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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.

Ogando NS, Ferron F, Decroly E, Canard B, Posthuma CC, Snijder EJ.

Front Microbiol. 2019 Aug 7;10:1813. doi: 10.3389/fmicb.2019.01813. eCollection 2019. Review.


Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain.

Tsika AC, Melekis E, Tsatsouli SA, Papageorgiou N, Maté MJ, Canard B, Coutard B, Bentrop D, Spyroulias GA.

J Mol Biol. 2019 May 31;431(12):2283-2297. doi: 10.1016/j.jmb.2019.04.013. Epub 2019 Apr 16.


Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose.

Makrynitsa GI, Ntonti D, Marousis KD, Birkou M, Matsoukas MT, Asami S, Bentrop D, Papageorgiou N, Canard B, Coutard B, Spyroulias GA.

J Struct Biol. 2019 Apr 1;206(1):119-127. doi: 10.1016/j.jsb.2019.02.008. Epub 2019 Feb 27.


C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system.

Jaïs PH, Decroly E, Jacquet E, Le Boulch M, Jaïs A, Jean-Jean O, Eaton H, Ponien P, Verdier F, Canard B, Goncalves S, Chiron S, Le Gall M, Mayeux P, Shmulevitz M.

Nucleic Acids Res. 2019 Mar 18;47(5):2681-2698. doi: 10.1093/nar/gkz069.


Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein.

Nguyen THV, Lichière J, Canard B, Papageorgiou N, Attoumani S, Ferron F, Coutard B.

Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):8-15. doi: 10.1107/S2059798318014948. Epub 2019 Jan 4.


Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.

Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B.

Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11.


Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

Saez-Ayala M, Laban Yekwa E, Mondielli C, Roux L, Hernández S, Bailly F, Cotelle P, Rogolino D, Canard B, Ferron F, Alvarez K.

Antiviral Res. 2019 Feb;162:79-89. doi: 10.1016/j.antiviral.2018.12.008. Epub 2018 Dec 14.


[Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs].

Martin B, Valle C, Coutard B, Canard B, Debart F, Decroly É.

Med Sci (Paris). 2018 Nov;34(11):919-921. doi: 10.1051/medsci/2018230. Epub 2018 Dec 10. French. No abstract available.


The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.

Martin B, Coutard B, Guez T, Paesen GC, Canard B, Debart F, Vasseur JJ, Grimes JM, Decroly E.

Nucleic Acids Res. 2018 Sep 6;46(15):7902-7912. doi: 10.1093/nar/gky637.


Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands.

Saez-Ayala M, Yekwa EL, Carcelli M, Canard B, Alvarez K, Ferron F.

IUCrJ. 2018 Feb 22;5(Pt 2):223-235. doi: 10.1107/S2052252518001021. eCollection 2018 Mar 1.


The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.

Chatrin C, Talapatra SK, Canard B, Kozielski F.

Oncotarget. 2017 Dec 14;9(3):3160-3171. doi: 10.18632/oncotarget.23223. eCollection 2018 Jan 9.


Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases.

Selisko B, Papageorgiou N, Ferron F, Canard B.

Viruses. 2018 Jan 30;10(2). pii: E59. doi: 10.3390/v10020059. Review.


Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.

Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M, Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E162-E171. doi: 10.1073/pnas.1718806115. Epub 2017 Dec 26.


Pre- and Post-Transfusion Alloimmunization in Dogs Characterized by 2 Antiglobulin-Enhanced Cross-match Tests.

Goy-Thollot I, Giger U, Boisvineau C, Perrin R, Guidetti M, Chaprier B, Barthélemy A, Pouzot-Nevoret C, Canard B.

J Vet Intern Med. 2017 Sep;31(5):1420-1429. doi: 10.1111/jvim.14801. Epub 2017 Aug 14.


Toscana virus nucleoprotein oligomer organization observed in solution.

Baklouti A, Goulet A, Lichière J, Canard B, Charrel RN, Ferron F, Coutard B, Papageorgiou N.

Acta Crystallogr D Struct Biol. 2017 Aug 1;73(Pt 8):650-659. doi: 10.1107/S2059798317008774. Epub 2017 Jul 28.


Activity inhibition and crystal polymorphism induced by active-site metal swapping.

Yekwa E, Khourieh J, Canard B, Papageorgiou N, Ferron F.

Acta Crystallogr D Struct Biol. 2017 Aug 1;73(Pt 8):641-649. doi: 10.1107/S205979831700866X. Epub 2017 Jul 28.


Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.

