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Environ Toxicol Pharmacol. 2017 Mar;50:167-174. doi: 10.1016/j.etap.2017.02.003. Epub 2017 Feb 4.

Impairment in the mesohippocampal dopamine circuit following exposure to the brominated flame retardant, HBCDD.

Author information

1
Department of Environmental Health, Rollins School of Public Health Emory University, Atlanta, GA 30322-3090, USA.
2
Department of Environmental Health, Rollins School of Public Health Emory University, Atlanta, GA 30322-3090, USA; Center for Neurodegenerative Disease, School of Medicine, Emory University Atlanta, GA 30322-3090, USA. Electronic address: William.m.caudle@emory.edu.

Abstract

Many chemicals have been used to increase the safety of consumer products by reducing their flammability and risk for ignition. Recent focus on brominated flame retardants, such as polybrominated diphenyl ethers (PBDEs) has shown them to contribute to neurobehavioral deficits in children, including learning and memory. As the manufacture and use of PBDEs have been reduced, replacement chemicals, such as hexabromocyclododecane (HBCDD) have been substituted. Our current study evaluated the neurotoxicity of HBCDD, concentrating on dopaminergic innervation to the hippocampus. Using an in vivo model, we exposed male mice to HBCDD and then assessed alterations to the dopamine synapse 6 weeks later. These exposures elicited significant reductions in presynaptic dopaminergic proteins, including TH, COMT, MAO-B, DAT, VMAT2, and alpha-synuclein. In contrast, postsynaptic dopamine receptors were not impaired. These findings suggest that the mesohippocampal dopamine circuit is vulnerable to HBCDD and the dopamine terminal may be a selective target for alteration.

KEYWORDS:

Dopamine transporter; Hexabromocyclododecane; Hippocampus; Substantia nigra pars compacta; Tyrosine hydroxylase; Vesicular monoamine transporter 2

PMID:
28214749
PMCID:
PMC5382642
DOI:
10.1016/j.etap.2017.02.003
[Indexed for MEDLINE]
Free PMC Article

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