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A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.

Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, Du YP, Canals M, Sessions RB, Kelly E, Capon RJ, Alewood PF, Christie MJ.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201908662. doi: 10.1073/pnas.1908662116. [Epub ahead of print]


Ligand-dependent spatiotemporal signaling profiles of the mu-opioid receptor are controlled by distinct protein-interaction networks.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M, Halls ML.

J Biol Chem. 2019 Sep 12. pii: jbc.RA119.008685. doi: 10.1074/jbc.RA119.008685. [Epub ahead of print]


Chronic Chagas disease: Quantification of Trypanosoma cruzi in peripheral blood and dejections of Triatoma infestans fed by xenodiagnosis in patients with and without cardiopathy.

Apt W, Carrasco D, Fuentealba C, Canals M, Muñoz G, Saavedra M, Castillo JP, Zulantay I.

Acta Trop. 2019 Sep 9;200:105167. doi: 10.1016/j.actatropica.2019.105167. [Epub ahead of print]


Beached microplastics in the Northwestern Mediterranean Sea.

Constant M, Kerhervé P, Mino-Vercellio-Verollet M, Dumontier M, Sànchez Vidal A, Canals M, Heussner S.

Mar Pollut Bull. 2019 May;142:263-273. doi: 10.1016/j.marpolbul.2019.03.032. Epub 2019 Apr 1.


Corrigendum to "Floating microplastics and aggregate formation in the Western Mediterranean Sea" [Mar. Pollut. Bull. 140 (2019) 523-535].

de Haan WP, Sanchez-Vidal A, Canals M; NUREIEV1 Shipboard Scientific Party.

Mar Pollut Bull. 2019 May;142:242. doi: 10.1016/j.marpolbul.2019.03.044. Epub 2019 Mar 29. No abstract available.


GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.

Gondin AB, Halls ML, Canals M, Briddon SJ.

Front Mol Neurosci. 2019 May 1;12:104. doi: 10.3389/fnmol.2019.00104. eCollection 2019.


Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1.

Sanchez J, Lane JR, Canals M, Stone MJ.

Int J Mol Sci. 2019 May 15;20(10). pii: E2417. doi: 10.3390/ijms20102417.


Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.

DiCello JJ, Rajasekhar P, Eriksson EM, Saito A, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G79-G89. doi: 10.1152/ajpgi.00085.2019. Epub 2019 May 15.


Agonist-dependent development of delta opioid receptor tolerance in the colon.

DiCello JJ, Saito A, Rajasekhar P, Sebastian BW, McQuade RM, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP.

Cell Mol Life Sci. 2019 Aug;76(15):3033-3050. doi: 10.1007/s00018-019-03077-6. Epub 2019 Mar 23.


Floating microplastics and aggregate formation in the Western Mediterranean Sea.

de Haan WP, Sanchez-Vidal A, Canals M; NUREIEV1 Shipboard Scientific Party.

Mar Pollut Bull. 2019 Mar;140:523-535. doi: 10.1016/j.marpolbul.2019.01.053. Epub 2019 Feb 11. Erratum in: Mar Pollut Bull. 2019 May;142:242.


G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Canals M, Poole DP, Veldhuis NA, Schmidt BL, Bunnett NW.

Gastroenterology. 2019 May;156(6):1600-1616. doi: 10.1053/j.gastro.2019.01.266. Epub 2019 Feb 13. Review.


Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E, Sánchez C.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3863-3872. doi: 10.1073/pnas.1815034116. Epub 2019 Feb 7. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6505.


Occupational disease due to Anisakis simplex in fish handlers.

Uña-Gorospe M, Herrera-Mozo I, Canals ML, Martí-Amengual G, Sanz-Gallen P.

Int Marit Health. 2018;69(4):264-269. doi: 10.5603/IMH.2018.0042.


Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1.

Sanchez J, E Huma Z, Lane JR, Liu X, Bridgford JL, Payne RJ, Canals M, Stone MJ.

J Biol Chem. 2019 Mar 8;294(10):3464-3475. doi: 10.1074/jbc.RA118.006535. Epub 2018 Dec 19.


The imprint of microfibres in southern European deep seas.

Sanchez-Vidal A, Thompson RC, Canals M, de Haan WP.

PLoS One. 2018 Nov 5;13(11):e0207033. doi: 10.1371/journal.pone.0207033. eCollection 2018.


Correction: Ticks from diverse genera encode chemokine-inhibitory evasin proteins.

Hayward J, Sanchez J, Perry A, Huang C, Valle MR, Canals M, Payne RJ, Stone MJ.

J Biol Chem. 2018 Oct 12;293(41):15888. doi: 10.1074/jbc.AAC118.005871. No abstract available.


Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.

Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M, Halls ML.

Sci Signal. 2018 Oct 9;11(551). pii: eaan1188. doi: 10.1126/scisignal.aan1188.


Influence of deep water formation by open-sea convection on the transport of low hydrophobicity organic pollutants in the NW Mediterranean Sea.

Salvadó JA, Grimalt JO, López JF, Palanques A, Canals M.

