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Items: 1 to 50 of 58

1.

Deregulation of miR-324/Kiss1/kisspeptin in early ectopic pregnancy: Mechanistic findings with clinical and diagnostic implications.

Romero-Ruiz A, Avendaño MS, Dominguez F, Lozoya T, Molina-Abril H, Sangiao-Alvarellos S, Gurrea M, Lara-Chica M, Fernandez-Sanchez M, Torres E, Perdices-Lopez C, Abbara A, Steffani L, Calzado MA, Dhillo WS, Pellicer A, Tena-Sempere M.

Am J Obstet Gynecol. 2019 Jan 29. pii: S0002-9378(19)30282-0. doi: 10.1016/j.ajog.2019.01.228. [Epub ahead of print]

PMID:
30707968
2.

LUBAC determines chemotherapy resistance in squamous cell lung cancer.

Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A.

J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742. Epub 2019 Jan 14.

3.

SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone.

Garrido-Rodríguez M, Ortea I, Calzado MA, Muñoz E, García V.

J Proteomics. 2019 Feb 20;193:217-229. doi: 10.1016/j.jprot.2018.10.012. Epub 2018 Oct 25.

PMID:
30626528
4.

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity.

Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sánchez-Garrido MA, Jimenez-Jimenez C, Pavicic C, Vazquez MJ, Appendino G, Bellido ML, Calzado MA, Tena-Sempere M, Muñoz E.

Sci Rep. 2018 Oct 31;8(1):16092. doi: 10.1038/s41598-018-34259-0.

5.

Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.

Minassi A, Rogati F, Cruz C, Prados ME, Galera N, Jinénez C, Appendino G, Bellido ML, Calzado MA, Caprioglio D, Muñoz E.

J Nat Prod. 2018 Oct 26;81(10):2235-2243. doi: 10.1021/acs.jnatprod.8b00514. Epub 2018 Oct 10.

PMID:
30350996
6.

Effect of N-acyl-dopamines on beta cell differentiation and wound healing in diabetic mice.

Jiménez-Jiménez C, Lara-Chica M, Palomares B, Collado JA, Lopez-Miranda J, Muñoz E, Calzado MA.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1539-1551. doi: 10.1016/j.bbamcr.2018.08.008. Epub 2018 Aug 16.

PMID:
30327197
7.

Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers.

Moreno P, Jiménez-Jiménez C, Garrido-Rodríguez M, Calderón-Santiago M, Molina S, Lara-Chica M, Priego-Capote F, Salvatierra Á, Muñoz E, Calzado MA.

Mol Oncol. 2018 Oct;12(10):1778-1796. doi: 10.1002/1878-0261.12369. Epub 2018 Sep 13.

8.

EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis.

García-Martín A, Garrido-Rodríguez M, Navarrete C, Del Río C, Bellido ML, Appendino G, Calzado MA, Muñoz E.

Biochem Pharmacol. 2018 Nov;157:304-313. doi: 10.1016/j.bcp.2018.07.047. Epub 2018 Aug 2.

PMID:
30076848
9.

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.

Del Rio C, Cantarero I, Palomares B, Gómez-Cañas M, Fernández-Ruiz J, Pavicic C, García-Martín A, Luz Bellido M, Ortega-Castro R, Pérez-Sánchez C, López-Pedrera C, Appendino G, Calzado MA, Muñoz E.

Br J Pharmacol. 2018 Oct;175(19):3813-3831. doi: 10.1111/bph.14450. Epub 2018 Aug 23.

PMID:
30033591
10.

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy.

Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL, Appendino G, Calzado MA, Guaza C, Muñoz E.

J Neuroinflammation. 2018 Mar 1;15(1):64. doi: 10.1186/s12974-018-1103-y.

11.

VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.

Díaz-Alonso J, Paraíso-Luna J, Navarrete C, Del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E.

Sci Rep. 2016 Jul 19;6:29789. doi: 10.1038/srep29789.

12.

The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways.

del Río C, Navarrete C, Collado JA, Bellido ML, Gómez-Cañas M, Pazos MR, Fernández-Ruiz J, Pollastro F, Appendino G, Calzado MA, Cantarero I, Muñoz E.

