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Items: 1 to 50 of 240

1.

CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.

Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M.

Mol Neurobiol. 2019 Dec;56(12):7977-7993. doi: 10.1007/s12035-019-1640-0. Epub 2019 Jun 2.

PMID:
31154574
2.

Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease.

West PK, Viengkhou B, Campbell IL, Hofer MJ.

Glia. 2019 Oct;67(10):1821-1841. doi: 10.1002/glia.23634. Epub 2019 Apr 29. Review.

PMID:
31033014
3.

"I Want to Know More!": Children Are Sensitive to Explanation Quality When Exploring New Information.

Mills CM, Sands KR, Rowles SP, Campbell IL.

Cogn Sci. 2019 Jan;43(1). doi: 10.1111/cogs.12706.

PMID:
30648794
4.

"Omics" data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy.

Campbell NV, Weitzenkamp DA, Campbell IL, Schmidt RF, Hicks C, Morgan MJ, Irwin DC, Tentler JJ.

BMC Med Genomics. 2018 Dec 12;11(1):110. doi: 10.1186/s12920-018-0439-6.

5.

Microglia have a more extensive and divergent response to interferon-α compared with astrocytes.

Li W, Viengkhou B, Denyer G, West PK, Campbell IL, Hofer MJ.

Glia. 2018 Oct;66(10):2058-2078. doi: 10.1002/glia.23460. Epub 2018 Jul 27.

PMID:
30051922
6.

IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ.

J Virol. 2017 Oct 27;91(22). pii: e01219-17. doi: 10.1128/JVI.01219-17. Print 2017 Nov 15.

7.

Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia.

Petković F, Campbell IL, Gonzalez B, Castellano B.

J Neuroimmunol. 2017 Sep 15;310:97-102. doi: 10.1016/j.jneuroim.2017.07.003. Epub 2017 Jul 6.

PMID:
28778453
8.

Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9.

Li W, Hofer MJ, Songkhunawej P, Jung SR, Hancock D, Denyer G, Campbell IL.

J Biol Chem. 2017 Apr 7;292(14):5845-5859. doi: 10.1074/jbc.M116.756510. Epub 2017 Feb 17.

9.

Children's success at detecting circular explanations and their interest in future learning.

Mills CM, Danovitch JH, Rowles SP, Campbell IL.

Psychon Bull Rev. 2017 Oct;24(5):1465-1477. doi: 10.3758/s13423-016-1195-2.

10.

IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.

Zimmermann J, Emrich M, Krauthausen M, Saxe S, Nitsch L, Heneka MT, Campbell IL, Müller M.

Mol Neurobiol. 2018 Feb;55(2):946-957. doi: 10.1007/s12035-016-0368-3. Epub 2017 Jan 13.

PMID:
28084589
11.

Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.

Petković F, Campbell IL, Gonzalez B, Castellano B.

Glia. 2016 Dec;64(12):2104-2119. doi: 10.1002/glia.23043. Epub 2016 Aug 18.

PMID:
27535761
12.

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Kavanagh D, McGlasson S, Jury A, Williams J, Scolding N, Bellamy C, Gunther C, Ritchie D, Gale DP, Kanwar YS, Challis R, Buist H, Overell J, Weller B, Flossmann O, Blunden M, Meyer EP, Krucker T, Evans SJ, Campbell IL, Jackson AP, Chandran S, Hunt DP.

Blood. 2016 Dec 15;128(24):2824-2833. Epub 2016 Sep 23.

13.

Immunoinflammatory diseases of the central nervous system - the tale of two cytokines.

Hofer MJ, Campbell IL.

Br J Pharmacol. 2016 Feb;173(4):716-28. doi: 10.1111/bph.13175. Epub 2015 Jun 12. Review.

14.

Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.

Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL.

Glia. 2015 Oct;63(10):1738-52. doi: 10.1002/glia.22841. Epub 2015 Apr 22.

15.

Cryptococcus strains with different pathogenic potentials have diverse protein secretomes.

Campbell LT, Simonin AR, Chen C, Ferdous J, Padula MP, Harry E, Hofer M, Campbell IL, Carter DA.

Eukaryot Cell. 2015 Jun;14(6):554-63. doi: 10.1128/EC.00052-15. Epub 2015 Apr 3.

16.

Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy.

Villacampa N, Almolda B, Vilella A, Campbell IL, González B, Castellano B.

Glia. 2015 Jul;63(7):1166-84. doi: 10.1002/glia.22807. Epub 2015 Feb 17.

PMID:
25691003
17.

Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.

