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Items: 1 to 50 of 172

1.

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization.

Zhang H, Hudson FZ, Xu Z, Tritz R, Rojas M, Patel C, Haigh SB, Bordán Z, Ingram DA, Fulton DJ, Weintraub NL, Caldwell RB, Stansfield BK.

Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2520-2528. doi: 10.1167/iovs.17-22588.

2.

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy.

Rojas MA, Shen ZT, Caldwell RB, Sigalov AB.

Biochim Biophys Acta. 2018 May 3. pii: S0925-4439(18)30170-4. doi: 10.1016/j.bbadis.2018.05.001. [Epub ahead of print]

PMID:
29730341
3.

Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.

Shosha E, Xu Z, Narayanan SP, Lemtalsi T, Fouda AY, Rojas M, Xing J, Fulton D, Caldwell RW, Caldwell RB.

Int J Mol Sci. 2018 Apr 17;19(4). pii: E1215. doi: 10.3390/ijms19041215.

4.

Gain-of-function analysis of cis-acting diversification elements in DT40 cells.

Caldwell RB, Braselmann H, Heuer S, Schötz U, Zitzelsberger H.

Immunol Cell Biol. 2018 Apr 17. doi: 10.1111/imcb.12158. [Epub ahead of print]

PMID:
29665088
5.

Arginase: A Multifaceted Enzyme Important in Health and Disease.

Caldwell RW, Rodriguez PC, Toque HA, Narayanan SP, Caldwell RB.

Physiol Rev. 2018 Apr 1;98(2):641-665. doi: 10.1152/physrev.00037.2016.

PMID:
29412048
6.

Netrin-1 is a novel regulator of vascular endothelial function in diabetes.

Toque HA, Fernandez-Flores A, Mohamed R, Caldwell RB, Ramesh G, Caldwell RW.

PLoS One. 2017 Oct 23;12(10):e0186734. doi: 10.1371/journal.pone.0186734. eCollection 2017.

7.

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.

Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW.

Cardiovasc Res. 2017 Nov 1;113(13):1664-1676. doi: 10.1093/cvr/cvx164.

PMID:
29048462
8.

Correction: Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2017 Oct 16;12(10):e0186749. doi: 10.1371/journal.pone.0186749. eCollection 2017.

9.

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.

Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y.

Nat Commun. 2017 Sep 19;8(1):584. doi: 10.1038/s41467-017-00551-2.

10.

Obesity-induced vascular inflammation involves elevated arginase activity.

Yao L, Bhatta A, Xu Z, Chen J, Toque HA, Chen Y, Xu Y, Bagi Z, Lucas R, Huo Y, Caldwell RB, Caldwell RW.

Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R560-R571. doi: 10.1152/ajpregu.00529.2016. Epub 2017 Aug 23.

PMID:
28835451
11.

NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence.

Rojas M, Lemtalsi T, Toque HA, Xu Z, Fulton D, Caldwell RW, Caldwell RB.

Antioxidants (Basel). 2017 Jun 15;6(2). pii: E43. doi: 10.3390/antiox6020043.

12.

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury.

Shosha E, Xu Z, Yokota H, Saul A, Rojas M, Caldwell RW, Caldwell RB, Narayanan SP.

Cell Death Dis. 2016 Nov 24;7(11):e2483. doi: 10.1038/cddis.2016.295.

13.

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB.

J Cell Sci. 2016 Aug 15;129(16):3203. doi: 10.1242/jcs.195966. No abstract available.

14.

Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells.

Caldwell RB, Braselmann H, Schoetz U, Heuer S, Scherthan H, Zitzelsberger H.

Sci Rep. 2016 Jul 4;6:28890. doi: 10.1038/srep28890.

15.

Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.

Penterling C, Drexler GA, Böhland C, Stamp R, Wilke C, Braselmann H, Caldwell RB, Reindl J, Girst S, Greubel C, Siebenwirth C, Mansour WY, Borgmann K, Dollinger G, Unger K, Friedl AA.

PLoS One. 2016 Jun 2;11(6):e0156599. doi: 10.1371/journal.pone.0156599. eCollection 2016.

16.

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.

Patel C, Xu Z, Shosha E, Xing J, Lucas R, Caldwell RW, Caldwell RB, Narayanan SP.

Biochim Biophys Acta. 2016 Sep;1862(9):1628-39. doi: 10.1016/j.bbadis.2016.05.020. Epub 2016 May 27.

17.

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.

Bhatta A, Sangani R, Kolhe R, Toque HA, Cain M, Wong A, Howie N, Shinde R, Elsalanty M, Yao L, Chutkan N, Hunter M, Caldwell RB, Isales C, Caldwell RW, Fulzele S.

Mol Cell Endocrinol. 2016 Feb 15;422:211-220. doi: 10.1016/j.mce.2015.12.005. Epub 2015 Dec 17.

18.

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma.