Sci Rep. 2016 Feb 18;6:21703. doi: 10.1038/srep21703.

13.

CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.

García-Limones C, Lara-Chica M, Jiménez-Jiménez C, Pérez M, Moreno P, Muñoz E, Calzado MA.

Oncogene. 2016 Aug 18;35(33):4289-301. doi: 10.1038/onc.2015.495. Epub 2016 Jan 11.

PMID:
26751770
14.

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.

García V, Lara-Chica M, Cantarero I, Sterner O, Calzado MA, Muñoz E.

Oncotarget. 2016 Jan 26;7(4):4490-506. doi: 10.18632/oncotarget.6606.

15.

The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer.

Moreno P, Lara-Chica M, Soler-Torronteras R, Caro T, Medina M, Álvarez A, Salvatierra Á, Muñoz E, Calzado MA.

PLoS One. 2015 Nov 18;10(11):e0143376. doi: 10.1371/journal.pone.0143376. eCollection 2015.

16.

AM404 inhibits NFAT and NF-κB signaling pathways and impairs migration and invasiveness of neuroblastoma cells.

Caballero FJ, Soler-Torronteras R, Lara-Chica M, García V, Fiebich BL, Muñoz E, Calzado MA.

Eur J Pharmacol. 2015 Jan 5;746:221-32. doi: 10.1016/j.ejphar.2014.11.023. Epub 2014 Nov 25.

PMID:
25460026
17.

Hypoximimetic activity of N-acyl-dopamines. N-arachidonoyl-dopamine stabilizes HIF-1α protein through a SIAH2-dependent pathway.

Soler-Torronteras R, Lara-Chica M, García V, Calzado MA, Muñoz E.

Biochim Biophys Acta. 2014 Nov;1843(11):2730-43. doi: 10.1016/j.bbamcr.2014.07.005. Epub 2014 Aug 2.

18.

The fungal metabolite galiellalactone interferes with the nuclear import of NF-κB and inhibits HIV-1 replication.

Pérez M, Soler-Torronteras R, Collado JA, Limones CG, Hellsten R, Johansson M, Sterner O, Bjartell A, Calzado MA, Muñoz E.

Chem Biol Interact. 2014 May 5;214:69-76. doi: 10.1016/j.cbi.2014.02.012. Epub 2014 Mar 11.

PMID:
24631022
19.

[Factors associated with early weaning in a Spanish region].

Rius JM, Ortuño J, Rivas C, Maravall M, Calzado MA, López A, Aguar M, Vento M.

An Pediatr (Barc). 2014 Jan;80(1):6-15. doi: 10.1016/j.anpedi.2013.05.011. Epub 2013 Oct 3. Spanish.

20.

Multiple anticancer effects of damsin and coronopilin isolated from Ambrosia arborescens on cell cultures.

Villagomez R, Rodrigo GC, Collado IG, Calzado MA, Muñoz E, Åkesson B, Sterner O, Almanza GR, Duan RD.

Anticancer Res. 2013 Sep;33(9):3799-805.

PMID:
24023312
21.

SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation.

Grishina I, Debus K, García-Limones C, Schneider C, Shresta A, García C, Calzado MA, Schmitz ML.

Biochim Biophys Acta. 2012 Dec;1823(12):2287-96. doi: 10.1016/j.bbamcr.2012.09.011. Epub 2012 Oct 6.

22.

A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.

Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E.

J Neuroimmune Pharmacol. 2012 Dec;7(4):1002-16. doi: 10.1007/s11481-012-9399-3. Epub 2012 Sep 14.

PMID:
22971837
23.

Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.

Pérez M, García-Limones C, Zapico I, Marina A, Schmitz ML, Muñoz E, Calzado MA.

J Mol Cell Biol. 2012 Oct;4(5):316-30. doi: 10.1093/jmcb/mjs047. Epub 2012 Aug 9.

PMID:
22878263
24.

Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.

