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Protective role of B cells in sterile particulate-induced lung injury.

Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP.

JCI Insight. 2019 May 16;5. pii: 125494. doi: 10.1172/jci.insight.125494.


A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.

Franks SE, Getahun A, Cambier JC.

J Immunol. 2019 Jun 15;202(12):3381-3393. doi: 10.4049/jimmunol.1801394. Epub 2019 May 10.


Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease.

Getahun A, Cambier JC.

Annu Rev Cell Dev Biol. 2019 Mar 18. doi: 10.1146/annurev-cellbio-100617-062518. [Epub ahead of print]


Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy.

Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC, Clambey ET, Costello JC, Korman AJ, Theodorescu D.

Sci Adv. 2019 Feb 20;5(2):eaav2437. doi: 10.1126/sciadv.aav2437. eCollection 2019 Feb.


Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity.

Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC.

JCI Insight. 2019 Feb 7;4(3). pii: 123384. doi: 10.1172/jci.insight.123384. [Epub ahead of print]


Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.

Leon MA, Wemlinger SM, Larson NR, Ruffalo JK, Sestak JO, Middaugh CR, Cambier JC, Berkland C.

Mol Pharm. 2019 Apr 1;16(4):1563-1572. doi: 10.1021/acs.molpharmaceut.8b01250. Epub 2019 Feb 25.


The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development.

Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D.

Front Immunol. 2018 Nov 22;9:2715. doi: 10.3389/fimmu.2018.02715. eCollection 2018.


B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses.

Walker MM, Crute BW, Cambier JC, Getahun A.

J Immunol. 2018 Nov 1;201(9):2641-2653. doi: 10.4049/jimmunol.1701405. Epub 2018 Oct 3.


Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice.

Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC.

Diabetologia. 2018 Dec;61(12):2621-2632. doi: 10.1007/s00125-018-4730-z. Epub 2018 Sep 25.


Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.

Franks SE, Cambier JC.

Front Immunol. 2018 Apr 6;9:665. doi: 10.3389/fimmu.2018.00665. eCollection 2018. Review.


High-efficiency RNA-based reprogramming of human primary fibroblasts.

Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G.

Nat Commun. 2018 Feb 21;9(1):745. doi: 10.1038/s41467-018-03190-3.


Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC.

Diabetes. 2018 Apr;67(4):697-703. doi: 10.2337/db17-0937. Epub 2018 Jan 17.


The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group.

PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829. eCollection 2018 Jan.


Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.

Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC.

J Autoimmun. 2018 May;89:82-89. doi: 10.1016/j.jaut.2017.12.001. Epub 2017 Dec 9.


cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J.

Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27.


B cells in type 1 diabetes mellitus and diabetic kidney disease.

Smith MJ, Simmons KM, Cambier JC.

Nat Rev Nephrol. 2017 Oct 17;13(11):712-720. doi: 10.1038/nrneph.2017.138. Review.


Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.

Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC.

J Exp Med. 2017 Apr 3;214(4):931-941. doi: 10.1084/jem.20160972. Epub 2017 Mar 24.


Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function.

Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC.

J Vis Exp. 2017 Feb 16;(120). doi: 10.3791/55382.


Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.

Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM.

JCI Insight. 2016 Dec 8;1(20):e88242. doi: 10.1172/jci.insight.88242.


B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.

Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC.

J Clin Med. 2016 Nov 8;5(11). pii: E98.


Targeting B cells in treatment of autoimmunity.

Franks SE, Getahun A, Hogarth PM, Cambier JC.

Curr Opin Immunol. 2016 Dec;43:39-45. doi: 10.1016/j.coi.2016.09.003. Epub 2016 Oct 5. Review.


Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines.

Noges LE, White J, Cambier JC, Kappler JW, Marrack P.

J Immunol. 2016 Aug 15;197(4):1221-30. doi: 10.4049/jimmunol.1501565. Epub 2016 Jun 29.


Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.

Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC.

J Exp Med. 2016 May 2;213(5):751-69. doi: 10.1084/jem.20150537. Epub 2016 Apr 25.


γδ T Cells Shape Preimmune Peripheral B Cell Populations.

Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK.

J Immunol. 2016 Jan 1;196(1):217-31. doi: 10.4049/jimmunol.1501064. Epub 2015 Nov 18.


Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.

Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH.

J Immunol. 2015 Dec 1;195(11):5461-5471. doi: 10.4049/jimmunol.1501375. Epub 2015 Oct 23.


Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.

Getahun A, Cambier JC.

Immunol Rev. 2015 Nov;268(1):66-73. doi: 10.1111/imr.12336. Review.