Ha Y, Liu H, Xu Z, Yokota H, Narayanan SP, Lemtalsi T, Smith SB, Caldwell RW, Caldwell RB, Zhang W.

Cell Death Dis. 2015 Oct 8;6:e1900. doi: 10.1038/cddis.2015.281.

19.

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury.

Shimouchi A, Yokota H, Ono S, Matsumoto C, Tamai T, Takumi H, Narayanan SP, Kimura S, Kobayashi H, Caldwell RB, Nagaoka T, Yoshida A.

Jpn J Ophthalmol. 2016 Jan;60(1):51-61. doi: 10.1007/s10384-015-0415-z. Epub 2015 Sep 25.

20.

Arginase: an old enzyme with new tricks.

Caldwell RB, Toque HA, Narayanan SP, Caldwell RW.

Trends Pharmacol Sci. 2015 Jun;36(6):395-405. doi: 10.1016/j.tips.2015.03.006. Epub 2015 Apr 27. Review.

21.

Correction: angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.

Bhatta A, Yao L, Toque HA, Shatanawi A, Xu Z, Caldwell RB, Caldwell RW.

PLoS One. 2015 Apr 21;10(4):e0127110. doi: 10.1371/journal.pone.0127110. eCollection 2015. No abstract available.

22.

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.

Bhatta A, Yao L, Toque HA, Shatanawi A, Xu Z, Caldwell RB, Caldwell RW.

PLoS One. 2015 Mar 25;10(3):e0121727. doi: 10.1371/journal.pone.0121727. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127110.

23.

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway.

Shatanawi A, Lemtalsi T, Yao L, Patel C, Caldwell RB, Caldwell RW.

Eur J Pharmacol. 2015 Jan 5;746:106-14. doi: 10.1016/j.ejphar.2014.10.042. Epub 2014 Oct 30.

24.

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.

Wang L, Bhatta A, Toque HA, Rojas M, Yao L, Xu Z, Patel C, Caldwell RB, Caldwell RW.

Microvasc Res. 2015 Mar;98:1-8. doi: 10.1016/j.mvr.2014.11.002. Epub 2014 Nov 7.

25.

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration.

Suwanpradid J, Rojas M, Behzadian MA, Caldwell RW, Caldwell RB.

PLoS One. 2014 Nov 6;9(11):e110604. doi: 10.1371/journal.pone.0110604. eCollection 2014.

26.

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.

Patel C, Narayanan SP, Zhang W, Xu Z, Sukumari-Ramesh S, Dhandapani KM, Caldwell RW, Caldwell RB.

Am J Pathol. 2014 Nov;184(11):3040-51. doi: 10.1016/j.ajpath.2014.07.012. Epub 2014 Sep 6.

27.

Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure.

Schoetz U, Deliolanis NC, Ng D, Pauli J, Resch-Genger U, Kühn E, Heuer S, Beisker W, Köster RW, Zitzelsberger H, Caldwell RB.

PLoS One. 2014 Sep 5;9(9):e107069. doi: 10.1371/journal.pone.0107069. eCollection 2014.

28.

Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin.

Jittiporn K, Suwanpradid J, Patel C, Rojas M, Thirawarapan S, Moongkarndi P, Suvitayavat W, Caldwell RB.

Microvasc Res. 2014 May;93:72-9. doi: 10.1016/j.mvr.2014.03.005. Epub 2014 Apr 8.

29.

Endothelial PFKFB3 plays a critical role in angiogenesis.

Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041. Epub 2014 Apr 3.

30.

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism.

Narayanan SP, Xu Z, Putluri N, Sreekumar A, Lemtalsi T, Caldwell RW, Caldwell RB.

Cell Death Dis. 2014 Feb 20;5:e1075. doi: 10.1038/cddis.2014.23.

31.

l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice.

Romero MJ, Yao L, Sridhar S, Bhatta A, Dou H, Ramesh G, Brands MW, Pollock DM, Caldwell RB, Cederbaum SD, Head CA, Bagi Z, Lucas R, Caldwell RW.

Front Immunol. 2013 Dec 24;4:480. doi: 10.3389/fimmu.2013.00480. eCollection 2013.

32.

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury.

Rojas M, Zhang W, Xu Z, Lemtalsi T, Chandler P, Toque HA, Caldwell RW, Caldwell RB.

PLoS One. 2013 Dec 17;8(12):e84357. doi: 10.1371/journal.pone.0084357. eCollection 2013.

33.

Proteomic strategies: SILAC and 2D-DIGE-powerful tool to investigate cellular alterations.

Sriharshan A, Azimzadeh O, Caldwell RB, Tapio S.

Methods Mol Biol. 2014;1101:369-92. doi: 10.1007/978-1-62703-721-1_18.

PMID:
24233791
34.

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.

Toque HA, Nunes KP, Yao L, Xu Z, Kondrikov D, Su Y, Webb RC, Caldwell RB, Caldwell RW.

