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SapM mutation to improve the BCG vaccine: Genomic, transcriptomic and preclinical safety characterization.

Festjens N, Vandewalle K, Houthuys E, Plets E, Vanderschaeghe D, Borgers K, Van Hecke A, Tiels P, Callewaert N.

Vaccine. 2019 Jun 12;37(27):3539-3551. doi: 10.1016/j.vaccine.2019.05.022. Epub 2019 May 20.


Characterization of Human Recombinant N-Acetylgalactosamine-6-Sulfate Sulfatase Produced in Pichia pastoris as Potential Enzyme for Mucopolysaccharidosis IVA Treatment.

Rodríguez-López A, Pimentel-Vera LN, Espejo-Mojica AJ, Van Hecke A, Tiels P, Tomatsu S, Callewaert N, Alméciga-Díaz CJ.

J Pharm Sci. 2019 Apr 5. pii: S0022-3549(19)30218-7. doi: 10.1016/j.xphs.2019.03.034. [Epub ahead of print]


Yeast-secreted, dried and food-admixed monomeric IgA prevents gastrointestinal infection in a piglet model.

Virdi V, Palaci J, Laukens B, Ryckaert S, Cox E, Vanderbeke E, Depicker A, Callewaert N.

Nat Biotechnol. 2019 May;37(5):527-530. doi: 10.1038/s41587-019-0070-x. Epub 2019 Apr 1.


N-Linked Glycosylation and Near-Infrared Spectroscopy in the Diagnosis of Prostate Cancer.

Vermassen T, De Bruyne S, Himpe J, Lumen N, Callewaert N, Rottey S, Delanghe J.

Int J Mol Sci. 2019 Mar 29;20(7). pii: E1592. doi: 10.3390/ijms20071592.


Prostate Protein N-Glycosylation Profiling by Means of DNA Sequencer-Assisted Fluorophore-Assisted Carbohydrate Electrophoresis.

Vermassen T, Callewaert N, Rottey S, Delanghe JR.

Methods Mol Biol. 2019;1972:235-250. doi: 10.1007/978-1-4939-9213-3_17.


Customized protein glycosylation to improve biopharmaceutical function and targeting.

Van Landuyt L, Lonigro C, Meuris L, Callewaert N.

Curr Opin Biotechnol. 2018 Dec 13;60:17-28. doi: 10.1016/j.copbio.2018.11.017. [Epub ahead of print] Review.


Engineering of Yeast Glycoprotein Expression.

De Wachter C, Van Landuyt L, Callewaert N.

Adv Biochem Eng Biotechnol. 2018 Nov 7. doi: 10.1007/10_2018_69. [Epub ahead of print]


Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.

Cambré I, Gaublomme D, Burssens A, Jacques P, Schryvers N, De Muynck A, Meuris L, Lambrecht S, Carter S, de Bleser P, Saeys Y, Van Hoorebeke L, Kollias G, Mack M, Simoens P, Lories R, Callewaert N, Schett G, Elewaut D.

Nat Commun. 2018 Nov 5;9(1):4613. doi: 10.1038/s41467-018-06933-4.


Endoglycosidase S Enables a Highly Simplified Clinical Chemistry Procedure for Direct Assessment of Serum IgG Undergalactosylation in Chronic Inflammatory Disease.

Vanderschaeghe D, Meuris L, Raes T, Grootaert H, Van Hecke A, Verhelst X, Van de Velde F, Lapauw B, Van Vlierberghe H, Callewaert N.

Mol Cell Proteomics. 2018 Dec;17(12):2508-2517. doi: 10.1074/mcp.TIR118.000740. Epub 2018 Sep 6.


Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection.

Gholobova D, Gerard M, Decroix L, Desender L, Callewaert N, Annaert P, Thorrez L.

Sci Rep. 2018 Aug 15;8(1):12206. doi: 10.1038/s41598-018-30123-3.


Capturing the 'ome': the expanding molecular toolbox for RNA and DNA library construction.

Boone M, De Koker A, Callewaert N.

Nucleic Acids Res. 2018 Apr 6;46(6):2701-2721. doi: 10.1093/nar/gky167.


A pragmatic bottom-up approach to harmonize the units of clinical chemistry tests among Belgian clinical laboratories, focusing on immunoassays.

Demarteau M, Cammaert P, Vandevelde NM, Callewaert N, Coucke W, China B, Verstraete AG.

