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Items: 1 to 50 of 63

1.

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability.

Sonego M, Pellarin I, Costa A, Vinciguerra GLR, Coan M, Kraut A, D'Andrea S, Dall'Acqua A, Castillo-Tong DC, Califano D, Losito S, Spizzo R, Couté Y, Vecchione A, Belletti B, Schiappacassi M, Baldassarre G.

Sci Adv. 2019 May 8;5(5):eaav3235. doi: 10.1126/sciadv.aav3235. eCollection 2019 May.

2.

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.

Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D.

Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3.

3.

Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain.

Califano D, Furuya Y, Metzger DW.

J Immunol. 2018 Jul 1;201(1):134-144. doi: 10.4049/jimmunol.1701406. Epub 2018 May 14.

4.

Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis.

Galdiero F, Bello AM, Spina A, Capiluongo A, Liuu S, De Marco M, Rosati A, Capunzo M, Napolitano M, Vuttariello E, Monaco M, Califano D, Turco MC, Chiappetta G, Vinh J, Chiappetta G.

Oncotarget. 2018 Jan 3;9(8):8016-8026. doi: 10.18632/oncotarget.23858. eCollection 2018 Jan 30.

5.

Trabectedin in Ovarian Cancer: is it now a Standard of Care?

Ventriglia J, Paciolla I, Cecere SC, Pisano C, Di Napoli M, Arenare L, Setola SV, Losito NS, Califano D, Orditura M, Pignata S.

Clin Oncol (R Coll Radiol). 2018 Aug;30(8):498-503. doi: 10.1016/j.clon.2018.01.008. Epub 2018 Feb 9.

PMID:
29429842
6.

Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives.

Ventriglia J, Paciolla I, Pisano C, Cecere SC, Di Napoli M, Tambaro R, Califano D, Losito S, Scognamiglio G, Setola SV, Arenare L, Pignata S, Della Pepa C.

Cancer Treat Rev. 2017 Sep;59:109-116. doi: 10.1016/j.ctrv.2017.07.008. Epub 2017 Jul 31. Review.

PMID:
28800469
7.

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation.

Dall'Acqua A, Sonego M, Pellizzari I, Pellarin I, Canzonieri V, D'Andrea S, Benevol S, Sorio R, Giorda G, Califano D, Bagnoli M, Militello L, Mezzanzanica D, Chiappetta G, Armenia J, Belletti B, Schiappacassi M, Baldassarre G.

EMBO Mol Med. 2017 Oct;9(10):1415-1433. doi: 10.15252/emmm.201607012.

8.

IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells.

Califano D, Furuya Y, Roberts S, Avram D, McKenzie ANJ, Metzger DW.

Mucosal Immunol. 2018 Jan;11(1):209-219. doi: 10.1038/mi.2017.41. Epub 2017 May 17.

9.

Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC.

Perrone F, Baldassarre G, Indraccolo S, Signoriello S, Chiappetta G, Esposito F, Ferrandina G, Franco R, Mezzanzanica D, Sonego M, Zulato E, Zannoni GF, Canzonieri V, Scambia G, Sorio R, Savarese A, Breda E, Scollo P, Ferro A, Tamberi S, Febbraro A, Natale D, Di Maio M, Califano D, Scognamiglio G, Lorusso D, Canevari S, Losito S, Gallo C, Pignata S.

Oncotarget. 2016 Nov 8;7(45):72654-72661. doi: 10.18632/oncotarget.12056.

10.

Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study.

Bagnoli M, Canevari S, Califano D, Losito S, Maio MD, Raspagliesi F, Carcangiu ML, Toffoli G, Cecchin E, Sorio R, Canzonieri V, Russo D, Scognamiglio G, Chiappetta G, Baldassarre G, Lorusso D, Scambia G, Zannoni GF, Savarese A, Carosi M, Scollo P, Breda E, Murgia V, Perrone F, Pignata S, De Cecco L, Mezzanzanica D; Multicentre Italian Trials in Ovarian cancer (MITO) translational group.

Lancet Oncol. 2016 Aug;17(8):1137-1146. doi: 10.1016/S1470-2045(16)30108-5. Epub 2016 Jul 9.

