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Items: 1 to 50 of 83

1.

Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading.

Kadry YA, Huet-Calderwood C, Simon B, Calderwood DA.

J Cell Sci. 2018 Oct 26;131(20). pii: jcs221184. doi: 10.1242/jcs.221184.

PMID:
30254023
2.

Structural basis of the filamin A actin-binding domain interaction with F-actin.

Iwamoto DV, Huehn A, Simon B, Huet-Calderwood C, Baldassarre M, Sindelar CV, Calderwood DA.

Nat Struct Mol Biol. 2018 Oct;25(10):918-927. doi: 10.1038/s41594-018-0128-3. Epub 2018 Sep 17.

PMID:
30224736
3.

Novel ecto-tagged integrins reveal their trafficking in live cells.

Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA.

Nat Commun. 2017 Sep 18;8(1):570. doi: 10.1038/s41467-017-00646-w.

4.

Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.

Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA.

J Biol Chem. 2017 Feb 3;292(5):1884-1898. doi: 10.1074/jbc.M116.762393. Epub 2016 Dec 21.

5.

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.

Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66. doi: 10.1073/pnas.1608319113. Epub 2016 Jul 18.

6.

The Rap1-RIAM pathway prefers β2 integrins.

Calderwood DA.

Blood. 2015 Dec 17;126(25):2658-9. doi: 10.1182/blood-2015-09-668962. No abstract available.

7.

PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.

Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA.

J Cell Sci. 2016 Jan 15;129(2):380-93. doi: 10.1242/jcs.177493. Epub 2015 Nov 23.

8.

Regulation of integrin-mediated adhesions.

Iwamoto DV, Calderwood DA.

Curr Opin Cell Biol. 2015 Oct;36:41-7. doi: 10.1016/j.ceb.2015.06.009. Epub 2015 Jul 17. Review.

9.

CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.

Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA.

J Cell Biol. 2015 Mar 30;208(7):987-1001. doi: 10.1083/jcb.201407129.

10.

Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.

Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ.

J Biol Chem. 2015 Mar 27;290(13):8360-72. doi: 10.1074/jbc.M115.638874. Epub 2015 Feb 18.

11.

The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.

Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G.

PLoS Genet. 2014 Nov 13;10(11):e1004756. doi: 10.1371/journal.pgen.1004756. eCollection 2014 Nov.

12.

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290(1):409-22. doi: 10.1074/jbc.M114.618421. Epub 2014 Nov 11.

13.

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.

Huet-Calderwood C, Brahme NN, Kumar N, Stiegler AL, Raghavan S, Boggon TJ, Calderwood DA.

J Cell Sci. 2014 Oct 1;127(Pt 19):4308-21. doi: 10.1242/jcs.155879. Epub 2014 Aug 1.

14.

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.

Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W.

J Cell Sci. 2014 Sep 15;127(Pt 18):3928-42. doi: 10.1242/jcs.143537. Epub 2014 Jul 11.

15.

Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC.

Development. 2014 Apr;141(7):1465-72. doi: 10.1242/dev.104539. Epub 2014 Mar 5.

16.

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S.

J Clin Invest. 2014 Mar;124(3):1098-113. doi: 10.1172/JCI69778. Epub 2014 Feb 17. Erratum in: J Clin Invest. 2015 Feb;125(2):882.

17.

Cerebral cavernous malformation proteins at a glance.

Draheim KM, Fisher OS, Boggon TJ, Calderwood DA.

J Cell Sci. 2014 Feb 15;127(Pt 4):701-7. doi: 10.1242/jcs.138388. Epub 2014 Jan 30. Review.

18.

Integrin cytoplasmic tail interactions.

Morse EM, Brahme NN, Calderwood DA.

Biochemistry. 2014 Feb 11;53(5):810-20. doi: 10.1021/bi401596q. Epub 2014 Jan 27. Review.

19.

Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.

Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ.

PLoS One. 2013 Oct 28;8(10):e77818. doi: 10.1371/journal.pone.0077818. eCollection 2013.

20.

Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.

Brahme NN, Harburger DS, Kemp-O'Brien K, Stewart R, Raghavan S, Parsons M, Calderwood DA.

J Biol Chem. 2013 Dec 6;288(49):35604-16. doi: 10.1074/jbc.M113.483016. Epub 2013 Oct 28.

21.

ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.

Razinia Z, Baldassarre M, Cantelli G, Calderwood DA.

J Biol Chem. 2013 Nov 1;288(44):32093-105. doi: 10.1074/jbc.M113.496604. Epub 2013 Sep 19.

22.

Talins and kindlins: partners in integrin-mediated adhesion.

Calderwood DA, Campbell ID, Critchley DR.

Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17. Review.

23.

Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex.

Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ.

PLoS One. 2013;8(1):e55591. doi: 10.1371/journal.pone.0055591. Epub 2013 Jan 31.

24.

Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ.

Mol Cell. 2013 Feb 21;49(4):719-29. doi: 10.1016/j.molcel.2012.12.005. Epub 2013 Jan 11.

25.

Structural and functional characterization of the kindlin-1 pleckstrin homology domain.

Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS, Gilbert RJ.

J Biol Chem. 2012 Dec 21;287(52):43246-61. doi: 10.1074/jbc.M112.422089. Epub 2012 Nov 6.

26.

Zasp regulates integrin activation.

Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA.

J Cell Sci. 2012 Dec 1;125(Pt 23):5647-57. doi: 10.1242/jcs.103291. Epub 2012 Sep 19.

27.

Cell adhesion: a FERM grasp of the tail sorts out integrins.

Brahme NN, Calderwood DA.

