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Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu Cheney syndrome.

Canalis E, Grossman TR, Carrer M, Schilling L, Yu J.

J Biol Chem. 2020 Jan 28. pii: jbc.RA119.011440. doi: 10.1074/jbc.RA119.011440. [Epub ahead of print]


The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α.

Yu J, Canalis E.

J Biol Chem. 2019 Sep 27;294(39):14203-14214. doi: 10.1074/jbc.RA119.009824. Epub 2019 Aug 1.


An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice.

Yu J, Siebel CW, Schilling L, Canalis E.

J Cell Physiol. 2020 Jan;235(1):210-220. doi: 10.1002/jcp.28960. Epub 2019 Jun 12.


Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism.

Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA.

J Immunol. 2019 Jul 1;203(1):105-116. doi: 10.4049/jimmunol.1801032. Epub 2019 May 20.


MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment.

Mazziotti G, Lania AGA, Canalis E.

Eur J Endocrinol. 2019 Aug;181(2):R45-R56. doi: 10.1530/EJE-19-0184. Review.


Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.

Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.

Nat Commun. 2019 Mar 29;10(1):1442. doi: 10.1038/s41467-019-09491-5.


Clinico-pathological features of the intradiaphragmatic bronchogenic cysts: report of a case and review of the literature.

Simonetti S, Canalís E, Macías L, Carrasco MA.

Pathologica. 2018 Sep;110(2):116-120. Review.


Correction to: Notch in skeletal physiology and disease.

Canalis E.

Osteoporos Int. 2019 Jan;30(1):251. doi: 10.1007/s00198-018-4742-z.


Notch in skeletal physiology and disease.

Canalis E.

Osteoporos Int. 2018 Dec;29(12):2611-2621. doi: 10.1007/s00198-018-4694-3. Epub 2018 Sep 7. Review. Erratum in: Osteoporos Int. 2018 Oct 19;:.


The lateral meningocele syndrome mutation causes marked osteopenia in mice.

Canalis E, Yu J, Schilling L, Yee SP, Zanotti S.

J Biol Chem. 2018 Sep 7;293(36):14165-14177. doi: 10.1074/jbc.RA118.004242. Epub 2018 Jul 24.


Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo.

Yu J, Zanotti S, Schilling L, Canalis E.

J Cell Biochem. 2018 Nov;119(11):9334-9345. doi: 10.1002/jcb.27212. Epub 2018 Jul 16.


Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.

Zanotti S, Yu J, Bridgewater D, Wolf JM, Canalis E.

Bone. 2018 Sep;114:198-205. doi: 10.1016/j.bone.2018.06.020. Epub 2018 Jun 22.


Glucocorticoids inhibit notch target gene expression in osteoblasts.

Zanotti S, Yu J, Adhikari S, Canalis E.

J Cell Biochem. 2018 Jul;119(7):6016-6023. doi: 10.1002/jcb.26798. Epub 2018 Mar 25.


Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

Yu J, Zanotti S, Schilling L, Schoenherr C, Economides AN, Sanjay A, Canalis E.

Am J Pathol. 2018 Jun;188(6):1430-1446. doi: 10.1016/j.ajpath.2018.02.010. Epub 2018 Mar 12.


MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

Canalis E.

Eur J Endocrinol. 2018 Feb;178(2):R33-R44. doi: 10.1530/EJE-17-0920. Epub 2017 Nov 7. Review.


The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.

Yu J, Zanotti S, Walia B, Jellison E, Sanjay A, Canalis E.

Am J Pathol. 2018 Jan;188(1):149-159. doi: 10.1016/j.ajpath.2017.09.010. Epub 2017 Oct 14.


Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders.

Canalis E.

Metabolism. 2018 Mar;80:48-56. doi: 10.1016/j.metabol.2017.08.002. Epub 2017 Aug 24. Review.


Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.

Zanotti S, Canalis E.

