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Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice.

Pandya CD, Lee B, Toque HA, Mendhe B, Bragg RT, Pandya B, Atawia RT, Isales C, Hamrick M, Caldwell RW, Fulzele S.

Oxid Med Cell Longev. 2019 May 8;2019:1704650. doi: 10.1155/2019/1704650. eCollection 2019.


Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation.

Mazrouei S, Sharifpanah F, Caldwell RW, Franz M, Shatanawi A, Muessig J, Fritzenwanger M, Schulze PC, Jung C.

Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1398-1411. doi: 10.1016/j.bbamcr.2019.05.004. Epub 2019 May 28.


Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress.

Lv H, Zhu C, Wu R, Ni H, Lian J, Xu Y, Xia Y, Shi G, Li Z, Caldwell RB, Caldwell RW, Yao L, Chen Y.

J Psychiatr Res. 2019 Jul;114:55-66. doi: 10.1016/j.jpsychires.2019.04.008. Epub 2019 Apr 23.


Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.

Atawia RT, Toque HA, Meghil MM, Benson TW, Yiew NKH, Cutler CW, Weintraub NL, Caldwell RB, Caldwell RW.

Int J Mol Sci. 2019 Mar 22;20(6). pii: E1462. doi: 10.3390/ijms20061462.


The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

Madaio MP, Czikora I, Kvirkvelia N, McMenamin M, Yue Q, Liu T, Toque HA, Sridhar S, Covington K, Alaisami R, O'Connor PM, Caldwell RW, Chen JK, Clauss M, Brands MW, Eaton DC, Romero MJ, Lucas R.

Kidney Int. 2019 Jun;95(6):1359-1372. doi: 10.1016/j.kint.2018.12.022. Epub 2019 Mar 21.


Mechanisms of obesity-induced metabolic and vascular dysfunctions.

Atawia RT, Bunch KL, Toque HA, Caldwell RB, Caldwell RW.

Front Biosci (Landmark Ed). 2019 Mar 1;24:890-934. Review.


Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2.

Xu Z, Fouda AY, Lemtalsi T, Shosha E, Rojas M, Liu F, Patel C, Caldwell RW, Narayanan SP, Caldwell RB.

Front Neurosci. 2018 Dec 20;12:970. doi: 10.3389/fnins.2018.00970. eCollection 2018.


Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.

Chandra S, Fulton DJR, Caldwell RB, Caldwell RW, Toque HA.

Eur J Pharmacol. 2019 Feb 5;844:26-37. doi: 10.1016/j.ejphar.2018.11.027. Epub 2018 Nov 28.


Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.

Fouda AY, Xu Z, Shosha E, Lemtalsi T, Chen J, Toque HA, Tritz R, Cui X, Stansfield BK, Huo Y, Rodriguez PC, Smith SB, Caldwell RW, Narayanan SP, Caldwell RB.

Cell Death Dis. 2018 Sep 25;9(10):1001. doi: 10.1038/s41419-018-1051-6.


Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.

Shosha E, Xu Z, Narayanan SP, Lemtalsi T, Fouda AY, Rojas M, Xing J, Fulton D, Caldwell RW, Caldwell RB.

Int J Mol Sci. 2018 Apr 17;19(4). pii: E1215. doi: 10.3390/ijms19041215.


Arginase: A Multifaceted Enzyme Important in Health and Disease.

Caldwell RW, Rodriguez PC, Toque HA, Narayanan SP, Caldwell RB.

Physiol Rev. 2018 Apr 1;98(2):641-665. doi: 10.1152/physrev.00037.2016. Review.


Netrin-1 is a novel regulator of vascular endothelial function in diabetes.

Toque HA, Fernandez-Flores A, Mohamed R, Caldwell RB, Ramesh G, Caldwell RW.

PLoS One. 2017 Oct 23;12(10):e0186734. doi: 10.1371/journal.pone.0186734. eCollection 2017.


Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.

Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW.

Cardiovasc Res. 2017 Nov 1;113(13):1664-1676. doi: 10.1093/cvr/cvx164. Erratum in: Cardiovasc Res. 2018 Jan 1;114(1):64.


Obesity-induced vascular inflammation involves elevated arginase activity.

Yao L, Bhatta A, Xu Z, Chen J, Toque HA, Chen Y, Xu Y, Bagi Z, Lucas R, Huo Y, Caldwell RB, Caldwell RW.

Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R560-R571. doi: 10.1152/ajpregu.00529.2016. Epub 2017 Aug 23.


NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence.

Rojas M, Lemtalsi T, Toque HA, Xu Z, Fulton D, Caldwell RW, Caldwell RB.

Antioxidants (Basel). 2017 Jun 15;6(2). pii: E43. doi: 10.3390/antiox6020043.


Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock.

Subramani K, Lu S, Warren M, Chu X, Toque HA, Caldwell RW, Diamond MP, Raju R.

