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Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A.

Mol Cell. 2019 Jun 4. pii: S1097-2765(19)30322-3. doi: 10.1016/j.molcel.2019.04.030. [Epub ahead of print]


Feasibility, Implementation and Outcomes of Tablet-Based Two-Step Screening for Adult ADHD in Primary Care Practice.

Loskutova NY, Callen E, Pinckney RG, Staton EW, Pace WD.

J Atten Disord. 2019 Apr 24:1087054719841133. doi: 10.1177/1087054719841133. [Epub ahead of print]


BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.

Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.


Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, Jaszczyszyn Y, Aladjem MI, Aplan PD, Hyrien O, Nussenzweig A.

Cell. 2018 Aug 23;174(5):1127-1142.e19. doi: 10.1016/j.cell.2018.07.011. Epub 2018 Aug 2.


Differences in perspectives regarding diabetes management between health care providers and patients.

Loskutova NY, Tsai AG, Callen E, Ajayi K, Carroll JK, Harrington M, Turner TJ, Pace WD.

Transl Behav Med. 2018 May 23;8(3):328-340. doi: 10.1093/tbm/iby024.


Genome Organization Drives Chromosome Fragility.

Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SSP, Huang SC, Mckinnon PJ, Aplan PD, Pommier Y, Aiden EL, Casellas R, Nussenzweig A.

Cell. 2017 Jul 27;170(3):507-521.e18. doi: 10.1016/j.cell.2017.06.034. Epub 2017 Jul 20.


Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Nov 17;539(7629):456. doi: 10.1038/nature19826. Epub 2016 Sep 28. No abstract available.


Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O.

Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643.


Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

Ding X, Ray Chaudhuri A, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T, Dewan A, Marks H, Tubbs AT, Wong N, Buehler E, Akagi K, Martin SE, Keller JR, Nussenzweig A, Sharan SK.

Nat Commun. 2016 Aug 8;7:12425. doi: 10.1038/ncomms12425.


Replication fork stability confers chemoresistance in BRCA-deficient cells.

Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Jul 21;535(7612):382-7. doi: 10.1038/nature18325. Erratum in: Nature. 2016 Nov 17;539(7629):456.


Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.

Robbiani DF, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC.

Cell. 2015 Aug 13;162(4):727-37. doi: 10.1016/j.cell.2015.07.019.


Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.

Zong D, Callén E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A.

Nucleic Acids Res. 2015 May 26;43(10):4950-61. doi: 10.1093/nar/gkv336. Epub 2015 Apr 27.


DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.

Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A.

Nature. 2014 Oct 2;514(7520):107-11. doi: 10.1038/nature13483. Epub 2014 Jul 27.


CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A.

J Exp Med. 2014 Jun 2;211(6):1027-36. doi: 10.1084/jem.20131939. Epub 2014 May 19.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.

Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.


Identification of early replicating fragile sites that contribute to genome instability.

Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.

Cell. 2013 Jan 31;152(3):620-32. doi: 10.1016/j.cell.2013.01.006. Epub 2013 Jan 24. Review.


Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.

Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC.

Science. 2013 Feb 8;339(6120):711-5. doi: 10.1126/science.1230624. Epub 2013 Jan 10.


The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.

Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.

Immunity. 2012 Dec 14;37(6):971-85. doi: 10.1016/j.immuni.2012.10.007. Epub 2012 Nov 15.


The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.

Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC.

EMBO J. 2012 Oct 17;31(20):4045-56. doi: 10.1038/emboj.2012.247. Epub 2012 Aug 31.


BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A.

Mol Cell. 2012 Apr 27;46(2):125-35. doi: 10.1016/j.molcel.2012.02.015. Epub 2012 Mar 22.


Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2011 May 6;42(3):319-29. doi: 10.1016/j.molcel.2011.03.019.


Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.

Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, Zhang CC, Chen DJ, Chen BP.

J Cell Biol. 2011 Apr 18;193(2):295-305. doi: 10.1083/jcb.201009074. Epub 2011 Apr 11.


Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations.

Castella M, Pujol R, Callén E, Trujillo JP, Casado JA, Gille H, Lach FP, Auerbach AD, Schindler D, Benítez J, Porto B, Ferro T, Muñoz A, Sevilla J, Madero L, Cela E, Beléndez C, de Heredia CD, Olivé T, de Toledo JS, Badell I, Torrent M, Estella J, Dasí A, Rodríguez-Villa A, Gómez P, Barbot J, Tapia M, Molinés A, Figuera A, Bueren JA, Surrallés J.

Blood. 2011 Apr 7;117(14):3759-69. doi: 10.1182/blood-2010-08-299917. Epub 2011 Jan 27.


Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2022-7. doi: 10.1073/pnas.1013295108. Epub 2011 Jan 18.


Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact.

Castella M, Pujol R, Callén E, Ramírez MJ, Casado JA, Talavera M, Ferro T, Muñoz A, Sevilla J, Madero L, Cela E, Beléndez C, de Heredia CD, Olivé T, de Toledo JS, Badell I, Estella J, Dasí Á, Rodríguez-Villa A, Gómez P, Tapia M, Molinés A, Figuera Á, Bueren JA, Surrallés J.

