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Items: 1 to 50 of 60

1.

Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.

Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G.

Sci Adv. 2019 Aug 28;5(8):eaaw9298. doi: 10.1126/sciadv.aaw9298. eCollection 2019 Aug.

2.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua AI, Norman H, McGlone ER, Klymchenko AS, Corrêa IR Jr, Walker A, Inoue A, Hanyaloglu A, Grimes J, Koszegi Z, Calebiro D, Rutter GA, Bloom SR, Jones B, Tomas A.

PLoS Biol. 2019 Aug 20;17(8):e3000097. doi: 10.1371/journal.pbio.3000097. eCollection 2019 Aug.

3.

Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.

Di Dalmazi G, Timmers HJLM, Arnaldi G, Küsters B, Scarpelli M, Bathon K, Calebiro D, Beuschlein F, Hermus A, Reincke M.

J Clin Endocrinol Metab. 2019 Jul 5. pii: jc.2018-02209. doi: 10.1210/jc.2018-02209. [Epub ahead of print]

PMID:
31276155
4.

Statistical testing approach for fractional anomalous diffusion classification.

Weron A, Janczura J, Boryczka E, Sungkaworn T, Calebiro D.

Phys Rev E. 2019 Apr;99(4-1):042149. doi: 10.1103/PhysRevE.99.042149.

PMID:
31108610
5.

Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.

Bathon K, Weigand I, Vanselow JT, Ronchi CL, Sbiera S, Schlosser A, Fassnacht M, Calebiro D.

Endocrinology. 2019 Feb 1;160(2):447-459. doi: 10.1210/en.2018-00775.

PMID:
30615103
6.

The subcellular dynamics of GPCR signaling.

Calebiro D, Koszegi Z.

Mol Cell Endocrinol. 2019 Mar 1;483:24-30. doi: 10.1016/j.mce.2018.12.020. Epub 2019 Jan 2. Review.

PMID:
30610913
7.

Publisher Correction: Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription.

Godbole A, Lyga S, Lohse MJ, Calebiro D.

Nat Commun. 2018 Dec 19;9(1):5459. doi: 10.1038/s41467-018-07821-7.

8.

Hot spots for GPCR signaling: lessons from single-molecule microscopy.

Calebiro D, Jobin ML.

Curr Opin Cell Biol. 2019 Apr;57:57-63. doi: 10.1016/j.ceb.2018.11.003. Epub 2018 Dec 3. Review.

PMID:
30522088
9.

Single-Molecule Microscopy Reveals Dynamic FLNA Interactions Governing SSTR2 Clustering and Internalization.

Treppiedi D, Jobin ML, Peverelli E, Giardino E, Sungkaworn T, Zabel U, Arosio M, Spada A, Mantovani G, Calebiro D.

Endocrinology. 2018 Aug 1;159(8):2953-2965. doi: 10.1210/en.2018-00368.

PMID:
29931263
10.

Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases.

Calebiro D, Godbole A.

Best Pract Res Clin Endocrinol Metab. 2018 Apr;32(2):83-91. doi: 10.1016/j.beem.2018.01.004. Epub 2018 Feb 6. Review.

PMID:
29678288
11.

Activating PRKACB somatic mutation in cortisol-producing adenomas.

Espiard S, Knape MJ, Bathon K, Assié G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J.

JCI Insight. 2018 Apr 19;3(8). pii: 98296. doi: 10.1172/jci.insight.98296. eCollection 2018 Apr 19.

12.

Single-Molecule Imaging of GPCR Interactions.

Calebiro D, Sungkaworn T.

Trends Pharmacol Sci. 2018 Feb;39(2):109-122. doi: 10.1016/j.tips.2017.10.010. Epub 2017 Nov 17. Review.

PMID:
29157577
13.

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.

Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D.

Nature. 2017 Oct 26;550(7677):543-547. doi: 10.1038/nature24264. Epub 2017 Oct 18.

PMID:
29045395
14.

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription.

Godbole A, Lyga S, Lohse MJ, Calebiro D.

