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Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility.

Yang D, Vandenbussche G, Vertommen D, Evrard D, Abskharon R, Cavalier JF, Berger G, Canaan S, Khan MS, Zeng S, Wohlkönig A, Prévost M, Soumillion P, Fontaine V.

FEBS Lett. 2019 Aug 7. doi: 10.1002/1873-3468.13555. [Epub ahead of print]


Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus.

Madani A, Ridenour JN, Martin BP, Paudel RR, Abdul Basir A, Le Moigne V, Herrmann JL, Audebert S, Camoin L, Kremer L, Spilling CD, Canaan S, Cavalier JF.

ACS Infect Dis. 2019 Jul 25. doi: 10.1021/acsinfecdis.9b00172. [Epub ahead of print]


Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria.

Santucci P, Johansen MD, Point V, Poncin I, Viljoen A, Cavalier JF, Kremer L, Canaan S.

Sci Rep. 2019 Jun 17;9(1):8667. doi: 10.1038/s41598-019-45164-5.


Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains.

Santucci P, Smichi N, Diomandé S, Poncin I, Point V, Gaussier H, Cavalier JF, Kremer L, Canaan S.

FEBS J. 2019 Apr 29. doi: 10.1111/febs.14864. [Epub ahead of print]


Haloarcula sebkhae sp. nov., an extremely halophilic archaeon from Algerian hypersaline environment.

Barreteau H, Vandervennet M, Guédon L, Point V, Canaan S, Rebuffat S, Peduzzi J, Carré-Mlouka A.

Int J Syst Evol Microbiol. 2019 Mar;69(3):732-738. doi: 10.1099/ijsem.0.003211. Epub 2019 Jan 10.


Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria.

Santucci P, Dedaki C, Athanasoulis A, Gallorini L, Munoz A, Canaan S, Cavalier JF, Magrioti V.

ChemMedChem. 2019 Feb 5;14(3):349-358. doi: 10.1002/cmdc.201800720. Epub 2019 Jan 17.


LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling.

Santucci P, Point V, Poncin I, Guy A, Crauste C, Serveau-Avesque C, Galano JM, Spilling CD, Cavalier JF, Canaan S.

Biosci Rep. 2018 Dec 18;38(6). pii: BSR20181953. doi: 10.1042/BSR20181953. Print 2018 Dec 21.


Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis.

Nguyen PC, Nguyen VS, Martin BP, Fourquet P, Camoin L, Spilling CD, Cavalier JF, Cambillau C, Canaan S.

J Mol Biol. 2018 Dec 7;430(24):5120-5136. doi: 10.1016/j.jmb.2018.09.017. Epub 2018 Oct 4.


Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis.

Nguyen PC, Delorme V, Bénarouche A, Guy A, Landry V, Audebert S, Pophillat M, Camoin L, Crauste C, Galano JM, Durand T, Brodin P, Canaan S, Cavalier JF.

Bioorg Chem. 2018 Dec;81:414-424. doi: 10.1016/j.bioorg.2018.08.025. Epub 2018 Aug 29.


Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way.

Santucci P, Canaan S.

Curr Protein Pept Sci. 2018;19(11):1131-1133. doi: 10.2174/1389203719666180809143000. No abstract available.


Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages.

Santucci P, Diomandé S, Poncin I, Alibaud L, Viljoen A, Kremer L, de Chastellier C, Canaan S.

Infect Immun. 2018 Aug 22;86(9). pii: e00394-18. doi: 10.1128/IAI.00394-18. Print 2018 Sep.


B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections.

Rénier W, Bourdin A, Rubbo PA, Peries M, Dedieu L, Bendriss S, Kremer L, Canaan S, Terru D, Godreuil S, Nagot N, Van de Perre P, Tuaillon E.

PLoS One. 2018 Apr 30;13(4):e0196470. doi: 10.1371/journal.pone.0196470. eCollection 2018.


The potent effect of mycolactone on lipid membranes.