Bone. 2017 Oct;103:159-167. doi: 10.1016/j.bone.2017.06.027. Epub 2017 Jul 1.


Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.

Zanotti S, Yu J, Sanjay A, Schilling L, Schoenherr C, Economides AN, Canalis E.

J Biol Chem. 2017 Jul 21;292(29):12232-12244. doi: 10.1074/jbc.M117.786129. Epub 2017 Jun 7.


An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice.

Canalis E, Sanjay A, Yu J, Zanotti S.

Endocrinology. 2017 Apr 1;158(4):730-742. doi: 10.1210/en.2016-1787.


Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice.

Canalis E, Zanotti S.

J Cell Biochem. 2017 Jul;118(7):1819-1826. doi: 10.1002/jcb.25859. Epub 2017 Mar 9.


Effects of Sex and Notch Signaling on the Osteocyte Cell Pool.

Canalis E, Schilling L, Zanotti S.

J Cell Physiol. 2017 Feb;232(2):363-370. doi: 10.1002/jcp.25433. Epub 2016 Jun 7.


Hajdu Cheney Syndrome; report of a novel NOTCH2 mutation and treatment with denosumab.

Adami G, Rossini M, Gatti D, Orsolini G, Idolazzi L, Viapiana O, Scarpa A, Canalis E.

Bone. 2016 Nov;92:150-156. doi: 10.1016/j.bone.2016.08.025. Epub 2016 Aug 31.


Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations.

Canalis E, Zanotti S.

Curr Osteoporos Rep. 2016 Aug;14(4):126-31. doi: 10.1007/s11914-016-0311-6. Review.


Notch Signaling and the Skeleton.

Zanotti S, Canalis E.

Endocr Rev. 2016 Jun;37(3):223-53. doi: 10.1210/er.2016-1002. Epub 2016 Apr 13. Review.


Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption.

Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S.

J Biol Chem. 2016 Jan 22;291(4):1538-51. doi: 10.1074/jbc.M115.685453. Epub 2015 Dec 1.


Canonical Notch activation in osteocytes causes osteopetrosis.

Canalis E, Bridgewater D, Schilling L, Zanotti S.

Am J Physiol Endocrinol Metab. 2016 Jan 15;310(2):E171-82. doi: 10.1152/ajpendo.00395.2015. Epub 2015 Nov 17.


Experience with the Nuss technique for the treatment of Pectus Excavatum in Spanish Thoracic Surgery Departments.

Fibla JJ, Molins L, Moradiellos J, Rodríguez P, Heras F, Canalis E, Bolufer S, Martínez P, Aragón J, Arroyo A, Pérez J, León P, Canela M.

Cir Esp. 2016 Jan;94(1):38-43. doi: 10.1016/j.ciresp.2015.08.001. Epub 2015 Nov 3. English, Spanish.


The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.

Zanotti S, Canalis E.

J Cell Biochem. 2016 May;117(5):1222-32. doi: 10.1002/jcb.25405. Epub 2015 Oct 20.


Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.

DeMambro VE, Le PT, Guntur AR, Maridas DE, Canalis E, Nagano K, Baron R, Clemmons DR, Rosen CJ.

Endocrinology. 2015 Nov;156(11):4129-40. doi: 10.1210/en.2014-1452. Epub 2015 Jul 31.


ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax.

Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, Krasnik M, Maskell N, Van Schil P, Tonia T, Waller DA, Marquette CH, Cardillo G.

Eur Respir J. 2015 Aug;46(2):321-35. doi: 10.1183/09031936.00219214. Epub 2015 Jun 25. Review.


Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.

Mirza F, Canalis E.

Eur J Endocrinol. 2015 Sep;173(3):R131-51. doi: 10.1530/EJE-15-0118. Epub 2015 May 13. Review.


Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice.

Choudhary S, Canalis E, Estus T, Adams D, Pilbeam C.