B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.

Akerlund J, Getahun A, Cambier JC.

J Autoimmun. 2015 Aug;62:45-54. doi: 10.1016/j.jaut.2015.06.007. Epub 2015 Jul 4.


γδ T cells affect IL-4 production and B-cell tolerance.

Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E39-48. doi: 10.1073/pnas.1415107111. Epub 2014 Dec 22.


Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT.

Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036.


Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.

Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC.

Diabetes. 2015 May;64(5):1703-12. doi: 10.2337/db13-1798. Epub 2014 Dec 18.


Role of B lymphocytes in the pathogenesis of type 1 diabetes.

Hinman RM, Cambier JC.

Curr Diab Rep. 2014;14(11):543. doi: 10.1007/s11892-014-0543-8. Review.


B cells and type 1 diabetes mice and men.

Hinman RM, Smith MJ, Cambier JC.

Immunol Lett. 2014 Aug;160(2):128-32. doi: 10.1016/j.imlet.2014.01.010. Epub 2014 Jan 25. Review.


Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.

Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC.

J Immunol. 2014 Feb 15;192(4):1641-50. doi: 10.4049/jimmunol.1302672. Epub 2014 Jan 17.


B lymphocyte antigen receptor signaling: initiation, amplification, and regulation.

Packard TA, Cambier JC.

F1000Prime Rep. 2013 Oct 1;5:40. doi: 10.12703/P5-40. Review.


Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.

Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C.

EMBO Rep. 2013 Oct;14(10):900-6. doi: 10.1038/embor.2013.132. Epub 2013 Sep 6.


Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.

Bounab Y, Getahun A, Cambier JC, Daëron M.

Curr Opin Immunol. 2013 Jun;25(3):313-20. doi: 10.1016/j.coi.2013.04.001. Epub 2013 May 15. Review.


Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.

Cambier JC.

J Clin Invest. 2013 May;123(5):1928-31. doi: 10.1172/JCI69289. Epub 2013 Apr 24.


STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.

Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC.

J Immunol. 2013 Mar 15;190(6):2835-43. doi: 10.4049/jimmunol.1201788. Epub 2013 Feb 1.


Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.

Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2784-93. doi: 10.1073/pnas.1202366109. Epub 2012 Sep 17.


Integrated immunology in Colorado.

Slansky JE, Cohen JJ, Cambier JC.

Immunol Res. 2013 Mar;55(1-3):1-2. doi: 10.1007/s12026-012-8376-5. No abstract available.


COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.

Packard TA, Li QZ, Cosgrove GP, Bowler RP, Cambier JC.

Immunol Res. 2013 Mar;55(1-3):48-57. doi: 10.1007/s12026-012-8347-x.


Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection.

Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC.

J Immunol. 2012 Sep 15;189(6):2965-74. doi: 10.4049/jimmunol.1201407. Epub 2012 Aug 17.


SMIP-016 in action: CD37 as a death receptor.

Jin L, Cambier JC.

Cancer Cell. 2012 May 15;21(5):597-8. doi: 10.1016/j.ccr.2012.04.034.


B cell maintenance and function in aging.

Kogut I, Scholz JL, Cancro MP, Cambier JC.

Semin Immunol. 2012 Oct;24(5):342-9. doi: 10.1016/j.smim.2012.04.004. Epub 2012 May 4. Review.


B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity.

Khalil AM, Cambier JC, Shlomchik MJ.

Science. 2012 Jun 1;336(6085):1178-81. doi: 10.1126/science.1213368. Epub 2012 May 3.


The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.

Waterman PM, Marschner S, Brandl E, Cambier JC.

Immunol Lett. 2012 Mar 30;143(1):122-30. doi: 10.1016/j.imlet.2012.02.009. Epub 2012 Feb 24.


αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells.

O'Brien RL, Chain JL, Aydintug MK, Bohrer-Kunter D, Huang Y, Hardy IR, Cambier JC, Lahmers K, Nuhsbaum T, Davidson R, Sun D, Born WK.

Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):301-8. doi: 10.1167/iovs.11-8855.


VISA is required for B cell expression of TLR7.

Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC.

J Immunol. 2012 Jan 1;188(1):248-58. doi: 10.4049/jimmunol.1100918. Epub 2011 Nov 21.


Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.

O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC.

Immunity. 2011 Nov 23;35(5):746-56. doi: 10.1016/j.immuni.2011.10.011. Epub 2011 Nov 9.


MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL.

J Immunol. 2011 Sep 1;187(5):2595-601. doi: 10.4049/jimmunol.1100088. Epub 2011 Aug 3.

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