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Items: 1 to 50 of 61

1.

Editorial: Metabolomics.

Caldwell GW.

Curr Top Med Chem. 2017;17(24):2715. doi: 10.2174/156802661724170828093315. No abstract available.

PMID:
28923000
2.

An In Vivo Rat α-D-glucose Stable Isotope Homeostasis Drug Discovery Screen: A Targeted Metabolomics Approach.

Caldwell GW, Lang W.

Curr Top Med Chem. 2017;17(24):2791-2804. doi: 10.2174/1568026617666170707130401.

PMID:
28685696
3.

Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?

Caldwell GW, Leo GC.

Curr Top Med Chem. 2017;17(24):2716-2739. doi: 10.2174/1568026617666170707130032. Review.

PMID:
28685690
4.

Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors.

Qi J, Masucci JA, Lang W, Connelly MA, Caldwell GW, Petrounia I, Kirkpatrick J, Barnakov AN, Struble G, Miller R, Dzordzorine K, Kuo GH, Gaul M, Pocai A, Lee S.

SLAS Discov. 2017 Apr;22(4):433-439. doi: 10.1177/2472555217690101. Epub 2017 Jan 31.

PMID:
28328322
5.

Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.

Qi J, Lang W, Connelly MA, Du F, Liang Y, Caldwell GW, Martin T, Hansen MK, Kuo GH, Gaul MD, Pocai A, Lee S.

Anal Biochem. 2017 May 1;524:68-75. doi: 10.1016/j.ab.2016.09.017. Epub 2016 Sep 22.

PMID:
27665677
6.

In silico tools used for compound selection during target-based drug discovery and development.

Caldwell GW.

Expert Opin Drug Discov. 2015;10(8):901-23. doi: 10.1517/17460441.2015.1043885. Epub 2015 May 8. Review.

PMID:
25952011
7.

In vitro identification of cytochrome P450 enzymes responsible for drug metabolism.

Yan Z, Caldwell GW.

Methods Mol Biol. 2013;1015:251-61. doi: 10.1007/978-1-62703-435-7_16.

PMID:
23824861
8.

Pharmaceutical R&D: a knowledge-intensive multidisciplinary approach.

Caldwell GW.

Curr Top Med Chem. 2012;12(11):1223. No abstract available.

PMID:
22757639
9.

Small molecule compound logistics outsourcing--going beyond the "thought experiment".

Ramsay DL, Kwasnoski JD, Caldwell GW.

Curr Top Med Chem. 2012;12(11):1298-308. Review.

PMID:
22571792
10.
11.

The IC(50) concept revisited.

Caldwell GW, Yan Z, Lang W, Masucci JA.

Curr Top Med Chem. 2012;12(11):1282-90. Review.

PMID:
22571790
12.

A novel method for determination of drug distribution in rat brain tissue sections by LC/MS/MS: functional tissue microanalysis.

Masucci JA, Mahan AD, Kwasnoski JD, Caldwell GW.

Curr Top Med Chem. 2012;12(11):1243-9.

PMID:
22571786
13.

Editorial:Pharmaceutical R &D: A Knowledge-Intensive MultiDisciplinary Approach.

Caldwell GW.

Curr Top Med Chem. 2012 May 7. [Epub ahead of print] No abstract available.

PMID:
22571784
14.

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA.

J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3.

15.

An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase.

Yan Z, Tounge B, Caldwell GW.

Rapid Commun Mass Spectrom. 2012 Jan 15;26(1):49-60. doi: 10.1002/rcm.5297.

PMID:
22215578
16.

High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity.

Qi J, Lang W, Giardino E, Caldwell GW, Smith C, Minor LK, Darrow AL, Willemsens G, Dewaepenaert K, Roevens P, Linders JT, Liang Y, Connelly MA.

J Lipid Res. 2010 Dec;51(12):3559-67. doi: 10.1194/jlr.D008029. Epub 2010 Aug 28.

17.

Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors.

Dasgupta M, Tang W, Caldwell GW, Yan Z.

Rapid Commun Mass Spectrom. 2010 Aug 15;24(15):2177-85. doi: 10.1002/rcm.4610.

PMID:
20583325
18.

ADME optimization and toxicity assessment in early- and late-phase drug discovery.

Caldwell GW, Yan Z, Tang W, Dasgupta M, Hasting B.

Curr Top Med Chem. 2009;9(11):965-80. Review.

PMID:
19747120
19.
20.

Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix.

Yan Z, Maher N, Torres R, Cotto C, Hastings B, Dasgupta M, Hyman R, Huebert N, Caldwell GW.

Rapid Commun Mass Spectrom. 2008 Jul;22(13):2021-8. doi: 10.1002/rcm.3577.

PMID:
18512848
21.

Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and implications.

Lang W, Caldwell GW, Li J, Leo GC, Jones WJ, Masucci JA.

Drug Metab Dispos. 2007 Jan;35(1):21-9. Epub 2006 Sep 29.

PMID:
17012542
22.

N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases.

Yan Z, Caldwell GW, Gauthier D, Leo GC, Mei J, Ho CY, Jones WJ, Masucci JA, Tuman RW, Galemmo RA Jr, Johnson DL.

Drug Metab Dispos. 2006 May;34(5):748-55. Epub 2006 Feb 2.

PMID:
16455802
23.

Screening for reactive intermediates and toxicity assessment in drug discovery.

