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Items: 38


TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells.

Benzing C, Lam H, Tsang CM, Rimmer A, Arroyo-Berdugo Y, Calle Y, Wells CM.

BMC Cancer. 2019 Dec 13;19(1):1214. doi: 10.1186/s12885-019-6429-z.


PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells.

Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y, Moreno VS, Cox S, Jones GE, Wells CM.

Cell Rep. 2019 Dec 10;29(11):3385-3393.e6. doi: 10.1016/j.celrep.2019.11.016.


Identification of novel targets for host-directed therapeutics against intracellular Staphylococcus aureus.

Bravo-Santano N, Capilla-Lasheras P, Mateos LM, Calle Y, Behrends V, Letek M.

Sci Rep. 2019 Oct 28;9(1):15435. doi: 10.1038/s41598-019-51894-3.


Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity.

Bravo-Santano N, Ellis JK, Calle Y, Keun HC, Behrends V, Letek M.

Metabolites. 2019 Jul 20;9(7). pii: E148. doi: 10.3390/metabo9070148.


Host-directed kinase inhibitors act as novel therapies against intracellular Staphylococcus aureus.

Bravo-Santano N, Stölting H, Cooper F, Bileckaja N, Majstorovic A, Ihle N, Mateos LM, Calle Y, Behrends V, Letek M.

Sci Rep. 2019 Mar 19;9(1):4876. doi: 10.1038/s41598-019-41260-8.


Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy.

Bravo-Santano N, Ellis JK, Mateos LM, Calle Y, Keun HC, Behrends V, Letek M.

mSphere. 2018 Aug 8;3(4). pii: e00374-18. doi: 10.1128/mSphere.00374-18.


BCR-ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy.

Pereira WO, De Carvalho DD, Zenteno ME, Ribeiro BF, Jacysyn JF, Sardinha LR, Zanichelli MA, Hamerschlak N, Jones GE, Pagnano KB, Castro FA, Calle Y, Amarante-Mendes GP.

Cell Death Dis. 2017 Oct 12;8(10):e3114. doi: 10.1038/cddis.2017.458.


Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.

Vijayakumar V, Monypenny J, Chen XJ, Machesky LM, Lilla S, Thrasher AJ, Antón IM, Calle Y, Jones GE.

J Cell Sci. 2015 Jan 15;128(2):251-65. doi: 10.1242/jcs.154880. Epub 2014 Nov 20.


Integrin linked kinase (ILK) regulates podosome maturation and stability in dendritic cells.

Griera M, Martin-Villar E, Banon-Rodríguez I, Blundell MP, Jones GE, Anton IM, Thrasher AJ, Rodriguez-Puyol M, Calle Y.

Int J Biochem Cell Biol. 2014 May;50:47-54. doi: 10.1016/j.biocel.2014.01.021. Epub 2014 Feb 6.


Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy.

Thakurta A, Gandhi AK, Waldman MF, Bjorklund C, Ning Y, Mendy D, Schafer P, Lopez-Girona A, Lentzsch S, Schey SA, Calle Y, Chelliah R, Orlowski RZ, Madan A, Avet-Loiseau H, Chopra R.

Leukemia. 2014 May;28(5):1129-31. doi: 10.1038/leu.2013.315. Epub 2013 Oct 29. No abstract available.


CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.

Tai YT, Landesman Y, Acharya C, Calle Y, Zhong MY, Cea M, Tannenbaum D, Cagnetta A, Reagan M, Munshi AA, Senapedis W, Saint-Martin JR, Kashyap T, Shacham S, Kauffman M, Gu Y, Wu L, Ghobrial I, Zhan F, Kung AL, Schey SA, Richardson P, Munshi NC, Anderson KC.

Leukemia. 2014 Jan;28(1):155-65. doi: 10.1038/leu.2013.115. Epub 2013 Apr 16.


Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.

Tai YT, Chang BY, Kong SY, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao JJ, Cagnetta A, Cea M, Sellitto MA, Zhong MY, Wang Q, Acharya C, Carrasco DR, Buggy JJ, Elias L, Treon SP, Matsui W, Richardson P, Munshi NC, Anderson KC.

Blood. 2012 Aug 30;120(9):1877-87. doi: 10.1182/blood-2011-12-396853. Epub 2012 Jun 11.


Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells.

Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA, Calle Y.

Br J Haematol. 2012 Jun;157(5):564-79. doi: 10.1111/j.1365-2141.2012.09103.x. Epub 2012 Mar 20.


Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly.

Macpherson L, Monypenny J, Blundell MP, Cory GO, Tomé-García J, Thrasher AJ, Jones GE, Calle Y.

Haematologica. 2012 May;97(5):687-91. doi: 10.3324/haematol.2011.048868. Epub 2011 Dec 1.


Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9.

Buggins AG, Levi A, Gohil S, Fishlock K, Patten PE, Calle Y, Yallop D, Devereux S.