Clin Chem Lab Med. 2018 Dec 19;57(1):12-19. doi: 10.1515/cclm-2017-0824.


Glycome Patterns of Perfusate in Livers Before Transplantation Associate With Primary Nonfunction.

Verhelst X, Geerts A, Jochmans I, Vanderschaeghe D, Paradissis A, Vanlander A, Berrevoet F, Dahlqvist G, Nevens F, Pirenne J, Rogiers X, Callewaert N, Troisi RI, Van Vlierberghe H.

Gastroenterology. 2018 Apr;154(5):1361-1368. doi: 10.1053/j.gastro.2017.12.027. Epub 2018 Jan 6.


Release of urinary extracellular vesicles in prostate cancer is associated with altered urinary N-glycosylation profile.

Vermassen T, D'Herde K, Jacobus D, Van Praet C, Poelaert F, Lumen N, Callewaert N, Decaestecker K, Villeirs G, Hoebeke P, Van Belle S, Rottey S, Delanghe J.

J Clin Pathol. 2017 Oct;70(10):838-846. doi: 10.1136/jclinpath-2016-204312. Epub 2017 Mar 30.


An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids.

Arendt P, Miettinen K, Pollier J, De Rycke R, Callewaert N, Goossens A.

Metab Eng. 2017 Mar;40:165-175. doi: 10.1016/j.ymben.2017.02.007. Epub 2017 Feb 16.


Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke S, Ehrhardt K, Kolpe A, El Bakkouri K, Deng L, Grootaert H, Schoonooghe S, Smet A, Bentahir M, Roose K, Schotsaert M, Schepens B, Callewaert N, Nimmerjahn F, Staeheli P, Hengel H, Saelens X.

J Virol. 2017 Mar 13;91(7). pii: e02500-16. doi: 10.1128/JVI.02500-16. Print 2017 Apr 1.


A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis.

Verhelst X, Vanderschaeghe D, Castéra L, Raes T, Geerts A, Francoz C, Colman R, Durand F, Callewaert N, Van Vlierberghe H.

Clin Cancer Res. 2017 Jun 1;23(11):2750-2758. doi: 10.1158/1078-0432.CCR-16-1500. Epub 2016 Dec 16.


Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.

Claes K, Vandewalle K, Laukens B, Laeremans T, Vosters O, Langer I, Parmentier M, Steyaert J, Callewaert N.

ACS Synth Biol. 2016 Oct 21;5(10):1070-1075. Epub 2016 May 20.


Outcome Indicators on Interprofessional Collaboration Interventions for Elderly.

Tsakitzidis G, Timmermans O, Callewaert N, Verhoeven V, Lopez-Hartmann M, Truijen S, Meulemans H, Van Royen P.

Int J Integr Care. 2016 May 16;16(2):5. doi: 10.5334/ijic.2017.


A simple colorimetric assay for measuring fructosamine 3 kinase activity.

Cikomola JC, Kishabongo AS, Vandepoele K, Mulder M, Katchunga PB, Laukens B, Schie LV, Grootaert H, Callewaert N, Speeckaert MM, Delanghe JR.

Clin Chem Lab Med. 2017 Jan 1;55(1):154-159. doi: 10.1515/cclm-2016-0441.


Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.

Zhou X, Weeks SD, Ameloot P, Callewaert N, Strelkov SV, Declerck PJ.

J Thromb Haemost. 2016 Aug;14(8):1629-38. doi: 10.1111/jth.13381. Epub 2016 Jul 27.


Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies.

Schotsaert M, Ysenbaert T, Smet A, Schepens B, Vanderschaeghe D, Stegalkina S, Vogel TU, Callewaert N, Fiers W, Saelens X.

Sci Rep. 2016 Apr 13;6:24402. doi: 10.1038/srep24402.


Synthetic biology for production of natural and new-to-nature terpenoids in photosynthetic organisms.

Arendt P, Pollier J, Callewaert N, Goossens A.

Plant J. 2016 Jul;87(1):16-37. doi: 10.1111/tpj.13138. Epub 2016 Mar 7. Review.


Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.

Zhang Z, Schepens B, Nuhn L, Saelens X, Schotsaert M, Callewaert N, De Rycke R, Zhang Q, Moins S, Benali S, Mespouille L, Hoogenboom R, De Geest BG.

Chem Commun (Camb). 2016 Feb 25;52(16):3352-5. doi: 10.1039/c6cc00501b.


Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds.

Piron R, Santens F, De Paepe A, Depicker A, Callewaert N.

Nat Biotechnol. 2015 Nov;33(11):1135-7. doi: 10.1038/nbt.3359. No abstract available.


Participant evaluation of an education module on interprofessional collaboration for students in healthcare studies.

Tsakitzidis G, Timmermans O, Callewaert N, Truijen S, Meulemans H, Van Royen P.

BMC Med Educ. 2015 Oct 27;15:188. doi: 10.1186/s12909-015-0477-0.


A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris.

Cerini F, Gaertner H, Madden K, Tolstorukov I, Brown S, Laukens B, Callewaert N, Harner JC, Oommen AM, Harms JT, Sump AR, Sealock RC, Peterson DJ, Johnson SK, Abramson SB, Meagher M, Offord R, Hartley O.

Protein Expr Purif. 2016 Mar;119:1-10. doi: 10.1016/j.pep.2015.10.011. Epub 2015 Oct 24.


Monitoring the patient response as an alternative to commercial negative quality control in infectious serology.

Wils J, Boudewijns M, Vandermarliere M, Callewaert N.

J Clin Virol. 2015 Nov;72:30-5. doi: 10.1016/j.jcv.2015.08.016. Epub 2015 Sep 9.


Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.

Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN.

Structure. 2015 Sep 1;23(9):1621-1631. doi: 10.1016/j.str.2015.06.019. Epub 2015 Jul 30.


Engineering the Pichia pastoris N-Glycosylation Pathway Using the GlycoSwitch Technology.

Laukens B, De Wachter C, Callewaert N.

Methods Mol Biol. 2015;1321:103-22. doi: 10.1007/978-1-4939-2760-9_8.


Characterization of genome-wide ordered sequence-tagged Mycobacterium mutant libraries by Cartesian Pooling-Coordinate Sequencing.

Vandewalle K, Festjens N, Plets E, Vuylsteke M, Saeys Y, Callewaert N.

Nat Commun. 2015 May 11;6:7106. doi: 10.1038/ncomms8106.


Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax.

Haynes CL, Ameloot P, Remaut H, Callewaert N, Sterckx YG, Magez S.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):577-85. doi: 10.1107/S2053230X15002496. Epub 2015 Apr 21.


Membrane protein expression and analysis in yeast.

Claes K, Guerfal M, Callewaert N.

Methods Enzymol. 2015;556:123-40. doi: 10.1016/bs.mie.2014.12.010. Epub 2015 Mar 20.


Routine serum creatinine measurements: how well do we perform?

Hoste L, Deiteren K, Pottel H, Callewaert N, Martens F.

BMC Nephrol. 2015 Feb 14;16:21. doi: 10.1186/s12882-015-0012-x.


Comparison of VHH-Fc antibody production in Arabidopsis thaliana, Nicotiana benthamiana and Pichia pastoris.

De Meyer T, Laukens B, Nolf J, Van Lerberge E, De Rycke R, De Beuckelaer A, De Buck S, Callewaert N, Depicker A.

Plant Biotechnol J. 2015 Sep;13(7):938-47. doi: 10.1111/pbi.12330. Epub 2015 Jan 30.


Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease.

Bontempi IA, Vicco MH, Cabrera G, Villar SR, González FB, Roggero EA, Ameloot P, Callewaert N, Pérez AR, Marcipar IS.

Vaccine. 2015 Mar 3;33(10):1274-83. doi: 10.1016/j.vaccine.2015.01.044. Epub 2015 Jan 25.


Engineering yeast for producing human glycoproteins: where are we now?

Laukens B, De Visscher C, Callewaert N.

Future Microbiol. 2015;10(1):21-34. doi: 10.2217/fmb.14.104.


Urinary prostate protein glycosylation profiling as a diagnostic biomarker for prostate cancer.

Vermassen T, Van Praet C, Lumen N, Decaestecker K, Vanderschaeghe D, Callewaert N, Villeirs G, Hoebeke P, Van Belle S, Rottey S, Delanghe J.

Prostate. 2015 Feb 15;75(3):314-22. doi: 10.1002/pros.22918. Epub 2014 Oct 30.


Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations.

Lin YC, Boone M, Meuris L, Lemmens I, Van Roy N, Soete A, Reumers J, Moisse M, Plaisance S, Drmanac R, Chen J, Speleman F, Lambrechts D, Van de Peer Y, Tavernier J, Callewaert N.