Almolda B, de Labra C, Barrera I, Gruart A, Delgado-Garcia JM, Villacampa N, Vilella A, Hofer MJ, Hidalgo J, Campbell IL, González B, Castellano B.

Brain Behav Immun. 2015 Mar;45:80-97. doi: 10.1016/j.bbi.2014.10.015. Epub 2014 Oct 31.

PMID:
25449577
18.

Defective inflammatory monocyte development in IRF8-deficient mice abrogates migration to the West Nile virus-infected brain.

Terry RL, Deffrasnes C, Getts DR, Minten C, van Vreden C, Ashhurst TM, Getts MT, Xie RD, Campbell IL, King NJ.

J Innate Immun. 2015;7(1):102-12. doi: 10.1159/000365972. Epub 2014 Sep 23.

19.

Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M.

Hsu MP, Frausto R, Rose-John S, Campbell IL.

Glia. 2015 Jan;63(1):132-41. doi: 10.1002/glia.22739. Epub 2014 Aug 7.

PMID:
25103368
20.

Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs.

Millington C, Sonego S, Karunaweera N, Rangel A, Aldrich-Wright JR, Campbell IL, Gyengesi E, Münch G.

Biomed Res Int. 2014;2014:309129. doi: 10.1155/2014/309129. Epub 2014 Jun 16.

21.

IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.

Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL.

J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.

22.

Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury.

Almolda B, Villacampa N, Manders P, Hidalgo J, Campbell IL, González B, Castellano B.

Glia. 2014 Jul;62(7):1142-61. doi: 10.1002/glia.22668. Epub 2014 Apr 2.

PMID:
24691898
23.

Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.

Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, Yang C, Morin B, Zhang H, Campbell IL, von Herrath MG.

J Autoimmun. 2014 Dec;55:24-32. doi: 10.1016/j.jaut.2014.02.002. Epub 2014 Feb 26.

24.

Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.

Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J.

J Neurosci. 2014 Feb 12;34(7):2503-13. doi: 10.1523/JNEUROSCI.2830-13.2014.

25.

Therapeutic inflammatory monocyte modulation using immune-modifying microparticles.

Getts DR, Terry RL, Getts MT, Deffrasnes C, Müller M, van Vreden C, Ashhurst TM, Chami B, McCarthy D, Wu H, Ma J, Martin A, Shae LD, Witting P, Kansas GS, Kühn J, Hafezi W, Campbell IL, Reilly D, Say J, Brown L, White MY, Cordwell SJ, Chadban SJ, Thorp EB, Bao S, Miller SD, King NJ.

Sci Transl Med. 2014 Jan 15;6(219):219ra7. doi: 10.1126/scitranslmed.3007563.

26.

The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis.

Noçon AL, Ip JP, Terry R, Lim SL, Getts DR, Müller M, Hofer MJ, King NJ, Campbell IL.

J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.

27.

Type I interferon in neurological disease-the devil from within.

Hofer MJ, Campbell IL.

Cytokine Growth Factor Rev. 2013 Jun;24(3):257-67. doi: 10.1016/j.cytogfr.2013.03.006. Epub 2013 Mar 30. Review.

PMID:
23548179
28.

Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice.

Li W, Hofer MJ, Noçon AL, Manders P, Campbell IL.

Virology. 2013 May 10;439(2):152-62. doi: 10.1016/j.virol.2013.02.015. Epub 2013 Mar 12.

29.

CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia.

Zimmermann J, Krauthausen M, Hofer MJ, Heneka MT, Campbell IL, Müller M.

PLoS One. 2013;8(2):e57307. doi: 10.1371/journal.pone.0057307. Epub 2013 Feb 27.

30.

Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.

Giralt M, Ramos R, Quintana A, Ferrer B, Erta M, Castro-Freire M, Comes G, Sanz E, Unzeta M, Pifarré P, García A, Campbell IL, Hidalgo J.

Glia. 2013 Apr;61(4):587-600. doi: 10.1002/glia.22457. Epub 2013 Jan 16.

PMID:
23322593
31.

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

Roberts K, Zeineddine R, Corcoran L, Li W, Campbell IL, Yerbury JJ.

Glia. 2013 Mar;61(3):409-19. doi: 10.1002/glia.22444. Epub 2012 Dec 22.

PMID:
23281114
32.

Inflammatory monocytes and the pathogenesis of viral encephalitis.

Terry RL, Getts DR, Deffrasnes C, van Vreden C, Campbell IL, King NJ.

J Neuroinflammation. 2012 Dec 17;9:270. doi: 10.1186/1742-2094-9-270. Review.