PLoS One. 2015 Mar 17;10(3):e0120164. doi: 10.1371/journal.pone.0120164. eCollection 2015.


Activation of Nfatc2 in osteoblasts causes osteopenia.

Zanotti S, Canalis E.

J Cell Physiol. 2015 Jul;230(7):1689-95. doi: 10.1002/jcp.24928.


Hajdu-Cheney syndrome: a review.

Canalis E, Zanotti S.

Orphanet J Rare Dis. 2014 Dec 10;9:200. doi: 10.1186/s13023-014-0200-y. Review.


Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage.

Canalis E, Zanotti S, Smerdel-Ramoya A.

Bone. 2014 Jul;64:273-80. doi: 10.1016/j.bone.2014.04.028. Epub 2014 May 2.


Nemo-like kinase regulates postnatal skeletal homeostasis.

Canalis E, Kranz L, Zanotti S.

J Cell Physiol. 2014 Nov;229(11):1736-43. doi: 10.1002/jcp.24625.


Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

Yang J, Velikoff M, Canalis E, Horowitz JC, Kim KK.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L786-96. doi: 10.1152/ajplung.00243.2013. Epub 2014 Feb 7.


Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.

Zanotti S, Canalis E.

Bone. 2014 May;62:22-8. doi: 10.1016/j.bone.2014.01.023. Epub 2014 Feb 4.


Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.

Zanotti S, Kalajzic I, Aguila HL, Canalis E.

PLoS One. 2014 Jan 28;9(1):e86757. doi: 10.1371/journal.pone.0086757. eCollection 2014.


Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.

He Q, Yang X, Gong Y, Kovalenko D, Canalis E, Rosen CJ, Friesel RE.

J Bone Miner Res. 2014;29(5):1217-31. doi: 10.1002/jbmr.2114.


Interleukin 6 mediates selected effects of Notch in chondrocytes.

Zanotti S, Canalis E.

Osteoarthritis Cartilage. 2013 Nov;21(11):1766-73. doi: 10.1016/j.joca.2013.08.010. Epub 2013 Aug 14.


Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches.

Canalis E.

Nat Rev Endocrinol. 2013 Oct;9(10):575-83. doi: 10.1038/nrendo.2013.154. Epub 2013 Aug 13. Review.


Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling.

Canalis E, Adams DJ, Boskey A, Parker K, Kranz L, Zanotti S.

J Biol Chem. 2013 Aug 30;288(35):25614-25. doi: 10.1074/jbc.M113.470492. Epub 2013 Jul 24.


Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice.

Zanotti S, Canalis E.

J Biol Chem. 2013 Jul 26;288(30):21547-57. doi: 10.1074/jbc.M113.489435. Epub 2013 Jun 19.


Notch signaling in skeletal health and disease.

Zanotti S, Canalis E.

Eur J Endocrinol. 2013 May 8;168(6):R95-103. doi: 10.1530/EJE-13-0115. Print 2013 Jun. Review.


Basal-cell adenoma of the subglottis: laryngotracheal resection with laryngotracheoplasty.

Larrosa F, Canalís E.

Arch Bronconeumol. 2013 Jul;49(7):314-5. doi: 10.1016/j.arbres.2013.01.004. Epub 2013 Mar 13. English, Spanish. No abstract available.


Osteoblast lineage-specific effects of notch activation in the skeleton.

Canalis E, Parker K, Feng JQ, Zanotti S.

Endocrinology. 2013 Feb;154(2):623-34. doi: 10.1210/en.2012-1732. Epub 2012 Dec 28.


Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes.

Zanotti S, Canalis E.

Endocrinology. 2013 Feb;154(2):762-72. doi: 10.1210/en.2012-1925. Epub 2012 Dec 21.


Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts.

Zanotti S, Smerdel-Ramoya A, Canalis E.

J Biol Chem. 2013 Jan 4;288(1):624-32. doi: 10.1074/jbc.M112.340455. Epub 2012 Nov 19.

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