Caldwell GW, Yan Z.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):47-60. Review.

PMID:
16445117
24.

Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats.

Caldwell GW, Wu WN, McKown LA, Diane Gauthier A, Masucci JA, Jones WJ, Leo GC, Reitz AB.

J Pharm Biomed Anal. 2006 May 3;41(2):500-9. Epub 2005 Dec 28.

PMID:
16386397
25.

Metabolism and excretion of the antiepileptic/antimigraine drug, Topiramate in animals and humans.

Caldwell GW, Wu WN, Masucci JA, McKown LA, Gauthier D, Jones WJ, Leo GC, Maryanoff BE.

Eur J Drug Metab Pharmacokinet. 2005 Jul-Sep;30(3):151-64.

PMID:
16250251
26.

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.

Yan Z, Maher N, Torres R, Caldwell GW, Huebert N.

Rapid Commun Mass Spectrom. 2005;19(22):3322-30.

PMID:
16235238
27.

Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.

Yan Z, Zhong HM, Maher N, Torres R, Leo GC, Caldwell GW, Huebert N.

Drug Metab Dispos. 2005 Dec;33(12):1867-76. Epub 2005 Sep 20.

PMID:
16174805
28.

The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens.

Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Cotto C, Hall J, Hasting B, Jones W.

Eur J Drug Metab Pharmacokinet. 2005 Jan-Jun;30(1-2):75-83.

PMID:
16010865
30.

The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model.

Leo GC, Caldwell GW, Crooke J, Malatynska E, Cotto C, Hastings B, Scowcroft J, Hall J, Browne K, Hageman W.

Anal Biochem. 2005 Apr 1;339(1):174-8.

PMID:
15766725
31.

Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.

Yan Z, Li J, Huebert N, Caldwell GW, Du Y, Zhong H.

Drug Metab Dispos. 2005 Jun;33(6):706-13. Epub 2005 Mar 11.

PMID:
15764717
32.
34.

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

Caldwell GW, Masucci JA, Yan Z, Hageman W.

Eur J Drug Metab Pharmacokinet. 2004 Apr-Jun;29(2):133-43.

PMID:
15230342
35.

A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry.

Yan Z, Caldwell GW, Zhao B, Reitz AB.

Rapid Commun Mass Spectrom. 2004;18(8):834-40.

PMID:
15095350
36.

Metabolic assessment in liver microsomes by co-activating cytochrome P450s and UDP-glycosyltransferases.

Yan Z, Caldwell GW.

Eur J Drug Metab Pharmacokinet. 2003 Jul-Sep;28(3):223-32.

PMID:
14527096
37.

Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses.

Yan Z, Caldwell GW, Jones WJ, Masucci JA.

Rapid Commun Mass Spectrom. 2003;17(13):1433-42.

PMID:
12820208
38.

Application of flow NMR to an open-access pharmaceutical environment.

Leo GC, Krikava A, Caldwell GW.

Anal Chem. 2003 Apr 15;75(8):1954-7.

PMID:
12713056
39.

Rapidly distinguishing reversible and irreversible CYP450 inhibitors by using fluorometric kinetic analyses.

Yan Z, Rafferty B, Caldwell GW, Masucci JA.

Eur J Drug Metab Pharmacokinet. 2002 Oct-Dec;27(4):281-7.

PMID:
12587958
40.

In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.

Yan Z, Caldwell GW, Wu WN, McKown LA, Rafferty B, Jones W, Masucci JA.

Xenobiotica. 2002 Nov;32(11):949-62.

PMID:
12487725
41.

Evaluation of the excretion and metabolism of the new analgesic agent RWJ-22757 in male and female CR Wistar rats.

Wu WN, Caldwell GW, Masucci JA.

J Pharm Biomed Anal. 2002 May 15;28(3-4):659-71.

PMID:
12008146
42.

Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery.

Yan Z, Caldwell GW.

Curr Top Med Chem. 2001 Nov;1(5):403-25. Review.

PMID:
11899105
43.

The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery.

Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Yan Z.

Curr Top Med Chem. 2001 Nov;1(5):353-66. Review.

PMID:
11899102
44.

Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs.

Wu WN, Caldwell GW, Masucci JA, Gauthier AD.

Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):263-71.

PMID:
11808869
45.

Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man.

Caldwell GW, Wu WN, Masucci JA.

Xenobiotica. 2001 Nov;31(11):823-39.

PMID:
11765144
46.
47.

A simple method to improve spectral quality in matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometric analysis by using Micro Mate labeling tape as a sample support.

Yan Z, Caldwell GW, Jones WJ, Masucci JA.

Anal Biochem. 2000 Jan 15;277(2):267-70. No abstract available. Erratum in: Anal Biochem 2000 Jul 1;282(2):266.

PMID:
10625517
49.

Using affinity capillary electrophoresis to study the interaction of the extracellular binding domain of erythropoietin receptor with peptides.

Caldwell GW, McDonnell PA, Masucci JA, Johnson DL, Jolliffe LK.

J Biochem Biophys Methods. 1999 Jul 28;40(1-2):17-25.

PMID:
10481948
50.

Identification of a gluconic acid derivative attached to the N-terminus of histidine-tagged proteins expressed in bacteria.

Yan Z, Caldwell GW, McDonell PA.

Biochem Biophys Res Commun. 1999 Sep 7;262(3):793-800.

PMID:
10471404

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