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Items: 19

1.

Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor.

Jin Y, Regev A, Kam J, Phipps K, Smith C, Henck J, Campanale K, Hu L, Hall DG, Yang XY, Nakano M, McNearney TA, Uetrecht J, Landschulz W.

Br J Clin Pharmacol. 2018 Jan;84(1):179-188. doi: 10.1111/bcp.13423. Epub 2017 Oct 8.

2.

Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals.

Knadler MP, Nguyen TH, Campanale K, De Veer MJ, Beals JM, Li S, Hansen R, Siesky A, Michael MD, Porter CJ.

Pharm Res. 2016 Dec;33(12):2920-2929. Epub 2016 Aug 15.

3.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP.

J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub 2015 Dec 18.

PMID:
26653180
4.

Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib.

Jin Y, Smith CL, Hu L, Campanale KM, Stoltz R, Huffman LG Jr, McNearney TA, Yang XY, Ackermann BL, Dean R, Regev A, Landschulz W.

Clin Pharmacol Ther. 2016 Mar;99(3):274-84. doi: 10.1002/cpt.260. Epub 2015 Nov 25.

PMID:
26351780
5.

Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans.

Yi P, Rehmel JF, Cassidy K, Hadden C, Campanale K, Patel N, Johnson J.

Drug Metab Dispos. 2012 Dec;40(12):2354-64. doi: 10.1124/dmd.112.047613. Epub 2012 Sep 7.

PMID:
22961682
6.

The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure.

He MM, Ji T, Barbuch RJ, Campanale K, Lantz R, Hadden C, Wilke A.

Xenobiotica. 2011 Dec;41(12):1108-21. doi: 10.3109/00498254.2011.604744. Epub 2011 Sep 5.

PMID:
21892880
7.

Disposition of [14C]ruboxistaurin in humans.

Burkey JL, Campanale KM, Barbuch R, O'Bannon D, Rash J, Benson C, Small D.

Drug Metab Dispos. 2006 Nov;34(11):1909-17. Epub 2006 Aug 8.

PMID:
16896067
8.

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P.

Drug Metab Dispos. 2006 Feb;34(2):213-24. Epub 2005 Oct 28.

PMID:
16258078
9.

Pharmacodynamics of oritavancin (LY333328) in a neutropenic-mouse thigh model of Staphylococcus aureus infection.

Boylan CJ, Campanale K, Iversen PW, Phillips DL, Zeckel ML, Parr TR Jr.

Antimicrob Agents Chemother. 2003 May;47(5):1700-6.

10.

Disposition of LY333531, a selective protein kinase C beta inhibitor, in the Fischer 344 rat and beagle dog.

Burkey JL, Campanale KM, O'Bannon DD, Cramer JW, Farid NA.

Xenobiotica. 2002 Nov;32(11):1045-52.

PMID:
12487733
11.

Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.

Williams JA, Ring BJ, Cantrell VE, Campanale K, Jones DR, Hall SD, Wrighton SA.

Drug Metab Dispos. 2002 Nov;30(11):1266-73.

PMID:
12386134
12.

The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

Ring BJ, Gillespie JS, Binkley SN, Campanale KM, Wrighton SA.

Drug Metab Dispos. 2002 Sep;30(9):957-61.

PMID:
12167559
13.

In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

Fisher MB, Campanale K, Ackermann BL, VandenBranden M, Wrighton SA.

Drug Metab Dispos. 2000 May;28(5):560-6.

PMID:
10772635
14.

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH.

J Med Chem. 1997 Nov 21;40(24):3979-85.

PMID:
9397180
15.

Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime.

Victor F, Brown TJ, Campanale K, Heinz BA, Shipley LA, Su KS, Tang J, Vance LM, Spitzer WA.

J Med Chem. 1997 May 9;40(10):1511-8.

PMID:
9154972
16.
17.

Nasal delivery of polypeptides I: nasal absorption of enkephalins in rats.

Su KS, Campanale KM, Mendelsohn LG, Kerchner GA, Gries CL.

J Pharm Sci. 1985 Apr;74(4):394-8.

PMID:
3889275
18.

Nonaqueous cephalosporin suspension for parenteral administration: cefazolin sodium.

Su KS, Quay JF, Campanale KM, Stucky JF.

J Pharm Sci. 1984 Nov;73(11):1602-6.

PMID:
6520763
19.

Nasal drug delivery system of a quaternary ammonium compound: clofilium tosylate.

Su KS, Campanale KM, Gries CL.

J Pharm Sci. 1984 Sep;73(9):1251-4.

PMID:
6491944

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