181. doi: 10.3389/fphys.2018.00181. eCollection 2018. Review.


Culture Medium Supplements Derived from Human Platelet and Plasma: Cell Commitment and Proliferation Support.

Muraglia A, Nguyen VT, Nardini M, Mogni M, Coviello D, Dozin B, Strada P, Baldelli I, Formica M, Cancedda R, Mastrogiacomo M.

Front Bioeng Biotechnol. 2017 Nov 20;5:66. doi: 10.3389/fbioe.2017.00066. eCollection 2017.


Platelet lysate activates quiescent cell proliferation and reprogramming in human articular cartilage: Involvement of hypoxia inducible factor 1.

Nguyen VT, Cancedda R, Descalzi F.

J Tissue Eng Regen Med. 2018 Mar;12(3):e1691-e1703. doi: 10.1002/term.2595. Epub 2017 Dec 5.


Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment.

Todeschi MR, El Backly RM, Varghese OP, Hilborn J, Cancedda R, Mastrogiacomo M.

Regen Med. 2017 Jul;12(5):525-539. doi: 10.2217/rme-2017-0023. Epub 2017 Aug 3.


Learning from Mother Nature: Innovative Tools to Boost Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects.

Cancedda R, Bollini S, Descalzi F, Mastrogiacomo M, Tasso R.

Front Bioeng Biotechnol. 2017 Apr 28;5:28. doi: 10.3389/fbioe.2017.00028. eCollection 2017. Review.


First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential.

Balbi C, Piccoli M, Barile L, Papait A, Armirotti A, Principi E, Reverberi D, Pascucci L, Becherini P, Varesio L, Mogni M, Coviello D, Bandiera T, Pozzobon M, Cancedda R, Bollini S.

Stem Cells Transl Med. 2017 May;6(5):1340-1355. doi: 10.1002/sctm.16-0297. Epub 2017 Mar 8.


Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization.

Lo Sicco C, Reverberi D, Balbi C, Ulivi V, Principi E, Pascucci L, Becherini P, Bosco MC, Varesio L, Franzin C, Pozzobon M, Cancedda R, Tasso R.

Stem Cells Transl Med. 2017 Mar;6(3):1018-1028. doi: 10.1002/sctm.16-0363. Epub 2017 Jan 31.


LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment.

Costa D, Principi E, Lazzarini E, Descalzi F, Cancedda R, Castagnola P, Tavella S.

J Cell Physiol. 2017 Nov;232(11):3077-3087. doi: 10.1002/jcp.25755. Epub 2017 Feb 21.


Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing.

Papait A, Cancedda R, Mastrogiacomo M, Poggi A.

J Tissue Eng Regen Med. 2018 Jan;12(1):30-43. doi: 10.1002/term.2361. Epub 2017 May 11.


Platelet-rich plasma-based bioactive membrane as a new advanced wound care tool.

Spanò R, Muraglia A, Todeschi MR, Nardini M, Strada P, Cancedda R, Mastrogiacomo M.

J Tissue Eng Regen Med. 2018 Jan;12(1):e82-e96. doi: 10.1002/term.2357. Epub 2017 Apr 18.


The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.

Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, Varesio L, Bosco MC, Coviello D, Pompilio G, Brunelli C, Cancedda R, Ameri P, Bollini S.

Sci Rep. 2016 Jul 21;6:29994. doi: 10.1038/srep29994.


A humanized system to expand in vitro amniotic fluid-derived stem cells intended for clinical application.

Martinelli D, Pereira RC, Mogni M, Benelli R, Mastrogiacomo M, Coviello D, Cancedda R, Gentili C.

Cytotherapy. 2016 Mar;18(3):438-51. doi: 10.1016/j.jcyt.2015.11.020.


Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential.

Muraglia A, Todeschi MR, Papait A, Poggi A, Spanò R, Strada P, Cancedda R, Mastrogiacomo M.

Cytotherapy. 2015 Dec;17(12):1793-806. doi: 10.1016/j.jcyt.2015.09.004.


Identification of a New Cell Population Constitutively Circulating in Healthy Conditions and Endowed with a Homing Ability Toward Injured Sites.

Lo Sicco C, Tasso R, Reverberi D, Cilli M, Pfeffer U, Cancedda R.

Sci Rep. 2015 Nov 12;5:16574. doi: 10.1038/srep16574.


High-Resolution X-Ray Techniques as New Tool to Investigate the 3D Vascularization of Engineered-Bone Tissue.

Bukreeva I, Fratini M, Campi G, Pelliccia D, Spanò R, Tromba G, Brun F, Burghammer M, Grilli M, Cancedda R, Cedola A, Mastrogiacomo M.

Front Bioeng Biotechnol. 2015 Sep 7;3:133. doi: 10.3389/fbioe.2015.00133. eCollection 2015.