PLoS One. 2013 Aug 19;8(8):e72277. doi: 10.1371/journal.pone.0072277. eCollection 2013.

35.

Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2013 Aug 7;8(8):e71868. doi: 10.1371/journal.pone.0071868. eCollection 2013. Erratum in: PLoS One. 2017 Oct 16;12 (10 ):e0186749.

36.

Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension.

Toque HA, Nunes KP, Rojas M, Bhatta A, Yao L, Xu Z, Romero MJ, Webb RC, Caldwell RB, Caldwell RW.

Front Immunol. 2013 Jul 29;4:219. doi: 10.3389/fimmu.2013.00219. eCollection 2013.

37.

Arginase as a mediator of diabetic retinopathy.

Patel C, Rojas M, Narayanan SP, Zhang W, Xu Z, Lemtalsi T, Jittiporn K, Caldwell RW, Caldwell RB.

Front Immunol. 2013 Jul 3;4:173. doi: 10.3389/fimmu.2013.00173. eCollection 2013.

38.

Arginase in retinopathy.

Narayanan SP, Rojas M, Suwanpradid J, Toque HA, Caldwell RW, Caldwell RB.

Prog Retin Eye Res. 2013 Sep;36:260-80. doi: 10.1016/j.preteyeres.2013.06.002. Epub 2013 Jul 3. Review.

39.

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS.

Elms S, Chen F, Wang Y, Qian J, Askari B, Yu Y, Pandey D, Iddings J, Caldwell RB, Fulton DJ.

Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H651-66. doi: 10.1152/ajpheart.00755.2012. Epub 2013 Jun 21.

40.

Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.

Toque HA, Nunes KP, Yao L, Liao JK, Webb RC, Caldwell RB, Caldwell RW.

J Sex Med. 2013 Jun;10(6):1502-15. doi: 10.1111/jsm.12134. Epub 2013 Apr 8.

41.

Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway.

Liu H, Zhang W, Xu Z, Caldwell RW, Caldwell RB, Brooks SE.

Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):918-31. doi: 10.1167/iovs.12-11291.

42.

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.

Yao L, Chandra S, Toque HA, Bhatta A, Rojas M, Caldwell RB, Caldwell RW.

Cardiovasc Res. 2013 Mar 1;97(3):509-19. doi: 10.1093/cvr/cvs371. Epub 2012 Dec 17.

43.

The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.

Elms SC, Toque HA, Rojas M, Xu Z, Caldwell RW, Caldwell RB.

Diabetologia. 2013 Mar;56(3):654-62. doi: 10.1007/s00125-012-2789-5. Epub 2012 Dec 12.

44.

Langerhans cell sarcoma in a patient with hairy cell leukemia: common clonal origin indicated by identical immunoglobulin gene rearrangements.

Furmanczyk PS, Lisle AE, Caldwell RB, Kraemer KG, Mercer SE, George E, Argenyi ZB.

J Cutan Pathol. 2012 Jun;39(6):644-50. doi: 10.1111/j.1600-0560.2012.01873.x.

PMID:
22616604
45.

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10.

46.

Blockade of VEGF-induced GSK/β-catenin signaling, uPAR expression and increased permeability by dominant negative p38α.

Yang J, Caldwell RB, Behzadian MA.

Exp Eye Res. 2012 Jul;100:101-8. doi: 10.1016/j.exer.2012.03.011. Epub 2012 Apr 30.

47.

Toxicity and cellular uptake of gold nanorods in vascular endothelium and smooth muscles of isolated rat blood vessel: importance of surface modification.

Alkilany AM, Shatanawi A, Kurtz T, Caldwell RB, Caldwell RW.

Small. 2012 Apr 23;8(8):1270-8. doi: 10.1002/smll.201101948. Epub 2012 Feb 15.

48.

Global photographic assessment of men aged 18 to 60 years with male pattern hair loss receiving finasteride 1 mg or placebo.

Olsen EA, Whiting DA, Savin R, Rodgers A, Johnson-Levonas AO, Round E, Rotonda J, Kaufman KD; Male Pattern Hair Loss Study Group.

J Am Acad Dermatol. 2012 Sep;67(3):379-86. doi: 10.1016/j.jaad.2011.10.027. Epub 2012 Feb 9.

PMID:
22325459
49.

Diabetes-induced vascular dysfunction involves arginase I.

Romero MJ, Iddings JA, Platt DH, Ali MI, Cederbaum SD, Stepp DW, Caldwell RB, Caldwell RW.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H159-66. doi: 10.1152/ajpheart.00774.2011. Epub 2011 Nov 4.

50.

Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice.

Nunes KP, Toque HA, Caldwell RB, Caldwell RW, Webb RC.

J Sex Med. 2011 Dec;8(12):3335-44. doi: 10.1111/j.1743-6109.2011.02499.x. Epub 2011 Oct 13. Erratum in: J Sex Med. 2015 Jul;12(7):1657.

PMID:
21995824

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