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STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.

Martin AP, Jacquemyn M, Lipecka J, Chhuon C, Aushev VN, Meunier B, Singh MK, Carpi N, Piel M, Codogno P, Hergovich A, Parrini MC, Zalcman G, Guerrera IC, Daelemans D, Camonis JH.

EMBO Rep. 2019 Nov 5;20(11):e48150. doi: 10.15252/embr.201948150. Epub 2019 Sep 23.


Publisher Correction: Localization of RalB signaling at endomembrane compartments and its modulation by autophagy.

Singh MK, Martin APJ, Joffre C, Zago G, Camonis J, Coppey M, Parrini MC.

Sci Rep. 2019 Aug 8;9(1):11797. doi: 10.1038/s41598-019-48085-5.


Localization of RalB signaling at endomembrane compartments and its modulation by autophagy.

Singh MK, Martin APJ, Joffre C, Zago G, Camonis J, Coppey M, Parrini MC.

Sci Rep. 2019 Jun 20;9(1):8910. doi: 10.1038/s41598-019-45443-1. Erratum in: Sci Rep. 2019 Aug 8;9(1):11797.


NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells.

Keller M, Dubois F, Teulier S, Martin APJ, Levallet J, Maille E, Brosseau S, Elie N, Hergovich A, Bergot E, Camonis J, Zalcman G, Levallet G.

J Exp Clin Cancer Res. 2019 Apr 12;38(1):158. doi: 10.1186/s13046-019-1145-8.


Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments.

Nguyen M, De Ninno A, Mencattini A, Mermet-Meillon F, Fornabaio G, Evans SS, Cossutta M, Khira Y, Han W, Sirven P, Pelon F, Di Giuseppe D, Bertani FR, Gerardino A, Yamada A, Descroix S, Soumelis V, Mechta-Grigoriou F, Zalcman G, Camonis J, Martinelli E, Businaro L, Parrini MC.

Cell Rep. 2018 Dec 26;25(13):3884-3893.e3. doi: 10.1016/j.celrep.2018.12.015.


Collective stresses drive competition between monolayers of normal and Ras-transformed cells.

Moitrier S, Blanch-Mercader C, Garcia S, Sliogeryte K, Martin T, Camonis J, Marcq P, Silberzan P, Bonnet I.

Soft Matter. 2019 Jan 28;15(4):537-545. doi: 10.1039/c8sm01523f. Epub 2018 Dec 5.


Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer.

Garrido MF, Martin NJ, Bertrand M, Gaudin C, Commo F, El Kalaany N, Al Nakouzi N, Fazli L, Del Nery E, Camonis J, Perez F, Lerondel S, Le Pape A, Compagno D, Gleave M, Loriot Y, Désaubry L, Vagner S, Fizazi K, Chauchereau A.

Clin Cancer Res. 2019 Jan 15;25(2):710-723. doi: 10.1158/1078-0432.CCR-18-0704. Epub 2018 Oct 15.


RalB directly triggers invasion downstream Ras by mobilizing the Wave complex.

Zago G, Veith I, Singh MK, Fuhrmann L, De Beco S, Remorino A, Takaoka S, Palmeri M, Berger F, Brandon N, El Marjou A, Vincent-Salomon A, Camonis J, Coppey M, Parrini MC.

Elife. 2018 Oct 15;7. pii: e40474. doi: 10.7554/eLife.40474.


VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX.

Bonin F, Taouis K, Azorin P, Petitalot A, Tariq Z, Nola S, Bouteille N, Tury S, Vacher S, Bièche I, Rais KA, Pierron G, Fuhrmann L, Vincent-Salomon A, Formstecher E, Camonis J, Lidereau R, Lallemand F, Driouch K.

BMC Biol. 2018 Oct 2;16(1):109. doi: 10.1186/s12915-018-0576-6.


Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AAD, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2018 Apr 27;9(32):22870. doi: 10.18632/oncotarget.25335. eCollection 2018 Apr 27.


A family affair: A Ral-exocyst-centered network links Ras, Rac, Rho signaling to control cell migration.

Zago G, Biondini M, Camonis J, Parrini MC.

Small GTPases. 2019 Sep;10(5):323-330. doi: 10.1080/21541248.2017.1310649. Epub 2017 May 12.


Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.

Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC.

J Cell Sci. 2016 Oct 15;129(20):3756-3769. Epub 2016 Sep 2.


Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AA, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2016 Jul 12;7(28):44142-44160. doi: 10.18632/oncotarget.9875. Erratum in: Oncotarget. 2018 Apr 27;9(32):22870.


RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases.

O Santos A, Parrini MC, Camonis J.

PLoS One. 2016 May 5;11(5):e0154840. doi: 10.1371/journal.pone.0154840. eCollection 2016.


STK38 at the crossroad between autophagy and apoptosis.

Joffre C, Codogno P, Fanto M, Hergovich A, Camonis J.