Effects of long time exposure to simulated micro- and hypergravity on skeletal architecture.

Canciani B, Ruggiu A, Giuliani A, Panetta D, Marozzi K, Tripodi M, Salvadori PA, Cilli M, Ohira Y, Cancedda R, Tavella S.

J Mech Behav Biomed Mater. 2015 Nov;51:1-12. doi: 10.1016/j.jmbbm.2015.06.014. Epub 2015 Jun 23.


Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice.

Neutelings T, Nusgens BV, Liu Y, Tavella S, Ruggiu A, Cancedda R, Gabriel M, Colige A, Lambert C.

NPJ Microgravity. 2015 May 27;1:15002. doi: 10.1038/npjmgrav.2015.2. eCollection 2015.


Transplanted Umbilical Cord Mesenchymal Stem Cells Modify the In Vivo Microenvironment Enhancing Angiogenesis and Leading to Bone Regeneration.

Todeschi MR, El Backly R, Capelli C, Daga A, Patrone E, Introna M, Cancedda R, Mastrogiacomo M.

Stem Cells Dev. 2015 Jul 1;24(13):1570-81. doi: 10.1089/scd.2014.0490. Epub 2015 Mar 18.


A modified rabbit ulna defect model for evaluating periosteal substitutes in bone engineering: a pilot study.

El Backly RM, Chiapale D, Muraglia A, Tromba G, Ottonello C, Santolini F, Cancedda R, Mastrogiacomo M.

Front Bioeng Biotechnol. 2015 Jan 6;2:80. doi: 10.3389/fbioe.2014.00080. eCollection 2014.


Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA.

Costa D, Gigoni A, Würth R, Cancedda R, Florio T, Pagano A.

Cancer Cell Int. 2014 Jul 2;14:59. doi: 10.1186/1475-2867-14-59. eCollection 2014.


Bone mechanobiology, gravity and tissue engineering: effects and insights.

Ruggiu A, Cancedda R.

J Tissue Eng Regen Med. 2015 Dec;9(12):1339-51. doi: 10.1002/term.1942. Epub 2014 Jul 23. Review.


Tissue engineering approaches in skeletal pediatric disorders.

Gentili C, Torre M, Cancedda R.

Eur J Pediatr Surg. 2014 Jun;24(3):263-9. doi: 10.1055/s-0034-1382777. Epub 2014 Jun 22. Review.


Effects of gravitational loading levels on protein expression related to metabolic and/or morphologic properties of mouse neck muscles.

Ohira T, Ohira T, Kawano F, Shibaguchi T, Okabe H, Goto K, Ogita F, Sudoh M, Roy RR, Edgerton VR, Cancedda R, Ohira Y.

Physiol Rep. 2014 Jan 13;2(1):e00183. doi: 10.1002/phy2.183. eCollection 2014 Jan 1.


Mesenchymal stem cell paracrine activity is modulated by platelet lysate: induction of an inflammatory response and secretion of factors maintaining macrophages in a proinflammatory phenotype.

Ulivi V, Tasso R, Cancedda R, Descalzi F.

Stem Cells Dev. 2014 Aug 15;23(16):1858-69. doi: 10.1089/scd.2013.0567. Epub 2014 May 22.


Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography.

Cedola A, Campi G, Pelliccia D, Bukreeva I, Fratini M, Burghammer M, Rigon L, Arfelli F, Chang Chen R, Dreossi D, Sodini N, Mohammadi S, Tromba G, Cancedda R, Mastrogiacomo M.

Phys Med Biol. 2014 Jan 6;59(1):189-201. doi: 10.1088/0031-9155/59/1/189. Epub 2013 Dec 13.


In vitro and in vivo osteoinductive and osteoconductive properties of a synthetic bone substitute.

Conserva E, Foschi F, Cancedda R, Mastrogiacomo M.

Int J Oral Maxillofac Implants. 2013 Nov-Dec;28(6):e432-9. doi: 10.11607/jomi.te23.


Scaffold-assisted cartilage tissue engineering using infant chondrocytes from human hip cartilage.

Kreuz PC, Gentili C, Samans B, Martinelli D, Krüger JP, Mittelmeier W, Endres M, Cancedda R, Kaps C.

Osteoarthritis Cartilage. 2013 Dec;21(12):1997-2005. doi: 10.1016/j.joca.2013.09.007. Epub 2013 Oct 2.


Effects of pleiotrophin overexpression on mouse skeletal muscles in normal loading and in actual and simulated microgravity.

Camerino GM, Pierno S, Liantonio A, De Bellis M, Cannone M, Sblendorio V, Conte E, Mele A, Tricarico D, Tavella S, Ruggiu A, Cancedda R, Ohira Y, Danieli-Betto D, Ciciliot S, Germinario E, Sandonà D, Betto R, Camerino DC, Desaphy JF.

