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Items: 12


Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5.

Warszawski S, Dekel E, Campeotto I, Marshall JM, Wright KE, Lyth O, Knop O, Regev-Rudzki N, Higgins MK, Draper SJ, Baum J, Fleishman SJ.

Proteins. 2020 Jan;88(1):187-195. doi: 10.1002/prot.25786. Epub 2019 Aug 2.


Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools.

Campeotto I, Lebedev A, Schreurs AMM, Kroon-Batenburg LMJ, Lowe E, Phillips SEV, Murshudov GN, Pearson AR.

Sci Rep. 2018 Oct 5;8(1):14876. doi: 10.1038/s41598-018-32962-6.


One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.

Campeotto I, Goldenzweig A, Davey J, Barfod L, Marshall JM, Silk SE, Wright KE, Draper SJ, Higgins MK, Fleishman SJ.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):998-1002. doi: 10.1073/pnas.1616903114. Epub 2017 Jan 17.


The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus.

Schuster CF, Bellows LE, Tosi T, Campeotto I, Corrigan RM, Freemont P, Gründling A.

Sci Signal. 2016 Aug 16;9(441):ra81. doi: 10.1126/scisignal.aaf7279.


Complex structure and biochemical characterization of the Staphylococcus aureus cyclic diadenylate monophosphate (c-di-AMP)-binding protein PstA, the founding member of a new signal transduction protein family.

Campeotto I, Zhang Y, Mladenov MG, Freemont PS, Gründling A.

J Biol Chem. 2015 Jan 30;290(5):2888-901. doi: 10.1074/jbc.M114.621789. Epub 2014 Dec 11.


The Chlamydia effector TarP mimics the mammalian leucine-aspartic acid motif of paxillin to subvert the focal adhesion kinase during invasion.

Thwaites T, Nogueira AT, Campeotto I, Silva AP, Grieshaber SS, Carabeo RA.

J Biol Chem. 2014 Oct 31;289(44):30426-42. doi: 10.1074/jbc.M114.604876. Epub 2014 Sep 5.


Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system.

Campeotto I, Percy MG, MacDonald JT, Förster A, Freemont PS, Gründling A.

J Biol Chem. 2014 Oct 10;289(41):28054-69. doi: 10.1074/jbc.M114.590570. Epub 2014 Aug 15.


Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis.

Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A.

ACS Chem Biol. 2014 Apr 18;9(4):1025-32. doi: 10.1021/cb500067z. Epub 2014 Feb 21.


Systematic identification of conserved bacterial c-di-AMP receptor proteins.

Corrigan RM, Campeotto I, Jeganathan T, Roelofs KG, Lee VT, Gründling A.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9084-9. doi: 10.1073/pnas.1300595110. Epub 2013 May 13.


Hijacking nature--new approaches to unravel enzyme mechanisms and engineer improved biocatalysts.

Campeotto I, Acevedo-Rocha CG.

EMBO Rep. 2013 Apr;14(4):299-301. doi: 10.1038/embor.2013.26. Epub 2013 Mar 12.


Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SE, Nelson A, Pearson AR, Berry A.

J Mol Biol. 2010 Nov 19;404(1):56-69. doi: 10.1016/j.jmb.2010.08.008. Epub 2010 Sep 6.


Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 angstrom resolution.

Campeotto I, Carr SB, Trinh CH, Nelson AS, Berry A, Phillips SE, Pearson AR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1088-90. doi: 10.1107/S1744309109037403. Epub 2009 Oct 24.

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