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Items: 40

1.

ENHANCED ATP RELEASE AND CD73-MEDIATED ADENOSINE FORMATION SUSTAIN ADENOSINE A2A RECEPTOR OVER-ACTIVATION IN A RAT MODEL OF PARKINSON'S DISEASE.

Carmo M, Gonçalves FQ, Canas PM, Oses JP, Fernandes FD, Duarte FV, Palmeira CM, Tomé AR, Agostinho P, Andrade GM, Cunha RA.

Br J Pharmacol. 2019 Jun 20. doi: 10.1111/bph.14771. [Epub ahead of print]

PMID:
31220343
2.

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.

Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA.

eNeuro. 2018 Dec 26;5(6). pii: ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec.

3.

Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats.

Moreira-Silva D, Carrettiero DC, Oliveira ASA, Rodrigues S, Dos Santos-Lopes J, Canas PM, Cunha RA, Almeida MC, Ferreira TL.

Front Neurosci. 2018 Sep 21;12:653. doi: 10.3389/fnins.2018.00653. eCollection 2018.

4.

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice.

Aguiar AS Jr, Speck AE, Amaral IM, Canas PM, Cunha RA.

Sci Rep. 2018 Jul 16;8(1):10742. doi: 10.1038/s41598-018-29050-0.

5.

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]

PMID:
29950682
6.

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease.

Silva AC, Lemos C, Gonçalves FQ, Pliássova AV, Machado NJ, Silva HB, Canas PM, Cunha RA, Lopes JP, Agostinho P.

Neurobiol Dis. 2018 Sep;117:72-81. doi: 10.1016/j.nbd.2018.05.024. Epub 2018 May 31.

PMID:
29859867
7.

Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex.

Kerkhofs A, Canas PM, Timmerman AJ, Heistek TS, Real JI, Xavier C, Cunha RA, Mansvelder HD, Ferreira SG.

Front Pharmacol. 2018 Mar 20;9:133. doi: 10.3389/fphar.2018.00133. eCollection 2018.

8.

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex.

Kerkhofs A, Xavier AC, da Silva BS, Canas PM, Idema S, Baayen JC, Ferreira SG, Cunha RA, Mansvelder HD.

Front Pharmacol. 2018 Jan 4;8:899. doi: 10.3389/fphar.2017.00899. eCollection 2017.

9.

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

Amorim JA, Canas PM, Tomé AR, Rolo AP, Agostinho P, Palmeira CM, Cunha RA.

J Alzheimers Dis. 2017;60(2):525-536. doi: 10.3233/JAD-170356.

PMID:
28869472
10.

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization.

Morató X, López-Cano M, Canas PM, Cunha RA, Ciruela F.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55661.

11.

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

Pliássova A, Canas PM, Xavier AC, da Silva BS, Cunha RA, Agostinho P.

J Alzheimers Dis. 2016 Apr 18;52(4):1209-14. doi: 10.3233/JAD-160213.

PMID:
27104908
12.

Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.

Viana SD, Fernandes RC, Canas PM, Silva AM, Carvalho F, Ali SF, Fontes Ribeiro CA, Pereira FC.

CNS Neurosci Ther. 2016 May;22(5):396-403. doi: 10.1111/cns.12508. Epub 2016 Feb 4.

PMID:
26843141
13.

Depression as a Glial-Based Synaptic Dysfunction.

Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, Prediger RD, Gonçalves N, Gomes CA, Canas PM, Agostinho P, Cunha RA.

Front Cell Neurosci. 2016 Jan 22;9:521. doi: 10.3389/fncel.2015.00521. eCollection 2015. Review.

14.

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.

Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues AL, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7833-8. doi: 10.1073/pnas.1423088112. Epub 2015 Jun 8.

15.

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F.

J Neurochem. 2015 Jul;134(1):135-46. doi: 10.1111/jnc.13109. Epub 2015 Apr 21.

16.

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.

Li P, Rial D, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJ, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, Zhou Y, PIJzerman A, Boyden ES, Cunha RA, Qu J, Chen JF.

Mol Psychiatry. 2015 Nov;20(11):1481. doi: 10.1038/mp.2015.43. Epub 2015 Mar 24. No abstract available.

PMID:
25802981
17.

Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus.

Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA, Rial D.

Eur J Neurosci. 2015 Apr;41(7):878-88. doi: 10.1111/ejn.12851. Epub 2015 Feb 19.

PMID:
25704806
18.

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.

Li P, Rial D, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJ, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, Zhou Y, IJzerman AP, Boyden ES, Cunha RA, Qu J, Chen JF.

Mol Psychiatry. 2015 Nov;20(11):1339-49. doi: 10.1038/mp.2014.182. Epub 2015 Feb 17. Erratum in: Mol Psychiatry. 2015 Nov;20(11):1481. PIJzerman, Ad [Corrected to IJzerman, AP].

19.

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E.

Neurobiol Dis. 2015 Feb;74:41-57. doi: 10.1016/j.nbd.2014.11.004. Epub 2014 Nov 11.