Nat Commun. 2017 Sep 5;8(1):443. doi: 10.1038/s41467-017-00357-2. Erratum in: Nat Commun. 2018 Dec 19;9(1):5459.

15.

Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.

Weigand I, Ronchi CL, Rizk-Rabin M, Dalmazi GD, Wild V, Bathon K, Rubin B, Calebiro D, Beuschlein F, Bertherat J, Fassnacht M, Sbiera S.

Sci Rep. 2017 Mar 8;7(1):49. doi: 10.1038/s41598-017-00125-8.

16.

Mechanisms of Aberrant PKA Activation by Cα Subunit Mutations.

Calebiro D, Bathon K, Weigand I.

Horm Metab Res. 2017 Apr;49(4):307-314. doi: 10.1055/s-0042-112817. Epub 2016 Nov 3. Review.

PMID:
27813054
17.

cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons.

Maiellaro I, Lohse MJ, Kittel RJ, Calebiro D.

Cell Rep. 2016 Oct 25;17(5):1238-1246. doi: 10.1016/j.celrep.2016.09.090.

18.

Somatostatin Receptor Type 2 (SSTR2) Internalization and Intracellular Trafficking in Pituitary GH-Secreting Adenomas: Role of Scaffold Proteins and Implications for Pharmacological Resistance.

Treppiedi D, Peverelli E, Giardino E, Ferrante E, Calebiro D, Spada A, Mantovani G.

Horm Metab Res. 2017 Apr;49(4):259-268. doi: 10.1055/s-0042-116025. Epub 2016 Sep 15. Review. No abstract available.

PMID:
27632151
19.

Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas.

Calebiro D, Grassi ES, Eszlinger M, Ronchi CL, Godbole A, Bathon K, Guizzardi F, de Filippis T, Krohn K, Jaeschke H, Schwarzmayr T, Bircan R, Gozu HI, Sancak S, Niedziela M, Strom TM, Fassnacht M, Persani L, Paschke R.

J Clin Invest. 2016 Sep 1;126(9):3383-8. doi: 10.1172/JCI84894. Epub 2016 Aug 8.

20.

Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.

Ronchi CL, Di Dalmazi G, Faillot S, Sbiera S, Assié G, Weigand I, Calebiro D, Schwarzmayr T, Appenzeller S, Rubin B, Waldmann J, Scaroni C, Bartsch DK, Mantero F, Mannelli M, Kastelan D, Chiodini I, Bertherat J, Reincke M, Strom TM, Fassnacht M, Beuschlein F; European Network for the Study of Adrenocortical Tumors (ENSAT).

J Clin Endocrinol Metab. 2016 Sep;101(9):3526-38. doi: 10.1210/jc.2016-1586. Epub 2016 Jul 7.

PMID:
27389594
21.

PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.

Rhayem Y, Perez-Rivas LG, Dietz A, Bathon K, Gebhard C, Riester A, Mauracher B, Gomez-Sanchez C, Eisenhofer G, Schwarzmayr T, Calebiro D, Strom TM, Reincke M, Beuschlein F.

J Clin Endocrinol Metab. 2016 Aug;101(8):3010-7. doi: 10.1210/jc.2016-1700. Epub 2016 Jun 7.

PMID:
27270477
22.

Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles.

Lyga S, Volpe S, Werthmann RC, Götz K, Sungkaworn T, Lohse MJ, Calebiro D.

Endocrinology. 2016 Apr;157(4):1613-21. doi: 10.1210/en.2015-1945. Epub 2016 Feb 1.

PMID:
26828746
23.

Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.

Ronchi CL, Peverelli E, Herterich S, Weigand I, Mantovani G, Schwarzmayr T, Sbiera S, Allolio B, Honegger J, Appenzeller S, Lania AG, Reincke M, Calebiro D, Spada A, Buchfelder M, Flitsch J, Strom TM, Fassnacht M.

Eur J Endocrinol. 2016 Mar;174(3):363-72. doi: 10.1530/EJE-15-1064. Epub 2015 Dec 23.

