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Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging.

Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van 't Veer LJ, Campisi J, Coppé JP.

JCI Insight. 2019 Jun 11;5. pii: 124716. doi: 10.1172/jci.insight.124716.


Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.

Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN.

Nat Commun. 2019 Jun 3;10(1):2387. doi: 10.1038/s41467-019-10335-5.


Sex differences in heart rate responses to occupational stress.

Lucas B, Grayson S, Hamidu H, Han A, No S, Varghese A, Campisi J.

Stress. 2019 May 30:1-6. doi: 10.1080/10253890.2019.1621282. [Epub ahead of print]


Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.

JCI Insight. 2019 Apr 4;4(7). pii: 125019. doi: 10.1172/jci.insight.125019. eCollection 2019 Apr 4.


Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL.

Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25.


Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration.

Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N.

Aging Cell. 2019 Jun;18(3):e12927. doi: 10.1111/acel.12927. Epub 2019 Mar 21.


Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice.

Kim HN, Chang J, Iyer S, Han L, Campisi J, Manolagas SC, Zhou D, Almeida M.

Aging Cell. 2019 Jun;18(3):e12923. doi: 10.1111/acel.12923. Epub 2019 Feb 17.


Epithelial innate immunity mediates tubular cell senescence after kidney injury.

Jin H, Zhang Y, Ding Q, Wang SS, Rastogi P, Dai DF, Lu D, Purvis M, Cao C, Wang A, Liu D, Ren C, Elhadi S, Hu MC, Chai Y, Zepeda-Orozco D, Campisi J, Attanasio M.

JCI Insight. 2019 Jan 24;4(2). pii: 125490. doi: 10.1172/jci.insight.125490. [Epub ahead of print]


Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.


Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Abdul-Aziz AM, Sun Y, Hellmich C, Marlein CR, Mistry J, Forde E, Piddock RE, Shafat MS, Morfakis A, Mehta T, Di Palma F, Macaulay I, Ingham CJ, Haestier A, Collins A, Campisi J, Bowles KM, Rushworth SA.

Blood. 2019 Jan 31;133(5):446-456. doi: 10.1182/blood-2018-04-845420. Epub 2018 Nov 6.


Oxidation resistance 1 is a novel senolytic target.

Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D.

Aging Cell. 2018 Aug;17(4):e12780. doi: 10.1111/acel.12780. Epub 2018 May 15.


Senescent cells and osteoarthritis: a painful connection.

Jeon OH, David N, Campisi J, Elisseeff JH.

J Clin Invest. 2018 Apr 2;128(4):1229-1237. doi: 10.1172/JCI95147. Epub 2018 Apr 2. Review.


A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors.

Kohli J, Campisi J, Demaria M.

Oncotarget. 2017 Dec 28;9(7):7274-7281. doi: 10.18632/oncotarget.23752. eCollection 2018 Jan 26.


Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.

Wiley CD, Schaum N, Alimirah F, Lopez-Dominguez JA, Orjalo AV, Scott G, Desprez PY, Benz C, Davalos AR, Campisi J.

Sci Rep. 2018 Feb 5;8(1):2410. doi: 10.1038/s41598-018-20000-4.


Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

Chinta SJ, Woods G, Demaria M, Rane A, Zou Y, McQuade A, Rajagopalan S, Limbad C, Madden DT, Campisi J, Andersen JK.

Cell Rep. 2018 Jan 23;22(4):930-940. doi: 10.1016/j.celrep.2017.12.092. Epub 2018 Jan 28.


Unmasking Transcriptional Heterogeneity in Senescent Cells.

Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M.

Curr Biol. 2017 Sep 11;27(17):2652-2660.e4. doi: 10.1016/j.cub.2017.07.033. Epub 2017 Aug 30.


Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence.

Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J.

Aging Cell. 2017 Oct;16(5):1043-1050. doi: 10.1111/acel.12632. Epub 2017 Jul 11.


Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.


Oncogenic senescence: a multi-functional perspective.

Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J.

Oncotarget. 2017 Apr 18;8(16):27661-27672. doi: 10.18632/oncotarget.15742.


Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells.

Perrott KM, Wiley CD, Desprez PY, Campisi J.

Geroscience. 2017 Apr;39(2):161-173. doi: 10.1007/s11357-017-9970-1. Epub 2017 Apr 4.


Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ.

Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031.


Cellular Senescence and Lung Function during Aging. Yin and Yang.

Campisi J.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S402-S406. doi: 10.1513/AnnalsATS.201609-703AW. Review.


Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J.

Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15.


Disease drivers of aging.

Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, Cohen HJ, Demark-Wahnefried W, Ahles TA, Barzilai N, Hurria A, Hunt PW.

Ann N Y Acad Sci. 2016 Dec;1386(1):45-68. doi: 10.1111/nyas.13299. Review.


Do p53 stress responses impact organismal aging?

Hasty P, Campisi J, Sharp ZD.