PLoS One. 2013 Aug 28;8(8):e72028. doi: 10.1371/journal.pone.0072028. eCollection 2013.


The effect of Platelet Lysate on osteoblast proliferation associated with a transient increase of the inflammatory response in bone regeneration.

Ruggiu A, Ulivi V, Sanguineti F, Cancedda R, Descalzi F.

Biomaterials. 2013 Dec;34(37):9318-30. doi: 10.1016/j.biomaterials.2013.08.018. Epub 2013 Sep 5.


Platelet rich plasma enhances osteoconductive properties of a hydroxyapatite-β-tricalcium phosphate scaffold (Skelite) for late healing of critical size rabbit calvarial defects.

El Backly RM, Zaky SH, Canciani B, Saad MM, Eweida AM, Brun F, Tromba G, Komlev VS, Mastrogiacomo M, Marei MK, Cancedda R.

J Craniomaxillofac Surg. 2014 Jul;42(5):e70-9. doi: 10.1016/j.jcms.2013.06.012. Epub 2013 Aug 7.


In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche.

Tasso R, Ulivi V, Reverberi D, Lo Sicco C, Descalzi F, Cancedda R.

Stem Cells Dev. 2013 Dec 15;22(24):3178-91. doi: 10.1089/scd.2013.0313. Epub 2013 Sep 14.


Biological activity of a standardized freeze-dried platelet derivative to be used as cell culture medium supplement.

Muraglia A, Ottonello C, Spanò R, Dozin B, Strada P, Grandizio M, Cancedda R, Mastrogiacomo M.

Platelets. 2014;25(3):211-20. doi: 10.3109/09537104.2013.803529. Epub 2013 Jul 25.


Altered bone development and turnover in transgenic mice over-expressing lipocalin-2 in bone.

Costa D, Lazzarini E, Canciani B, Giuliani A, Spanò R, Marozzi K, Manescu A, Cancedda R, Tavella S.

J Cell Physiol. 2013 Nov;228(11):2210-21. doi: 10.1002/jcp.24391.


Amniotic fluid stem cells in a bone microenvironment: driving host angiogenic response.

Mirabella T, Gentili C, Daga A, Cancedda R.

Stem Cell Res. 2013 Jul;11(1):540-51. doi: 10.1016/j.scr.2013.02.006. Epub 2013 Feb 24.


Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism.

Descalzi F, Ulivi V, Cancedda R, Piscitelli F, Luongo L, Guida F, Gatta L, Maione S, Di Marzo V.

Tissue Eng Part A. 2013 Oct;19(19-20):2120-9. doi: 10.1089/ten.TEA.2012.0557. Epub 2013 Jun 6.


Cartilage repair in the knee with subchondral drilling augmented with a platelet-rich plasma-immersed polymer-based implant.

Siclari A, Mascaro G, Gentili C, Kaps C, Cancedda R, Boux E.

Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1225-34. doi: 10.1007/s00167-013-2484-1. Epub 2013 Apr 7.


A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing.

Penna I, Vassallo I, Nizzari M, Russo D, Costa D, Menichini P, Poggi A, Russo C, Dieci G, Florio T, Cancedda R, Pagano A.

Biochim Biophys Acta. 2013 Jun;1833(6):1511-26. doi: 10.1016/j.bbamcr.2013.02.020. Epub 2013 Feb 26.


Dual effect of platelet lysate on human articular cartilage: a maintenance of chondrogenic potential and a transient proinflammatory activity followed by an inflammation resolution.

Pereira RC, Scaranari M, Benelli R, Strada P, Reis RL, Cancedda R, Gentili C.

Tissue Eng Part A. 2013 Jun;19(11-12):1476-88. doi: 10.1089/ten.TEA.2012.0225.


The Regenerative Role of the Fetal and Adult Stem Cell Secretome.

Bollini S, Gentili C, Tasso R, Cancedda R.

J Clin Med. 2013 Dec 17;2(4):302-27. doi: 10.3390/jcm2040302. Review.


The Murine PSE/TATA-dependent transcriptome: evidence of functional homologies with its human counterpart.

Bruzzone MJ, Gavazzo P, Massone S, Balbi C, Villa F, Conti A, Dieci G, Cancedda R, Pagano A.

Int J Mol Sci. 2012 Nov 13;13(11):14813-27. doi: 10.3390/ijms131114813.


A novel collection of snRNA-like promoters with tissue-specific transcription properties.

Garritano S, Gigoni A, Costa D, Malatesta P, Florio T, Cancedda R, Pagano A.

Int J Mol Sci. 2012;13(9):11323-32. doi: 10.3390/ijms130911323. Epub 2012 Sep 11.

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