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Items: 1 to 50 of 54

1.

In vitro activities of adamantylidene-substituted alkylphosphocholine TCAN26 against Trypanosoma cruzi: Antiproliferative and ultrastructural effects.

Barrias E, Reignault LC, Calogeropoulou T, de Souza W.

Exp Parasitol. 2019 Nov;206:107730. doi: 10.1016/j.exppara.2019.107730. Epub 2019 Sep 5.

PMID:
31494215
2.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

3.

Discovery of New non-steroidal selective glucocorticoid receptor agonists.

Potamitis C, Siakouli D, Papavasileiou KD, Boulaka A, Ganou V, Roussaki M, Calogeropoulou T, Zoumpoulakis P, Alexis MN, Zervou M, Mitsiou DJ.

J Steroid Biochem Mol Biol. 2019 Feb;186:142-153. doi: 10.1016/j.jsbmb.2018.10.007. Epub 2018 Oct 12.

PMID:
30321666
4.

Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro.

Fragiadaki I, Katogiritis A, Calogeropoulou T, Brückner H, Scoulica E.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):194-202. doi: 10.1016/j.ijpddr.2018.03.005. Epub 2018 Mar 20.

5.

Ultraestructural study of effects of alkylphospholipid analogs against nematodes.

Sant'Anna V, Railbolt M, Oliveira-Menezes A, Calogeropoulou T, Pinheiro J, de Souza W.

Exp Parasitol. 2018 Apr;187:49-58. doi: 10.1016/j.exppara.2018.02.004. Epub 2018 Feb 26.

6.

Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells.

Stagno MJ, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al-Maghout T, Kallergi G, Alkahtani S, Alevizopoulos K, Dimas K, Calogeropoulou T, Warmann SW, Lang F, Schmid E, Stournaras C.

Cell Physiol Biochem. 2017;42(4):1366-1376. doi: 10.1159/000479200. Epub 2017 Jul 14.

7.

BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.

Pediaditakis I, Kourgiantaki A, Prousis KC, Potamitis C, Xanthopoulos KP, Zervou M, Calogeropoulou T, Charalampopoulos I, Gravanis A.

Front Pharmacol. 2016 Dec 26;7:512. doi: 10.3389/fphar.2016.00512. eCollection 2016.

8.

Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, Charalampopoulos I, Gravanis A.

Neuropharmacology. 2016 Dec;111:266-282. doi: 10.1016/j.neuropharm.2016.09.007. Epub 2016 Sep 9.

PMID:
27618740
9.

Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine.

Borba-Santos LP, Ishida K, Calogeropoulou T, Souza Wd, Rozental S.

Mem Inst Oswaldo Cruz. 2016 Aug;111(8):523-7. doi: 10.1590/0074-02760160088. Epub 2016 Jul 11.

10.

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

Benítez D, Medeiros A, Fiestas L, Panozzo-Zenere EA, Maiwald F, Prousis KC, Roussaki M, Calogeropoulou T, Detsi A, Jaeger T, Šarlauskas J, Peterlin Mašič L, Kunick C, Labadie GR, Flohé L, Comini MA.

PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004617. doi: 10.1371/journal.pntd.0004617. eCollection 2016 Apr.

11.

Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.

Alevizopoulos K, Dimas K, Papadopoulou N, Schmidt EM, Tsapara A, Alkahtani S, Honisch S, Prousis KC, Alarifi S, Calogeropoulou T, Lang F, Stournaras C.

Oncotarget. 2016 Apr 26;7(17):24415-28. doi: 10.18632/oncotarget.8329.

12.

Binding and stabilisation effects of glycodendritic compounds with peanut agglutinin.

Sleiman MH, Csonka R, Arbez-Gindre C, Heropoulos GA, Calogeropoulou T, Signorelli M, Schiraldi A, Steele BR, Fessas D, Micha-Screttas M.

Int J Biol Macromol. 2015 Sep;80:692-701. doi: 10.1016/j.ijbiomac.2015.07.036. Epub 2015 Jul 20.

PMID:
26206739
13.

Design and synthesis of 21-alkynylaryl pregnenolone derivatives and evaluation of their anticancer activity.

Szalóki G, Pantzou A, Prousis KC, Mavrofrydi O, Papazafiri P, Calogeropoulou T.