J Med Genet. 2011 Apr;48(4):242-50. doi: 10.1136/jmg.2010.084210. Epub 2011 Jan 7.


53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.

Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.

Cell. 2010 Apr 16;141(2):243-54. doi: 10.1016/j.cell.2010.03.012. Epub 2010 Apr 1.


Mycobacterium fortuitum infections associated with laparoscopic gastric banding.

Callen EC, Kessler TL.

Obes Surg. 2011 Mar;21(3):404-6. doi: 10.1007/s11695-010-0123-1.


Myxedema coma associated with combination aripiprazole and sertraline therapy.

Church CO, Callen EC.

Ann Pharmacother. 2009 Dec;43(12):2113-6. doi: 10.1345/aph.1M369. Epub 2009 Nov 24.


New indices in scholarship assessment.

Thompson DF, Callen EC, Nahata MC.

Am J Pharm Educ. 2009 Oct 1;73(6):111. Review.


Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.

Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A.

Cell Cycle. 2009 Aug;8(15):2408-12. Epub 2009 Aug 21.


Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.

Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.

Mol Cell. 2009 May 15;34(3):285-97. doi: 10.1016/j.molcel.2009.04.025.


Current strategies in the diagnosis and treatment of childhood attention-deficit/hyperactivity disorder.

Rader R, McCauley L, Callen EC.

Am Fam Physician. 2009 Apr 15;79(8):657-65. Review.


Histone H2AX is integral to hypoxia-driven neovascularization.

Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.

Nat Med. 2009 May;15(5):553-8. doi: 10.1038/nm.1947. Epub 2009 Apr 19.


Publication metrics and record of pharmacy practice chairs.

Thompson DF, Callen EC, Nahata MC.

Ann Pharmacother. 2009 Feb;43(2):268-75. doi: 10.1345/aph.1L400. Epub 2009 Jan 20.


AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.


53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.

Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.


AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.

Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R.

J Exp Med. 2008 Sep 1;205(9):1949-57. doi: 10.1084/jem.20081007. Epub 2008 Aug 4.


A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.

Genes Dev. 2008 Aug 1;22(15):2048-61. doi: 10.1101/gad.476008.


[Validation of the Spanish version of the Benign Prostatic Hyperplasia Impact Index Questionnaire. "Validart Study"].

Rodríguez CJ, Abellán GA, Callen EA, Bermejo GF, Regadera-Anechina L, Llach BX.

Actas Urol Esp. 2008 Feb;32(2):230-9. Spanish. Erratum in: Actas Urol Esp. 2008 Jul-Aug;32(7):following 770.


Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly.

Callén E, Nussenzweig MC, Nussenzweig A.

Oncogene. 2007 Dec 10;26(56):7759-64. Review.


Publication records among college of pharmacy deans.

Thompson DF, Callen EC.

Ann Pharmacother. 2008 Jan;42(1):142-3. Epub 2007 Nov 27. No abstract available.


Aseptic meningitis associated with chronic sulindac use for osteoarthritis: a case report.

Callen EC, Church CO, Patel M, Sikes TL.

Rheumatol Int. 2008 Feb;28(4):391-3. Epub 2007 Aug 17.


ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.

Cell. 2007 Jul 13;130(1):63-75. Epub 2007 Jun 28.


Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.

Kalb R, Neveling K, Hoehn H, Schneider H, Linka Y, Batish SD, Hunt C, Berwick M, Callen E, Surralles J, Casado JA, Bueren J, Dasi A, Soulier J, Gluckman E, Zwaan CM, van Spaendonk R, Pals G, de Winter JP, Joenje H, Grompe M, Auerbach AD, Hanenberg H, Schindler D.

Am J Hum Genet. 2007 May;80(5):895-910. Epub 2007 Apr 6. Erratum in: Am J Hum Genet. 2007 Jul;81(1):196.


Stevens-Johnson syndrome associated with oral minoxidil: a case report.

Callen EC, Church CO, Hernandez CL, Thompson ED.

J Nephrol. 2007 Jan-Feb;20(1):91-3.


Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.

Bogliolo M, Lyakhovich A, Callén E, Castellà M, Cappelli E, Ramírez MJ, Creus A, Marcos R, Kalb R, Neveling K, Schindler D, Surrallés J.

EMBO J. 2007 Mar 7;26(5):1340-51. Epub 2007 Feb 15.


A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network.

Antonio Casado J, Callén E, Jacome A, Río P, Castella M, Lobitz S, Ferro T, Muñoz A, Sevilla J, Cantalejo A, Cela E, Cervera J, Sánchez-Calero J, Badell I, Estella J, Dasí A, Olivé T, José Ortega J, Rodriguez-Villa A, Tapia M, Molinés A, Madero L, Segovia JC, Neveling K, Kalb R, Schindler D, Hanenberg H, Surrallés J, Bueren JA.

J Med Genet. 2007 Apr;44(4):241-9. Epub 2006 Nov 14.


Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

Callen EC, Church CO.

Pharmacotherapy. 2006 Oct;26(10):1526-8.


Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC.

Nature. 2006 Mar 2;440(7080):105-9. Epub 2006 Jan 8.

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