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Immune modulation of head and neck squamous cell carcinoma and the tumor microenvironment by conventional therapeutics.

Miyauchi S, Kim SS, Pang J, Gold KA, Gutkind JS, Califano J, Mell LK, Cohen EEW, Sharabi AB.

Clin Cancer Res. 2019 Feb 27. pii: clincanres.0871.2018. doi: 10.1158/1078-0432.CCR-18-0871. [Epub ahead of print]


Implementation of submandibular gland transfer: A multi-institutional study of feasibility and time to treatment.

Pang J, Ching HH, Sobel RH, Orosco RK, Califano JA 3rd, Wang RC, Sanghvi P, Coffey CS.

Head Neck. 2019 Feb 5. doi: 10.1002/hed.25685. [Epub ahead of print]


Variations in HPV function are associated with survival in squamous cell carcinoma.

Gleber-Netto FO, Rao X, Guo T, Xi Y, Gao M, Shen L, Erikson K, Kalu NN, Ren S, Xu G, Fisch KM, Akagi K, Seiwert T, Gillison M, Frederick MJ, Johnson FM, Wang J, Myers JN, Califano J, Skinner HD, Pickering CR.

JCI Insight. 2019 Jan 10;4(1). pii: 124762. doi: 10.1172/jci.insight.124762. [Epub ahead of print]


Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma.

Califano JA, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha PK, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I.

Clin Cancer Res. 2018 Dec 1;24(23):6100. doi: 10.1158/1078-0432.CCR-18-3298. No abstract available.


Association of Preoperative Anemia With 30-Day Morbidity and Mortality Among Patients With Thyroid Cancer Who Undergo Thyroidectomy.

Burton BN, Okwuegbuna O, Jafari A, Califano J, Brumund KT, Gabriel RA.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 29. doi: 10.1001/jamaoto.2018.3099. [Epub ahead of print]


Identification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach.

Babu N, Mohan S, Nanjappa V, Chavan S, Advani J, Khan AA, Renuse S, Radhakrishnan A, Prasad TSK, Kumar RV, Ray JG, Biswas M, Thiyagarajan S, Califano JA, Sidransky D, Gowda H, Chatterjee A.

Data Brief. 2018 May 24;19:1124-1130. doi: 10.1016/j.dib.2018.05.100. eCollection 2018 Aug.


Effects of a Comprehensive Performance Improvement Strategy on Postoperative Adverse Events in Head and Neck Surgery.

Panuganti B, Qiu Y, Messing B, Lee G, Fakhry C, Blanco R, Ha P, Messer K, Califano JA.

Otolaryngol Head Neck Surg. 2018 Aug 28:194599818793887. doi: 10.1177/0194599818793887. [Epub ahead of print]


Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma.

Kelley DZ, Flam EL, Guo T, Danilova LV, Zamuner FT, Bohrson C, Considine M, Windsor EJ, Bishop JA, Zhang C, Koch WM, Sidransky D, Westra WH, Chung CH, Califano JA, Wheelan S, Favorov AV, Florea L, Fertig EJ, Gaykalova DA.

Transl Res. 2018 Dec;202:109-119. doi: 10.1016/j.trsl.2018.07.007. Epub 2018 Jul 26.


Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma.

Ren S, Gaykalova D, Wang J, Guo T, Danilova L, Favorov A, Fertig E, Bishop J, Khan Z, Flam E, Wysocki PT, DeJong P, Ando M, Liu C, Sakai A, Fukusumi T, Haft S, Sadat S, Califano JA.

Int J Cancer. 2018 Nov 15;143(10):2425-2436. doi: 10.1002/ijc.31778. Epub 2018 Sep 21.


Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.

Liu C, Guo T, Xu G, Sakai A, Ren S, Fukusumi T, Ando M, Sadat S, Saito Y, Khan Z, Fisch KM, Califano J.

Clin Cancer Res. 2018 Oct 15;24(20):5123-5132. doi: 10.1158/1078-0432.CCR-18-0752. Epub 2018 Jun 26.


HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma.

Rettig EM, Bishop JA, Agrawal N, Chung CH, Sharma R, Zamuner F, Li RJ, Koch WM, Califano JA, Guo T, Gaykalova DA, Fakhry C.

Oral Oncol. 2018 Jul;82:168-175. doi: 10.1016/j.oraloncology.2018.05.017. Epub 2018 Jun 1.


Prognostic Role of p16 in Nonoropharyngeal Head and Neck Cancer.

Bryant AK, Sojourner EJ, Vitzthum LK, Zakeri K, Shen H, Nguyen C, Murphy JD, Califano JA, Cohen EEW, Mell LK.

J Natl Cancer Inst. 2018 Dec 1;110(12):1393-1399. doi: 10.1093/jnci/djy072.


Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance.

Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano JA, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ.

Genome Med. 2018 May 23;10(1):37. doi: 10.1186/s13073-018-0545-2.


HPV status, like politics, is local-evaluating p16 staining and a new staging system in a Dutch cohort of oropharynx cancer.

Orosco RK, Califano JA.

Ann Oncol. 2018 May 1;29(5):1089-1090. doi: 10.1093/annonc/mdy110. No abstract available.


Opioid prescribing practices in patients undergoing surgery for oral cavity cancer.

Pang J, Tringale KR, Tapia VJ, Panuganti BA, Qualliotine JR, Jafari A, Haft SJ, Friedman LS, Furnish T, Brumund KT, Califano JA, Coffey CS.

Laryngoscope. 2018 Oct;128(10):2361-2366. doi: 10.1002/lary.27215. Epub 2018 May 14.


Needle Biopsy of Routine Thyroid Nodules Should Be Performed Using a Capillary Action Technique with 24- to 27-Gauge Needles: A Systematic Review and Meta-Analysis.

Moss WJ, Finegersh A, Pang J, Califano JA, Coffey CS, Orosco RK, Brumund KT.

Thyroid. 2018 Jul;28(7):857-863. doi: 10.1089/thy.2017.0643. Epub 2018 Jun 5.


Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes.

Bhat MY, Advani J, Rajagopalan P, Patel K, Nanjappa V, Solanki HS, Patil AH, Bhat FA, Mathur PP, Nair B, Prasad TSK, Califano JA, Sidransky D, Gowda H, Chatterjee A.

Sci Rep. 2018 May 4;8(1):7040. doi: 10.1038/s41598-018-25498-2.


Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.

Rajagopalan P, Patel K, Jain AP, Nanjappa V, Datta KK, Subbannayya T, Mangalaparthi KK, Kumari A, Manoharan M, Coral K, Murugan S, Nair B, Prasad TSK, Mathur PP, Gupta R, Gupta R, Khanna-Gupta A, Califano J, Sidransky D, Gowda H, Chatterjee A.

Cancer Biol Ther. 2018;19(9):773-785. doi: 10.1080/15384047.2018.1470724. Epub 2018 May 29.


Positive Surgical Margins in the 10 Most Common Solid Cancers.

Orosco RK, Tapia VJ, Califano JA, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD, Pang J, Sacco A, Tringale KR, Wallace A, Nguyen QT.

Sci Rep. 2018 Apr 9;8(1):5686. doi: 10.1038/s41598-018-23403-5.


The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.

Fukusumi T, Califano JA.

J Dent Res. 2018 Jun;97(6):645-653. doi: 10.1177/0022034518760297. Epub 2018 Feb 28.


Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.

Rajagopalan P, Nanjappa V, Patel K, Jain AP, Mangalaparthi KK, Patil AH, Nair B, Mathur PP, Keshava Prasad TS, Califano JA, Sidransky D, Gowda H, Chatterjee A.

J Cell Commun Signal. 2018 Dec;12(4):709-721. doi: 10.1007/s12079-017-0442-2. Epub 2018 Feb 26.


Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma.

Krishnan AR, Qu Y, Li PX, Zou AE, Califano JA, Wang-Rodriguez J, Ongkeko WM.