11.

Tumor genotype and immune microenvironment in POLE-ultramutated and MSI-hypermutated Endometrial Cancers: New candidates for checkpoint blockade immunotherapy?

Gargiulo P, Della Pepa C, Berardi S, Califano D, Scala S, Buonaguro L, Ciliberto G, Brauchli P, Pignata S.

Cancer Treat Rev. 2016 Jul;48:61-8. doi: 10.1016/j.ctrv.2016.06.008. Epub 2016 Jun 18. Review.

PMID:
27362548
12.

Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival.

Uddin MN, Sultana DA, Lorentsen KJ, Cho JJ, Kirst ME, Brantly ML, Califano D, Sant'Angelo DB, Avram D.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7608-13. doi: 10.1073/pnas.1521846113. Epub 2016 Jun 21.

13.

Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy.

Trotta AM, Ottaiano A, Romano C, Nasti G, Nappi A, De Divitiis C, Napolitano M, Zanotta S, Casaretti R, D'Alterio C, Avallone A, Califano D, Iaffaioli RV, Scala S.

Cancer Immunol Res. 2016 Apr;4(4):366-74. doi: 10.1158/2326-6066.CIR-15-0184. Epub 2016 Jan 27.

14.

Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells.

Califano D, Cho JJ, Uddin MN, Lorentsen KJ, Yang Q, Bhandoola A, Li H, Avram D.

Immunity. 2015 Aug 18;43(2):354-68. doi: 10.1016/j.immuni.2015.07.005. Epub 2015 Jul 28.

15.

Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer.

Galdiero F, Romano A, Pasquinelli R, Pignata S, Greggi S, Vuttariello E, Bello AM, Calise C, Scaffa C, Pisano C, Losito NS, Fusco A, Califano D, Chiappetta G.

Oncotarget. 2015 Aug 7;6(22):19328-35.

16.

The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth.

Chiappetta G, Basile A, Barbieri A, Falco A, Rosati A, Festa M, Pasquinelli R, Califano D, Palma G, Costanzo R, Barcaroli D, Capunzo M, Franco R, Rocco G, Pascale M, Turco MC, De Laurenzi V, Arra C.

Oncotarget. 2014 Aug 30;5(16):6846-53.

17.

The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases.

Avram D, Califano D.

J Immunol. 2014 Sep 1;193(5):2059-65. doi: 10.4049/jimmunol.1400930. Review.

18.

Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis.

Califano D, Sweeney KJ, Le H, VanValkenburgh J, Yager E, O'Connor W Jr, Kennedy JS, Jones DM, Avram D.

J Clin Invest. 2014 Jan;124(1):174-87. doi: 10.1172/JCI70103. Epub 2013 Dec 9.

19.

High HMGA2 expression and high body mass index negatively affect the prognosis of patients with ovarian cancer.

Califano D, Pignata S, Losito NS, Ottaiano A, Greggi S, De Simone V, Cecere S, Aiello C, Esposito F, Fusco A, Chiappetta G.

J Cell Physiol. 2014 Jan;229(1):53-9. doi: 10.1002/jcp.24416.

PMID:
23765903
20.

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis.

Vecchione A, Belletti B, Lovat F, Volinia S, Chiappetta G, Giglio S, Sonego M, Cirombella R, Onesti EC, Pellegrini P, Califano D, Pignata S, Losito S, Canzonieri V, Sorio R, Alder H, Wernicke D, Stoppacciaro A, Baldassarre G, Croce CM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9845-50. doi: 10.1073/pnas.1305472110. Epub 2013 May 22.

21.

BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein.

Chiappetta G, Basile A, Arra C, Califano D, Pasquinelli R, Barbieri A, De Simone V, Rea D, Giudice A, Pezzullo L, De Laurenzi V, Botti G, Losito S, Conforti D, Turco MC.

J Clin Endocrinol Metab. 2012 Jan;97(1):E115-20. doi: 10.1210/jc.2011-0484. Epub 2011 Nov 9.

PMID:
22072743
22.

miR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting.