Bioorg Med Chem. 2014 Dec 15;22(24):6980-8. doi: 10.1016/j.bmc.2014.10.012. Epub 2014 Oct 25.

PMID:
25456391
14.

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.

Ramaswamy S, Sleiman MH, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR.

FEBS J. 2015 Jan;282(2):372-87. doi: 10.1111/febs.13140. Epub 2014 Nov 24.

15.

Na+/K+ ATPase inhibitors in cancer.

Alevizopoulos K, Calogeropoulou T, Lang F, Stournaras C.

Curr Drug Targets. 2014;15(10):988-1000. Review.

PMID:
25198786
16.

A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells.

Honisch S, Alkahtani S, Kounenidakis M, Liu G, Alarifi S, Al-Yahya H, Dimas K, AlKahtane AA, Prousis KC, Al-Dahmash B, Calogeropoulou T, Alevizopoulos K, Lang F, Stournaras C.

Anticancer Agents Med Chem. 2014;14(8):1161-8.

PMID:
24942548
17.

FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction.

Prousis KC, Avlonitis N, Heropoulos GA, Calogeropoulou T.

Ultrason Sonochem. 2014 May;21(3):937-42. doi: 10.1016/j.ultsonch.2013.10.018. Epub 2013 Oct 29.

PMID:
24262761
18.

Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo.

Dimas K, Papadopoulou N, Baskakis C, Prousis KC, Tsakos M, Alkahtani S, Honisch S, Lang F, Calogeropoulou T, Alevizopoulos K, Stournaras C.

Anticancer Agents Med Chem. 2014 Jun;14(5):762-70.

PMID:
24066843
19.

A novel alkyl phosphocholine-dinitroaniline hybrid molecule exhibits biological activity in vitro against Leishmania amazonensis.

Godinho JL, Georgikopoulou K, Calogeropoulou T, de Souza W, Rodrigues JC.

Exp Parasitol. 2013 Sep;135(1):153-65. doi: 10.1016/j.exppara.2013.06.015. Epub 2013 Jul 8.

PMID:
23845259
20.

Neurosteroids and microneurotrophins signal through NGF receptors to induce prosurvival signaling in neuronal cells.

Gravanis A, Calogeropoulou T, Panoutsakopoulou V, Thermos K, Neophytou C, Charalampopoulos I.

Sci Signal. 2012 Oct 16;5(246):pt8. doi: 10.1126/scisignal.2003387.

PMID:
23074265
21.

Effect of alkylphospholipids on Candida albicans biofilm formation and maturation.

Vila TV, Ishida K, de Souza W, Prousis K, Calogeropoulou T, Rozental S.

J Antimicrob Chemother. 2013 Jan;68(1):113-25. doi: 10.1093/jac/dks353. Epub 2012 Sep 19.

PMID:
22995097
22.

Inhibition of PrP(Sc) formation in scrapie infected N2a cells by 5,7,8-trimethyl-3,4-dihydro-2H-1,4-benzoxazine derivatives.

Koukouli F, Paspaltsis I, Salta E, Xanthopoulos K, Koini EN, Calogeropoulou T, Sklaviadis T.

Prion. 2012 Nov-Dec;6(5):470-6. doi: 10.4161/pri.21913. Epub 2012 Aug 23.

23.

Regulation of the Escherichia coli AtoSC two component system by synthetic biologically active 5;7;8-trimethyl-1;4-benzoxazine analogues.

Filippou PS, Koini EN, Calogeropoulou T, Kalliakmani P, Panagiotidis CA, Kyriakidis DA.

Bioorg Med Chem. 2011 Aug 15;19(16):5061-70. doi: 10.1016/j.bmc.2011.06.029. Epub 2011 Jun 21.

PMID:
21757361
24.

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

Lazaridis I, Charalampopoulos I, Alexaki VI, Avlonitis N, Pediaditakis I, Efstathopoulos P, Calogeropoulou T, Castanas E, Gravanis A.

PLoS Biol. 2011 Apr;9(4):e1001051. doi: 10.1371/journal.pbio.1001051. Epub 2011 Apr 26.

25.

Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids.

Papanastasiou I, Prousis KC, Georgikopoulou K, Pavlidis T, Scoulica E, Kolocouris N, Calogeropoulou T.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5484-7. doi: 10.1016/j.bmcl.2010.07.078. Epub 2010 Jul 22.