Oncotarget. 2017 Dec 19;9(4):4614-4624. doi: 10.18632/oncotarget.23464. eCollection 2018 Jan 12.


Splice Expression Variation Analysis (SEVA) for inter-tumor heterogeneity of gene isoform usage in cancer.

Afsari B, Guo T, Considine M, Florea L, Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Zambo KD, Ha PK, Geman D, Ochs MF, Califano JA, Gaykalova DA, Favorov AV, Fertig EJ.

Bioinformatics. 2018 Jun 1;34(11):1859-1867. doi: 10.1093/bioinformatics/bty004.


Comparison of Tumor Classifications for Cutaneous Squamous Cell Carcinoma of the Head and Neck in the 7th vs 8th Edition of the AJCC Cancer Staging Manual.

Karia PS, Morgan FC, Califano JA, Schmults CD.

JAMA Dermatol. 2018 Feb 1;154(2):175-181. doi: 10.1001/jamadermatol.2017.3960.


The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA.

Clin Cancer Res. 2018 Feb 1;24(3):619-633. doi: 10.1158/1078-0432.CCR-17-1366. Epub 2017 Nov 16.


DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma.

Finegersh A, Kulich S, Guo T, Favorov AV, Fertig EJ, Danilova LV, Gaykalova DA, Califano JA, Duvvuri U.

Sci Rep. 2017 Nov 9;7(1):15173. doi: 10.1038/s41598-017-15634-9.


Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline.

Quon H, Vapiwala N, Forastiere A, Kennedy EB, Adelstein DJ, Boykin H, Califano JA, Holsinger FC, Nussenbaum B, Rosenthal DI, Siu LL, Waldron JN.

J Clin Oncol. 2017 Dec 20;35(36):4078-4090. doi: 10.1200/JCO.2017.73.8633. Epub 2017 Oct 24.


Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks.

Kelley DZ, Flam EL, Izumchenko E, Danilova LV, Wulf HA, Guo T, Singman DA, Afsari B, Skaist AM, Considine M, Welch JA, Stavrovskaya E, Bishop JA, Westra WH, Khan Z, Koch WM, Sidransky D, Wheelan SJ, Califano JA, Favorov AV, Fertig EJ, Gaykalova DA.

Cancer Res. 2017 Dec 1;77(23):6538-6550. doi: 10.1158/0008-5472.CAN-17-0833. Epub 2017 Sep 25.


A comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma.

Krishnan AR, Zheng H, Kwok JG, Qu Y, Zou AE, Korrapati A, Li PX, Califano JA, Hovell MF, Wang-Rodriguez J, Ongkeko WM.

Oral Oncol. 2017 Sep;72:56-64. doi: 10.1016/j.oraloncology.2017.07.009. Epub 2017 Jul 13.


A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers.

Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J.

Cancer Res. 2017 Oct 1;77(19):5248-5258. doi: 10.1158/0008-5472.CAN-16-3106. Epub 2017 Jul 21.


Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer.

Qualliotine JR, Califano JA, Li RJ, Gold D, Messing B, Lee G, Ha P, Fakhry C.

J Laryngol Otol. 2017 Sep;131(9):760-767. doi: 10.1017/S0022215117001098. Epub 2017 Jul 19.


Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma.

Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TSK, Santosh V, Sukumar G, Califano JA, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A.

Sci Rep. 2017 Jun 26;7:46864. doi: 10.1038/srep46864.


Chronic Opioid Use Following Surgery for Oral Cavity Cancer.

Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano JA 3rd.

JAMA Otolaryngol Head Neck Surg. 2017 Dec 1;143(12):1187-1194. doi: 10.1001/jamaoto.2017.0582. No abstract available.


Prophylactic Swallow Therapy for Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Randomized Trial.

Messing BP, Ward EC, Lazarus CL, Kim M, Zhou X, Silinonte J, Gold D, Harrer K, Ulmer K, Merritt S, Neuner G, Levine M, Blanco R, Saunders J, Califano J.

