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Items: 1 to 50 of 141

1.

Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model.

Alessandrini F, Menotti L, Avitabile E, Appolloni I, Ceresa D, Marubbi D, Campadelli-Fiume G, Malatesta P.

Oncogene. 2019 Jun;38(23):4467-4479. doi: 10.1038/s41388-019-0737-2. Epub 2019 Feb 12.

PMID:
30755732
2.

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.

Leoni V, Vannini A, Gatta V, Rambaldi J, Sanapo M, Barboni C, Zaghini A, Nanni P, Lollini PL, Casiraghi C, Campadelli-Fiume G.

PLoS Pathog. 2018 Aug 6;14(8):e1007209. doi: 10.1371/journal.ppat.1007209. eCollection 2018 Aug.

3.

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses.

Menotti L, Avitabile E, Gatta V, Malatesta P, Petrovic B, Campadelli-Fiume G.

Viruses. 2018 Jun 30;10(7). pii: E352. doi: 10.3390/v10070352.

4.

Spotlight on… Gabriella Campadelli-Fiume.

Campadelli-Fiume G.

FEMS Microbiol Lett. 2018 Jun 1;365(11). doi: 10.1093/femsle/fny019. No abstract available.

5.

Dual Ligand Insertion in gB and gD of Oncolytic Herpes Simplex Viruses for Retargeting to a Producer Vero Cell Line and to Cancer Cells.

Petrovic B, Leoni V, Gatta V, Zaghini A, Vannini A, Campadelli-Fiume G.

J Virol. 2018 Feb 26;92(6). pii: e02122-17. doi: 10.1128/JVI.02122-17. Print 2018 Mar 15.

6.

Simultaneous Insertion of Two Ligands in gD for Cultivation of Oncolytic Herpes Simplex Viruses in Noncancer Cells and Retargeting to Cancer Receptors.

Leoni V, Petrovic B, Gianni T, Gatta V, Campadelli-Fiume G.

J Virol. 2018 Feb 26;92(6). pii: e02132-17. doi: 10.1128/JVI.02132-17. Print 2018 Mar 15.

7.

Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins.

Petrovic B, Gianni T, Gatta V, Campadelli-Fiume G.

PLoS Pathog. 2017 Apr 19;13(4):e1006352. doi: 10.1371/journal.ppat.1006352. eCollection 2017 Apr.

8.

A Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells.

Leoni V, Gatta V, Casiraghi C, Nicosia A, Petrovic B, Campadelli-Fiume G.

J Virol. 2017 Apr 28;91(10). pii: e00067-17. doi: 10.1128/JVI.00067-17. Print 2017 May 15.

9.

Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.

Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD.

Annu Rev Virol. 2016 Sep 29;3(1):215-236. Epub 2016 Aug 3. Review.

PMID:
27501260
10.

Retargeting Strategies for Oncolytic Herpes Simplex Viruses.

Campadelli-Fiume G, Petrovic B, Leoni V, Gianni T, Avitabile E, Casiraghi C, Gatta V.

Viruses. 2016 Feb 26;8(3):63. doi: 10.3390/v8030063. Review.

11.

αvβ3 Integrin Boosts the Innate Immune Response Elicited in Epithelial Cells through Plasma Membrane and Endosomal Toll-Like Receptors.

Casiraghi C, Gianni T, Campadelli-Fiume G.

J Virol. 2016 Mar 28;90(8):4243-4248. doi: 10.1128/JVI.03175-15. Print 2016 Apr.

12.

Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases.

Leoni V, Gatta V, Palladini A, Nicoletti G, Ranieri D, Dall'Ora M, Grosso V, Rossi M, Alviano F, Bonsi L, Nanni P, Lollini PL, Campadelli-Fiume G.

Oncotarget. 2015 Oct 27;6(33):34774-87. doi: 10.18632/oncotarget.5793.

13.

Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry.

Gianni T, Massaro R, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3901-10. doi: 10.1073/pnas.1506846112. Epub 2015 Jul 8.

14.

The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors.

Gatta V, Petrovic B, Campadelli-Fiume G.

PLoS Pathog. 2015 May 21;11(5):e1004907. doi: 10.1371/journal.ppat.1004907. eCollection 2015 May.