Nitenberg M, Bénarouche A, Maniti O, Marion E, Marsollier L, Géan J, Dufourc EJ, Cavalier JF, Canaan S, Girard-Egrot AP.

PLoS Pathog. 2018 Jan 10;14(1):e1006814. doi: 10.1371/journal.ppat.1006814. eCollection 2018 Jan.


Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L.

J Biol Chem. 2018 Feb 23;293(8):2755-2769. doi: 10.1074/jbc.RA117.000760. Epub 2018 Jan 4.


Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases.

Nguyen PC, Madani A, Santucci P, Martin BP, Paudel RR, Delattre S, Herrmann JL, Spilling CD, Kremer L, Canaan S, Cavalier JF.

Int J Antimicrob Agents. 2018 Apr;51(4):651-654. doi: 10.1016/j.ijantimicag.2017.12.001. Epub 2017 Dec 11.


Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.

Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S.

Sci Rep. 2017 Sep 18;7(1):11751. doi: 10.1038/s41598-017-11843-4.


Mycobacterium canettii Infection of Adipose Tissues.

Bouzid F, Brégeon F, Poncin I, Weber P, Drancourt M, Canaan S.

Front Cell Infect Microbiol. 2017 May 17;7:189. doi: 10.3389/fcimb.2017.00189. eCollection 2017.


Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm.

Parra J, Marcoux J, Poncin I, Canaan S, Herrmann JL, Nigou J, Burlet-Schiltz O, Rivière M.

Sci Rep. 2017 Mar 8;7:43682. doi: 10.1038/srep43682.


Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage.

Guerrini V, Subbian S, Santucci P, Canaan S, Gennaro ML, Pozzi G.

PLoS One. 2016 Dec 13;11(12):e0167989. doi: 10.1371/journal.pone.0167989. eCollection 2016.


Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis.

Santucci P, Bouzid F, Smichi N, Poncin I, Kremer L, De Chastellier C, Drancourt M, Canaan S.

Front Cell Infect Microbiol. 2016 Oct 7;6:122. eCollection 2016. Review.


Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.

Gilleron M, Lepore M, Layre E, Cala-De Paepe D, Mebarek N, Shayman JA, Canaan S, Mori L, Carrière F, Puzo G, De Libero G.

Cell Chem Biol. 2016 Sep 22;23(9):1147-1156. doi: 10.1016/j.chembiol.2016.07.021.


Smooth Tubercle Bacilli: Neglected Opportunistic Tropical Pathogens.

Aboubaker Osman D, Bouzid F, Canaan S, Drancourt M.

Front Public Health. 2016 Jan 11;3:283. doi: 10.3389/fpubh.2015.00283. eCollection 2015. Review.


A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery.

Flaugnatti N, Le TT, Canaan S, Aschtgen MS, Nguyen VS, Blangy S, Kellenberger C, Roussel A, Cambillau C, Cascales E, Journet L.

Mol Microbiol. 2016 Mar;99(6):1099-118. doi: 10.1111/mmi.13292. Epub 2016 Feb 10.


New lipase assay using Pomegranate oil coating in microtiter plates.

Ülker S, Placidi C, Point V, Gadenne B, Serveau-Avesque C, Canaan S, Carrière F, Cavalier JF.

Biochimie. 2016 Jan;120:110-8. doi: 10.1016/j.biochi.2015.09.004. Epub 2015 Sep 3.


Bacterial phospholipases C as vaccine candidate antigens against cystic fibrosis respiratory pathogens: the Mycobacterium abscessus model.

Le Moigne V, Rottman M, Goulard C, Barteau B, Poncin I, Soismier N, Canaan S, Pitard B, Gaillard JL, Herrmann JL.

Vaccine. 2015 Apr 27;33(18):2118-24. doi: 10.1016/j.vaccine.2015.03.030. Epub 2015 Mar 21.


Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice.