Sci Total Environ. 2019 Jan 10;647:597-605. doi: 10.1016/j.scitotenv.2018.07.458. Epub 2018 Aug 1.


Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M.

Sci Signal. 2018 Jul 17;11(539). pii: eaas9609. doi: 10.1126/scisignal.aas9609.


Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.


Inflammation-associated changes in DOR expression and function in the mouse colon.

DiCello JJ, Saito A, Rajasekhar P, Eriksson EM, McQuade RM, Nowell CJ, Sebastian BW, Fichna J, Veldhuis NA, Canals M, Bunnett NW, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G544-G559. doi: 10.1152/ajpgi.00025.2018. Epub 2018 Jun 21.


Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Huang C, Lewis C, Borg NA, Canals M, Diep H, Drummond GR, Goode RJ, Schittenhelm RB, Vinh A, Zhu M, Kemp-Harper B, Kleifeld O, Stone MJ.

J Proteome Res. 2018 Apr 6;17(4):1485-1499. doi: 10.1021/acs.jproteome.7b00828. Epub 2018 Mar 13.


Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.

Lam R, Gondin AB, Canals M, Kellam B, Briddon SJ, Graham B, Scammells PJ.

J Med Chem. 2018 Feb 8;61(3):1316-1329. doi: 10.1021/acs.jmedchem.7b01811. Epub 2018 Jan 10.


The sexual health approach in postmenopause: The five-minutes study.

Cuerva MJ, Gonzalez D, Canals M, Otero B, Espinosa JA, Molero F, Senturk LM, Mendoza N; SMS Young Experts Group.

Maturitas. 2018 Feb;108:31-36. doi: 10.1016/j.maturitas.2017.11.009. Epub 2017 Nov 11.


Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

Livingston KE, Stanczyk MA, Burford NT, Alt A, Canals M, Traynor JR.

Mol Pharmacol. 2018 Feb;93(2):157-167. doi: 10.1124/mol.117.109561. Epub 2017 Dec 12.


Assessing the risk zones of Chagas' disease in Chile, in a world marked by global climatic change.

Tapia-Garay V, Figueroa DP, Maldonado A, Frías-Laserre D, Gonzalez CR, Parra A, Canals L, Apt W, Alvarado S, Cáceres D, Canals M.

Mem Inst Oswaldo Cruz. 2018 Jan;113(1):24-29. doi: 10.1590/0074-02760170172.


Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, Porter CJH, McLean P, Hicks GA, Geppetti P, Halls ML, Canals M, Bunnett NW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314. doi: 10.1073/pnas.1706656114. Epub 2017 Oct 30.


Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.

Halls ML, Canals M.

Trends Pharmacol Sci. 2018 Feb;39(2):148-157. doi: 10.1016/ Epub 2017 Oct 17. Review.


Corrigendum: A submarine volcanic eruption leads to a novel microbial habitat.

Danovaro R, Canals M, Tangherlini M, Dell'Anno A, Gambi C, Lastras G, Amblas D, Sanchez-Vidal A, Frigola J, Calafat AM, Pedrosa-Pàmies R, Rivera J, Rayo X, Corinaldesi C.

Nat Ecol Evol. 2017 May 22;1(6):187. doi: 10.1038/s41559-017-0187.


A submarine volcanic eruption leads to a novel microbial habitat.

Danovaro R, Canals M, Tangherlini M, Dell'Anno A, Gambi C, Lastras G, Amblas D, Sanchez-Vidal A, Frigola J, Calafat AM, Pedrosa-Pàmies R, Rivera J, Rayo X, Corinaldesi C.

Nat Ecol Evol. 2017 Apr 24;1(6):144. doi: 10.1038/s41559-017-0144. Erratum in: Nat Ecol Evol. 2017 May 22;1(6):187.


Ticks from diverse genera encode chemokine-inhibitory evasin proteins.

Hayward J, Sanchez J, Perry A, Huang C, Rodriguez Valle M, Canals M, Payne RJ, Stone MJ.

J Biol Chem. 2017 Sep 22;292(38):15670-15680. doi: 10.1074/jbc.M117.807255. Epub 2017 Aug 4. Erratum in: J Biol Chem. 2018 Oct 12;293(41):15888.


[What do the numbers tell us about the temporal evolution of Chagas' disease?]

Canals M, González C, Canals L, Canals A, Cáceres D, Alvarado S, Cattan PE, Saavedra M, Zulantay I, Apt W.

Rev Chilena Infectol. 2017 Apr;34(2):120-127. doi: 10.4067/S0716-10182017000200004. Spanish.


Mercury concentrations in lean fish from the Western Mediterranean Sea: Dietary exposure and risk assessment in the population of the Balearic Islands.

Llull RM, Garí M, Canals M, Rey-Maquieira T, Grimalt JO.

Environ Res. 2017 Oct;158:16-23. doi: 10.1016/j.envres.2017.05.033. Epub 2017 Jun 6.


Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW.

Sci Transl Med. 2017 May 31;9(392). pii: eaal3447. doi: 10.1126/scitranslmed.aal3447.


Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Huma ZE, Sanchez J, Lim HD, Bridgford JL, Huang C, Parker BJ, Pazhamalil JG, Porebski BT, Pfleger KDG, Lane JR, Canals M, Stone MJ.

Sci Signal. 2017 May 23;10(480). pii: eaai8529. doi: 10.1126/scisignal.aai8529.


Environmental hazard assessment of a marine mine tailings deposit site and potential implications for deep-sea mining.

Mestre NC, Rocha TL, Canals M, Cardoso C, Danovaro R, Dell'Anno A, Gambi C, Regoli F, Sanchez-Vidal A, Bebianno MJ.

Environ Pollut. 2017 Sep;228:169-178. doi: 10.1016/j.envpol.2017.05.027. Epub 2017 May 19.


Resilience of benthic deep-sea fauna to mining activities.

Gollner S, Kaiser S, Menzel L, Jones DOB, Brown A, Mestre NC, van Oevelen D, Menot L, Colaço A, Canals M, Cuvelier D, Durden JM, Gebruk A, Egho GA, Haeckel M, Marcon Y, Mevenkamp L, Morato T, Pham CK, Purser A, Sanchez-Vidal A, Vanreusel A, Vink A, Martinez Arbizu P.

Mar Environ Res. 2017 Aug;129:76-101. doi: 10.1016/j.marenvres.2017.04.010. Epub 2017 Apr 13. Review.


Modeling Chagas disease in Chile: From vector to congenital transmission.

Canals M, Cáceres D, Alvarado S, Canals A, Cattan PE.

Biosystems. 2017 Jun - Jul;156-157:63-71. doi: 10.1016/j.biosystems.2017.04.004. Epub 2017 Apr 20.


Wing Polymorphism and Trypanosoma cruzi Infection in Wild, Peridomestic, and Domestic Collections of Mepraia spinolai (Hemiptera: Reduviidae) From Chile.

Frías-Lasserre D, González CR, Valenzuela CR, de Carvalho DB, Oliveira J, Canals M, da Rosa JA.

J Med Entomol. 2017 Jul 1;54(4):1061-1066. doi: 10.1093/jme/tjx061. Erratum in: J Med Entomol. 2017 Jul 1;54(4):1099.


Niche modelling of the Chilean recluse spider Loxosceles laeta and araneophagic spitting spider Scytodes globula and risk for loxoscelism in Chile.

Canals M, Taucare-Rios A, Brescovit AD, Peña-Gomez F, Bizama G, Canals A, Moreno L, Bustamante R.

Med Vet Entomol. 2016 Dec;30(4):383-391. doi: 10.1111/mve.12184. Epub 2016 Jul 18.


Estimation of the Effect of the Predator Scytodes globula (Araneae: Scytodidae) on Loxosceles laeta (Araneae: Sicariidae) Populations.

Canals M, Moreno L, Solís R.

Environ Entomol. 2016 Aug;45(4):841-7. doi: 10.1093/ee/nvw075. Epub 2016 Jul 1.


Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

Lay J, Carbone SE, DiCello JJ, Bunnett NW, Canals M, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G252-66. doi: 10.1152/ajpgi.00184.2016. Epub 2016 Jun 30.


Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

Thompson GL, Lane JR, Coudrat T, Sexton PM, Christopoulos A, Canals M.

Biochem Pharmacol. 2016 Aug 1;113:70-87. doi: 10.1016/j.bcp.2016.05.014. Epub 2016 Jun 7.


Morphometry of Concepcion Bank: Evidence of Geological and Biological Processes on a Large Volcanic Seamount of the Canary Islands Seamount Province.

Rivera J, Canals M, Lastras G, Hermida N, Amblas D, Arrese B, Martín-Sosa P, Acosta J.

PLoS One. 2016 May 31;11(5):e0156337. doi: 10.1371/journal.pone.0156337. eCollection 2016.


Cold-Water Corals and Anthropogenic Impacts in La Fonera Submarine Canyon Head, Northwestern Mediterranean Sea.

Lastras G, Canals M, Ballesteros E, Gili JM, Sanchez-Vidal A.

PLoS One. 2016 May 16;11(5):e0155729. doi: 10.1371/journal.pone.0155729. eCollection 2016.


Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.

Jensen DD, Zhao P, Jimenez-Vargas NN, Lieu T, Gerges M, Yeatman HR, Canals M, Vanner SJ, Poole DP, Bunnett NW.

J Biol Chem. 2016 May 20;291(21):11285-99. doi: 10.1074/jbc.M115.710681. Epub 2016 Mar 30.


The role of kinetic context in apparent biased agonism at GPCRs.

Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR.

Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842.


Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.


Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.

Shang Y, Yeatman HR, Provasi D, Alt A, Christopoulos A, Canals M, Filizola M.

ACS Chem Biol. 2016 May 20;11(5):1220-9. doi: 10.1021/acschembio.5b00712. Epub 2016 Feb 17.


Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

Schembri LS, Stoddart LA, Briddon SJ, Kellam B, Canals M, Graham B, Scammells PJ.

J Med Chem. 2015 Dec 24;58(24):9754-67. doi: 10.1021/acs.jmedchem.5b01664. Epub 2015 Dec 16.


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