Vinuesa AG, Sancho R, García-Limones C, Behrens A, ten Dijke P, Calzado MA, Muñoz E.

Cancer Res. 2012 Apr 1;72(7):1705-16. doi: 10.1158/0008-5472.CAN-11-3693. Epub 2012 Mar 6.

25.

Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

de la Vega L, Fröbius K, Moreno R, Calzado MA, Geng H, Schmitz ML.

Biochim Biophys Acta. 2011 Feb;1813(2):283-97. doi: 10.1016/j.bbamcr.2010.11.022. Epub 2010 Dec 8.

26.

Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs.

Sánchez-Duffhues G, Vo MQ, Pérez M, Calzado MA, Moreno S, Appendino G, Muñoz E.

Curr Drug Targets. 2011 Mar 1;12(3):348-56. Review.

PMID:
20955147
27.

Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency.

Pérez M, de Vinuesa AG, Sanchez-Duffhues G, Marquez N, Bellido ML, Muñoz-Fernandez MA, Moreno S, Castor TP, Calzado MA, Muñoz E.

Curr HIV Res. 2010 Sep;8(6):418-29.

PMID:
20636281
28.

Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.

Navarrete CM, Pérez M, de Vinuesa AG, Collado JA, Fiebich BL, Calzado MA, Muñoz E.

Biochem Pharmacol. 2010 Jun 15;79(12):1805-14. doi: 10.1016/j.bcp.2010.02.014. Epub 2010 Mar 3.

PMID:
20206142
29.

High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin.

Wirth S, Ribes-Koninckx C, Calzado MA, Bortolotti F, Zancan L, Jara P, Shelton M, Kerkar N, Galoppo M, Pedreira A, Rodriguez-Baez N, Ciocca M, Lachaux A, Lacaille F, Lang T, Kullmer U, Huber WD, Gonzalez T, Pollack H, Alonso E, Broue P, Ramakrishna J, Neigut D, Valle-Segarra AD, Hunter B, Goodman Z, Xu CR, Zheng H, Noviello S, Sniukiene V, Brass C, Albrecht JK.

J Hepatol. 2010 Apr;52(4):501-7. doi: 10.1016/j.jhep.2010.01.016. Epub 2010 Feb 4.

PMID:
20189674
30.

Synthesis of structurally simplified analogues of aplidinone A, a pro-apoptotic marine thiazinoquinone.

Aiello A, Fattorusso E, Luciano P, Menna M, Calzado MA, Muñoz E, Bonadies F, Guiso M, Sanasi MF, Cocco G, Nicoletti R.

Bioorg Med Chem. 2010 Jan 15;18(2):719-27. doi: 10.1016/j.bmc.2009.11.063. Epub 2009 Dec 6.

PMID:
20031419
31.

Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation.

Calzado MA, de la Vega L, Muñoz E, Schmitz ML.

Biol Chem. 2009 Oct;390(10):1079-83. doi: 10.1515/BC.2009.112.

PMID:
19642869
32.

From top to bottom: the two faces of HIPK2 for regulation of the hypoxic response.

Calzado MA, De La Vega L, Munoz E, Schmitz ML.

Cell Cycle. 2009 Jun 1;8(11):1659-64.

PMID:
19448429
33.

Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.

Sánchez-Duffhues G, Calzado MA, de Vinuesa AG, Appendino G, Fiebich BL, Loock U, Lefarth-Risse A, Krohn K, Muñoz E.

Biochem Pharmacol. 2009 Apr 15;77(8):1401-9. doi: 10.1016/j.bcp.2009.01.004. Epub 2009 Jan 21.

PMID:
19426679
34.

Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators.

Bremner P, Rivera D, Calzado MA, Obón C, Inocencio C, Beckwith C, Fiebich BL, Muñoz E, Heinrich M.

J Ethnopharmacol. 2009 Jul 15;124(2):295-305. doi: 10.1016/j.jep.2009.04.035. Epub 2009 May 3.

PMID:
19397975
35.

Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.

Navarrete CM, Fiebich BL, de Vinuesa AG, Hess S, de Oliveira AC, Candelario-Jalil E, Caballero FJ, Calzado MA, Muñoz E.