Br J Haematol. 2011 Jul;154(2):216-22. doi: 10.1111/j.1365-2141.2011.08725.x. Epub 2011 May 14.


The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cells.

Bañón-Rodríguez I, Monypenny J, Ragazzini C, Franco A, Calle Y, Jones GE, Antón IM.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):213-23. doi: 10.1016/j.ejcb.2010.09.001. Epub 2010 Oct 16.


Role of WASP in cell polarity and podosome dynamics of myeloid cells.

Monypenny J, Chou HC, Bañón-Rodríguez I, Thrasher AJ, Antón IM, Jones GE, Calle Y.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):198-204. doi: 10.1016/j.ejcb.2010.05.009. Epub 2010 Jul 6. Review.


Phosphorylation of WASp is a key regulator of activity and stability in vivo.

Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15738-43. doi: 10.1073/pnas.0904346106. Epub 2009 Sep 1.


Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy.

Holt MR, Calle Y, Sutton DH, Critchley DR, Jones GE, Dunn GA.

J Microsc. 2008 Oct;232(1):73-81. doi: 10.1111/j.1365-2818.2008.02069.x.


WASP and WIP regulate podosomes in migrating leukocytes.

Calle Y, Antón IM, Thrasher AJ, Jones GE.

J Microsc. 2008 Sep;231(3):494-505. doi: 10.1111/j.1365-2818.2008.02062.x. Review.


Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.

Blundell MP, Bouma G, Calle Y, Jones GE, Kinnon C, Thrasher AJ.

Mol Ther. 2008 May;16(5):836-44. doi: 10.1038/mt.2008.43. Epub 2008 Mar 18.


Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ.

J Exp Med. 2007 Sep 3;204(9):2213-24. Epub 2007 Aug 27.


WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells.

Chou HC, Antón IM, Holt MR, Curcio C, Lanzardo S, Worth A, Burns S, Thrasher AJ, Jones GE, Calle Y.

Curr Biol. 2006 Dec 5;16(23):2337-44.


Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ.

Blood. 2006 Oct 1;108(7):2182-9. Epub 2006 Jun 27.


Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.

Calle Y, Carragher NO, Thrasher AJ, Jones GE.

J Cell Sci. 2006 Jun 1;119(Pt 11):2375-85.


The leukocyte podosome.

Calle Y, Burns S, Thrasher AJ, Jones GE.

Eur J Cell Biol. 2006 Apr;85(3-4):151-7. Epub 2005 Oct 10. Review.


Role of Cdc42 in neurite outgrowth of PC12 cells and cerebellar granule neurons.

Ahmed I, Calle Y, Iwashita S, Nur-E-Kamal A.

Mol Cell Biochem. 2006 Jan;281(1-2):17-25.


Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells.

Calle Y, Chou HC, Thrasher AJ, Jones GE.

J Pathol. 2004 Nov;204(4):460-9. Review.


Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK.

Ahmed I, Calle Y, Sayed MA, Kamal JM, Rengaswamy P, Manser E, Meiners S, Nur-E-Kamal A.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):571-9.


WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption.

Calle Y, Jones GE, Jagger C, Fuller K, Blundell MP, Chow J, Chambers T, Thrasher AJ.

Blood. 2004 May 1;103(9):3552-61. Epub 2004 Jan 15.


Removal of N-glycans from cell surface proteins induces apoptosis by reducing intracellular glutathione levels in the rhabdomyosarcoma cell line S4MH.

Calle Y, Palomares T, Castro B, del Olmo M, Alonso-Varona A.

Biol Cell. 2000 Dec;92(8-9):639-46.


Tunicamycin treatment reduces intracellular glutathione levels: effect on the metastatic potential of the rhabdomyosarcoma cell line S4MH.

Calle Y, Palomares T, Castro B, del Olmo M, Bilbao P, Alonso-Varona A.

Chemotherapy. 2000 Nov-Dec;46(6):408-28.


Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.

del Olmo M, Alonso-Varona A, Castro B, Calle Y, Bilbao P, Palomares T.

Melanoma Res. 2000 Apr;10(2):103-12.


Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells.

Palomares T, Alonso-Varona A, Alvarez A, Castro B, Calle Y, Bilbao P.

Clin Exp Metastasis. 1997 May;15(3):329-37.


HOX genes and cell adhesion molecules in cancers.

Alonso Varona A, Castro B, Calle Y, Palomares T, Bilbao P, Flagiello D, Poupon MF, Malfoy B.

Int J Dev Biol. 1996;Suppl 1:309S-310S. No abstract available.


Tumor-host interaction in non-random metastatic pattern distribution.

Alonso-Varona A, Palomares T, Bilbao P, Calle Y, Castro B, Barberá-Guillem E.

Bull Cancer. 1996 Jan;83(1):27-38. Review.


A simple cell labeling technique by means of lectins linked to fluorochromes for the detection of cells on tissue sections.

Alonso-Varona A, Calle Y, Palomares T, Castro B, Barberá-Guillem E.

Biol Cell. 1995;83(1):87-92.


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