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Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.

Banaszynski LA, Wen D, Dewell S, Whitcomb SJ, Lin M, Diaz N, Elsässer SJ, Chapgier A, Goldberg AD, Canaani E, Rafii S, Zheng D, Allis CD.

Cell. 2013 Sep 26;155(1):107-20. doi: 10.1016/j.cell.2013.08.061.


TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.

Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A.

Cell. 2012 Aug 31;150(5):922-33. doi: 10.1016/j.cell.2012.06.046. Epub 2012 Aug 23.


The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH.

Nature. 2012 Aug 16;488(7411):409-13. doi: 10.1038/nature11272.


Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7956-61. doi: 10.1073/pnas.1103154108. Epub 2011 Apr 25.


Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.

Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA.

Genes Dev. 2008 Dec 15;22(24):3403-8. doi: 10.1101/gad.1741408.


Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes.

Gregory GD, Vakoc CR, Rozovskaia T, Zheng X, Patel S, Nakamura T, Canaani E, Blobel GA.

Mol Cell Biol. 2007 Dec;27(24):8466-79. Epub 2007 Oct 8.


A histone H3 lysine 27 demethylase regulates animal posterior development.

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.

Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.


ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias.

Nakanishi H, Nakamura T, Canaani E, Croce CM.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14442-7. Epub 2007 Aug 28.


UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.

Nature. 2007 Oct 11;449(7163):731-4. Epub 2007 Aug 22.


Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.

Nakamura T, Canaani E, Croce CM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10980-5. Epub 2007 Jun 20.


Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E.

Mol Cell Biol. 2007 Mar;27(5):1889-903. Epub 2006 Dec 18.


Global and Hox-specific roles for the MLL1 methyltransferase.

Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8603-8. Epub 2005 Jun 7.


Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.

Muyrers-Chen I, Rozovskaia T, Lee N, Kersey JH, Nakamura T, Canaani E, Paro R.

Oncogene. 2004 Nov 11;23(53):8639-48.


Purification and biochemical properties of the Drosophila TAC1 complex.

Petruk S, Sedkov Y, Smith ST, Krajewski W, Nakamura T, Canaani E, Croce CM, Mazo A.

Methods Enzymol. 2004;377:255-66. No abstract available.


ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.

Canaani E, Nakamura T, Rozovskaia T, Smith ST, Mori T, Croce CM, Mazo A.

Br J Cancer. 2004 Feb 23;90(4):756-60. Review.


Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex.

Smith ST, Petruk S, Sedkov Y, Cho E, Tillib S, Canaani E, Mazo A.

Nat Cell Biol. 2004 Feb;6(2):162-7. Epub 2004 Jan 18.


Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila.

Sedkov Y, Cho E, Petruk S, Cherbas L, Smith ST, Jones RS, Cherbas P, Canaani E, Jaynes JB, Mazo A.

Nature. 2003 Nov 6;426(6962):78-83.


Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements.

Rozovskaia T, Ravid-Amir O, Tillib S, Getz G, Feinstein E, Agrawal H, Nagler A, Rappaport EF, Issaeva I, Matsuo Y, Kees UR, Lapidot T, Lo Coco F, Foa R, Mazo A, Nakamura T, Croce CM, Cimino G, Domany E, Canaani E.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7853-8. Epub 2003 Jun 2.


ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E.

Mol Cell. 2002 Nov;10(5):1119-28.


Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene.

Petruk S, Sedkov Y, Smith S, Tillib S, Kraevski V, Nakamura T, Canaani E, Croce CM, Mazo A.

Science. 2001 Nov 9;294(5545):1331-4.


Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality.

Rozovskaia T, Feinstein E, Mor O, Foa R, Blechman J, Nakamura T, Croce CM, Cimino G, Canaani E.

Oncogene. 2001 Feb 15;20(7):874-8.


huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions.

Nakamura T, Blechman J, Tada S, Rozovskaia T, Itoyama T, Bullrich F, Mazo A, Croce CM, Geiger B, Canaani E.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7284-9.


Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins.

Rozovskaia T, Rozenblatt-Rosen O, Sedkov Y, Burakov D, Yano T, Nakamura T, Petruck S, Ben-Simchon L, Croce CM, Mazo A, Canaani E.

Oncogene. 2000 Jan 20;19(3):351-7.


Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter.

Rozovskaia T, Tillib S, Smith S, Sedkov Y, Rozenblatt-Rosen O, Petruk S, Yano T, Nakamura T, Ben-Simchon L, Gildea J, Croce CM, Shearn A, Canaani E, Mazo A.

Mol Cell Biol. 1999 Sep;19(9):6441-7.


The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain.

Buchert M, Schneider S, Meskenaite V, Adams MT, Canaani E, Baechi T, Moelling K, Hovens CM.

J Cell Biol. 1999 Jan 25;144(2):361-71.


Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene.

Arakawa H, Nakamura T, Zhadanov AB, Fidanza V, Yano T, Bullrich F, Shimizu M, Blechman J, Mazo A, Canaani E, Croce CM.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4573-8.