PMID:
25449908
20.

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV.

Front Psychiatry. 2014 Jun 13;5:67. doi: 10.3389/fpsyt.2014.00067. eCollection 2014.

21.

Sequential inoculation versus co-inoculation in Cabernet Franc wine fermentation.

Cañas PM, Romero EG, Pérez-Martín F, Seseña S, Palop ML.

Food Sci Technol Int. 2015 Apr;21(3):203-12. doi: 10.1177/1082013214524585. Epub 2014 Feb 28.

PMID:
24583599
22.

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

Carmo MR, Menezes AP, Nunes AC, Pliássova A, Rolo AP, Palmeira CM, Cunha RA, Canas PM, Andrade GM.

Neuropharmacology. 2014 Jun;81:142-52. doi: 10.1016/j.neuropharm.2014.01.045. Epub 2014 Feb 6.

PMID:
24508709
23.

Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF.

PLoS One. 2013 Nov 28;8(11):e80902. doi: 10.1371/journal.pone.0080902. eCollection 2013.

24.

Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease.

Canas PM, Simões AP, Rodrigues RJ, Cunha RA.

Neuropharmacology. 2014 Jan;76 Pt A:51-6. doi: 10.1016/j.neuropharm.2013.08.026. Epub 2013 Sep 9.

PMID:
24029236
25.

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway.

Simões AP, Duarte JA, Agasse F, Canas PM, Tomé AR, Agostinho P, Cunha RA.

J Neuroinflammation. 2012 Aug 20;9:204. doi: 10.1186/1742-2094-9-204.

26.

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.

Costenla AR, Diógenes MJ, Canas PM, Rodrigues RJ, Nogueira C, Maroco J, Agostinho PM, Ribeiro JA, Cunha RA, de Mendonça A.

Eur J Neurosci. 2011 Jul;34(1):12-21. doi: 10.1111/j.1460-9568.2011.07719.x. Epub 2011 May 25.

PMID:
21615561
27.

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA.

J Neurochem. 2011 Apr;117(1):100-11. doi: 10.1111/j.1471-4159.2011.07178.x. Epub 2011 Feb 9.

28.

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.

Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA.

J Neurosci. 2009 Nov 25;29(47):14741-51. doi: 10.1523/JNEUROSCI.3728-09.2009.

29.

Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway.

Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S.

ScientificWorldJournal. 2009 Nov 18;9:1321-44. doi: 10.1100/tsw.2009.143.

30.

Ecological study of lactic acid microbiota isolated from Tempranillo wines of Castilla-La Mancha.

Cañas PM, Pérez PR, Prieto SS, Herreros ML.

J Biosci Bioeng. 2009 Sep;108(3):220-4. doi: 10.1016/j.jbiosc.2009.04.001.

PMID:
19664556
31.

Spermine improves recognition memory deficit in a rodent model of Huntington's disease.

Velloso NA, Dalmolin GD, Gomes GM, Rubin MA, Canas PM, Cunha RA, Mello CF.

Neurobiol Learn Mem. 2009 Nov;92(4):574-80. doi: 10.1016/j.nlm.2009.07.006. Epub 2009 Jul 24.

PMID:
19632348
32.

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors.

Gomes CA, Simões PF, Canas PM, Quiroz C, Sebastião AM, Ferré S, Cunha RA, Ribeiro JA.

J Neurochem. 2009 Mar;108(5):1208-19. doi: 10.1111/j.1471-4159.2009.05876.x. Epub 2009 Jan 29.

33.

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF.

J Neurosci. 2008 Mar 19;28(12):2970-5. doi: 10.1523/JNEUROSCI.5255-07.2008.

34.

Modification upon aging of the density of presynaptic modulation systems in the hippocampus.

Canas PM, Duarte JM, Rodrigues RJ, Köfalvi A, Cunha RA.

Neurobiol Aging. 2009 Nov;30(11):1877-84. doi: 10.1016/j.neurobiolaging.2008.01.003. Epub 2008 Mar 4.

PMID:
18304697
35.

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF.

Ann Neurol. 2008 Mar;63(3):338-46. doi: 10.1002/ana.21313.

PMID:
18300283
36.

Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA.

Exp Neurol. 2008 Apr;210(2):776-81. doi: 10.1016/j.expneurol.2007.11.013. Epub 2007 Nov 29.

PMID:
18191838
37.

Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.

Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA.

Neurobiol Dis. 2007 Aug;27(2):182-9. Epub 2007 May 26.

PMID:
17596953
38.

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats.

Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA.

Neurobiol Aging. 2008 Oct;29(10):1597-601. Epub 2007 May 3.

PMID:
17481781
39.

Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress.

Cunha GM, Canas PM, Oliveira CR, Cunha RA.

Neuroscience. 2006 Sep 15;141(4):1775-81. Epub 2006 Jun 22.

PMID:
16797134
40.

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.

Rebola N, Canas PM, Oliveira CR, Cunha RA.

Neuroscience. 2005;132(4):893-903.

PMID:
15857695

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