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Items: 35

1.

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Brackenborough K, Briggs MA, Brough S, Calver AR, Crook B, Davis RK, Davis RP, Davis S, Dean DK, Harris L, Heslop T, Holland V, Jeffrey P, Panchal TA, Parr CA, Quashie N, Schogger J, Sehmi SS, Stean TO, Steadman JG, Trail B, Wald J, Worby A, Takle AK, Witherington J, Medhurst AD.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6890-6. doi: 10.1016/j.bmcl.2013.09.090. Epub 2013 Oct 5.

PMID:
24269482
2.

The discovery of the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Briggs MA, Calver AR, Crook B, Davis RP, Davis S, Dean DK, Harris L, Heightman TD, Panchal T, Parr CA, Quashie N, Steadman JG, Schogger J, Sehmi SS, Stean TO, Takle AK, Trail BK, White T, Witherington J, Worby A, Medhurst AD.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6897-901. doi: 10.1016/j.bmcl.2013.09.089. Epub 2013 Oct 5.

PMID:
24161834
3.

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases.

Sriskantharajah S, Hamblin N, Worsley S, Calver AR, Hessel EM, Amour A.

Ann N Y Acad Sci. 2013 Mar;1280:35-9. doi: 10.1111/nyas.12039. Review.

PMID:
23551101
4.

Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies.

Ray AM, Kelsell RE, Houp JA, Kelly FM, Medhurst AD, Cox HM, Calver AR.

Eur J Pharmacol. 2009 Feb 14;604(1-3):1-11. doi: 10.1016/j.ejphar.2008.11.056. Epub 2008 Dec 6.

PMID:
19100256
5.

GABAB receptors role in cell migration and positioning within the ventromedial nucleus of the hypothalamus.

McClellan KM, Calver AR, Tobet SA.

Neuroscience. 2008 Feb 19;151(4):1119-31. doi: 10.1016/j.neuroscience.2007.11.048. Epub 2007 Dec 8.

6.

Dissociation and trafficking of rat GABAB receptor heterodimer upon chronic capsaicin stimulation.

Laffray S, Tan K, Dulluc J, Bouali-Benazzouz R, Calver AR, Nagy F, Landry M.

Eur J Neurosci. 2007 Mar;25(5):1402-16.

PMID:
17425567
7.

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.

Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst WD, Jennings C, Jones DN, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM.

J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. Epub 2007 Feb 27.

PMID:
17327487
8.

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.

Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, White T, Orlek B, Wilson DM.

Biochem Pharmacol. 2007 Apr 15;73(8):1182-94. Epub 2007 Jan 7.

PMID:
17276409
9.

Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit.

Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH.

Epilepsy Res. 2005 Jun;65(1-2):41-51.

PMID:
15979855
10.

Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathway.

Restituito S, Couve A, Bawagan H, Jourdain S, Pangalos MN, Calver AR, Freeman KB, Moss SJ.

Mol Cell Neurosci. 2005 Apr;28(4):747-56.

PMID:
15797721
11.

Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C.

J Neurosci. 2005 Feb 9;25(6):1459-69.

12.

Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence.

Wu Y, Ali S, Ahmadian G, Liu CC, Wang YT, Gibson KM, Calver AR, Francis J, Pangalos MN, Carter Snead O 3rd.

Neuropharmacology. 2004 Dec;47(8):1146-56.

PMID:
15567424
13.

Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease.

Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD.

Neuroscience. 2004;129(1):49-54.

PMID:
15489027
14.

The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors.

Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JH, Topps S, Medhurst AD, Randall AD, Couve A, Moss SJ, Collingridge GL, Pangalos MN, Davies CH, Calver AR.

Biochem Pharmacol. 2004 Oct 15;68(8):1655-66.

PMID:
15451409
15.

Unravelling the unusual signalling properties of the GABA(B) receptor.

Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN.

Biochem Pharmacol. 2004 Oct 15;68(8):1527-36. Review.

PMID:
15451395
16.

Marlin-1, a novel RNA-binding protein associates with GABA receptors.

