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Items: 5

1.

Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.

Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5497-E5505. doi: 10.1073/pnas.1805046115. Epub 2018 May 29.

2.

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS.

Cell Rep. 2016 Oct 11;17(3):759-773. doi: 10.1016/j.celrep.2016.09.034.

3.

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R.

Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209.

4.

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA.

Oncotarget. 2016 Apr 12;7(15):20919-33. doi: 10.18632/oncotarget.8062.

5.

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.

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