Nat Commun. 2014 Sep 3;5:4767. doi: 10.1038/ncomms5767.


GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins.

Meuris L, Santens F, Elson G, Festjens N, Boone M, Dos Santos A, Devos S, Rousseau F, Plets E, Houthuys E, Malinge P, Magistrelli G, Cons L, Chatel L, Devreese B, Callewaert N.

Nat Biotechnol. 2014 May;32(5):485-9. doi: 10.1038/nbt.2885. Epub 2014 Apr 20.


Multiple phenotypes in phosphoglucomutase 1 deficiency.

Tegtmeyer LC, Rust S, van Scherpenzeel M, Ng BG, Losfeld ME, Timal S, Raymond K, He P, Ichikawa M, Veltman J, Huijben K, Shin YS, Sharma V, Adamowicz M, Lammens M, Reunert J, Witten A, Schrapers E, Matthijs G, Jaeken J, Rymen D, Stojkovic T, Laforêt P, Petit F, Aumaître O, Czarnowska E, Piraud M, Podskarbi T, Stanley CA, Matalon R, Burda P, Seyyedi S, Debus V, Socha P, Sykut-Cegielska J, van Spronsen F, de Meirleir L, Vajro P, DeClue T, Ficicioglu C, Wada Y, Wevers RA, Vanderschaeghe D, Callewaert N, Fingerhut R, van Schaftingen E, Freeze HH, Morava E, Lefeber DJ, Marquardt T.

N Engl J Med. 2014 Feb 6;370(6):533-42. doi: 10.1056/NEJMoa1206605.


Enhanced membrane protein expression by engineering increased intracellular membrane production.

Guerfal M, Claes K, Knittelfelder O, De Rycke R, Kohlwein SD, Callewaert N.

Microb Cell Fact. 2013 Dec 9;12:122. doi: 10.1186/1475-2859-12-122.


Capillary electrophoresis of urinary prostate glycoproteins assists in the diagnosis of prostate cancer.

Vermassen T, Van Praet C, Vanderschaeghe D, Maenhout T, Lumen N, Callewaert N, Hoebeke P, Van Belle S, Rottey S, Delanghe J.

Electrophoresis. 2014 Apr;35(7):1017-24. doi: 10.1002/elps.201300332. Epub 2013 Dec 20.


Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris.

Al Atalah B, Vanderschaeghe D, Bloch Y, Proost P, Plas K, Callewaert N, Savvides SN, Van Damme EJ.

Biol Chem. 2014 Apr;395(4):413-24. doi: 10.1515/hsz-2013-0267.


Structure of Ostertagia ostertagi ASP-1: insights into disulfide-mediated cyclization and dimerization.

Borloo J, Geldhof P, Peelaers I, Van Meulder F, Ameloot P, Callewaert N, Vercruysse J, Claerebout E, Strelkov SV, Weeks SD.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):493-503. doi: 10.1107/S0907444912050019. Epub 2013 Mar 9.


Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models.

Vandenabeele P, Grootjans S, Callewaert N, Takahashi N.

Cell Death Differ. 2013 Feb;20(2):185-7. doi: 10.1038/cdd.2012.151. Epub 2012 Nov 30. No abstract available.


Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, Vandenabeele P.

Cell Death Dis. 2012 Nov 29;3:e437. doi: 10.1038/cddis.2012.176.


A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes.

Tiels P, Baranova E, Piens K, De Visscher C, Pynaert G, Nerinckx W, Stout J, Fudalej F, Hulpiau P, Tännler S, Geysens S, Van Hecke A, Valevska A, Vervecken W, Remaut H, Callewaert N.

Nat Biotechnol. 2012 Dec;30(12):1225-31. doi: 10.1038/nbt.2427. Epub 2012 Nov 18.


CE analysis of γ-globulin mobility and potential clinical utility.

Vanderschaeghe D, Debruyne E, Van Vlierberghe H, Callewaert N, Delanghe J.

Methods Mol Biol. 2013;919:249-57. doi: 10.1007/978-1-62703-029-8_22.


High-throughput profiling of the serum N-glycome on capillary electrophoresis microfluidics systems.

Vanderschaeghe D, Guttman A, Callewaert N.

Methods Mol Biol. 2013;919:87-96. doi: 10.1007/978-1-62703-029-8_9.


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