15.

The epithelial αvβ3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.

Gianni T, Campadelli-Fiume G.

PLoS Pathog. 2014 Nov 6;10(11):e1004477. doi: 10.1371/journal.ppat.1004477. eCollection 2014 Nov.

16.

αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.

Gianni T, Salvioli S, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G.

PLoS Pathog. 2013;9(12):e1003806. doi: 10.1371/journal.ppat.1003806. Epub 2013 Dec 19.

17.

Type I interferon and NF-κB activation elicited by herpes simplex virus gH/gL via αvβ3 integrin in epithelial and neuronal cell lines.

Gianni T, Leoni V, Campadelli-Fiume G.

J Virol. 2013 Dec;87(24):13911-6. doi: 10.1128/JVI.01894-13. Epub 2013 Oct 9.

18.

Preclinical therapy of disseminated HER-2⁺ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.

Nanni P, Gatta V, Menotti L, De Giovanni C, Ianzano M, Palladini A, Grosso V, Dall'ora M, Croci S, Nicoletti G, Landuzzi L, Iezzi M, Campadelli-Fiume G, Lollini PL.

PLoS Pathog. 2013 Jan;9(1):e1003155. doi: 10.1371/journal.ppat.1003155. Epub 2013 Jan 31.

19.

αvβ3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.

Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19792-7. doi: 10.1073/pnas.1212597109. Epub 2012 Nov 12.

20.

Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB.

Leoni V, Gianni T, Salvioli S, Campadelli-Fiume G.

J Virol. 2012 Jun;86(12):6555-62. doi: 10.1128/JVI.00295-12. Epub 2012 Apr 11.

21.

Viral and cellular contributions to herpes simplex virus entry into the cell.

Campadelli-Fiume G, Menotti L, Avitabile E, Gianni T.

Curr Opin Virol. 2012 Feb;2(1):28-36. doi: 10.1016/j.coviro.2011.12.001. Epub 2012 Jan 4. Review.

PMID:
22440963
22.

Replication-competent herpes simplex virus retargeted to HER2 as therapy for high-grade glioma.

Gambini E, Reisoli E, Appolloni I, Gatta V, Campadelli-Fiume G, Menotti L, Malatesta P.

Mol Ther. 2012 May;20(5):994-1001. doi: 10.1038/mt.2012.22. Epub 2012 Feb 21.

23.

αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.

Gianni T, Campadelli-Fiume G.

J Virol. 2012 Mar;86(5):2850-5. doi: 10.1128/JVI.06689-11. Epub 2011 Dec 14.

24.

The molecular basis of herpesviruses as oncolytic agents.

Menotti L, Campadelli-Fiume G, Nanni P, Lollini PL, De Giovanni C.

Curr Pharm Biotechnol. 2012 Jul;13(9):1795-803. Review.

PMID:
21740356
25.

Rethinking herpes simplex virus: the way to oncolytic agents.

Campadelli-Fiume G, De Giovanni C, Gatta V, Nanni P, Lollini PL, Menotti L.

Rev Med Virol. 2011 Jul;21(4):213-26. doi: 10.1002/rmv.691. Epub 2011 May 27. Review.

PMID:
21626603
26.

The egress of alphaherpesviruses from the cell.

Campadelli-Fiume G.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 12.

27.

Entry of alphaherpesviruses into the cell.

Campadelli-Fiume G, Menotti L.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 7.

28.

Alphaherpes viral genes and their functions.

Roizman B, Campadelli-Fiume G.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 6.

29.

{alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2.

Gianni T, Gatta V, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22260-5. doi: 10.1073/pnas.1014923108. Epub 2010 Dec 6.

30.

Updates and achievements in virology.

Buonaguro FM, Campadelli-Fiume G, De Giuli Morghen C, Palù G.

Expert Rev Vaccines. 2010 Jul;9(7):703-6. doi: 10.1586/erv.10.69.

PMID:
20624042
31.

Glycoprotein D of bovine herpesvirus 5 (BoHV-5) confers an extended host range to BoHV-1 but does not contribute to invasion of the brain.

Gabev E, Tobler K, Abril C, Hilbe M, Senn C, Franchini M, Campadelli-Fiume G, Fraefel C, Ackermann M.

