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Items: 46

1.

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology.

Cerisier N, Petitjean M, Regad L, Bayard Q, Réau M, Badel A, Camproux AC.

Molecules. 2019 Jul 10;24(14). pii: E2529. doi: 10.3390/molecules24142529.

2.

Characterizing the structural variability of HIV-2 protease upon the binding of diverse ligands using a structural alphabet approach.

Triki D, Fartek S, Visseaux B, Descamps D, Camproux AC, Regad L.

J Biomol Struct Dyn. 2019 Oct;37(17):4658-4670. doi: 10.1080/07391102.2018.1562985. Epub 2019 Feb 1.

PMID:
30593258
3.

SAFlex: A structural alphabet extension to integrate protein structural flexibility and missing data information.

Allam I, Flatters D, Caumes G, Regad L, Delos V, Nuel G, Camproux AC.

PLoS One. 2018 Jul 5;13(7):e0198854. doi: 10.1371/journal.pone.0198854. eCollection 2018.

4.

Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases.

Triki D, Billot T, Visseaux B, Descamps D, Flatters D, Camproux AC, Regad L.

Sci Rep. 2018 Apr 10;8(1):5789. doi: 10.1038/s41598-018-24124-5.

5.

Analysis of the HIV-2 protease's adaptation to various ligands: characterization of backbone asymmetry using a structural alphabet.

Triki D, Cano Contreras ME, Flatters D, Visseaux B, Descamps D, Camproux AC, Regad L.

Sci Rep. 2018 Jan 15;8(1):710. doi: 10.1038/s41598-017-18941-3.

6.

Characterization of Ionizable Groups' Environments in Proteins and Protein-Ligand Complexes through a Statistical Analysis of the Protein Data Bank.

Borrel A, Camproux AC, Xhaard H.

ACS Omega. 2017 Oct 30;2(10):7359-7374. doi: 10.1021/acsomega.7b00739. eCollection 2017 Oct 31.

7.

Exploring the potential of a structural alphabet-based tool for mining multiple target conformations and target flexibility insight.

Regad L, Chéron JB, Triki D, Senac C, Flatters D, Camproux AC.

PLoS One. 2017 Aug 17;12(8):e0182972. doi: 10.1371/journal.pone.0182972. eCollection 2017.

8.

Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain.

Cerisier N, Regad L, Triki D, Petitjean M, Flatters D, Camproux AC.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700040. Epub 2017 Jul 11.

PMID:
28696518
9.

Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.

Janel N, Alexopoulos P, Badel A, Lamari F, Camproux AC, Lagarde J, Simon S, Feraudet-Tarisse C, Lamourette P, Arbones M, Paul JL, Dubois B, Potier MC, Sarazin M, Delabar JM.

Transl Psychiatry. 2017 Jun 20;7(6):e1154. doi: 10.1038/tp.2017.123.

10.

Cavity Versus Ligand Shape Descriptors: Application to Urokinase Binding Pockets.

Cerisier N, Regad L, Triki D, Camproux AC, Petitjean M.

J Comput Biol. 2017 Nov;24(11):1134-1137. doi: 10.1089/cmb.2017.0061. Epub 2017 Jun 1.

11.

Investigating the Importance of the Pocket-estimation Method in Pocket-based Approaches: An Illustration Using Pocket-ligand Classification.

Caumes G, Borrel A, Abi Hussein H, Camproux AC, Regad L.

Mol Inform. 2017 Sep;36(9). doi: 10.1002/minf.201700025. Epub 2017 Apr 27.

PMID:
28452177
12.

Structural Isosteres of Phosphate Groups in the Protein Data Bank.

Zhang Y, Borrel A, Ghemtio L, Regad L, Boije Af Gennäs G, Camproux AC, Yli-Kauhaluoma J, Xhaard H.

J Chem Inf Model. 2017 Mar 27;57(3):499-516. doi: 10.1021/acs.jcim.6b00519. Epub 2017 Mar 13.

PMID:
28234462
13.

Global vision of druggability issues: applications and perspectives.

Abi Hussein H, Geneix C, Petitjean M, Borrel A, Flatters D, Camproux AC.

Drug Discov Today. 2017 Feb;22(2):404-415. doi: 10.1016/j.drudis.2016.11.021. Epub 2016 Dec 6. Review.

PMID:
27939283
14.

PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins.

Hussein HA, Borrel A, Geneix C, Petitjean M, Regad L, Camproux AC.

Nucleic Acids Res. 2015 Jul 1;43(W1):W436-42. doi: 10.1093/nar/gkv462. Epub 2015 May 8.

15.