Couve A, Restituito S, Brandon JM, Charles KJ, Bawagan H, Freeman KB, Pangalos MN, Calver AR, Moss SJ.

J Biol Chem. 2004 Apr 2;279(14):13934-43. Epub 2004 Jan 12.

17.

Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability.

Fairfax BP, Pitcher JA, Scott MG, Calver AR, Pangalos MN, Moss SJ, Couve A.

J Biol Chem. 2004 Mar 26;279(13):12565-73. Epub 2004 Jan 5.

19.

Distribution of a GABAB-like receptor protein in the rat central nervous system.

Charles KJ, Calver AR, Jourdain S, Pangalos MN.

Brain Res. 2003 Nov 7;989(2):135-46.

PMID:
14556935
20.

Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor.

Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN.

Brain Res Mol Brain Res. 2003 Feb 20;110(2):305-17.

PMID:
12591167
21.

GABA(B) receptors: from monogamy to promiscuity.

Calver AR, Davies CH, Pangalos M.

Neurosignals. 2002 Nov-Dec;11(6):299-314. Review.

22.

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues.

Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN.

Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):95-104.

PMID:
12531519
23.

Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling.

Couve A, Thomas P, Calver AR, Hirst WD, Pangalos MN, Walsh FS, Smart TG, Moss SJ.

Nat Neurosci. 2002 May;5(5):415-24.

PMID:
11976702
24.

Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.

Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN.

J Biol Chem. 2002 Apr 5;277(14):12302-9. Epub 2002 Jan 22.

25.

Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion.

Charles KJ, Evans ML, Robbins MJ, Calver AR, Leslie RA, Pangalos MN.

Neuroscience. 2001;106(3):447-67.

PMID:
11591450
26.

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Robbins MJ, Calver AR, Filippov AK, Hirst WD, Russell RB, Wood MD, Nasir S, Couve A, Brown DA, Moss SJ, Pangalos MN.

J Neurosci. 2001 Oct 15;21(20):8043-52.

27.

Control of progenitor cell number by mitogen supply and demand.

van Heyningen P, Calver AR, Richardson WD.

Curr Biol. 2001 Feb 20;11(4):232-41.

28.

Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins.

Couve A, Kittler JT, Uren JM, Calver AR, Pangalos MN, Walsh FS, Moss SJ.

Mol Cell Neurosci. 2001 Feb;17(2):317-28.

PMID:
11178869
29.

The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.

Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, Hirst WD, Boyfield I, Wood MD, Russell RB, Price GW, Couve A, Moss SJ, Pangalos MN.

J Neurosci. 2001 Feb 15;21(4):1203-10.

30.

Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons.

Fruttiger M, Calver AR, Richardson WD.

Curr Biol. 2000 Oct 19;10(20):1283-6.

31.

The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues.

Calver AR, Medhurst AD, Robbins MJ, Charles KJ, Evans ML, Harrison DC, Stammers M, Hughes SA, Hervieu G, Couve A, Moss SJ, Middlemiss DN, Pangalos MN.

Neuroscience. 2000;100(1):155-70.

PMID:
10996466
32.

Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).

Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN.

Genomics. 2000 Jul 1;67(1):8-18.

PMID:
10945465
33.

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.

Fruttiger M, Karlsson L, Hall AC, Abramsson A, Calver AR, Boström H, Willetts K, Bertold CH, Heath JK, Betsholtz C, Richardson WD.

Development. 1999 Feb;126(3):457-67.

34.

Oligodendrocyte population dynamics and the role of PDGF in vivo.

Calver AR, Hall AC, Yu WP, Walsh FS, Heath JK, Betsholtz C, Richardson WD.

Neuron. 1998 May;20(5):869-82.

35.

PDGF mediates a neuron-astrocyte interaction in the developing retina.

Fruttiger M, Calver AR, Krüger WH, Mudhar HS, Michalovich D, Takakura N, Nishikawa S, Richardson WD.

Neuron. 1996 Dec;17(6):1117-31.

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