Sci Rep. 2017 Jun 1;7(1):2671. doi: 10.1038/s41598-017-02495-5.


Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury.

Shosha E, Xu Z, Yokota H, Saul A, Rojas M, Caldwell RW, Caldwell RB, Narayanan SP.

Cell Death Dis. 2016 Nov 24;7(11):e2483. doi: 10.1038/cddis.2016.295.


Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.

Patel C, Xu Z, Shosha E, Xing J, Lucas R, Caldwell RW, Caldwell RB, Narayanan SP.

Biochim Biophys Acta. 2016 Sep;1862(9):1628-39. doi: 10.1016/j.bbadis.2016.05.020. Epub 2016 May 27.


Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.

Bhatta A, Sangani R, Kolhe R, Toque HA, Cain M, Wong A, Howie N, Shinde R, Elsalanty M, Yao L, Chutkan N, Hunter M, Caldwell RB, Isales C, Caldwell RW, Fulzele S.

Mol Cell Endocrinol. 2016 Feb 15;422:211-220. doi: 10.1016/j.mce.2015.12.005. Epub 2015 Dec 17.


δPKC interaction with the d subunit of F1Fo ATP synthase impairs energetics and exacerbates ischemia/reperfusion injury in isolated rat hearts.

Walker M, Caldwell RW, Yoon Y, Nguyen TT, Johnson JA.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):232-40. doi: 10.1016/j.yjmcc.2015.10.030. Epub 2015 Oct 28.


Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma.

Ha Y, Liu H, Xu Z, Yokota H, Narayanan SP, Lemtalsi T, Smith SB, Caldwell RW, Caldwell RB, Zhang W.

Cell Death Dis. 2015 Oct 8;6:e1900. doi: 10.1038/cddis.2015.281.


Arginase: an old enzyme with new tricks.

Caldwell RB, Toque HA, Narayanan SP, Caldwell RW.

Trends Pharmacol Sci. 2015 Jun;36(6):395-405. doi: 10.1016/ Epub 2015 Apr 27. Review.


Correction: angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.

Bhatta A, Yao L, Toque HA, Shatanawi A, Xu Z, Caldwell RB, Caldwell RW.

PLoS One. 2015 Apr 21;10(4):e0127110. doi: 10.1371/journal.pone.0127110. eCollection 2015. No abstract available.


Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.

Bhatta A, Yao L, Toque HA, Shatanawi A, Xu Z, Caldwell RB, Caldwell RW.

PLoS One. 2015 Mar 25;10(3):e0121727. doi: 10.1371/journal.pone.0121727. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127110.


Arginase in the vascular endothelium: friend or foe?

Lucas R, Fulton D, Caldwell RW, Romero MJ.

Front Immunol. 2014 Nov 17;5:589. doi: 10.3389/fimmu.2014.00589. eCollection 2014. No abstract available.


Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway.

Shatanawi A, Lemtalsi T, Yao L, Patel C, Caldwell RB, Caldwell RW.

Eur J Pharmacol. 2015 Jan 5;746:106-14. doi: 10.1016/j.ejphar.2014.10.042. Epub 2014 Oct 30.


Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.

Wang L, Bhatta A, Toque HA, Rojas M, Yao L, Xu Z, Patel C, Caldwell RB, Caldwell RW.

Microvasc Res. 2015 Mar;98:1-8. doi: 10.1016/j.mvr.2014.11.002. Epub 2014 Nov 7.


Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration.

Suwanpradid J, Rojas M, Behzadian MA, Caldwell RW, Caldwell RB.

PLoS One. 2014 Nov 6;9(11):e110604. doi: 10.1371/journal.pone.0110604. eCollection 2014.


Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.

Patel C, Narayanan SP, Zhang W, Xu Z, Sukumari-Ramesh S, Dhandapani KM, Caldwell RW, Caldwell RB.

Am J Pathol. 2014 Nov;184(11):3040-51. doi: 10.1016/j.ajpath.2014.07.012. Epub 2014 Sep 6.


New approaches to the design and discovery of therapies to prevent erectile dysfunction.

Toque HA, Caldwell RW.

Expert Opin Drug Discov. 2014 Dec;9(12):1447-69. doi: 10.1517/17460441.2014.949234. Epub 2014 Sep 6. Review.


Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism.

Narayanan SP, Xu Z, Putluri N, Sreekumar A, Lemtalsi T, Caldwell RW, Caldwell RB.

Cell Death Dis. 2014 Feb 20;5:e1075. doi: 10.1038/cddis.2014.23.


l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice.

Romero MJ, Yao L, Sridhar S, Bhatta A, Dou H, Ramesh G, Brands MW, Pollock DM, Caldwell RB, Cederbaum SD, Head CA, Bagi Z, Lucas R, Caldwell RW.