PMID:
20719503
26.

Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity.

Calogeropoulou T, Avlonitis N, Minas V, Alexi X, Pantzou A, Charalampopoulos I, Zervou M, Vergou V, Katsanou ES, Lazaridis I, Alexis MN, Gravanis A.

J Med Chem. 2009 Nov 12;52(21):6569-87. doi: 10.1021/jm900468p.

PMID:
19845386
27.

5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.

Koini EN, Papazafiri P, Vassilopoulos A, Koufaki M, Horváth Z, Koncz I, Virág L, Papp GJ, Varró A, Calogeropoulou T.

J Med Chem. 2009 Apr 23;52(8):2328-40. doi: 10.1021/jm801228h.

PMID:
19309156
28.

Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives.

Calogeropoulou T, Angelou P, Detsi A, Fragiadaki I, Scoulica E.

J Med Chem. 2008 Feb 28;51(4):897-908. doi: 10.1021/jm701166b. Epub 2008 Jan 26.

PMID:
18220332
29.

A 17beta-derivative of allopregnanolone is a neurosteroid antagonist at a cerebellar subpopulation of GABA A receptors with nanomolar affinity.

Maksay G, Fodor L, Bíró T, Avlonitis N, Calogeropoulou T.

Br J Pharmacol. 2007 Aug;151(7):1078-86. Epub 2007 Jun 11.

30.

pH-responsive aggregates from double hydrophilic block copolymers carrying zwitterionic groups. Encapsulation of antiparasitic compounds for the treatment of leishmaniasis.

Karanikolopoulos N, Pitsikalis M, Hadjichristidis N, Georgikopoulou K, Calogeropoulou T, Dunlap JR.

Langmuir. 2007 Apr 10;23(8):4214-24. Epub 2007 Mar 16.

PMID:
17362035
31.

Neuroprotective effects of steroid analogues on P19-N neurons.

Xilouri M, Avlonitis N, Calogeropoulou T, Papazafiri P.

Neurochem Int. 2007 Mar;50(4):660-70. Epub 2007 Jan 13.

PMID:
17316905
32.

3D-Quantitative structure-activity relationships of synthetic antileishmanial ring-substituted ether phospholipids.

Kapou A, Benetis NP, Avlonitis N, Calogeropoulou T, Koufaki M, Scoulica E, Nikolaropoulos SS, Mavromoustakos T.

Bioorg Med Chem. 2007 Feb 1;15(3):1252-65. Epub 2006 Nov 14.

PMID:
17158053
33.

Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.

Tsotinis A, Vlachou M, Papahatjis DP, Calogeropoulou T, Nikas SP, Garratt PJ, Piccio V, Vonhoff S, Davidson K, Teh MT, Sugden D.

J Med Chem. 2006 Jun 15;49(12):3509-19.

PMID:
16759094
34.

G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone.

Charalampopoulos I, Alexaki VI, Lazaridis I, Dermitzaki E, Avlonitis N, Tsatsanis C, Calogeropoulou T, Margioris AN, Castanas E, Gravanis A.

FASEB J. 2006 Mar;20(3):577-9. Epub 2006 Jan 11.

PMID:
16407456
35.

Novel 17beta-substituted conformationally constrained neurosteroids that modulate GABA A receptors.

Souli C, Avlonitis N, Calogeropoulou T, Tsotinis A, Maksay G, Bíró T, Politi A, Mavromoustakos T, Makriyannis A, Reis H, Papadopoulos M.

J Med Chem. 2005 Aug 11;48(16):5203-14.

PMID:
16078839
36.

Structure-activity relationships of antineoplastic ring-substituted ether phospholipid derivatives.

Papazafiri P, Avlonitis N, Angelou P, Calogeropoulou T, Koufaki M, Scoulica E, Fragiadaki I.

Cancer Chemother Pharmacol. 2005 Sep;56(3):261-70. Epub 2005 Apr 26.

PMID:
15856232
37.

Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias.

Koufaki M, Detsi A, Theodorou E, Kiziridi C, Calogeropoulou T, Vassilopoulos A, Kourounakis AP, Rekka E, Kourounakis PN, Gaitanaki C, Papazafiri P.