PockDrug: A Model for Predicting Pocket Druggability That Overcomes Pocket Estimation Uncertainties.

Borrel A, Regad L, Xhaard H, Petitjean M, Camproux AC.

J Chem Inf Model. 2015 Apr 27;55(4):882-95. doi: 10.1021/ci5006004. Epub 2015 Apr 16.

PMID:
25835082
16.

A Medicago truncatula rdr6 allele impairs transgene silencing and endogenous phased siRNA production but not development.

Bustos-Sanmamed P, Hudik E, Laffont C, Reynes C, Sallet E, Wen J, Mysore KS, Camproux AC, Hartmann C, Gouzy J, Frugier F, Crespi M, Lelandais-Brière C.

Plant Biotechnol J. 2014 Dec;12(9):1308-18. doi: 10.1111/pbi.12230. Epub 2014 Jul 24.

17.

Insights into an original pocket-ligand pair classification: a promising tool for ligand profile prediction.

Pérot S, Regad L, Reynès C, Spérandio O, Miteva MA, Villoutreix BO, Camproux AC.

PLoS One. 2013 Jun 20;8(6):e63730. doi: 10.1371/journal.pone.0063730. Print 2013.

18.

Dissecting protein loops with a statistical scalpel suggests a functional implication of some structural motifs.

Regad L, Martin J, Camproux AC.

BMC Bioinformatics. 2011 Jun 20;12:247. doi: 10.1186/1471-2105-12-247.

19.

SA-Mot: a web server for the identification of motifs of interest extracted from protein loops.

Regad L, Saladin A, Maupetit J, Geneix C, Camproux AC.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W203-9. doi: 10.1093/nar/gkr410. Epub 2011 Jun 10.

20.

Deciphering the shape and deformation of secondary structures through local conformation analysis.

Baussand J, Camproux AC.

BMC Struct Biol. 2011 Feb 1;11:9. doi: 10.1186/1472-6807-11-9.

21.

Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery.

Pérot S, Sperandio O, Miteva MA, Camproux AC, Villoutreix BO.

Drug Discov Today. 2010 Aug;15(15-16):656-67. doi: 10.1016/j.drudis.2010.05.015. Epub 2010 Jun 4. Review.

PMID:
20685398
22.

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods.

Reynès C, Host H, Camproux AC, Laconde G, Leroux F, Mazars A, Deprez B, Fahraeus R, Villoutreix BO, Sperandio O.

PLoS Comput Biol. 2010 Mar 5;6(3):e1000695. doi: 10.1371/journal.pcbi.1000695.

23.

Exact distribution of a pattern in a set of random sequences generated by a Markov source: applications to biological data.

Nuel G, Regad L, Martin J, Camproux AC.

Algorithms Mol Biol. 2010 Jan 26;5:15. doi: 10.1186/1748-7188-5-15.

24.

Mining protein loops using a structural alphabet and statistical exceptionality.

Regad L, Martin J, Nuel G, Camproux AC.

BMC Bioinformatics. 2010 Feb 4;11:75. doi: 10.1186/1471-2105-11-75.

25.

Rationalizing the chemical space of protein-protein interaction inhibitors.

Sperandio O, Reynès CH, Camproux AC, Villoutreix BO.

Drug Discov Today. 2010 Mar;15(5-6):220-9. doi: 10.1016/j.drudis.2009.11.007. Epub 2009 Dec 5. Review.

PMID:
19969101
26.

Taking advantage of local structure descriptors to analyze interresidue contacts in protein structures and protein complexes.

Martin J, Regad L, Etchebest C, Camproux AC.

Proteins. 2008 Nov 15;73(3):672-89. doi: 10.1002/prot.22091.

PMID:
18491388
27.

Structural deformation upon protein-protein interaction: a structural alphabet approach.

Martin J, Regad L, Lecornet H, Camproux AC.

BMC Struct Biol. 2008 Feb 28;8:12. doi: 10.1186/1472-6807-8-12.

28.

Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice.

Hamelet J, Aït-Yahya-Graison E, Matulewicz E, Noll C, Badel-Chagnon A, Camproux AC, Demuth K, Paul JL, Delabar JM, Janel N.

Eur J Clin Invest. 2007 Dec;37(12):933-8. Epub 2007 Oct 30.

PMID:
17971175
29.

In silico local structure approach: a case study on outer membrane proteins.

Martin J, de Brevern AG, Camproux AC.

Proteins. 2008 Apr;71(1):92-109.

PMID:
17932925
30.

A reduced amino acid alphabet for understanding and designing protein adaptation to mutation.

