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Clin Vaccine Immunol. 2009 Apr;16(4):587-8. doi: 10.1128/CVI.00462-08. Epub 2009 Feb 18.

Frequency of missed cases of probable acute West Nile virus (WNV) infection when testing for WNV RNA alone or WNV immunoglobulin M alone.

Author information

1
Focus Diagnostics, Inc., Cypress, CA 90630, USA. hprince@focusdx.com

Abstract

To estimate the frequency of missed cases of acute West Nile virus (WNV) infection if only WNV RNA or immunoglobulin M (IgM) testing is requested, we measured IgM in specimens negative for RNA and vice versa. Whereas 6 (5.5%) of 110 RNA-negative sera were IgM positive, only 3 (1.0%) of 299 IgM-negative sera were RNA positive (P < 0.05). Similarly, 11 (7.8%) of 141 RNA-negative cerebrospinal fluid specimens (CSF) were IgM positive, but 0 (0%) of 118 IgM-negative CSF were RNA positive (P < 0.05). WNV infections may be missed if only RNA or IgM testing is requested, with a higher frequency of missed cases if only RNA testing is requested.

PMID:
19225078
PMCID:
PMC2668283
DOI:
10.1128/CVI.00462-08
[Indexed for MEDLINE]
Free PMC Article

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