Aouadi W, Eydoux C, Coutard B, Martin B, Debart F, Vasseur JJ, Contreras JM, Morice C, Quérat G, Jung ML, Canard B, Guillemot JC, Decroly E.

Antiviral Res. 2017 Aug;144:330-339. doi: 10.1016/j.antiviral.2017.06.021. Epub 2017 Jul 1.


Biochemical principles and inhibitors to interfere with viral capping pathways.

Decroly E, Canard B.

Curr Opin Virol. 2017 Jun;24:87-96. doi: 10.1016/j.coviro.2017.04.003. Epub 2017 May 18. Review.


Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.

Abdelnabi R, Morais ATS, Leyssen P, Imbert I, Beaucourt S, Blanc H, Froeyen M, Vignuzzi M, Canard B, Neyts J, Delang L.

J Virol. 2017 May 26;91(12). pii: e00487-17. doi: 10.1128/JVI.00487-17. Print 2017 Jun 15.


Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle.

Martin B, Canard B, Decroly E.

Antiviral Res. 2017 May;141:48-61. doi: 10.1016/j.antiviral.2017.02.004. Epub 2017 Feb 10. Review.


Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues.

Potisopon S, Ferron F, Fattorini V, Selisko B, Canard B.

Antiviral Res. 2017 Apr;140:25-36. doi: 10.1016/j.antiviral.2016.12.021. Epub 2016 Dec 30.


Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.

Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E.

J Virol. 2017 Feb 14;91(5). pii: e02217-16. doi: 10.1128/JVI.02217-16. Print 2017 Mar 1.


Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.

Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E.

J Virol. 2017 Feb 14;91(5). pii: e02202-16. doi: 10.1128/JVI.02202-16. Print 2017 Mar 1.


Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights.

Fili S, Valmas A, Christopoulou M, Spiliopoulou M, Nikolopoulos N, Lichière J, Logotheti S, Karavassili F, Rosmaraki E, Fitch A, Wright J, Beckers D, Degen T, Nénert G, Hilgenfeld R, Papageorgiou N, Canard B, Coutard B, Margiolaki I.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):877-884. Epub 2016 Nov 25.


Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry.

Martin B, Hoenen T, Canard B, Decroly E.

Antiviral Res. 2016 Nov;135:1-14. doi: 10.1016/j.antiviral.2016.09.001. Epub 2016 Sep 14. Review.


The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

Delang L, Li C, Tas A, Quérat G, Albulescu IC, De Burghgraeve T, Guerrero NA, Gigante A, Piorkowski G, Decroly E, Jochmans D, Canard B, Snijder EJ, Pérez-Pérez MJ, van Hemert MJ, Coutard B, Leyssen P, Neyts J.

Sci Rep. 2016 Aug 22;6:31819. doi: 10.1038/srep31819.


Viral Macro Domains Reverse Protein ADP-Ribosylation.

Li C, Debing Y, Jankevicius G, Neyts J, Ahel I, Coutard B, Canard B.

J Virol. 2016 Sep 12;90(19):8478-86. doi: 10.1128/JVI.00705-16. Print 2016 Oct 1.


Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering.

Papageorgiou N, Lichière J, Baklouti A, Ferron F, Sévajol M, Canard B, Coutard B.

Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):192-202. doi: 10.1107/S2059798315024328. Epub 2016 Jan 22.


Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C.

Ulferts R, de Boer SM, van der Linden L, Bauer L, Lyoo HR, Maté MJ, Lichière J, Canard B, Lelieveld D, Omta W, Egan D, Coutard B, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38. doi: 10.1128/AAC.02182-15. Print 2016 May.


Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.

Benmansour F, Eydoux C, Querat G, de Lamballerie X, Canard B, Alvarez K, Guillemot JC, Barral K.

Eur J Med Chem. 2016 Feb 15;109:146-56. doi: 10.1016/j.ejmech.2015.12.046. Epub 2015 Dec 29.


The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain.

Potisopon S, Priet S, Collet A, Decroly E, Canard B, Selisko B.

Nucleic Acids Res. 2016 Apr 7;44(6):2974. doi: 10.1093/nar/gkv1294. Epub 2015 Nov 17. No abstract available.


X-ray structure and activities of an essential Mononegavirales L-protein domain.

Paesen GC, Collet A, Sallamand C, Debart F, Vasseur JJ, Canard B, Decroly E, Grimes JM.

Nat Commun. 2015 Nov 9;6:8749. doi: 10.1038/ncomms9749.


mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research.