Etchebest C, Benros C, Bornot A, Camproux AC, de Brevern AG.

Eur Biophys J. 2007 Nov;36(8):1059-69. Epub 2007 Jun 13.

PMID:
17565494
31.

Hidden Markov model-derived structural alphabet for proteins: the learning of protein local shapes captures sequence specificity.

Camproux AC, Tufféry P.

Biochim Biophys Acta. 2005 Aug 5;1724(3):394-403. Review.

PMID:
16040198
32.

SA-Search: a web tool for protein structure mining based on a Structural Alphabet.

Guyon F, Camproux AC, Hochez J, Tufféry P.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W545-8.

33.

SCit: web tools for protein side chain conformation analysis.

Gautier R, Camproux AC, Tufféry P.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W508-11.

34.

A hidden markov model derived structural alphabet for proteins.

Camproux AC, Gautier R, Tufféry P.

J Mol Biol. 2004 Jun 4;339(3):591-605.

PMID:
15147844
35.

Prognostic value of lymph node involvement in oral cancers: a study of 137 cases.

Tankéré F, Camproux A, Barry B, Guedon C, Depondt J, Gehanno P.

Laryngoscope. 2000 Dec;110(12):2061-5.

PMID:
11129021
36.

A new approach for rapid detection and typing of serum monoclonal components.

Cacoub P, Camproux AC, Thiolières JM, Assogba U, Hausfater P, Mallet A, Foglietti MJ, Piette JC, Bernard M.

Clin Chim Acta. 2000 Dec;302(1-2):105-24.

PMID:
11074068
37.

The role of percutaneous transluminal coronary angioplasty in heart transplant recipients.

Schnetzler B, Drobinski G, Dorent R, Camproux AC, Ghossoub J, Thomas D, Gandjbakhch I.

J Heart Lung Transplant. 2000 Jun;19(6):557-65.

PMID:
10867336
38.

[Prognostic influence of cutaneous involvement in malignant tumors of the oral cavity].

Tankéré F, Camproux A, Barry B, Guedon C, Depondt J, Gehanno P.

Ann Otolaryngol Chir Cervicofac. 2000 Mar;117(2):85-90. French.

PMID:
10739997
39.

Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d'Etude et de Recherche en Medecine Interne et Maladies Infectieuses sur le Virus de l'Hepatite C.

Cacoub P, Renou C, Rosenthal E, Cohen P, Loury I, Loustaud-Ratti V, Yamamoto AM, Camproux AC, Hausfater P, Musset L, Veyssier P, Raguin G, Piette JC.

Medicine (Baltimore). 2000 Jan;79(1):47-56.

40.

Hidden Markov model approach for identifying the modular framework of the protein backbone.

Camproux AC, Tuffery P, Chevrolat JP, Boisvieux JF, Hazout S.

Protein Eng. 1999 Dec;12(12):1063-73.

PMID:
10611400
41.

[Mobility of a polyethylene tibial insert in a mobile total knee prosthesis].

Castel E, Roger B, Camproux A, Saillant G.

Rev Chir Orthop Reparatrice Appar Mot. 1999 Mar;85(1):33-41. French.

PMID:
10327465
42.

Interrelationships between postprandial lipoprotein B:CIII particle changes and high-density lipoprotein subpopulation profiles in mixed hyperlipoproteinemia.

Saïdi Y, Sich D, Camproux A, Egloff M, Federspiel MC, Gautier V, Raisonnier A, Turpin G, Beucler I.

Metabolism. 1999 Jan;48(1):60-7.

PMID:
9920146
43.

Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene.

Charron P, Dubourg O, Desnos M, Bennaceur M, Carrier L, Camproux AC, Isnard R, Hagege A, Langlard JM, Bonne G, Richard P, Hainque B, Bouhour JB, Schwartz K, Komajda M.

Circulation. 1998 Jun 9;97(22):2230-6.

PMID:
9631872
44.

Heart retransplantation: a 23-year single-center clinical experience.

Schnetzler B, Pavie A, Dorent R, Camproux AC, Leger P, Delcourt A, Gandjbakhch I.

Ann Thorac Surg. 1998 Apr;65(4):978-83.

PMID:
9564913
45.

A hidden Markov model approach to neuron firing patterns.

Camproux AC, Saunier F, Chouvet G, Thalabard JC, Thomas G.

Biophys J. 1996 Nov;71(5):2404-12.

46.

Stochastic modeling of the hypothalamic pulse generator activity.

Camproux AC, Thalabard JC, Thomas G.

Am J Physiol. 1994 Nov;267(5 Pt 1):E795-800.

PMID:
7977733

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