Transl Cancer Res. 2016 Dec;5(6):685-691. doi: 10.21037/tcr.2016.12.02.


Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.


Whole Chromosome Instability induces senescence and promotes SASP.

Andriani GA, Almeida VP, Faggioli F, Mauro M, Tsai WL, Santambrogio L, Maslov A, Gadina M, Campisi J, Vijg J, Montagna C.

Sci Rep. 2016 Oct 12;6:35218. doi: 10.1038/srep35218.


Aging of the immune system: Focus on inflammation and vaccination.

Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A.

Eur J Immunol. 2016 Oct;46(10):2286-2301. doi: 10.1002/eji.201546178. Review.


From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.

Wiley CD, Campisi J.

Cell Metab. 2016 Jun 14;23(6):1013-1021. doi: 10.1016/j.cmet.2016.05.010. Review.


Context-dependent effects of cellular senescence in cancer development.

Lecot P, Alimirah F, Desprez PY, Campisi J, Wiley C.

Br J Cancer. 2016 May 24;114(11):1180-4. doi: 10.1038/bjc.2016.115. Epub 2016 May 3. Review.


Placental membrane aging and HMGB1 signaling associated with human parturition.

Menon R, Behnia F, Polettini J, Saade GR, Campisi J, Velarde M.

Aging (Albany NY). 2016 Feb;8(2):216-30.


Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.

Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JHJ, Sung P, Wiese C, Campisi J, Cooper PK.

Mol Cell. 2016 Feb 18;61(4):535-546. doi: 10.1016/j.molcel.2015.12.026. Epub 2016 Jan 28.


Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.

Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J.

Cell Metab. 2016 Feb 9;23(2):303-14. doi: 10.1016/j.cmet.2015.11.011. Epub 2015 Dec 10.


Simvastatin suppresses breast cancer cell proliferation induced by senescent cells.

Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P.

Sci Rep. 2015 Dec 14;5:17895. doi: 10.1038/srep17895.


Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D.

Nat Med. 2016 Jan;22(1):78-83. doi: 10.1038/nm.4010. Epub 2015 Dec 14.


The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ.

Science. 2015 Sep 25;349(6255):aaa5612. doi: 10.1126/science.aaa5612.


Heregulin, a new interactor of the telosome/shelterin complex in human telomeres.

Menendez JA, Benboudjema L, Vellon L, Rubio MA, Espinoza I, Campisi J, Lupu R.

Oncotarget. 2015 Nov 24;6(37):39408-21. doi: 10.18632/oncotarget.4962.


Heregulin, a new regulator of telomere length in human cells.

Menendez JA, Rubio MA, Campisi J, Lupu R.

Oncotarget. 2015 Nov 24;6(37):39422-36. doi: 10.18632/oncotarget.4964.


Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.

Kruiswijk F, Hasenfuss SC, Sivapatham R, Baar MP, Putavet D, Naipal KA, van den Broek NJ, Kruit W, van der Spek PJ, van Gent DC, Brenkman AB, Campisi J, Burgering BM, Hoeijmakers JH, de Keizer PL.

Oncogene. 2016 Apr 28;35(17):2166-77. doi: 10.1038/onc.2015.282. Epub 2015 Aug 17.


Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.

Velarde MC, Demaria M, Melov S, Campisi J.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10407-12. doi: 10.1073/pnas.1505675112. Epub 2015 Aug 3.


p53 and rapamycin are additive.

Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P.

Oncotarget. 2015 Jun 30;6(18):15802-13.


MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.


Social media users have different experiences, motivations, and quality of life.

Campisi J, Folan D, Diehl G, Kable T, Rademeyer C.

Psychiatry Res. 2015 Aug 30;228(3):774-80. doi: 10.1016/j.psychres.2015.04.042. Epub 2015 Jun 2.


Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.

White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J.

Nat Commun. 2015 Apr 10;6:6790. doi: 10.1038/ncomms7790.


Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.

Demaria M, Desprez PY, Campisi J, Velarde MC.

J Invest Dermatol. 2015 Jul;135(7):1722-1726. doi: 10.1038/jid.2015.108. Epub 2015 Apr 9. Review.


Montagna Symposium 2014-skin aging: molecular mechanisms and tissue consequences.

Gilchrest BA, Campisi J, Chang HY, Fisher GJ, Kulesz-Martin MF.

J Invest Dermatol. 2015 Apr;135(4):950-3. doi: 10.1038/jid.2014.546. No abstract available.


Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.

Neves J, Demaria M, Campisi J, Jasper H.

Dev Cell. 2015 Jan 12;32(1):9-18. doi: 10.1016/j.devcel.2014.11.028. Review.


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J.

Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11.


Stress and aging.

Simm A, Campisi J.

Exp Gerontol. 2014 Nov;59:1-2. doi: 10.1016/j.exger.2014.11.015. No abstract available.


Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

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