Dysphagia. 2017 Aug;32(4):487-500. doi: 10.1007/s00455-017-9790-6. Epub 2017 Apr 25.


Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012.

Tota JE, Anderson WF, Coffey C, Califano J, Cozen W, Ferris RL, St John M, Cohen EE, Chaturvedi AK.

Oral Oncol. 2017 Apr;67:146-152. doi: 10.1016/j.oraloncology.2017.02.019. Epub 2017 Feb 28.


MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.

Zhao Y, Ling Z, Hao Y, Pang X, Han X, Califano JA, Shan L, Gu X.

Oncotarget. 2017 Apr 11;8(15):25005-25020. doi: 10.18632/oncotarget.15334.


Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.

Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA.

Oncotarget. 2017 Feb 28;8(9):15349-15363. doi: 10.18632/oncotarget.14856.


Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma.

Krishnan AR, Korrapati A, Zou AE, Qu Y, Wang XQ, Califano JA, Wang-Rodriguez J, Lippman SM, Hovell MF, Ongkeko WM.

Oral Oncol. 2017 Feb;65:68-75. doi: 10.1016/j.oraloncology.2016.12.022. Epub 2016 Dec 31.


Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma.

Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J.

Head Neck. 2017 Apr;39(4):662-667. doi: 10.1002/hed.24658. Epub 2017 Jan 11.


Matrix stiffening promotes a tumor vasculature phenotype.

Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):492-497. doi: 10.1073/pnas.1613855114. Epub 2016 Dec 29.


Favorable Swallowing Outcomes following Vagus Nerve Sacrifice for Vagal Schwannoma Resection.

Patel MA, Eytan DF, Bishop J, Califano JA.

Otolaryngol Head Neck Surg. 2017 Feb;156(2):329-333. doi: 10.1177/0194599816678210.


Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors.

Oweida A, Bhatia S, Hirsch K, Calame D, Griego A, Keysar S, Pitts T, Sharma J, Eckhardt G, Jimeno A, Wang XJ, Parkash G, Califano J, Karam SD.

Mol Carcinog. 2017 Mar;56(3):1189-1196. doi: 10.1002/mc.22574. Epub 2016 Nov 1.


A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma.

Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TS, Santosh V, Sukumar G, Califano JA, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A.

Sci Rep. 2016 Oct 31;6:36132. doi: 10.1038/srep36132. Erratum in: Sci Rep. 2017 Jun 26;7:46864.


mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS.

Carcinogenesis. 2016 Oct;37(10):1014-25. doi: 10.1093/carcin/bgw086. Epub 2016 Aug 18.


Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer.

D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C.

Oral Oncol. 2016 Sep;60:90-5. doi: 10.1016/j.oraloncology.2016.06.009. Epub 2016 Jul 17.


Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models.

Sobel RH, Blanco R, Ha PK, Califano JA, Kumar R, Richmon JD.

Head Neck. 2016 Oct;38(10):1553-63. doi: 10.1002/hed.24475. Epub 2016 May 6.


Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66].

Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano JA.

Oral Oncol. 2016 Jun;57:e8. doi: 10.1016/j.oraloncology.2016.03.018. Epub 2016 Apr 13. No abstract available.


Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma.

Guo T, Gaykalova DA, Considine M, Wheelan S, Pallavajjala A, Bishop JA, Westra WH, Ideker T, Koch WM, Khan Z, Fertig EJ, Califano JA.

Int J Cancer. 2016 Jul 15;139(2):373-82. doi: 10.1002/ijc.30081. Epub 2016 Mar 30.


Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination.

Stansfield JC, Rusay M, Shan R, Kelton C, Gaykalova DA, Fertig EJ, Califano JA, Ochs MF.

Cancer Inform. 2016 Feb 10;15:15-21. doi: 10.4137/CIN.S32468. eCollection 2016.


A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers.

Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS.

Oncotarget. 2016 Mar 8;7(10):10696-709. doi: 10.18632/oncotarget.7372.

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