J Neurochem. 2009 Apr;109(2):452-64. doi: 10.1111/j.1471-4159.2009.05966.x. Epub 2009 Feb 7.

36.

SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro.

Bedoya LM, Márquez N, Martínez N, Gutiérrez-Eisman S, Alvarez A, Calzado MA, Rojas JM, Appendino G, Muñoz E, Alcamí J.

Biochem Pharmacol. 2009 Mar 15;77(6):965-78. doi: 10.1016/j.bcp.2008.11.025. Epub 2008 Dec 3.

PMID:
19100719
37.

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML.

Nat Cell Biol. 2009 Jan;11(1):85-91. doi: 10.1038/ncb1816. Epub 2008 Nov 30.

PMID:
19043406
38.

Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway.

Sánchez-Duffhues G, Calzado MA, de Vinuesa AG, Caballero FJ, Ech-Chahad A, Appendino G, Krohn K, Fiebich BL, Muñoz E.

Biochem Pharmacol. 2008 Nov 15;76(10):1240-50. doi: 10.1016/j.bcp.2008.09.006. Epub 2008 Sep 18.

PMID:
18840408
39.

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.

Márquez N, Calzado MA, Sánchez-Duffhues G, Pérez M, Minassi A, Pagani A, Appendino G, Diaz L, Muñoz-Fernández MA, Muñoz E.

Biochem Pharmacol. 2008 Mar 15;75(6):1370-80. doi: 10.1016/j.bcp.2007.12.004. Epub 2007 Dec 23.

PMID:
18241838
40.

The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein.

de la Vega L, Sánchez-Duffhues G, Fresno M, Schmitz ML, Muñoz E, Calzado MA.

J Mol Biol. 2007 Sep 14;372(2):317-30. Epub 2007 Jul 3.

PMID:
17669424
41.

NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer.

Calzado MA, Bacher S, Schmitz ML.

Curr Med Chem. 2007;14(3):367-76. Review.

PMID:
17305539
42.

HIPK2: a versatile switchboard regulating the transcription machinery and cell death.

Calzado MA, Renner F, Roscic A, Schmitz ML.

Cell Cycle. 2007 Jan 15;6(2):139-43. Epub 2007 Jan 29. Review.

PMID:
17245128
43.

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

Roscic A, Möller A, Calzado MA, Renner F, Wimmer VC, Gresko E, Lüdi KS, Schmitz ML.

Mol Cell. 2006 Oct 6;24(1):77-89.

44.

The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways.

Garita-Hernandez M, Calzado MA, Caballero FJ, Macho A, Muñoz E, Meier B, Brattström A, Fiebich BL, Appel K.

Planta Med. 2006 Mar;72(4):317-23.

PMID:
16557472
45.

Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus.

Calzado MA, Lüdi KS, Fiebich B, Ben-Neriah Y, Bacher S, Munoz E, Ballero M, Prosperini S, Appendino G, Schmitz ML.

Biochim Biophys Acta. 2005 Jun 30;1729(2):88-93.

PMID:
15949852
46.

The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway.

Vega Lde L, Muñoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Färber L, Mueller W, Stratz T, Fiebich BL.

Biochem Pharmacol. 2005 Aug 1;70(3):369-80.

PMID:
15922994
47.

Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway.

Sancho R, Márquez N, Gómez-Gonzalo M, Calzado MA, Bettoni G, Coiras MT, Alcamí J, López-Cabrera M, Appendino G, Muñoz E.

J Biol Chem. 2004 Sep 3;279(36):37349-59. Epub 2004 Jun 24.

49.

Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways.

Sancho R, Macho A, de La Vega L, Calzado MA, Fiebich BL, Appendino G, Muñoz E.

J Immunol. 2004 Feb 15;172(4):2341-51.

50.

Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors.

Márquez N, Sancho R, Macho A, Calzado MA, Fiebich BL, Muñoz E.

J Pharmacol Exp Ther. 2004 Mar;308(3):993-1001. Epub 2003 Nov 14.

PMID:
14617683

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