Front Immunol. 2013 Dec 24;4:480. doi: 10.3389/fimmu.2013.00480. eCollection 2013.


Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury.

Rojas M, Zhang W, Xu Z, Lemtalsi T, Chandler P, Toque HA, Caldwell RW, Caldwell RB.

PLoS One. 2013 Dec 17;8(12):e84357. doi: 10.1371/journal.pone.0084357. eCollection 2013.


Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.

Toque HA, Nunes KP, Yao L, Xu Z, Kondrikov D, Su Y, Webb RC, Caldwell RB, Caldwell RW.

PLoS One. 2013 Aug 19;8(8):e72277. doi: 10.1371/journal.pone.0072277. eCollection 2013.


Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Front Immunol. 2013 Aug 7;4:228. doi: 10.3389/fimmu.2013.00228. eCollection 2013.


Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension.

Toque HA, Nunes KP, Rojas M, Bhatta A, Yao L, Xu Z, Romero MJ, Webb RC, Caldwell RB, Caldwell RW.

Front Immunol. 2013 Jul 29;4:219. doi: 10.3389/fimmu.2013.00219. eCollection 2013.


Arginase as a mediator of diabetic retinopathy.

Patel C, Rojas M, Narayanan SP, Zhang W, Xu Z, Lemtalsi T, Jittiporn K, Caldwell RW, Caldwell RB.

Front Immunol. 2013 Jul 3;4:173. doi: 10.3389/fimmu.2013.00173. eCollection 2013.


Arginase in retinopathy.

Narayanan SP, Rojas M, Suwanpradid J, Toque HA, Caldwell RW, Caldwell RB.

Prog Retin Eye Res. 2013 Sep;36:260-80. doi: 10.1016/j.preteyeres.2013.06.002. Epub 2013 Jul 3. Review.


Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.

Toque HA, Nunes KP, Yao L, Liao JK, Webb RC, Caldwell RB, Caldwell RW.

J Sex Med. 2013 Jun;10(6):1502-15. doi: 10.1111/jsm.12134. Epub 2013 Apr 8.


Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway.

Liu H, Zhang W, Xu Z, Caldwell RW, Caldwell RB, Brooks SE.

Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):918-31. doi: 10.1167/iovs.12-11291.


Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.

Yao L, Chandra S, Toque HA, Bhatta A, Rojas M, Caldwell RB, Caldwell RW.

Cardiovasc Res. 2013 Mar 1;97(3):509-19. doi: 10.1093/cvr/cvs371. Epub 2012 Dec 17.


The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.

Elms SC, Toque HA, Rojas M, Xu Z, Caldwell RW, Caldwell RB.

Diabetologia. 2013 Mar;56(3):654-62. doi: 10.1007/s00125-012-2789-5. Epub 2012 Dec 12.


Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.

Anea CB, Cheng B, Sharma S, Kumar S, Caldwell RW, Yao L, Ali MI, Merloiu AM, Stepp DW, Black SM, Fulton DJ, Rudic RD.

Circ Res. 2012 Oct 12;111(9):1157-65. doi: 10.1161/CIRCRESAHA.111.261750. Epub 2012 Aug 20.


Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10.


Toxicity and cellular uptake of gold nanorods in vascular endothelium and smooth muscles of isolated rat blood vessel: importance of surface modification.

Alkilany AM, Shatanawi A, Kurtz T, Caldwell RB, Caldwell RW.

Small. 2012 Apr 23;8(8):1270-8. doi: 10.1002/smll.201101948. Epub 2012 Feb 15.


Diabetes-induced vascular dysfunction involves arginase I.

Romero MJ, Iddings JA, Platt DH, Ali MI, Cederbaum SD, Stepp DW, Caldwell RB, Caldwell RW.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H159-66. doi: 10.1152/ajpheart.00774.2011. Epub 2011 Nov 4.


Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.

Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y.

J Clin Invest. 2011 Nov;121(11):4548-66. doi: 10.1172/JCI57734. Epub 2011 Oct 17.


Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice.

Nunes KP, Toque HA, Caldwell RB, Caldwell RW, Webb RC.

J Sex Med. 2011 Dec;8(12):3335-44. doi: 10.1111/j.1743-6109.2011.02499.x. Epub 2011 Oct 13. Erratum in: J Sex Med. 2015 Jul;12(7):1657.


Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.

Cheng B, Anea CB, Yao L, Chen F, Patel V, Merloiu A, Pati P, Caldwell RW, Fulton DJ, Rudic RD.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17147-52. doi: 10.1073/pnas.1112998108. Epub 2011 Oct 3.


Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion.

Yokota H, Narayanan SP, Zhang W, Liu H, Rojas M, Xu Z, Lemtalsi T, Nagaoka T, Yoshida A, Brooks SE, Caldwell RW, Caldwell RB.

Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8123-31. doi: 10.1167/iovs.11-8318.

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