Bakala N'Goma JC, Le Moigne V, Soismier N, Laencina L, Le Chevalier F, Roux AL, Poncin I, Serveau-Avesque C, Rottman M, Gaillard JL, Etienne G, Brosch R, Herrmann JL, Canaan S, Girard-Misguich F.

Infect Immun. 2015 Feb;83(2):780-91. doi: 10.1128/IAI.02032-14. Epub 2014 Dec 8.


Supported inhibitor for fishing lipases in complex biological media and mass spectrometry identification.

Delorme V, Raux B, Puppo R, Leclaire J, Cavalier JF, Marc S, Kamarajugadda PK, Buono G, Fotiadu F, Canaan S, Carrière F.

Biochimie. 2014 Dec;107 Pt A:124-34. doi: 10.1016/j.biochi.2014.07.015. Epub 2014 Jul 24.


Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during latency and reactivation of tuberculosis.

Caire-Brändli I, Papadopoulos A, Malaga W, Marais D, Canaan S, Thilo L, de Chastellier C.

Infect Immun. 2014 Feb;82(2):476-90. doi: 10.1128/IAI.01196-13. Epub 2013 Nov 25.


Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis.

Dedieu L, Serveau-Avesque C, Canaan S.

PLoS One. 2013 Jul 2;8(7):e66913. doi: 10.1371/journal.pone.0066913. Print 2013.


Enantioselective inhibition of microbial lipolytic enzymes by nonracemic monocyclic enolphosphonate analogues of cyclophostin.

Point V, Malla RK, Carrière F, Canaan S, Spilling CD, Cavalier JF.

J Med Chem. 2013 Jun 13;56(11):4393-401. doi: 10.1021/jm4000787. Epub 2013 May 16.


Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones.

Point V, Pavan Kumar KV, Marc S, Delorme V, Parsiegla G, Amara S, Carrière F, Buono G, Fotiadu F, Canaan S, Leclaire J, Cavalier JF.

Eur J Med Chem. 2012 Dec;58:452-63. doi: 10.1016/j.ejmech.2012.10.040. Epub 2012 Oct 29.


Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.

Point V, Malla RK, Diomande S, Martin BP, Delorme V, Carriere F, Canaan S, Rath NP, Spilling CD, Cavalier JF.

J Med Chem. 2012 Nov 26;55(22):10204-19. doi: 10.1021/jm301216x. Epub 2012 Nov 7.


MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.

Delorme V, Diomandé SV, Dedieu L, Cavalier JF, Carrière F, Kremer L, Leclaire J, Fotiadu F, Canaan S.

PLoS One. 2012;7(9):e46493. doi: 10.1371/journal.pone.0046493. Epub 2012 Sep 28.


Mycobacterial lipolytic enzymes: a gold mine for tuberculosis research.

Dedieu L, Serveau-Avesque C, Kremer L, Canaan S.

Biochimie. 2013 Jan;95(1):66-73. doi: 10.1016/j.biochi.2012.07.008. Epub 2012 Jul 20. Review.


LipC (Rv0220) is an immunogenic cell surface esterase of Mycobacterium tuberculosis.

Shen G, Singh K, Chandra D, Serveau-Avesque C, Maurin D, Canaan S, Singla R, Behera D, Laal S.

Infect Immun. 2012 Jan;80(1):243-53. doi: 10.1128/IAI.05541-11. Epub 2011 Oct 28.


Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis.

Brust B, Lecoufle M, Tuaillon E, Dedieu L, Canaan S, Valverde V, Kremer L.

PLoS One. 2011;6(9):e25078. doi: 10.1371/journal.pone.0025078. Epub 2011 Sep 22.


Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies.

Palmieri-Thiers C, Alberti JC, Canaan S, Brunini V, Gambotti C, Tomi F, Oliw EH, Berti L, Maury J.

Arch Biochem Biophys. 2011 May 1;509(1):82-9. doi: 10.1016/ Epub 2011 Feb 21.


Watching intracellular lipolysis in mycobacteria using time lapse fluorescence microscopy.