Autophagy. 2016;12(3):594-5. doi: 10.1080/15548627.2015.1135283. Epub 2016 Feb 18.


RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.

Dubois F, Keller M, Calvayrac O, Soncin F, Hoa L, Hergovich A, Parrini MC, Mazières J, Vaisse-Lesteven M, Camonis J, Levallet G, Zalcman G.

Cancer Res. 2016 Mar 15;76(6):1627-40. doi: 10.1158/0008-5472.CAN-15-1008. Epub 2016 Jan 12.


A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1.

Canal F, Anthony E, Lescure A, Del Nery E, Camonis J, Perez F, Ragazzon B, Perret C.

BMC Cancer. 2015 Dec 29;15:1020. doi: 10.1186/s12885-015-2037-8.


The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.

Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C, Cascone I, Codogno P, Fanto M, Hergovich A, Camonis J.

Curr Biol. 2015 Oct 5;25(19):2479-92. doi: 10.1016/j.cub.2015.08.031. Epub 2015 Sep 17.


RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1.

Biondini M, Duclos G, Meyer-Schaller N, Silberzan P, Camonis J, Parrini MC.

Sci Rep. 2015 Jul 8;5:11759. doi: 10.1038/srep11759.


The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells.

El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F.

Mol Cancer Res. 2015 May;13(5):902-12. doi: 10.1158/1541-7786.MCR-14-0180. Epub 2015 Feb 12.


Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers.

Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F.

Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788.


Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.

Bonnay F, Nguyen XH, Cohen-Berros E, Troxler L, Batsche E, Camonis J, Takeuchi O, Reichhart JM, Matt N.

EMBO J. 2014 Oct 16;33(20):2349-62. doi: 10.15252/embj.201488456. Epub 2014 Sep 1.


[Collective cell migration: a fair sharing between leader cells and supracellular coordination].

Reffay M, Parrini MC, Cochet-Escartin O, Ladoux B, Buguin A, Coscoy S, Amblard F, Camonis J, Silberzan P.

Med Sci (Paris). 2014 Aug-Sep;30(8-9):736-8. doi: 10.1051/medsci/20143008007. Epub 2014 Sep 1. French. No abstract available.


Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.

Amirouchene-Angelozzi N, Nemati F, Gentien D, Nicolas A, Dumont A, Carita G, Camonis J, Desjardins L, Cassoux N, Piperno-Neumann S, Mariani P, Sastre X, Decaudin D, Roman-Roman S.

Mol Oncol. 2014 Dec;8(8):1508-20. doi: 10.1016/j.molonc.2014.06.004. Epub 2014 Jun 13.


Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.

Reffay M, Parrini MC, Cochet-Escartin O, Ladoux B, Buguin A, Coscoy S, Amblard F, Camonis J, Silberzan P.

Nat Cell Biol. 2014 Mar;16(3):217-23. doi: 10.1038/ncb2917. Erratum in: Nat Cell Biol. 2014 Apr;16(4):382.


A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.

Mahmood SF, Gruel N, Chapeaublanc E, Lescure A, Jones T, Reyal F, Vincent-Salomon A, Raynal V, Pierron G, Perez F, Camonis J, Del Nery E, Delattre O, Radvanyi F, Bernard-Pierrot I.

Carcinogenesis. 2014 Mar;35(3):670-82. doi: 10.1093/carcin/bgt351. Epub 2013 Oct 22.


Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.

Teodoro RO, Pekkurnaz G, Nasser A, Higashi-Kovtun ME, Balakireva M, McLachlan IG, Camonis J, Schwarz TL.

EMBO J. 2013 Jul 17;32(14):2039-55. doi: 10.1038/emboj.2013.147. Epub 2013 Jun 28. Erratum in: EMBO J. 2013 Aug 28;32(17):2418-9.


[Evolution and cancer: expansion of dangerous gene repertoire by whole genome duplications].

Affeldt S, Singh PP, Cascone I, Selimoglu R, Camonis J, Isambert H.

Med Sci (Paris). 2013 Apr;29(4):358-61. doi: 10.1051/medsci/2013294008. Epub 2013 Apr 26. French. No abstract available.


On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates.

Singh PP, Affeldt S, Cascone I, Selimoglu R, Camonis J, Isambert H.

Cell Rep. 2012 Nov 29;2(5):1387-98. doi: 10.1016/j.celrep.2012.09.034. Epub 2012 Nov 15.


Automated velocity mapping of migrating cell populations (AVeMap).

Deforet M, Parrini MC, Petitjean L, Biondini M, Buguin A, Camonis J, Silberzan P.

Nat Methods. 2012 Nov;9(11):1081-3. doi: 10.1038/nmeth.2209. Epub 2012 Oct 14.


RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.

Neyraud V, Aushev VN, Hatzoglou A, Meunier B, Cascone I, Camonis J.

J Biol Chem. 2012 Aug 24;287(35):29397-405. doi: 10.1074/jbc.M112.357764. Epub 2012 Jun 14.