Bioorg Med Chem. 2004 Sep 15;12(18):4835-41.

PMID:
15336262
38.

Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics.

Koufaki M, Calogeropoulou T, Rekka E, Chryselis M, Papazafiri P, Gaitanaki C, Makriyannis A.

Bioorg Med Chem. 2003 Nov 17;11(23):5209-19.

PMID:
14604685
39.

Strategies in the design of prodrugs of anti-HIV agents.

Calogeropoulou T, Detsi A, Lekkas E, Koufaki M.

Curr Top Med Chem. 2003;3(13):1467-95. Review.

PMID:
14529522
40.

Antileishmanial ring-substituted ether phospholipids.

Avlonitis N, Lekka E, Detsi A, Koufaki M, Calogeropoulou T, Scoulica E, Siapi E, Kyrikou I, Mavromoustakos T, Tsotinis A, Grdadolnik SG, Makriyannis A.

J Med Chem. 2003 Feb 27;46(5):755-67.

PMID:
12593656
41.

Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1butenyl]phenoxyacetic acid.

Detsi A, Koufaki M, Calogeropoulou T.

J Org Chem. 2002 Jun 28;67(13):4608-11.

PMID:
12076167
42.

Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias.

Koufaki M, Calogeropoulou T, Detsi A, Roditis A, Kourounakis AP, Papazafiri P, Tsiakitzis K, Gaitanaki C, Beis I, Kourounakis PN.

J Med Chem. 2001 Nov 22;44(24):4300-3.

PMID:
11708933
43.

Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.

Mavromoustakos T, Calogeropoulou T, Koufaki M, Kolocouris A, Daliani I, Demetzos C, Meng Z, Makriyannis A, Balzarini J, De Clercq E.

J Med Chem. 2001 May 24;44(11):1702-9.

PMID:
11356105
44.

Up-regulation of a novel mRNA (NY-CO-1) involved in the methyl 4-methoxy-3-(3-methyl-2-butenoyl) benzoate (VT1)-induced proliferation arrest of a non-small-cell lung carcinoma cell line (NSCLC-N6).

Carbonnelle D, Jacquot C, Lanco X, Le Dez G, Tomasoni C, Briand G, Tsotinis A, Calogeropoulou T, Roussakis C.

Int J Cancer. 2001 May 1;92(3):388-97.

45.

Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives.

Varvaresou A, Iakovou K, Filippatos E, Souli C, Calogeropoulou T, Ioannidou I, Kourounakis AP, Pannecouque C, Witvrouw M, Padalko E, Neyts J, De Clercq E, Tsotinis A.

Arzneimittelforschung. 2001 Feb;51(2):156-62.

PMID:
11258046
46.

Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.

Faust R, Garratt PJ, Jones R, Yeh LK, Tsotinis A, Panoussopoulou M, Calogeropoulou T, Teh MT, Sugden D.

J Med Chem. 2000 Mar 23;43(6):1050-61.

PMID:
10737738
47.

Synthesis and antimicrobial evaluation of indole containing derivatives of 1,3,4-thiadiazole, 1,2,4-triazole and their open-chain counterparts.

Tsotinis A, Varvaresou A, Calogeropoulou T, Siatra-Papastaikoudi T, Tiligada A.

Arzneimittelforschung. 1997 Mar;47(3):307-10.

PMID:
9105551
48.

Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine.

Tsotinis A, Calogeropoulou T, Koufaki M, Souli C, Balzarini J, De Clercq E, Makriyannis A.

J Med Chem. 1996 Aug 16;39(17):3418-22.

PMID:
8765527
49.

Alkyl and alkoxyethyl antineoplastic phospholipids.

Koufaki M, Polychroniou V, Calogeropoulou T, Tsotinis A, Drees M, Fiebig HH, LeClerc S, Hendriks HR, Makriyannis A.

J Med Chem. 1996 Jun 21;39(13):2609-14.

PMID:
8691459
50.

Antineoplastic activity, synergism, and antagonism of triarylalkylphosphonium salts and their combinations.

Patel J, Rideout D, McCarthy MR, Calogeropoulou T, Wadwa KS, Oseroff AR.

Anticancer Res. 1994 Jan-Feb;14(1A):21-8.

PMID:
8166451

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