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The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.

Domínguez-Iturza N, Lo AC, Shah D, Armendáriz M, Vannelli A, Mercaldo V, Trusel M, Li KW, Gastaldo D, Santos AR, Callaerts-Vegh Z, D'Hooge R, Mameli M, Van der Linden A, Smit AB, Achsel T, Bagni C.

Nat Commun. 2019 Aug 1;10(1):3454. doi: 10.1038/s41467-019-11203-y.


Differential effects of post-training scopolamine on spatial and non-spatial learning tasks in mice.

Thonnard D, Callaerts-Vegh Z, D'Hooge R.

Brain Res Bull. 2019 Oct;152:52-62. doi: 10.1016/j.brainresbull.2019.07.012. Epub 2019 Jul 11.


Impaired Reversal Learning in APPPS1-21 Mice in the Touchscreen Visual Discrimination Task.

Van den Broeck L, Hansquine P, Callaerts-Vegh Z, D'Hooge R.

Front Behav Neurosci. 2019 May 9;13:92. doi: 10.3389/fnbeh.2019.00092. eCollection 2019.


NMDA receptor dependence of reversal learning and the flexible use of cognitively demanding search strategies in mice.

Thonnard D, Dreesen E, Callaerts-Vegh Z, D'Hooge R.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 2;90:235-244. doi: 10.1016/j.pnpbp.2018.12.003. Epub 2018 Dec 6.


Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice.

Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B.

J Alzheimers Dis. 2018;66(2):801-809. doi: 10.3233/JAD-180410.


Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology.

Sierksma A, Lu A, Salta E, Vanden Eynden E, Callaerts-Vegh Z, D'Hooge R, Blum D, Buée L, Fiers M, De Strooper B.

Mol Neurodegener. 2018 Oct 12;13(1):54. doi: 10.1186/s13024-018-0285-1.


A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G.

Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5.


Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice.

Stroobants S, Wolf H, Callaerts-Vegh Z, Dierks T, Lübke T, D'Hooge R.

Front Behav Neurosci. 2018 Apr 12;12:69. doi: 10.3389/fnbeh.2018.00069. eCollection 2018.


High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG.

Neurobiol Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001. Epub 2018 Feb 7.


Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains.

van Boxelaere M, Clements J, Callaerts P, D'Hooge R, Callaerts-Vegh Z.

PLoS One. 2017 Nov 22;12(11):e0188537. doi: 10.1371/journal.pone.0188537. eCollection 2017.


Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Oct 24;12(10):e0187179. doi: 10.1371/journal.pone.0187179. eCollection 2017.


Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Jul 7;12(7):e0178016. doi: 10.1371/journal.pone.0178016. eCollection 2017.


Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Feb 16;12(2):e0171968. doi: 10.1371/journal.pone.0171968. eCollection 2017. Erratum in: PLoS One. 2017 Jul 7;12 (7):e0178016. PLoS One. 2017 Oct 24;12 (10 ):e0187179.


Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity.

Latif-Hernandez A, Shah D, Ahmed T, Lo AC, Callaerts-Vegh Z, Van der Linden A, Balschun D, D'Hooge R.

Sci Rep. 2016 Nov 7;6:36489. doi: 10.1038/srep36489.


Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A.

Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492.


Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice.

Callaerts-Vegh Z, Ahmed T, Vermaercke B, Marynen P, Balschun D, Froyen G, D'Hooge R.

Front Behav Neurosci. 2015 Jul 10;9:179. doi: 10.3389/fnbeh.2015.00179. eCollection 2015.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


Functional Dissociation of Group III Metabotropic Glutamate Receptors Revealed by Direct Comparison between the Behavioral Profiles of Knockout Mouse Lines.

Goddyn H, Callaerts-Vegh Z, D'Hooge R.

Int J Neuropsychopharmacol. 2015 May 21;18(11):pyv053. doi: 10.1093/ijnp/pyv053.


Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory.

Pooters T, Van der Jeugd A, Callaerts-Vegh Z, D'Hooge R.

Brain Res. 2015 Sep 24;1621:294-308. doi: 10.1016/j.brainres.2015.01.015. Epub 2015 Jan 22.


Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.

Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh Z, Dooley J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS, Silahtaroglu A, Liston A, D'Hooge R, Glatzel M, De Strooper B.