J Virol. 2010 Jun;84(11):5583-93. doi: 10.1128/JVI.00228-10. Epub 2010 Mar 10.

32.

Herpes simplex virus glycoproteins H/L bind to cells independently of {alpha}V{beta}3 integrin and inhibit virus entry, and their constitutive expression restricts infection.

Gianni T, Cerretani A, Dubois R, Salvioli S, Blystone SS, Rey F, Campadelli-Fiume G.

J Virol. 2010 Apr;84(8):4013-25. doi: 10.1128/JVI.02502-09. Epub 2010 Feb 10.

33.

Oncolytic herpes virus retargeted to HER-2.

Lollini PL, Menotti L, De Giovanni C, Campadelli-Fiume G, Nanni P.

Cell Cycle. 2009 Sep 15;8(18):2859-60. Epub 2009 Sep 26. No abstract available.

PMID:
19729994
34.

Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD.

Avitabile E, Forghieri C, Campadelli-Fiume G.

J Virol. 2009 Oct;83(20):10752-60. doi: 10.1128/JVI.01287-09. Epub 2009 Aug 5.

35.

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells.

Menotti L, Nicoletti G, Gatta V, Croci S, Landuzzi L, De Giovanni C, Nanni P, Lollini PL, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9039-44. doi: 10.1073/pnas.0812268106. Epub 2009 May 20.

36.

Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain.

Gianni T, Amasio M, Campadelli-Fiume G.

J Biol Chem. 2009 Jun 26;284(26):17370-82. doi: 10.1074/jbc.M109.005728. Epub 2009 Apr 22.

37.

Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2.

Menotti L, Cerretani A, Hengel H, Campadelli-Fiume G.

J Virol. 2008 Oct;82(20):10153-61. doi: 10.1128/JVI.01133-08. Epub 2008 Aug 6.

38.

Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies.

Calistri A, Sette P, Salata C, Cancellotti E, Forghieri C, Comin A, Göttlinger H, Campadelli-Fiume G, Palù G, Parolin C.

J Virol. 2007 Oct;81(20):11468-78. Epub 2007 Aug 8.

39.
40.

The multipartite system that mediates entry of herpes simplex virus into the cell.

Campadelli-Fiume G, Amasio M, Avitabile E, Cerretani A, Forghieri C, Gianni T, Menotti L.

Rev Med Virol. 2007 Sep-Oct;17(5):313-26. Review.

PMID:
17573668
41.

The herpesvirus glycoproteins B and H.L are sequentially recruited to the receptor-bound gD to effect membrane fusion at virus entry.

Gianni T, Forghieri C, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3668. Epub 2007 Feb 20. No abstract available.

43.

Hydrophobic alpha-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion.

Gianni T, Fato R, Bergamini C, Lenaz G, Campadelli-Fiume G.

J Virol. 2006 Aug;80(16):8190-8. Erratum in: J Virol. 2007 Mar;81(5):2542.

44.

The egress of herpesviruses from cells: the unanswered questions.

Campadelli-Fiume G, Roizman B.

J Virol. 2006 Jul;80(13):6716-7; author replies 6717-9. No abstract available.

46.

Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion.

Gianni T, Piccoli A, Bertucci C, Campadelli-Fiume G.

J Virol. 2006 Mar;80(5):2216-24. Erratum in: J Virol. 2007 Mar;81(5):2541.

47.

The pro-fusion domain of herpes simplex virus glycoprotein D (gD) interacts with the gD N terminus and is displaced by soluble forms of viral receptors.

Fusco D, Forghieri C, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9323-8. Epub 2005 Jun 21.

48.

A heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion.

Gianni T, Menotti L, Campadelli-Fiume G.

J Virol. 2005 Jun;79(11):7042-9. Erratum in: J Virol. 2007 Mar;81(5):2540.

49.

The ectodomain of herpes simplex virus glycoprotein H contains a membrane alpha-helix with attributes of an internal fusion peptide, positionally conserved in the herpesviridae family.

Gianni T, Martelli PL, Casadio R, Campadelli-Fiume G.

J Virol. 2005 Mar;79(5):2931-40. Erratum in: J Virol. 2007 Mar;81(5):2539.

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