The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex.

Rozenblatt-Rosen O, Rozovskaia T, Burakov D, Sedkov Y, Tillib S, Blechman J, Nakamura T, Croce CM, Mazo A, Canaani E.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4152-7.


The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells.

Yamamoto T, Harada N, Kano K, Taya S, Canaani E, Matsuura Y, Mizoguchi A, Ide C, Kaibuchi K.

J Cell Biol. 1997 Nov 3;139(3):785-95.


Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E.

Oncogene. 1997 Jul 31;15(5):549-60.


Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias.

Cimino G, Rapanotti MC, Biondi A, Elia L, Lo Coco F, Price C, Rossi V, Rivolta A, Canaani E, Croce CM, Mandelli F, Greaves M.

Cancer Res. 1997 Jul 15;57(14):2879-83.


Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein.

Yano T, Nakamura T, Blechman J, Sorio C, Dang CV, Geiger B, Canaani E.

Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7286-91.


Multigenetic lesions in infant acute leukaemias: correlations with ALL-1 gene status.

Cimino G, Lanza C, Elia L, Lo Coco F, Gaidano G, Biondi A, Pastore C, Serra A, Canaani E, Croce CM, Mandelli F, Saglio G.

Br J Haematol. 1997 Feb;96(2):308-13.


ALL-1 interacts with unr, a protein containing multiple cold shock domains.

Leshkowitz D, Rozenblatt O, Nakamura T, Yano T, Dautry F, Croce CM, Canaani E.

Oncogene. 1996 Nov 7;13(9):2027-31.


Complete exon structure of the ALL1 gene.

Rasio D, Schichman SA, Negrini M, Canaani E, Croce CM.

Cancer Res. 1996 Apr 15;56(8):1766-9.


Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

Fidanza V, Melotti P, Yano T, Nakamura T, Bradley A, Canaani E, Calabretta B, Croce CM.

Cancer Res. 1996 Mar 15;56(6):1179-83.


Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL-1/AF-4 positive-acute lymphoblastic leukaemia.

Cimino G, Elia L, Rivolta A, Rapanotti MC, Rossi V, Alimena G, Annino L, Canaani E, Lo Coco F, Biondi A.

Br J Haematol. 1996 Mar;92(3):659-64.


Identification of AF-6 and canoe as putative targets for Ras.

Kuriyama M, Harada N, Kuroda S, Yamamoto T, Nakafuku M, Iwamatsu A, Yamamoto D, Prasad R, Croce C, Canaani E, Kaibuchi K.

J Biol Chem. 1996 Jan 12;271(2):607-10.


Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.

Prasad R, Yano T, Sorio C, Nakamura T, Rallapalli R, Gu Y, Leshkowitz D, Croce CM, Canaani E.

Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12160-4.


The effects of passive anti-viral immunotherapy in AKR mice: II. Susceptibility to B cell lymphomagenesis.

Haran-Ghera N, Peled A, Canaani E, Caspi Y, Haimovich J, Shaft D, Resnitzky P, Brightman BK, Fan H.

Leukemia. 1995 Nov;9(11):1940-7.


ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age.

Cimino G, Rapanotti MC, Elia L, Biondi A, Fizzotti M, Testi AM, Tosti S, Croce CM, Canaani E, Mandelli F, et al.

Cancer Res. 1995 Apr 15;55(8):1625-8.


Self-fusion of the ALL1 gene. A new genetic mechanism for acute leukemia.

Schichman SA, Canaani E, Croce CM.

JAMA. 1995 Feb 15;273(7):571-6. Review. No abstract available.


Molecular genetics of 11q23 chromosome translocations.

Canaani E, Nowell PC, Croce CM.

Adv Cancer Res. 1995;66:213-34. Review. No abstract available.


Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.

Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E.

Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8107-11.


ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

Schichman SA, Caligiuri MA, Strout MP, Carter SL, Gu Y, Canaani E, Bloomfield CD, Croce CM.

Cancer Res. 1994 Aug 15;54(16):4277-80.


ALL-1 partial duplication in acute leukemia.

Schichman SA, Caligiuri MA, Gu Y, Strout MP, Canaani E, Bloomfield CD, Croce CM.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6236-9.


Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.

Skorski T, Kanakaraj P, Ku DH, Nieborowska-Skorska M, Canaani E, Zon G, Perussia B, Calabretta B.

J Exp Med. 1994 Jun 1;179(6):1855-65.


Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Saito H, Croce CM, Canaani E.

Cancer Res. 1994 May 1;54(9):2327-30.


Dependence of nucleic acid degradation on in situ free-radical production by adriamycin.

Feinstein E, Canaani E, Weiner LM.

Biochemistry. 1993 Dec 7;32(48):13156-61.


Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.

Negrini M, Felix CA, Martin C, Lange BJ, Nakamura T, Canaani E, Croce CM.

Cancer Res. 1993 Oct 1;53(19):4489-92.


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