PMID:
26701869
24.

The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases.

Brüser A, Schulz A, Rothemund S, Ricken A, Calebiro D, Kleinau G, Schöneberg T.

J Biol Chem. 2016 Jan 8;291(2):508-20. doi: 10.1074/jbc.M115.701102. Epub 2015 Nov 18.

25.

Single-Molecule Fluorescence Microscopy for the Analysis of Fast Receptor Dynamics.

Wagner J, Sungkaworn T, Heinze KG, Lohse MJ, Calebiro D.

Methods Mol Biol. 2015;1335:53-66. doi: 10.1007/978-1-4939-2914-6_5.

PMID:
26260594
26.

cAMP signaling in cortisol-producing adrenal adenoma.

Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F.

Eur J Endocrinol. 2015 Oct;173(4):M99-106. doi: 10.1530/EJE-15-0353. Epub 2015 Jul 2. Review.

PMID:
26139209
27.

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ.

Nat Commun. 2014 Dec 5;5:5680. doi: 10.1038/ncomms6680.

PMID:
25477193
28.

cAMP signaling microdomains and their observation by optical methods.

Calebiro D, Maiellaro I.

Front Cell Neurosci. 2014 Oct 28;8:350. doi: 10.3389/fncel.2014.00350. eCollection 2014. Review.

29.

Trafficking and function of GPCRs in the endosomal compartment.

Calebiro D, Godbole A, Lyga S, Lohse MJ.

Methods Mol Biol. 2015;1234:197-211. doi: 10.1007/978-1-4939-1755-6_16.

PMID:
25304358
30.

High-resolution spatiotemporal analysis of receptor dynamics by single-molecule fluorescence microscopy.

Sungkaworn T, Rieken F, Lohse MJ, Calebiro D.

J Vis Exp. 2014 Jul 25;(89):e51784. doi: 10.3791/51784.

31.

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.

Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M.

J Clin Endocrinol Metab. 2014 Oct;99(10):E2093-100. doi: 10.1210/jc.2014-2152. Epub 2014 Jul 24.

PMID:
25057884
32.

Real-time monitoring of GPCR/cAMP signalling by FRET and single-molecule microscopy.

Calebiro D, Sungkaworn T, Maiellaro I.

Horm Metab Res. 2014 Nov;46(12):827-32. doi: 10.1055/s-0034-1384523. Epub 2014 Jul 23. Review.

PMID:
25054437
33.

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B.

N Engl J Med. 2014 Mar 13;370(11):1019-28. doi: 10.1056/NEJMoa1310359. Epub 2014 Feb 26.

34.

Kinetics and mechanism of G protein-coupled receptor activation.

Lohse MJ, Maiellaro I, Calebiro D.

Curr Opin Cell Biol. 2014 Apr;27:87-93. doi: 10.1016/j.ceb.2013.11.009. Epub 2013 Dec 17. Review.

PMID:
24530699
35.

Cell biology: Receptor signals come in waves.

Lohse MJ, Calebiro D.

Nature. 2013 Mar 28;495(7442):457-8. doi: 10.1038/nature12086. Epub 2013 Mar 20. No abstract available.

PMID:
23515157
36.

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization.

Calebiro D, Rieken F, Wagner J, Sungkaworn T, Zabel U, Borzi A, Cocucci E, Zürn A, Lohse MJ.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):743-8. doi: 10.1073/pnas.1205798110. Epub 2012 Dec 24.

37.

Dissecting signaling and functions of adhesion G protein-coupled receptors.

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T.

Ann N Y Acad Sci. 2012 Dec;1276:1-25. doi: 10.1111/j.1749-6632.2012.06820.x. Epub 2012 Dec 7.

PMID:
23215895
38.

Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish.

Porazzi P, Marelli F, Benato F, de Filippis T, Calebiro D, Argenton F, Tiso N, Persani L.

Endocrinology. 2012 Nov;153(11):5645-58. doi: 10.1210/en.2011-1888. Epub 2012 Sep 24.

PMID:
23008514
39.