33.

IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS.

Minten C, Terry R, Deffrasnes C, King NJ, Campbell IL.

PLoS One. 2012;7(11):e49851. doi: 10.1371/journal.pone.0049851. Epub 2012 Nov 14. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/492fdf80-c999-4947-b569-96af8cb4e9d9.

34.

Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages.

Getts DR, Terry RL, Getts MT, Müller M, Rana S, Deffrasnes C, Ashhurst TM, Radford J, Hofer M, Thomas S, Campbell IL, King NJ.

J Neuroinflammation. 2012 Oct 30;9:246. doi: 10.1186/1742-2094-9-246.

35.

Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus.

Hofer MJ, Li W, Manders P, Terry R, Lim SL, King NJ, Campbell IL.

J Virol. 2012 Jun;86(12):6932-46. doi: 10.1128/JVI.07147-11. Epub 2012 Apr 11.

36.

Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration.

Ip JP, Noçon AL, Hofer MJ, Lim SL, Müller M, Campbell IL.

J Neuroinflammation. 2011 Sep 26;8:124. doi: 10.1186/1742-2094-8-124.

37.

Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12.

Krauthausen M, Ellis SL, Zimmermann J, Sarris M, Wakefield D, Heneka MT, Campbell IL, Müller M.

Am J Pathol. 2011 Nov;179(5):2346-59. doi: 10.1016/j.ajpath.2011.07.041. Epub 2011 Sep 15.

38.

The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.

Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Müller M, Campbell IL.

J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28.

39.

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum.

Müller M, Carter S, Hofer MJ, Campbell IL.

Neuropathol Appl Neurobiol. 2010 Aug;36(5):368-87. doi: 10.1111/j.1365-2990.2010.01089.x. Epub 2010 May 6. Review.

PMID:
20487305
40.

Community dynamics in the mouse gut microbiota: a possible role for IRF9-regulated genes in community homeostasis.

Thompson CL, Hofer MJ, Campbell IL, Holmes AJ.

PLoS One. 2010 Apr 23;5(4):e10335. doi: 10.1371/journal.pone.0010335.

41.

The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9.

Hofer MJ, Li W, Lim SL, Campbell IL.

J Neurosci. 2010 Jan 20;30(3):1149-57. doi: 10.1523/JNEUROSCI.3711-09.2010.

42.

Transgenic models for cytokine-induced neurological disease.

Campbell IL, Hofer MJ, Pagenstecher A.

Biochim Biophys Acta. 2010 Oct;1802(10):903-17. doi: 10.1016/j.bbadis.2009.10.004. Epub 2009 Oct 14. Review.

43.

Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis.

Quintana A, Müller M, Frausto RF, Ramos R, Getts DR, Sanz E, Hofer MJ, Krauthausen M, King NJ, Hidalgo J, Campbell IL.

J Immunol. 2009 Aug 1;183(3):2079-88. doi: 10.4049/jimmunol.0900242. Epub 2009 Jul 13.

44.

Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period.

Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL.

J Virol. 2009 Sep;83(18):9356-69. doi: 10.1128/JVI.02382-07. Epub 2009 Jul 1.

45.

Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong.

Hofer MJ, Carter SL, Müller M, Campbell IL.

Viral Immunol. 2008 Dec;21(4):425-33. doi: 10.1089/vim.2008.0057.

46.

Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis.

Getts DR, Terry RL, Getts MT, Müller M, Rana S, Shrestha B, Radford J, Van Rooijen N, Campbell IL, King NJ.

J Exp Med. 2008 Sep 29;205(10):2319-37. doi: 10.1084/jem.20080421. Epub 2008 Sep 8.

47.

Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency.

Miu J, Mitchell AJ, Müller M, Carter SL, Manders PM, McQuillan JA, Saunders BM, Ball HJ, Lu B, Campbell IL, Hunt NH.

J Immunol. 2008 Jan 15;180(2):1217-30.

48.

Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6.

Quintana A, Giralt M, Molinero A, Campbell IL, Penkowa M, Hidalgo J.

Neuroimmunomodulation. 2007;14(3-4):139-43. Epub 2007 Dec 5.

PMID:
18073505
49.

Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain.

Sanz E, Hofer MJ, Unzeta M, Campbell IL.

Glia. 2008 Jan 15;56(2):190-9.

PMID:
18023015
50.

Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome.

Quintana A, Molinero A, Borup R, Nielsen FC, Campbell IL, Penkowa M, Hidalgo J.

Dev Neurobiol. 2008 Feb 1;68(2):195-208.

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