Cell motility: The necessity of Rac1 GDP/GTP flux.

Parrini MC, Camonis J.

Commun Integr Biol. 2011 Nov 1;4(6):772-4.


High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.

Levallet G, Bergot E, Antoine M, Creveuil C, Santos AO, Beau-Faller M, de Fraipont F, Brambilla E, Levallet J, Morin F, Westeel V, Wislez M, Quoix E, Debieuvre D, Dubois F, Rouquette I, Pujol JL, Moro-Sibilot D, Camonis J, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT).

Mol Cancer Ther. 2012 May;11(5):1203-13. doi: 10.1158/1535-7163.MCT-11-0899. Epub 2012 Mar 12.


SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.

Parrini MC, Sadou-Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, Poullet P, Formstecher E, Yeaman C, Matsuda M, Rossé C, Camonis J.

Mol Cell. 2011 Jun 10;42(5):650-61. doi: 10.1016/j.molcel.2011.03.032.


RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.

Bodemann BO, Orvedahl A, Cheng T, Ram RR, Ou YH, Formstecher E, Maiti M, Hazelett CC, Wauson EM, Balakireva M, Camonis JH, Yeaman C, Levine B, White MA.

Cell. 2011 Jan 21;144(2):253-67. doi: 10.1016/j.cell.2010.12.018.


Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7).

Takahashi-Fujigasaki J, Breidert T, Fujigasaki H, Duyckaerts C, Camonis JH, Brice A, Lebre AS.

Neurobiol Dis. 2011 Jan;41(1):33-42. doi: 10.1016/j.nbd.2010.08.016. Epub 2010 Aug 20.


Characterization of single chain antibody targets through yeast two hybrid.

Vielemeyer O, Nizak C, Jimenez AJ, Echard A, Goud B, Camonis J, Rain JC, Perez F.

BMC Biotechnol. 2010 Aug 22;10:59. doi: 10.1186/1472-6750-10-59.


The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion.

Coon BG, Burgner J, Camonis JH, Aguilar RC.

J Biol Chem. 2010 Oct 22;285(43):33073-81. doi: 10.1074/jbc.M110.124123. Epub 2010 Aug 13.


The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.

Fenwick RB, Campbell LJ, Rajasekar K, Prasannan S, Nietlispach D, Camonis J, Owen D, Mott HR.

Structure. 2010 Aug 11;18(8):985-95. doi: 10.1016/j.str.2010.05.013.


An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.

Rosse C, Formstecher E, Boeckeler K, Zhao Y, Kremerskothen J, White MD, Camonis JH, Parker PJ.

PLoS Biol. 2009 Nov;7(11):e1000235. doi: 10.1371/journal.pbio.1000235. Epub 2009 Nov 3.


Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.

Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura V, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L.

Mol Cancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009 Aug 11.


Dissecting activation of the PAK1 kinase at protrusions in living cells.

Parrini MC, Camonis J, Matsuda M, de Gunzburg J.

J Biol Chem. 2009 Sep 4;284(36):24133-43. doi: 10.1074/jbc.M109.015271. Epub 2009 Jul 1.


Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.

Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, Lidereau R, Lallemand F.

Oncogene. 2009 Jul 16;28(28):2569-80. doi: 10.1038/onc.2009.120. Epub 2009 May 25.


Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.

Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D.

Biochemistry. 2009 Mar 17;48(10):2192-206. doi: 10.1021/bi802129d.


DLG1/SAP97 modulates transforming growth factor alpha bioavailability.

Surena AL, de Faria GP, Studler JM, Peiretti F, Pidoux M, Camonis J, Chneiweiss H, Formstecher E, Junier MP.

Biochim Biophys Acta. 2009 Feb;1793(2):264-72. doi: 10.1016/j.bbamcr.2008.09.005. Epub 2008 Sep 27.


Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration.

Pamonsinlapatham P, Gril B, Dufour S, Hadj-Slimane R, Gigoux V, Pethe S, L'hoste S, Camonis J, Garbay C, Raynaud F, Vidal M.

Cell Signal. 2008 Nov;20(11):2119-26. doi: 10.1016/j.cellsig.2008.08.005. Epub 2008 Aug 13.


Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J.

EMBO J. 2008 Sep 17;27(18):2375-87. doi: 10.1038/emboj.2008.166. Epub 2008 Aug 28.


The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.

Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P.

J Cell Biol. 2008 Jun 16;181(6):985-98. doi: 10.1083/jcb.200709076. Epub 2008 Jun 9.


IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules.

Nicolas CS, Park KH, El Harchi A, Camonis J, Kass RS, Escande D, Mérot J, Loussouarn G, Le Bouffant F, Baró I.

Cardiovasc Res. 2008 Aug 1;79(3):427-35. doi: 10.1093/cvr/cvn085. Epub 2008 Apr 5.


RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.

Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M Jr, Yeaman C, Camonis JH, Zhao Y, White MA.

Cell. 2006 Oct 6;127(1):157-70.

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