Li C, Guillén J, Rabah N, Blanjoie A, Debart F, Vasseur JJ, Canard B, Decroly E, Coutard B.

J Virol. 2015 Aug;89(16):8292-303. doi: 10.1128/JVI.00599-15. Epub 2015 Jun 3.


The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.


Primer-dependent and primer-independent initiation of double stranded RNA synthesis by purified Arabidopsis RNA-dependent RNA polymerases RDR2 and RDR6.

Devert A, Fabre N, Floris M, Canard B, Robaglia C, Crété P.

PLoS One. 2015 Mar 20;10(3):e0120100. doi: 10.1371/journal.pone.0120100. eCollection 2015.


Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: effect of the α-phosphorus configuration on HIV-1 RT activity.

Priet S, Roux L, Saez-Ayala M, Ferron F, Canard B, Alvarez K.

Antiviral Res. 2015 May;117:122-31. doi: 10.1016/j.antiviral.2015.03.003. Epub 2015 Mar 9.


Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain.

Guillén J, Lichière J, Rabah N, Beitzel BF, Canard B, Coutard B.

Virus Res. 2015 Apr 2;201:94-100. doi: 10.1016/j.virusres.2015.02.018. Epub 2015 Feb 25.


Regulation of Flavivirus RNA synthesis and replication.

Selisko B, Wang C, Harris E, Canard B.

Curr Opin Virol. 2014 Dec;9:74-83. doi: 10.1016/j.coviro.2014.09.011. Epub 2014 Oct 17. Review.


Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus.

Sevajol M, Subissi L, Decroly E, Canard B, Imbert I.

Virus Res. 2014 Dec 19;194:90-9. doi: 10.1016/j.virusres.2014.10.008. Epub 2014 Oct 17. Review.


The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain.

Potisopon S, Priet S, Collet A, Decroly E, Canard B, Selisko B.

Nucleic Acids Res. 2014 Oct;42(18):11642-56. doi: 10.1093/nar/gku666. Epub 2014 Sep 10. Erratum in: Nucleic Acids Res. 2016 Apr 7;44(6):2974.


One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.

Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3900-9. doi: 10.1073/pnas.1323705111. Epub 2014 Sep 2.


Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.

Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X.

J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29.


The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.

Vives-Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, Canard B, van Kuppeveld FJ, Ferrer-Orta C, Verdaguer N.

J Virol. 2014 May;88(10):5595-607. doi: 10.1128/JVI.03502-13. Epub 2014 Mar 5.


Improving the soluble expression of recombinant proteins by randomly shuffling 5' and 3' coding-sequence ends.

Bignon C, Li C, Lichière J, Canard B, Coutard B.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2580-2. doi: 10.1107/S0907444913018751. Epub 2013 Nov 19.


SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.

Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B.

Antiviral Res. 2014 Jan;101:122-30. doi: 10.1016/j.antiviral.2013.11.006. Epub 2013 Nov 20. Review.


Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.

Coulerie P, Nour M, Maciuk A, Eydoux C, Guillemot JC, Lebouvier N, Hnawia E, Leblanc K, Lewin G, Canard B, Figadère B.

Planta Med. 2013 Sep;79(14):1313-8. doi: 10.1055/s-0033-1350672. Epub 2013 Aug 8.


Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Barral K, Sallamand C, Petzold C, Coutard B, Collet A, Thillier Y, Zimmermann J, Vasseur JJ, Canard B, Rohayem J, Debart F, Decroly E.

Antiviral Res. 2013 Sep;99(3):292-300. doi: 10.1016/j.antiviral.2013.06.001. Epub 2013 Jun 12.


Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.

Roux L, Priet S, Payrot N, Weck C, Fournier M, Zoulim F, Balzarini J, Canard B, Alvarez K.

Eur J Med Chem. 2013 May;63:869-81. doi: 10.1016/j.ejmech.2013.02.039. Epub 2013 Mar 14.


3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

De Burghgraeve T, Selisko B, Kaptein S, Chatelain G, Leyssen P, Debing Y, Jacobs M, Van Aerschot A, Canard B, Neyts J.

Antiviral Res. 2013 May;98(2):242-7. doi: 10.1016/j.antiviral.2013.01.011. Epub 2013 Mar 5.


Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling.

Kumar A, Bühler S, Selisko B, Davidson A, Mulder K, Canard B, Miller S, Bartenschlager R.

J Virol. 2013 Apr;87(8):4545-57. doi: 10.1128/JVI.03083-12. Epub 2013 Feb 13.

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