Colamaio M, Borbone E, Russo L, Bianco M, Federico A, Califano D, Chiappetta G, Pallante P, Troncone G, Battista S, Fusco A.

J Clin Endocrinol Metab. 2011 Dec;96(12):E1915-24. doi: 10.1210/jc.2011-0408. Epub 2011 Sep 28.

PMID:
21956418
23.

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease.

Vanvalkenburgh J, Albu DI, Bapanpally C, Casanova S, Califano D, Jones DM, Ignatowicz L, Kawamoto S, Fagarasan S, Jenkins NA, Copeland NG, Liu P, Avram D.

J Exp Med. 2011 Sep 26;208(10):2069-81. doi: 10.1084/jem.20102683. Epub 2011 Aug 29.

24.

Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes.

Albu DI, VanValkenburgh J, Morin N, Califano D, Jenkins NA, Copeland NG, Liu P, Avram D.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6211-6. doi: 10.1073/pnas.1014304108. Epub 2011 Mar 28.

25.

Flow cytometry analysis of transcription factors in T lymphocytes.

Albu DI, Califano D, Avram D.

Methods Mol Biol. 2010;647:377-90. doi: 10.1007/978-1-60761-738-9_23.

26.

Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.

Zhang S, Rozell M, Verma RK, Albu DI, Califano D, VanValkenburgh J, Merchant A, Rangel-Moreno J, Randall TD, Jenkins NA, Copeland NG, Liu P, Avram D.

J Exp Med. 2010 Aug 2;207(8):1687-99. doi: 10.1084/jem.20092136. Epub 2010 Jul 26.

27.

FEZ1/LZTS1 protein expression in ovarian cancer.

Califano D, Pignata S, Pisano C, Greggi S, Laurelli G, Losito NS, Ottaiano A, Gallipoli A, Pasquinelli R, De Simone V, Cirombella R, Fusco A, Chiappetta G.

J Cell Physiol. 2010 Feb;222(2):382-6. doi: 10.1002/jcp.21962.

PMID:
19885841
28.

BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.

Cismasiu VB, Duque J, Paskaleva E, Califano D, Ghanta S, Young HA, Avram D.

Biochem J. 2009 Jan 15;417(2):457-66. doi: 10.1042/BJ20080925.

29.

HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias.

Chiappetta G, Ferraro A, Vuttariello E, Monaco M, Galdiero F, De Simone V, Califano D, Pallante P, Botti G, Pezzullo L, Pierantoni GM, Santoro M, Fusco A.

Eur J Cancer. 2008 May;44(7):1015-21. doi: 10.1016/j.ejca.2008.02.039. Epub 2008 Mar 28.

PMID:
18375116
30.

Loss of p27 expression through RAS-->BRAF-->MAP kinase-dependent pathway in human thyroid carcinomas.

Motti ML, De Marco C, Califano D, De Gisi S, Malanga D, Troncone G, Persico A, Losito S, Fabiani F, Santoro M, Chiappetta G, Fusco A, Viglietto G.

Cell Cycle. 2007 Nov 15;6(22):2817-25. Epub 2007 Aug 13.

PMID:
18032931
31.

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.

Chiappetta G, De Marco C, Quintiero A, Califano D, Gherardi S, Malanga D, Scrima M, Montero-Conde C, Cito L, Monaco M, Motti ML, Pasquinelli R, Agosti V, Robledo M, Fusco A, Viglietto G.

Endocr Relat Cancer. 2007 Jun;14(2):405-20.

PMID:
17639054
32.

Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives.

Gomez-Monterrey I, Campiglia P, Carotenuto A, Califano D, Pisano C, Vesci L, Lama T, Bertamino A, Sala M, di Bosco AM, Grieco P, Novellino E.

J Med Chem. 2007 Apr 19;50(8):1787-98. Epub 2007 Mar 22.

PMID:
17375902
33.

Significance of erb-B2 immunoreactivity in cervical cancer.

Califano D, Losito S, Pisano C, Santelli G, Greggi S, Iodice F, DiVagno G, Silvestro G, Tambaro R, Formato R, Iaffaioli VR, Di Maio M, Pignata S.

Front Biosci. 2006 Sep 1;11:2071-6.