Neurobiol Dis. 2015 Jan;73:275-88. doi: 10.1016/j.nbd.2014.10.006. Epub 2014 Oct 12.


SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice.

Lo AC, De Maeyer JH, Vermaercke B, Callaerts-Vegh Z, Schuurkes JA, D'Hooge R.

Neuropharmacology. 2014 Oct;85:178-89. doi: 10.1016/j.neuropharm.2014.05.013. Epub 2014 May 23.


Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R.

Neuropharmacology. 2013 Dec;75:458-66. doi: 10.1016/j.neuropharm.2013.08.030. Epub 2013 Sep 10.


Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease.

Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D'Hooge R.

J Alzheimers Dis. 2013;37(1):109-25. doi: 10.3233/JAD-122296.


Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice.

Iscru E, Goddyn H, Ahmed T, Callaerts-Vegh Z, D'Hooge R, Balschun D.

Genes Brain Behav. 2013 Aug;12(6):615-25. doi: 10.1111/gbb.12052. Epub 2013 Jun 20.


Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.

Vanmarsenille L, Verbeeck J, Belet S, Roebroek AJ, Van de Putte T, Nevelsteen J, Callaerts-Vegh Z, D'Hooge R, Marynen P, Froyen G.

PLoS One. 2013 May 13;8(5):e64144. doi: 10.1371/journal.pone.0064144. Print 2013.


Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG.

Nat Neurosci. 2013 Apr;16(4):449-55. doi: 10.1038/nn.3342. Epub 2013 Feb 24.


Haploinsufficiency of VGluT1 but not VGluT2 impairs extinction of spatial preference and response suppression.

Callaerts-Vegh Z, Moechars D, Van Acker N, Daneels G, Goris I, Leo S, Naert A, Meert T, Balschun D, D'Hooge R.

Behav Brain Res. 2013 May 15;245:13-21. doi: 10.1016/j.bbr.2013.01.042. Epub 2013 Feb 5.


Behavioural alterations relevant to developmental brain disorders in mice with neonatally induced ventral hippocampal lesions.

Naert A, Gantois I, Laeremans A, Vreysen S, Van den Bergh G, Arckens L, Callaerts-Vegh Z, D'Hooge R.

Brain Res Bull. 2013 May;94:71-81. doi: 10.1016/j.brainresbull.2013.01.008. Epub 2013 Jan 26.


LPA5 receptor plays a role in pain sensitivity, emotional exploration and reversal learning.

Callaerts-Vegh Z, Leo S, Vermaercke B, Meert T, D'Hooge R.

Genes Brain Behav. 2012 Nov;11(8):1009-19. doi: 10.1111/j.1601-183X.2012.00840.x. Epub 2012 Oct 8.


Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice.

Lo AC, Callaerts-Vegh Z, Nunes AF, Rodrigues CM, D'Hooge R.

Neurobiol Dis. 2013 Feb;50:21-9. doi: 10.1016/j.nbd.2012.09.003. Epub 2012 Sep 10.


Stimulus generalization and return of fear in C57BL/6J mice.

Boddez Y, Callaerts-Vegh Z, Vervliet B, Baeyens F, D'Hooge R, Hermans D, Beckers T.

Front Behav Neurosci. 2012 Jul 16;6:41. doi: 10.3389/fnbeh.2012.00041. eCollection 2012.


TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.

Nunes AF, Amaral JD, Lo AC, Fonseca MB, Viana RJ, Callaerts-Vegh Z, D'Hooge R, Rodrigues CM.

Mol Neurobiol. 2012 Jun;45(3):440-54. doi: 10.1007/s12035-012-8256-y. Epub 2012 Mar 23.


Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Wallays G, Nuyens D, Silasi-Mansat R, Souffreau J, Callaerts-Vegh Z, Van Nuffelen A, Moons L, D'Hooge R, Lupu F, Carmeliet P, Collen D, Dewerchin M.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2881-8. doi: 10.1161/ATVBAHA.111.237859. Epub 2011 Sep 22.


Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice.

Naert A, Callaerts-Vegh Z, Moechars D, Meert T, D'Hooge R.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jul 1;35(5):1316-21. doi: 10.1016/j.pnpbp.2011.03.023. Epub 2011 Apr 14.