Dhouib R, Ducret A, Hubert P, Carrière F, Dukan S, Canaan S.

Biochim Biophys Acta. 2011 Apr;1811(4):234-41. doi: 10.1016/j.bbalip.2011.01.001. Epub 2011 Jan 14.


Effects of surfactants on lipase structure, activity, and inhibition.

Delorme V, Dhouib R, Canaan S, Fotiadu F, Carrière F, Cavalier JF.

Pharm Res. 2011 Aug;28(8):1831-42. doi: 10.1007/s11095-010-0362-9. Epub 2011 Jan 14. Review.


Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.

Bakala N'goma JC, Schué M, Carrière F, Geerlof A, Canaan S.

Biochim Biophys Acta. 2010 Dec;1801(12):1305-13. doi: 10.1016/j.bbalip.2010.08.007. Epub 2010 Aug 21.


A monoacylglycerol lipase from Mycobacterium smegmatis Involved in bacterial cell interaction.

Dhouib R, Laval F, Carrière F, Daffé M, Canaan S.

J Bacteriol. 2010 Sep;192(18):4776-85. doi: 10.1128/JB.00261-10. Epub 2010 Jul 2.


Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.

Schué M, Maurin D, Dhouib R, Bakala N'Goma JC, Delorme V, Lambeau G, Carrière F, Canaan S.

FASEB J. 2010 Jun;24(6):1893-903. doi: 10.1096/fj.09-144766. Epub 2010 Jan 26.


First evidence for the salt-dependent folding and activity of an esterase from the halophilic archaea Haloarcula marismortui.

Müller-Santos M, de Souza EM, Pedrosa Fde O, Mitchell DA, Longhi S, Carrière F, Canaan S, Krieger N.

Biochim Biophys Acta. 2009 Aug;1791(8):719-29. doi: 10.1016/j.bbalip.2009.03.006. Epub 2009 Mar 17.


A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.

Palmieri-Thiers C, Canaan S, Brunini V, Lorenzi V, Tomi F, Desseyn JL, Garscha U, Oliw EH, Berti L, Maury J.

Biochim Biophys Acta. 2009 May;1791(5):339-46. doi: 10.1016/j.bbalip.2009.02.012.


Green fluorescent protein and factorial approach: an effective partnership for screening the soluble expression of recombinant proteins in Escherichia coli.

Coutard B, Gagnaire M, Guilhon AA, Berro M, Canaan S, Bignon C.

Protein Expr Purif. 2008 Oct;61(2):184-90. doi: 10.1016/j.pep.2008.05.014. Epub 2008 Jun 3.


A genomic search approach to identify esterases in Propionibacterium freudenreichii involved in the formation of flavour in Emmental cheese.

Dherbécourt J, Falentin H, Canaan S, Thierry A.

Microb Cell Fact. 2008 May 22;7:16. doi: 10.1186/1475-2859-7-16.


Lipolytic enzymes in Mycobacterium tuberculosis.

Côtes K, Bakala N'goma JC, Dhouib R, Douchet I, Maurin D, Carrière F, Canaan S.

Appl Microbiol Biotechnol. 2008 Apr;78(5):741-9. doi: 10.1007/s00253-008-1397-2. Epub 2008 Feb 29. Review.


Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids.

Côtes K, Dhouib R, Douchet I, Chahinian H, de Caro A, Carrière F, Canaan S.

Biochem J. 2007 Dec 15;408(3):417-27.


Gene overexpression and biochemical characterization of the biotechnologically relevant chlorogenic acid hydrolase from Aspergillus niger.

Benoit I, Asther M, Bourne Y, Navarro D, Canaan S, Lesage-Meessen L, Herweijer M, Coutinho PM, Asther M, Record E.

Appl Environ Microbiol. 2007 Sep;73(17):5624-32. Epub 2007 Jul 13.


Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, Lambeau G.

Biochemistry. 2006 May 9;45(18):5800-16.

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