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Items: 13

1.

Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.

Zielińska M, Jarmuż A, Wasilewski A, Cami-Kobeci G, Husbands S, Fichna J.

Pharmacol Rep. 2017 Apr;69(2):350-357. doi: 10.1016/j.pharep.2016.12.001. Epub 2016 Dec 5.

2.

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.

Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5511-8. doi: 10.1073/pnas.1605295113. Epub 2016 Aug 29.

3.

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.

Zielińska M, Ben Haddou T, Cami-Kobeci G, Sałaga M, Jarmuż A, Padysz M, Kordek R, Spetea M, Husbands SM, Fichna J.

Eur J Pharmacol. 2015 Oct 15;765:582-90. doi: 10.1016/j.ejphar.2015.09.021. Epub 2015 Sep 25.

4.

BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice.

Khroyan TV, Wu J, Polgar WE, Cami-Kobeci G, Fotaki N, Husbands SM, Toll L.

Br J Pharmacol. 2015 Jan;172(2):668-80. doi: 10.1111/bph.12796. Epub 2014 Nov 5.

5.

Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms.

Sobczak M, Cami-Kobeci G, Sałaga M, Husbands SM, Fichna J.

Eur J Pharmacol. 2014 Aug 5;736:63-9. doi: 10.1016/j.ejphar.2014.04.038. Epub 2014 May 6.

6.

Orvinols with mixed kappa/mu opioid receptor agonist activity.

Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, Bosse K, Clark MJ, Aceto M, Lewis JW, Traynor JR, Husbands SM.

J Med Chem. 2013 Apr 25;56(8):3207-16. doi: 10.1021/jm301543e. Epub 2013 Apr 3.

7.

Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.

Cami-Kobeci G, Polgar WE, Khroyan TV, Toll L, Husbands SM.

J Med Chem. 2011 Oct 13;54(19):6531-7. doi: 10.1021/jm2003238. Epub 2011 Sep 7.

9.

Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines.

Cami-Kobeci G, Neal AP, Bradbury FA, Purington LC, Aceto MD, Harris LS, Lewis JW, Traynor JR, Husbands SM.

J Med Chem. 2009 Mar 26;52(6):1546-52. doi: 10.1021/jm8015552.

10.

Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.

Rennison D, Neal AP, Cami-Kobeci G, Aceto MD, Martinez-Bermejo F, Lewis JW, Husbands SM.

J Med Chem. 2007 Oct 18;50(21):5176-82. Epub 2007 Sep 22.

11.

Borrowing hydrogen: iridium-catalysed reactions for the formation of C-C bonds from alcohols.

Black PJ, Cami-Kobeci G, Edwards MG, Slatford PA, Whittlesey MK, Williams JM.

Org Biomol Chem. 2006 Jan 7;4(1):116-25. Epub 2005 Nov 25.

PMID:
16358005
12.

N-Alkylation of phenethylamine and tryptamine.

Cami-Kobeci G, Slatford PA, Whittlesey MK, Williams JM.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):535-7.

PMID:
15664808
13.

Conversion of alcohols into N-alkyl anilines via an indirect aza-Wittig reaction.

Cami-Kobeci G, Williams JM.

Chem Commun (Camb). 2004 May 7;(9):1072-3. Epub 2004 Apr 1.

PMID:
15116190

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