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Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.

Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM.

Sci Rep. 2019 Dec 17;9(1):19291. doi: 10.1038/s41598-019-55132-8.


LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.

Brifault C, Kwon H, Campana WM, Gonias SL.

Glia. 2019 Jun;67(6):1210-1224. doi: 10.1002/glia.23599. Epub 2019 Feb 11.


PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology.

Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E.

J Cell Sci. 2018 Jul 26;131(14). pii: jcs217083. doi: 10.1242/jcs.217083.


Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury.

Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM.

Glia. 2018 Aug;66(8):1577-1590. doi: 10.1002/glia.23325. Epub 2018 Mar 9.


Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit.

Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS.

J Biomed Mater Res A. 2017 Dec;105(12):3392-3399. doi: 10.1002/jbm.a.36186. Epub 2017 Sep 25.


Tissue-type plasminogen activator regulates macrophage activation and innate immunity.

Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL.

Blood. 2017 Sep 14;130(11):1364-1374. doi: 10.1182/blood-2017-04-780205. Epub 2017 Jul 6.


Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords.

Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS.

Tissue Eng Part A. 2017 May;23(9-10):415-425. doi: 10.1089/ten.TEA.2016.0378. Epub 2017 Mar 31.


Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.

Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL.

FASEB J. 2017 Apr;31(4):1744-1755. doi: 10.1096/fj.201601121R. Epub 2017 Jan 10.


Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells.

Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM.

Neuroreport. 2016 Dec 14;27(18):1305-1311.


BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration.

Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M.

J Neural Eng. 2016 Dec;13(6):066011. Epub 2016 Oct 20.


Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury.

Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM.

Exp Neurol. 2016 Apr;278:91-104. doi: 10.1016/j.expneurol.2016.01.009. Epub 2016 Jan 22.


The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.

Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL.

J Cell Sci. 2015 Sep 15;128(18):3478-88. doi: 10.1242/jcs.173765. Epub 2015 Aug 13.


LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system.

Gonias SL, Campana WM.

Am J Pathol. 2014 Jan;184(1):18-27. doi: 10.1016/j.ajpath.2013.08.029. Epub 2013 Oct 12. Review.


Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons.

Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM.

PLoS One. 2013 Sep 23;8(9):e75497. doi: 10.1371/journal.pone.0075497. eCollection 2013.


Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration.

Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM.

J Biol Chem. 2013 Sep 13;288(37):26557-68. doi: 10.1074/jbc.M113.478552. Epub 2013 Jul 18.


Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain.

Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM.

J Neurosci. 2013 Mar 27;33(13):5590-602. doi: 10.1523/JNEUROSCI.3342-12.2013.


The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury.

Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM.

J Neurosci. 2011 Sep 21;31(38):13376-85. doi: 10.1523/JNEUROSCI.2850-11.2011.


Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1.

Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias SL.

J Neurosci Res. 2011 Apr;89(4):544-51. doi: 10.1002/jnr.22576. Epub 2011 Feb 2.


Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.

Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL.

J Leukoc Biol. 2010 Oct;88(4):769-78. doi: 10.1189/jlb.0410220. Epub 2010 Jul 7.


Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.

Mantuano E, Jo M, Gonias SL, Campana WM.

J Biol Chem. 2010 May 7;285(19):14259-66. doi: 10.1074/jbc.M109.085126. Epub 2010 Mar 2.


Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface.

Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM.

Glia. 2010 Mar;58(4):399-409. doi: 10.1002/glia.20931.


Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.

Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL.

Sci Signal. 2009 Apr 28;2(68):ra18. doi: 10.1126/scisignal.2000188.


Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis.

Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias SL.

J Cell Sci. 2009 Apr 15;122(Pt 8):1155-62. doi: 10.1242/jcs.040717. Epub 2009 Mar 19.


The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein.

Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM.

J Neurosci. 2008 Nov 5;28(45):11571-82. doi: 10.1523/JNEUROSCI.3053-08.2008.


Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat.

Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM.