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells.

Werthmann RC, Volpe S, Lohse MJ, Calebiro D.

FASEB J. 2012 May;26(5):2043-8. doi: 10.1096/fj.11-195248. Epub 2012 Jan 30.

PMID:
22291442
40.

Frequent TSH receptor genetic alterations with variable signaling impairment in a large series of children with nonautoimmune isolated hyperthyrotropinemia.

Calebiro D, Gelmini G, Cordella D, Bonomi M, Winkler F, Biebermann H, de Marco A, Marelli F, Libri DV, Antonica F, Vigone MC, Cappa M, Mian C, Sartorio A, Beck-Peccoz P, Radetti G, Weber G, Persani L.

J Clin Endocrinol Metab. 2012 Jan;97(1):E156-60. doi: 10.1210/jc.2011-1938. Epub 2011 Nov 2.

PMID:
22049173
41.

8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms.

Lucchi S, Calebiro D, de Filippis T, Grassi ES, Borghi MO, Persani L.

PLoS One. 2011;6(6):e20785. doi: 10.1371/journal.pone.0020785. Epub 2011 Jun 10.

42.

Thyroid-stimulating hormone receptor activity after internalization.

Calebiro D.

Ann Endocrinol (Paris). 2011 Apr;72(2):64-7. doi: 10.1016/j.ando.2011.03.008. Epub 2011 Apr 20.

PMID:
21511242
43.

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells.

Börner S, Schwede F, Schlipp A, Berisha F, Calebiro D, Lohse MJ, Nikolaev VO.

Nat Protoc. 2011 Apr;6(4):427-38. doi: 10.1038/nprot.2010.198. Epub 2011 Mar 10.

PMID:
21412271
44.

Absence of primary hypothyroidism and goiter in Slc26a4 (-/-) mice fed on a low iodine diet.

Calebiro D, Porazzi P, Bonomi M, Lisi S, Grindati A, De Nittis D, Fugazzola L, Marinò M, Bottà G, Persani L.

J Endocrinol Invest. 2011 Sep;34(8):593-8. doi: 10.3275/7262. Epub 2010 Sep 9.

PMID:
20834201
45.

Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary.

Jacobs S, Calebiro D, Nikolaev VO, Lohse MJ, Schulz S.

Endocrinology. 2010 Sep;151(9):4560-5. doi: 10.1210/en.2010-0341. Epub 2010 Jul 7.

PMID:
20610560
46.

Imaging of persistent cAMP signaling by internalized G protein-coupled receptors.

Calebiro D, Nikolaev VO, Lohse MJ.

J Mol Endocrinol. 2010 Jul;45(1):1-8. doi: 10.1677/JME-10-0014. Epub 2010 Apr 8. Review.

PMID:
20378719
47.

Signaling by internalized G-protein-coupled receptors.

Calebiro D, Nikolaev VO, Persani L, Lohse MJ.

Trends Pharmacol Sci. 2010 May;31(5):221-8. doi: 10.1016/j.tips.2010.02.002. Epub 2010 Mar 18. Review.

PMID:
20303186
48.

Genetics and phenomics of hypothyroidism due to TSH resistance.

Persani L, Calebiro D, Cordella D, Weber G, Gelmini G, Libri D, de Filippis T, Bonomi M.

Mol Cell Endocrinol. 2010 Jun 30;322(1-2):72-82. doi: 10.1016/j.mce.2010.01.008. Epub 2010 Jan 18. Review.

PMID:
20083154
49.

Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1.

Klenk C, Schulz S, Calebiro D, Lohse MJ.

J Biol Chem. 2010 Mar 19;285(12):8665-74. doi: 10.1074/jbc.M109.058685. Epub 2010 Jan 15.

50.

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.

Calebiro D, Nikolaev VO, Gagliani MC, de Filippis T, Dees C, Tacchetti C, Persani L, Lohse MJ.

PLoS Biol. 2009 Aug;7(8):e1000172. doi: 10.1371/journal.pbio.1000172. Epub 2009 Aug 18.

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