Nocturnal hyperactivity, increased social novelty preference and delayed extinction of fear responses in post-weaning socially isolated mice.

Naert A, Callaerts-Vegh Z, D'Hooge R.

Brain Res Bull. 2011 Jul 15;85(6):354-62. doi: 10.1016/j.brainresbull.2011.03.027. Epub 2011 Apr 8.


The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.

Goossens T, Kang YY, Wuytens G, Zimmermann P, Callaerts-Végh Z, Pollarolo G, Islam R, Hortsch M, Callaerts P.

Development. 2011 Apr;138(8):1595-605. doi: 10.1242/dev.052787. Epub 2011 Mar 9.


Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 mice.

Callaerts-Vegh Z, Hoyer D, Kelly PH.

Psychopharmacology (Berl). 2009 Oct;206(3):389-401. doi: 10.1007/s00213-009-1614-4. Epub 2009 Jul 22.


Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning.

Balschun D, Moechars D, Callaerts-Vegh Z, Vermaercke B, Van Acker N, Andries L, D'Hooge R.

Cereb Cortex. 2010 Mar;20(3):684-93. doi: 10.1093/cercor/bhp133. Epub 2009 Jul 2.


Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity.

Leo S, Moechars D, Callaerts-Vegh Z, D'Hooge R, Meert T.

Eur J Pain. 2009 Nov;13(10):1008-17. doi: 10.1016/j.ejpain.2008.12.001. Epub 2009 Jan 26.


Spred1 is required for synaptic plasticity and hippocampus-dependent learning.

Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D.

J Neurosci. 2008 Dec 31;28(53):14443-9. doi: 10.1523/JNEUROSCI.4698-08.2008.


The temporal hormesis of drug therapies.

Dudekula N, Arora V, Callaerts-Vegh Z, Bond RA.

Dose Response. 2006 May 1;3(3):414-24. doi: 10.2203/dose-response.003.03.009.


Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice.

Goddyn H, Callaerts-Vegh Z, Stroobants S, Dirikx T, Vansteenwegen D, Hermans D, van der Putten H, D'Hooge R.

Neurobiol Learn Mem. 2008 Jul;90(1):103-11. doi: 10.1016/j.nlm.2008.01.001. Epub 2008 Mar 4.


Induction of tolerance to human arylsulfatase A in a mouse model of metachromatic leukodystrophy.

Matzner U, Matthes F, Herbst E, Lüllmann-Rauch R, Callaerts-Vegh Z, D'Hooge R, Weigelt C, Eistrup C, Fogh J, Gieselmann V.

Mol Med. 2007 Sep-Oct;13(9-10):471-9.


The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila.

Rollmann SM, Yamamoto A, Goossens T, Zwarts L, Callaerts-Végh Z, Callaerts P, Norga K, Mackay TF, Anholt RR.

Genetics. 2007 Jun;176(2):947-56. Epub 2007 Apr 15.


Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.

Moechars D, Weston MC, Leo S, Callaerts-Vegh Z, Goris I, Daneels G, Buist A, Cik M, van der Spek P, Kass S, Meert T, D'Hooge R, Rosenmund C, Hampson RM.

J Neurosci. 2006 Nov 15;26(46):12055-66.


Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice.

Callaerts-Vegh Z, Beckers T, Ball SM, Baeyens F, Callaerts PF, Cryan JF, Molnar E, D'Hooge R.

J Neurosci. 2006 Jun 14;26(24):6573-82.


TBP as a candidate gene for mental retardation in patients with subtelomeric 6q deletions.

Rooms L, Reyniers E, Scheers S, van Luijk R, Wauters J, Van Aerschot L, Callaerts-Vegh Z, D'Hooge R, Mengus G, Davidson I, Courtens W, Kooy RF.

Eur J Hum Genet. 2006 Oct;14(10):1090-6. Epub 2006 Jun 14.


Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma.

Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4948-53.


Effects of different beta adrenoceptor ligands in mice with permanent occlusion of the left anterior descending coronary artery.

Callaerts-Vegh Z, Evans KL, Shipley GL, Davies PJ, Cuba DL, Gurji HA, Giles H, Bond RA.

Br J Pharmacol. 2003 Apr;138(8):1505-16.

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