Curr Biol. 2012 Sep 11;22(17):R692-4. doi: 10.1016/j.cub.2012.07.049.

28.

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension.

Coyer SR, Singh A, Dumbauld DW, Calderwood DA, Craig SW, Delamarche E, García AJ.

J Cell Sci. 2012 Nov 1;125(Pt 21):5110-23. doi: 10.1242/jcs.108035. Epub 2012 Aug 16.

29.

Structural basis for paxillin binding and focal adhesion targeting of β-parvin.

Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA, Boggon TJ.

J Biol Chem. 2012 Sep 21;287(39):32566-77. Epub 2012 Aug 6.

30.

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.

Baldassarre M, Razinia Z, Brahme NN, Buccione R, Calderwood DA.

J Cell Sci. 2012 Aug 15;125(Pt 16):3858-69. doi: 10.1242/jcs.104018. Epub 2012 May 17.

31.

Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ.

J Biol Chem. 2012 Jun 22;287(26):22317-27. doi: 10.1074/jbc.M112.361295. Epub 2012 May 10.

32.

Filamins in mechanosensing and signaling.

Razinia Z, Mäkelä T, Ylänne J, Calderwood DA.

Annu Rev Biophys. 2012;41:227-46. doi: 10.1146/annurev-biophys-050511-102252. Epub 2012 Feb 23. Review.

33.

Macrophage mesenchymal migration requires podosome stabilization by filamin A.

Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG, Maridonneau-Parini I.

J Biol Chem. 2012 Apr 13;287(16):13051-62. doi: 10.1074/jbc.M111.307124. Epub 2012 Feb 9.

34.

Functional differences between kindlin-1 and kindlin-2 in keratinocytes.

Bandyopadhyay A, Rothschild G, Kim S, Calderwood DA, Raghavan S.

J Cell Sci. 2012 May 1;125(Pt 9):2172-84. doi: 10.1242/jcs.096214. Epub 2012 Feb 10.

35.

FAK promotes recruitment of talin to nascent adhesions to control cell motility.

Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD.

J Cell Biol. 2012 Jan 23;196(2):223-32. doi: 10.1083/jcb.201108078. Erratum in: J Cell Biol. 2012 Feb 6;196(3):387.

36.

A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.

Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR, Calderwood DA.

J Biol Chem. 2012 Mar 2;287(10):6979-90. doi: 10.1074/jbc.M111.330845. Epub 2012 Jan 10.

37.

Talin and signaling through integrins.

Bouaouina M, Harburger DS, Calderwood DA.

Methods Mol Biol. 2012;757:325-47. doi: 10.1007/978-1-61779-166-6_20.

38.

The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain.

Razinia Z, Baldassarre M, Bouaouina M, Lamsoul I, Lutz PG, Calderwood DA.

J Cell Sci. 2011 Aug 1;124(Pt 15):2631-41. doi: 10.1242/jcs.084343. Epub 2011 Jul 12.

39.

Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.

Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, Baldassarre M, Erard M, Moog-Lutz C, Calderwood DA, Lutz PG.

J Biol Chem. 2011 Sep 2;286(35):30571-81. doi: 10.1074/jbc.M111.220921. Epub 2011 Jul 7.

40.

Kindlins.

Bouaouina M, Calderwood DA.

Curr Biol. 2011 Feb 8;21(3):R99-101. doi: 10.1016/j.cub.2010.12.002. No abstract available.

41.

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.

Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL.

EMBO J. 2010 Mar 17;29(6):1069-80. doi: 10.1038/emboj.2010.4. Epub 2010 Feb 11.

42.

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.

Chiswell BP, Stiegler AL, Razinia Z, Nalibotski E, Boggon TJ, Calderwood DA.

J Struct Biol. 2010 Apr;170(1):157-63. doi: 10.1016/j.jsb.2009.12.002. Epub 2009 Dec 4.

43.

Filamins regulate cell spreading and initiation of cell migration.

Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA.

PLoS One. 2009 Nov 13;4(11):e7830. doi: 10.1371/journal.pone.0007830.

44.

The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.

Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR.

J Mol Biol. 2009 Dec 18;394(5):944-56. doi: 10.1016/j.jmb.2009.09.061. Epub 2009 Oct 3.

45.

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.

Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ.

Mol Biol Cell. 2009 Jul;20(14):3224-38. doi: 10.1091/mbc.E08-12-1186. Epub 2009 May 20.

46.

The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C, Lutz PG.

Cell Death Differ. 2009 Jun;16(6):921-32. doi: 10.1038/cdd.2009.27. Epub 2009 Mar 20.

47.

Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.

Harburger DS, Bouaouina M, Calderwood DA.

J Biol Chem. 2009 Apr 24;284(17):11485-97. doi: 10.1074/jbc.M809233200. Epub 2009 Feb 23.

48.

The role of FilGAP-filamin A interactions in mechanoprotection.

Shifrin Y, Arora PD, Ohta Y, Calderwood DA, McCulloch CA.

Mol Biol Cell. 2009 Mar;20(5):1269-79. doi: 10.1091/mbc.E08-08-0872. Epub 2009 Jan 14.

49.

Integrin signalling at a glance.

Harburger DS, Calderwood DA.

J Cell Sci. 2009 Jan 15;122(Pt 2):159-63. doi: 10.1242/jcs.018093. Review. No abstract available. Erratum in: J Cell Sci. 2009 May 1;122(Pt 9):1472.

50.

The structural basis of integrin-linked kinase-PINCH interactions.

Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20677-82. doi: 10.1073/pnas.0811415106. Epub 2008 Dec 12.

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