PMID:
16720293
34.

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.

Santagada V, Caliendo G, Severino B, Lavecchia A, Perissutti E, Fiorino F, Zampella A, Sepe V, Califano D, Santelli G, Novellino E.

J Med Chem. 2006 Mar 23;49(6):1882-90.

PMID:
16539374
35.

Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.

Motti ML, Califano D, Troncone G, De Marco C, Migliaccio I, Palmieri E, Pezzullo L, Palombini L, Fusco A, Viglietto G.

Am J Pathol. 2005 Mar;166(3):737-49.

36.

p27Kip1 is expressed in proliferating cells in its form phosphorylated on threonine 187.

Troncone G, Martinez JC, Iaccarino A, Zeppa P, Caleo A, Russo M, Migliaccio I, Motti ML, Califano D, Palmieri EA, Palombini L.

BMC Clin Pathol. 2005 Feb 23;5(1):3.

37.

Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.

Motti ML, Califano D, Baldassarre G, Celetti A, Merolla F, Forzati F, Napolitano M, Tavernise B, Fusco A, Viglietto G.

Carcinogenesis. 2005 Jun;26(6):1021-34. Epub 2005 Feb 17.

PMID:
15718252
38.

Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.

Gomez-Monterrey I, Santelli G, Campiglia P, Califano D, Falasconi F, Pisano C, Vesci L, Lama T, Grieco P, Novellino E.

J Med Chem. 2005 Feb 24;48(4):1152-7.

PMID:
15715481
39.

Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.

Motti ML, De Marco C, Califano D, Fusco A, Viglietto G.

Cell Cycle. 2004 Aug;3(8):1074-80. Epub 2004 Aug 7.

PMID:
15280662
40.

Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias.

Chiappetta G, Pentimalli F, Monaco M, Fedele M, Pasquinelli R, Pierantoni GM, Ribecco MT, Santelli G, Califano D, Pezzullo L, Fusco A.

Oncol Rep. 2004 Aug;12(2):239-43.

PMID:
15254683
41.

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants.

D'Alessio A, Califano D, Incoronato M, Santelli G, Florio T, Schettini G, Carlomagno MS, Cerchia L, de Franciscis V.

Endocrinology. 2003 Oct;144(10):4298-305. Epub 2003 Jun 19.

PMID:
12959980
42.

Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.

Santelli G, Bartoli PC, Giuliano A, Porcellini A, Mineo A, Barone MV, Busiello I, Trapasso F, Califano D, Fusco A.

Thyroid. 2002 Sep;12(9):765-72.

PMID:
12481941
43.

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.

De Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, Santelli G, Fusco A.

Br J Cancer. 2002 Dec 2;87(12):1479. No abstract available.

44.

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.

Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M.

Nat Med. 2002 Oct;8(10):1136-44. Epub 2002 Sep 16.

PMID:
12244303
45.

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.

de Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, Santelli G, Fusco A.

Br J Cancer. 2002 Mar 18;86(6):917-23. Erratum in: Br J Cancer 2002 Dec 2;87(12):1479.

46.

Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site.

Palmieri G, de Franciscis V, Casamassimi A, Romano G, Torino A, Pingitore P, Califano D, Santelli G, Eva A, Vecchio G, D'Urso M, Ciccodicola A.

Gene. 2000 Jul 25;253(1):107-15.

PMID:
10925207
47.

Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK.

Colucci-D'Amato GL, D'Alessio A, Califano D, Cali G, Rizzo C, Nitsch L, Santelli G, de Franciscis V.

J Biol Chem. 2000 Jun 23;275(25):19306-14.

48.

Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells.

Califano D, Rizzo C, D'Alessio A, Colucci-D'Amato GL, Cali G, Bartoli PC, Santelli G, Vecchio G, de Franciscis V.

J Biol Chem. 2000 Jun 23;275(25):19297-305.

49.

Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids.

Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V.

Farmaco. 1999 Nov-Dec;54(11-12):785-90.

PMID:
10668180
50.

Thymosin beta-10 gene overexpression is a general event in human carcinogenesis.

Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A.

Am J Pathol. 1999 Sep;155(3):799-804.

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