J Neurosci Res. 2009 Mar;87(4):948-55. doi: 10.1002/jnr.21905.


Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.

Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL.

J Biol Chem. 2008 Jul 18;283(29):19904-11. doi: 10.1074/jbc.M801762200. Epub 2008 May 22.


Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF 3rd, Gonias SL.

Blood. 2008 Jun 1;111(11):5316-25. doi: 10.1182/blood-2007-12-127613. Epub 2008 Mar 27.


A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.

Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM.

J Clin Invest. 2008 Jan;118(1):161-72.


The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.

Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL.

Cancer Res. 2007 Oct 15;67(20):9817-24.


A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.

Arandjelovic S, Dragojlovic N, Li X, Myers RR, Campana WM, Gonias SL.

J Neurochem. 2007 Oct;103(2):694-705. Epub 2007 Aug 23.


Schwann cells: activated peripheral glia and their role in neuropathic pain.

Campana WM.

Brain Behav Immun. 2007 Jul;21(5):522-7. Epub 2007 Feb 26. Review.


The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.

Campana WM, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias SL.

J Neurosci. 2006 Oct 25;26(43):11197-207.


TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica.

Takahashi N, Kikuchi S, Shubayev VI, Campana WM, Myers RR.

Spine (Phila Pa 1976). 2006 Mar 1;31(5):523-9.


Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury.

Campana WM, Li X, Shubayev VI, Angert M, Cai K, Myers RR.

Eur J Neurosci. 2006 Feb;23(3):617-26.


The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets.

Myers RR, Campana WM, Shubayev VI.

Drug Discov Today. 2006 Jan;11(1-2):8-20. Review.


TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve.

Shubayev VI, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR.

Mol Cell Neurosci. 2006 Mar;31(3):407-15. Epub 2005 Nov 16.


Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow.

Bouaziz H, Iohom G, Estèbe JP, Campana WM, Myers RR.

Br J Anaesth. 2005 Nov;95(5):696-700. Epub 2005 Sep 23.


Inhibition of p38 MAP kinase activity enhances axonal regeneration.

Myers RR, Sekiguchi Y, Kikuchi S, Scott B, Medicherla S, Protter A, Campana WM.

Exp Neurol. 2003 Dec;184(2):606-14.


ISSLS prize winner: Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush.

Sekiguchi Y, Kikuchi S, Myers RR, Campana WM.

Spine (Phila Pa 1976). 2003 Dec 1;28(23):2577-84.


Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.

Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL.

J Neurochem. 2003 Sep;86(6):1534-44.


Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury.

Campana WM, Myers RR.

FASEB J. 2001 Aug;15(10):1804-6. No abstract available.


Prosaposin-derived peptides enhanced sprouting of sensory neurons in vitro and induced sprouting at motor endplates in vivo.

Campana WM, Mohiuddin L, Misasi R, O'Brien JS, Calcutt NA.

J Peripher Nerv Syst. 2000 Sep;5(3):126-30.


Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury.

Rende M, Brizi E, Donato R, Provenzano C, Bruno R, Mizisin AP, Garrett RS, Calcutt NA, Campana WM, O'Brien JS.

Muscle Nerve. 2001 Jun;24(6):799-808.


A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.

Hiraiwa M, Campana WM, Wang CY, Otero DA, O'Brien JS.

Brain Res Dev Brain Res. 2001 May 31;128(1):73-6.


Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase.

Misasi R, Sorice M, Di Marzio L, Campana WM, Molinari S, Cifone MG, Pavan A, Pontieri GM, O'Brien JS.

FASEB J. 2001 Feb;15(2):467-74.


Transforming growth factor-beta1 and glial growth factor 2 reduce neurotrophin-3 mRNA expression in cultured Schwann cells via a cAMP-dependent pathway.

Cai F, Campana WM, Tomlinson DR, Fernyhough P.

Brain Res Mol Brain Res. 1999 Aug 25;71(2):256-64.


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